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Hepatocellular carcinoma and hepatitis C virus infection in Latin America: epidemiology, diagnosis and treatment

Hepatoma Research 2020年第5期6卷 1-18页

作者： marina galic.a-moreno Hugo Christian Monroy-Ramirez marina Campos-Valdez Jaime Sanchez-Meza Laura Sanchez-Orozco Juan Armendariz-Borunda University of Guadalajara Institute of Molecular Biology in Medicine and Gene TherapyDepartment of Molecular Biology and GenomicsHealth Science University Center(CUCS)Jalisco 44340Mexico Tecnologico de Monterrey Campus GuadalajaraJalisco 45138Mexico

Hepatocellular carcinoma(HCC)is the most common cancer associated with chronic liver disease and *** most common cause of HCC is chronic hepatitis C virus infection and many studies in Europe,Asia and North America have focused on its etiology,epidemiology,diagnostic tools,and therapeutic ***,little is known about these issues in Latin *** aim of this review is to address these aspects of HCC in Latin *** main risk factors associated with developing HCC in this region are:age,concomitant cirrhosis,hepatitis C infection,obesity and hereditary disease such as *** the other hand,screening tests and diagnostic methods of HCC are mostly serum alpha fetoprotein quantification,liver ultrasound,computed tomography,magnetic resonance,and *** diagnostic methods include gut microbiota analysis and the use of nanotechnology and they continue to be ***,according to the Barcelona Clinic Liver Cancer,curative treatments used in HCC patients are mainly liver resection,liver transplantation,and local ablation,each with advantages and *** conclusion,clear strategies are urgently needed to understand the extent of HCC and related problems in this part of the *** review provides greater knowledge of HCC for the proper design of preventive programs by taking into consideration specific characteristics of our ***,this review allows for an understanding of individualizing treatments according to the patient’s needs.

关键词： Liver hepatitis C epidemiology diagnosis treatment hepatocellular carcinoma Latin America

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Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients

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World Journal of Hepatology 2021年第2期13卷 218-232页

作者： Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos marina galic.a-moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes Liver Pancreas and Motility LaboratoryUnit of Experimental MedicineSchool of MedicineGeneral Hospital of MexicoUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Department of Molecular Biology and Genomics Institute of Molecular Biology in Medicine and Gene TherapyHealth Science University CenterUniversity of GuadalajaraGuadalajara 06726Mexico Department of Gastroenterology General Hospital of Mexico“Dr.Eduardo Liceaga”Mexico City 06726Mexico Department of General Surgery General Hospital of Mexico“Dr.Eduardo Liceaga”School of MedicineUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Hepatology and Liver Transplant National Institute of Medical Sciences and Nutrition“Salvador Zubirán”Mexico City 06726Mexico University Hospital“Dr.JoséEleuterio González ”Autonomous University of Nuevo LeonMonterrey 06726Mexico

BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the ***,there are few studies on the regulation of liver MMPs in fibrosis progression in *** To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was *** patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array *** were validated by the Kruskal-Wallis and Mann-Whitney U *** Spearman correlation coefficient and area under the receiver operating characteristic curve were *** and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot *** Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy ***-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis *** inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis *** could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC.

关键词： Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C Fibrogenesis Fibrolysis

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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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Journal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria Teresa moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David J. Fink marina Mata Kinichi Nakashima Xavier Navarro Francisco Javier Rodríguez Michal Schwartz Mikael Svensson Erik Sundstrom Joan Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Injury Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Injury Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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Antitumor effects of electrochemical treatment

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Chinese Journal of Cancer Research 2013年第2期25卷 223-234页

作者： Héctor Manuel Camué Ciria Maraelys Morales González Lisset Ortíz Zamora Luis Enrique Bergues Cabrales Gustavo Victoriano Sierra González Luciana Oliveira de Oliveira Rodrigo Zanella Antonio Carlos Buzaid Orlando Parise Luciana Macedo Brito Cesar Augusto Antunes Teixeira marina das Neves Gomes Gleyce moreno Venicio Feo da Veiga Marcos Telló Carla Holandino Research Department National Centre of Applied Electromagnetism Oriente University Pharmacy Department Oriente University Finlay Institute La lisa. La Habana Cuba Veterinary Teaching Hospital Federal University of Rio Grande do Sul. Porto Alegre Sírio e Libanês Hospital Faculty of Pharmacy Medicine Department Federal University of Rio de Janeiro Professor Paulo de Góes Institute of Microbiology Federal University of Rio de Janeiro Pontifical Catholic University of Rio Grande do Sul. Porto Alegre

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the anfitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor ceils. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods.

关键词： Direct electric current electrochemical treatment antimmoral treatment tumor tumor electrolysis rumor entropy dissipative structure

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Temporal Variation of the Pelagic Copepod Community in Acapulco Bay, México

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Open Journal of Marine Science 2016年第1期6卷 40-48页

作者： Agustín A. Rojas-Herrera Juan Violante-González Sergio García-Ibáñez Salvador Villerías-Salinas Giovanni moreno-Díaz Unidad Académica de Ecología marina Universidad Autónoma de Guerrero Acapulco México Centro de Investigación y Posgrado en Estudios Socioterritoriales Universidad Autónoma de Guerrero Chilpancingo México

Between September 2009 and April 2010, superficial samples of plankton were collected in Acapulco Bay, using 150-μm mesh net, with the objective of studying the temporal variation in the abundance, species composition of the copepod community, and their relationship with some environmental parameters. Twenty-nine species of four orders were identified: 11 of Calanoida, 4 of Cyclopoida, 3 of Harpacticoida and 11 of Poecilostomatoida. A multivariate analysis (PCA) used to detect association between the abundance of copepod populations, and the environmental conditions through time, indicates a marked effect of the temperature and salinity parameters, on the abundance of the four copepod groups. The calanoids dominated numerically during most of the sampling months. The more important copepods genus were Corycaeus (7 species), andOithona (4 species). Nevertheless that the abundance of all copepod groups was affected temporarily by variations in the environmental conditions, the species composition inside the copepods community remained very stable.

关键词： Copepod Community Temporal Variation Acapulco Bay Mexico

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Temporal Variation in Composition and Abundance of Phytoplankton Species during 2011 and 2012 in Acapulco Bay,Mexico

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Open Journal of Marine Science 2015年第3期5卷 358-367页

作者： Giovanni moreno-Díaz Agustín A. Rojas-Herrera Juan Violante-González Justiniano González-González Jose Luis Rosas Acevedo Sergio García Ibánez Unidad de Ciencias de Desarrollo Regional Universidad Autónoma de GuerreroAcapulcoMéxico Unidad Académica de Ecología marina Universidad Autónoma de GuerreroAcapulcoMéxico

Phytoplankton samples were collected in Acapulco Bay during 2011 (January-April and September) and 2012 (April-July, October, and November) with the objective of determining the abundance and species composition. Samples were collected in two stations located in the bay. A total of 82 species were identified: 42 dinoflagellates, 35 diatoms, three cyanobacteria, and two silicoflagellates. Dinoflagellates were more abundant in the dry season, while diatoms dominated during rainy season. At least seven dinoflagellate species were recorded as potentially toxic, which may increase their populations and turn into harmful algal blooms (HABs) if environmental conditions within the bay are modified. In April 2012 a HAB of the non-toxic species Neoceratium balechii was documented.

关键词： Marine Phytoplankton Species Composition Acapulco Bay Mexico

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