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Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Silver impregnated carbon for adsorption and desorption of elemental mercury vapors

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Journal of Environmental Sciences 2011年第9期23卷 1578-1583页

作者： Despina Karatza marina Prisciandaro Amedeo Lancia Dino Musmarra Dipartimento di Ingegneria Chimica Universitàdi Napoli "Federico II" Dipartimento di Chimica Ingegneria Chimica e MaterialiUniversitàde L’Aquila centro Interdipartimentale di Ricerca in Ingegneria Ambientale Dipartimento di Ingegneria CivileSeconda Universitàdegli Studi di NapoliReal Casa dell’AnnunziataVia Roma 2981031 Aversa (CE)Italy

The Hg 0 vapor adsorption experimental results on a novel sorbent obtained by impregnating a commercially available activated carbon （Darco G60 from BDH） with silver nitrate were *** study was performed by using a fundamental approach,in an apparatus at laboratory scale in which a synthetic flue gas,formed by Hg 0 vapors in a nitrogen gas stream,at a given temperature and mercury concentration,was flowed through a fixed bed of adsorbent *** curves and adsorption isotherms were obtained for bed temperatures of 90,120 and 150°C and for Hg 0 concentrations in the gas varying in the range of 0.8–5.0 mg/m 3 .The experimental gas-solid equilibrium data were used to evaluate the Langmuir parameters and the heat of *** experimental results showed that silver impregnated carbon was very effective to capture elemental mercury and the amount of mercury adsorbed by the carbon decreased as the bed temperature *** addition,to evaluate the possibility of adsorbent recovery,desorption was also *** runs showed that both the adsorbing material and the mercury could be easily recovered,since at the end of desorption the residue on solid was almost *** material balance on mercury and the constitutive equations of the adsorption phenomenon were integrated,leading to the evaluation of only one kinetic parameter which fits well both the experimentally determined breakthrough and desorption curves.

关键词： mercury carbon MSW incinerators adsorption desorption silver nitrate

A pilot study of the relative number of circulating tumor cells and leukocytes containing actin-binding proteins in head and neck cancer patients

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The Journal of Biomedical Research 2023年第3期37卷 213-224页

作者： Gelena Kakurina marina Stakheeva Elena Sereda Evgenia Sidenko Olga Cheremisina Evgeny Choinzonov Irina Kondakova Cancer Research Institute Tomsk National Research Medical CenterRussian Academy of SciencesTomsk 634009Russia Department of Biochemistry and Molecular Biology Faculty of Medicine and BiologySiberian State Medical UniversityTomsk 634050Russia.

Circulating tumor cells(CTCs)play an important role in tumor metastases,which is positively correlated with an increased risk of ***-binding proteins,including cofilin(CFL1),profilin 1(PFN1),and adenylate cyclase-associated protein 1(cap1),are thought to be involved in tumor cell motility and metastasis,specifically in head and neck squamous cell carcinoma(HNSCC).However,currently,there are no published studies on CFL1,PFN1,and cap1 in CTCs and leukocytes in HNSCC *** assessed serum levels of CFL1,PFN1,and cap1 and the number of CTCs and leukocytes containing these proteins in blood from 31 HNSCC patients(T1-4N0-2M0).The analysis used flow cytometry and an enzyme-linked immunosorbent assay *** found that cap1+CTCs and cap1+leukocyte subpopulations were prevalent in these HNSCC patient samples,while the prevalence rates of CFL1+and PFN1+CTCs were relatively *** with stage T2-4N1-2M0 had CFL1+and PFN1+CTCs with an elevated PFN1 serum level,compared with the T1-3N0M0 *** summary,the PFN1 serum level and the relative number of PFN1+CD326+CTCs could be valuable prognostic markers for HNSCC *** current study is the first to obtain data regarding the contents of actin-binding proteins(ABPs)in CTCs,and leukocytes in blood from HNSCC *** is also the first to assess the relationship between the number of CTCs subgroups and disease characteristics.

关键词： head and neck squamous cell carcinoma metastasis circulating tumor cells actin-binding proteins adenylyl cyclase-associated protein 1

Diffusion of Solar Energy Use in the Built Environment Supported by New Design

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Journal of Civil Engineering and Architecture 2014年第2期8卷 253-260页

作者： marina van Geenhuizen Joop Schoonman Angèle Reinders Faculty of Technology Policy and Management Delft University of Technology Delft 2628 CE The Netherlands Faculty of Applied Sciences Delft University of Technology Delft 2628 CE The Netherlands Faculty of Engineering Technology Univiversity of Twente Enschede 7500 AR The Netherlands Faculty of lndustrial Design Engineering Delft University of Technology Delft 2628 CE The Netherlands

Places of large potentials of sustainable energy production and places of large energy consumption are often very different and separated by large distances across the globe. This paper first discusses potentials of solar technology in terms of global availability using PV （photovoltaic） technology and actual energy production. Solar energy is widely under-used and one way to reduce this is to improve production in low-energy places with high demand： large cities. According to this option, about 40% of the electricity consumption in the built environment could be produced by solar PV systems and energy storage systems. This paper discusses conditions in the built environment and functional and design qualities enabling an increased diffusion of the technologies In a comparative analysis of PV technologies, the criteria taken into account encompass efficiency of the type of solar cell and commercial availability. Special attention is paid to the design features of different PV systems, like flexibility, colour and transparency that might help in their utilization as integrated in building material and ornaments in modem architecture. The same procedure is followed for electricity storage devices. The preliminary conclusion is that at present the freedom of design is largest for a combination of crystalline silicon PV cells and Li-ion batteries.

关键词： Solar PV energy systems battery storage systems design qualities built environment.

Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

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Neural Regeneration Research 2021年第4期16卷 780-786页

作者： Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton Postgraduation Program in Biochemistry Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Pharmaceutical Science Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Biochemistry and Bioprospecting Federal University of Pelotas(UFPEL)Capão do LeãoRSBrazil

Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s ***,there is data suggesting that inflammation plays a role in its development and ***,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease *** purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in *** were prepared by the nanoprecipitation *** Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in *** the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in ***,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition ***,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 *** study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 *** study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(app

关键词： Alzheimer’s disease curcumin cyclooxygenase-2 lipid core nanocapsules meloxicam memory rats inflammation

Differences in Trace Element Content between Non-Indigenous Farmed and Invasive Bivalve Mollusks of the South African Coast

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American Journal of Analytical Chemistry 2015年第11期6卷 886-897页

作者： Dmitry F. Pavlov Jacques Bezuidenhout marina V. Frontasyeva Zoya I. Goryainova I. D. Papanin Institute of the Biology of Inland Waters Borok Russian Federation Faculty of Military Science Physics Department Stellenbosch University Saldanha South Africa Joint Institute for Nuclear Research Moscow Region Russian Federation

contents of 23 trace elements (Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Br, Rb, Sr, Mo, Ag, Sb, I, Ba, La, ce, Sm, Eu, Hf, Ta) were quantitatively determined in soft tissues and shells of mass non-indigenous bivalve mussels—farmed Pacific oysters (Crassostrea gigas) and farmed and wild invasive Mediterranean mussels (Mytilus galloprovincialis) at the Atlantic coast of South Africa. The study revealed that the contents of the majority of elements in the soft tissues of both species were higher than those in the shells. The tissues of wild invasive Mediterranean mussels contain higher levels of a range of trace elements comparing to farmed mussels. The tissues of Pacific oysters contain much higher levels of almost all elements studied compared to the tissues of Mediterranean mussels. Higher content of zinc in the mussels and oysters from Saldanha Bay may evidence anthropogenic pollution of the bay’s ecosystem by this metal, which necessitates continued monitoring of levels of potentially toxic metals. Both alien species, and especially Pacific oysters, may serve as reliable biomonitors for trace elements in marine ecosystems. Both species are rich in essential elements and provide nutritionally-valuable seafoods.

关键词： Invasive Bivalve Mollusks Chemical Composition Crassostrea gigas Mytilus galloprovincialis Aquaculture Water Quality South Africa

Assessment of Minor and Trace Elements in Aquatic Macrophytes, Soils and Bottom Sediments Collected along Different Water Objects in the Black Sea Coastal Zone by Using Neutron Activation Analysis

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American Journal of Analytical Chemistry 2017年第4期8卷 225-244页

作者： Pavel Nekhoroshkov Alexandra Kravtsova Alexander Kamnev Olga Bun’kova Octavian Duliu marina Frontasyeva Igor Yermakov Frank Laboratory of Neutron Physics Joint Institute for Nuclear Research Dubna Russia Faculty of Biology Lomonosov Moscow State University Moscow Russia Faculty of Soil Science Lomonosov Moscow State University Moscow Russia Department of the Structure of Matter Earth and Atmospheric Physics and Astrophysics Faculty of Physics University of Bucharest Bucharest Romania

The levels and compartmentalization of Na, Mg, Al, Cl, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Zn, As, Se, Br, Rb, Sr, Mo, Sb, I, Cs, Ba, La, ce, Sm, Eu, Tb, Hf, Ta, Au, Th, and U in Phragmites australis (Cav.) Trin. ex Steud., Carex conescens L. and Cladophora sericea (Hudson) Kutzing from the Caucasian coast of the Black Sea-Anapa recreational region was investigated by Neutron Activation Analysis. The study touches upon subject of the sediment-to-plant and root-to-leaf elemental transfer as well as of the influence of anthropogenic pollution on wetland ecosystems in zone of resort. The content of the majority of considered elements was found higher in the belowground organs of P. australis than in the aboveground tissues while a reverse regularity was evidenced for C. conescens. The levels of elements decrease from bottom sediments to aquatic plants with the notable exception of the halogens Cl, Br and I that presented 5 to 100 fold higher content in plants than in sediments. The increased levels of As, Mo, and Sb in some soil and sediment samples most probably indicate the anthropogenic pollution. It recommends them for a continuous monitoring of the same area.

关键词： Trace Elements Neutron Activation Analysis The Black Sea Phragmites Australis (Cav.) Trin. ex Steud. Carex conescens L. Cladophora sericea (Hudson) Kutzing

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic marina Konopleva Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Department of cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance Dana-Farber Cancer Institute BostonMAUSA Department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina Department of Lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

脱落酸介导的逆境响应信号传导系统及在藻类中的分布与功能

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海洋科学集刊 2016年第1期 77-85页

作者：牛建峰王霞余斌王广策中国科学院海洋研究所实验海洋生物学重点实验室青岛海洋科学与技术国家实验室海洋生物与生物技术实验室中国科学院大学

植物激素是一类由植物合成的痕量有机物质,调控着植物的生长发育及对环境的适应。藻类属低级植物类群,且具有与高等植物类似的激素类型,相对而言,藻类中激素含量更少,却发挥着更高效的生理活性。无论针对藻类还是高等陆地植物,胁迫响应... 详细信息

植物激素是一类由植物合成的痕量有机物质,调控着植物的生长发育及对环境的适应。藻类属低级植物类群,且具有与高等植物类似的激素类型,相对而言,藻类中激素含量更少,却发挥着更高效的生理活性。无论针对藻类还是高等陆地植物,胁迫响应研究一直是十分活跃的领域。其中,脱落酸(abscisic acid,ABA)作为应激激素,所起的调节作用已得到人们的普遍共识。本文总结了近年来ABA在藻类中的分布,ABA对抗氧化酶系的调控,ABA信号传导路径在陆地植物中的发现与代谢机制,以及利用蛋白质分子系统学对ABA信号传导途径的起源与进化。在此基础上提出:未来藻类ABA参与的抗逆代谢调控研究应着重以潮间带海藻为材料,参考陆地植物研究的成果,应用生物信息学,结合生物化学等手段,进行相关机制的探索。

关键词：植物激素 ABA 活性氧逆境响应信号传导