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Design of functional biomaterials as substrates for corneal endothelium tissue engineering

Regenerative Biomaterials 2022年第1期9卷 1018-1036页

作者： Begona M.Bosch Elia Bosch-Rue marina perpiñan-blasco Roman A.Perez Bioengineering Institute of Technology(BIT) Universitat Internacional de CatalunyaBarcelona 08195Spain Basic Sciences Department Universitat Internacional de CatalunyaBarcelona 08195Spain

Corneal endothelium defects are one of the leading causes of blindness *** actual treatment is transplantation,which requires the use of human cadaveric donors,but it faces several problems,such as global shortage of ***,new alternatives are being developed and,among them,cell therapy has gained interest in the last years due to its promising results in tissue ***,the direct administration of cells may sometimes have limited success due to the immune response,hence requiring the combination with extracellular mimicking *** this review,we present different methods to obtain corneal endothelial cells from diverse cell sources such as pluripotent or multipotent stem ***,we discuss different substrates in order to allow a correct implantation as a cell sheet and to promote an enhanced cell *** this reason,natural or synthetic matrixes that mimic the native environment have been *** matrixes have been optimized in terms of their physicochemical properties,such as stiffness,topography,composition and *** further enhance the matrixes properties,these can be tuned by incorporating certain molecules that can be delivered in a sustained manner in order to enhance biological ***,we elucidate future directions for corneal endothelial regeneration,such as 3D printing,in order to obtain patient-specific substrates.

关键词： corneal endothelium tissue engineering cell therapy biomaterials

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Nanotechnology in aquaculture: Applications, perspectives and regulatory challenges

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Aquaculture and Fisheries 2022年第2期7卷 185-200页

作者： Carlos Fajardo Gonzalo Martinez-Rodriguez Julian blasco Juan Miguel Mancera Bolaji Thomas Marcos De Donato School of Tourism and Maritime Technology Polytechnic of Leiria(MARE-IPLeiria)Santuario de Nossa Senhora dos RemediosCampus 4Peniche2520-641Portugal Department of Biology Faculty of Marine and Environmental SciencesInstituto Universitario de Investi-gaci´on Marina(INMAR)Campus de Excelencia Internacional del Mar(CEI⋅MAR)University of Cadiz(UCA)Puerto Real11519Spain Institute of Marine Sciences of Andalusia(ICMAN) Department of Marine Biology and AquacultureSpanish National Research Council(CSIC)Puerto Real11519Spain Department of Biomedical Sciences Rochester Institute of TechnologyRochester14623USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaro76130Mexico

Aquaculture is considered one of the most important food production systems both in terms of economic impact and food security,and the ongoing development of this industry is a key factor in the strategy to guarantee global nutritional ***,different types of nanotechnology-based systems have been employed to increase its production,efficiency and *** efforts have been made in the fields of health management,enhancement of fish and shellfish development by dietary supplementation with nutraceuticals,but also in the processing and preservation of seafood and water treatment,among ***,nanotechnology has a significant role to play in the improvement of the efficiency and the environmental impact of this *** this perspective,we propose to review the current situation of nanotechnology in the field of aquaculture and fisheries,emphasizing not only in current applications,and future prospects,but also in the ethical and governance aspects associated with this topic.

关键词： Health management Nano-regulation Nutraceuticals Preservation of seafood Risk assessment

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