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Combined effects of oncolytic vaccinia virus and dendritic cells on the progression of melanoma B16-F10 in mice

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 67-80页

作者： Elena P.Goncharova Tatiana A.Gamburg Oleg V.Markov marina a.zenkova Laboratory of Biochemistry of Nucleic Acid Institute of Chemical Biology and Fundamental Medicine SB RASNovosibirsk 630090Russia Faculty of natural science Novosibirsk State UniversityNovosibirsk 630090Russia

Aim:We aimed to test the hypothesis that loading of dendritic cells(DCs)with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic ***:Vaccinia virus LIVP/GFP and melanoma B16-F10 were used in this *** were pulsed with various combinations of viral and tumor-associated *** maturation status of DCs was verified by expression of the markers CD80,CD86,and CCR7 and assessment of IL-6,TNF-α,and IL-12 *** most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T *** therapy using vaccinia virus LIVP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor ***:We found that loading of DCs with viral antigens,or with a combination of viral and tumor antigens,resulted in similar levels of expression of DC maturation *** maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia virus LIVP/GFP infected tumor *** results show that the combination of vaccinia virus LIVP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than ***:Combination therapy with oncolytic vaccinia virus LIVP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10,but no synergistic antitumor effects were *** propose that optimization of the therapy regimen could enhance the efficiency of combination therapy.

关键词： Oncolytic virus vaccinia virus melanoma B16 dendritic cells cytotoxic T lymphocytes cancer immunotherapy

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