检索结果-南通市图书馆

城市环境设计 2010年第Z1期 224-229页

作者： Saa Begovi Marko Dabrovi Tatjana Grozdani Begovi Silvije Novak Ljerka Vui marin mikeli 3LHD

关键词：体育馆巴勒

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

萨格勒布舞蹈中心

城市环境设计 2010年第Z1期 252-255页

作者： Saa Begovi Marko Dabrovi Tatjana Grozdani Begovi Silvije Novak Jasminka Jug Zorislav Petri Zeljko Mohorovi Dijana Vandekar marin mikeli 3LHD

关键词：萨格勒布克罗地亚 LHD

New opportunities for light-based tumor treatment with an“iron fist”

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第4期11卷 457-459页

作者： Riccardo marin Erving Ximendes Daniel Jaque Nanomaterials for Bioimaging Group(NanoBIG) Departamento de Ffsica de MaterialesFacultad de CienciasUniversidad Aut6noma de MadridMadrid 28030Spain

The efficacy of photodynamic treatments of tumors can be significantly improved by using a new generation of nanoparticles that take advantage of the unique properties of the tumor microenvironment.

关键词： protective light treatment

A Simple and Efficient Structural Topology Optimization Implementation Using Open-Source Software for All Steps of the Algorithm:Modeling, Sensitivity Analysis and Optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第8期136卷 1371-1397页

作者： Rafael marin Ferro Renato Pavanello Coordination of Mechanical Engineering Federal Institute of Science and Technology of ES-IFESAracruz-ES29192-733Brazil Department of Computational Mechanics Faculty of Mechanical EngineeringUnicampCampinas-SP13083-860Brazil

This work analyzes the implementation of a continuous method of structural topology optimization(STO)using open-source software for all stages of the topology optimization problem:modeling,sensitivity analysis and *** implementation involves three main components:numerical analysis using the Finite Element Method(FEM),sensitivity analysis using an Adjoint method and an optimization *** order to allow the automated numerical solution of Partial Differential Equations(PDEs)and perform a sensitivity analysis,FEniCS and Dolfin Adjoint software are used as tools,which are open-source *** the optimization process,Ipopt(Interior Point OPTimizer)is used,which is a software package for nonlinear optimization scale designed to find(local)solutions of mathematical optimization *** topological optimization method used is based on the SIMP-Solid IsotropicMaterial with Penalization *** considered problem is the minimization of compliance/maximization of stiffness,considering the examples of recurrent structures in the literature in 2D and 3D.A density filtering algorithm based on Helmholtz formulation is *** complete code involves 51 lines of programming and is presented and commented in detail in this article.

关键词： Structural topology optimization finite element method FEniCS Dolfin Adjoint

How we have learned about the complexity of physiology,pathobiology and pharmacology of bile acids and biliary secretion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第37期14卷 5617-5619页

作者： Jose JG marin Laboratory of Experimental Hepatology and Drug Targeting CIBERehd University of SalamancaSalamanca 37007 Spain

During the last decades the concept of bile secretion as merely a way to add detergent components to the intestinal mixture to facilitate fat digestion/absorption and to eliminate side products of heine metabolism has evolved considerably. In the series of mini-reviews that the World Journal of Gastroenterology is to publish in its section of ＂Highlight Topics＇; we will intend to give a brief but updated overview of our knowledge in this field. This introductory letter is intended to thank all scientists who have contributed to the development of this area of knowledge in gastroenterology.

关键词： Bile flow Cholestasis Hepatocyte Liver Transport

Thickness-dependent wrinkling of PDMS films for programmable mechanochromic responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2020年第7期13卷 1882-1888页

作者： Zhiwei Li Yun Liu Melinda marin Yadong Yin Department of Chemistry University of CaliforniaRiversideCA 92521USA

We report a remarkable thickness-dependent wrinkling behavior of oxygen plasma-treated polydimethylsiloxane(PDMS)flms,in which an energy barrier separates the wrinkling mechanics into two *** thick films,the film wrinkles with a constant periodicity which can be precisely predicted by the classic nonlinear finite *** the film thickness below 1 mm leads to nonuniform wrinkles with an increasing periodicity which gives rise to random scattering and transparency changes under mechanical *** tuning the flm thickness,we were able to control both the quality and size of the periodic wrinkles and further design mechanochromic devices featuring briliant structural colors and programmable colorimetric *** work sheds light on the fundamental understanding of the wrinkling mechanics of bilayer systems and their intriguing mechanochromic applications.

关键词： wrinkle polydimethylsiloxane(PDMS) structural colors mechanochromic thickness-dependent

Survey on Simulation for Mobile Ad-Hoc Communication for Disaster Scenarios

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2016年第2期31卷 326-349页

作者： Erika Rosas Nicolas Hidalgo Veronica Gil-Costa Carolina Bonacic Mauricio marin Hermes Senger Luciana Arantes CesarMarcondes Olivier marin Department of Informatics Engineering University of Santiago Santiago 9170022 Chile National Council of Scientific and Technical Research National University of San Luis San Luis 5700 Argentina Department of Computer Science Federal University of Sao Carlos Sao Carlos 13565-905 Brazil Laboratoire d'Informaique de Paris 6 University of Pierre and Marie C'urrie Sorbonne Universitds UIVttS 11VRIA Paris 75005 France Engineering and Computer Science New York University Shanghai Shanghai 200122 China

Mobile ad-hoc communication is a demonstrated solution to mitigate the impact of infrastructure failures during large-scale disasters. A very complex issue in this domain is the design validation of software applications that support decision-making and communication during natural disasters. Such disasters are irreproducible, highly unpredictable, and impossible to scale down, and thus extensive assessments cannot be led in situ. In this context, simulation constitutes the best approach towards the testing of software solutions for natural disaster responses. The present survey reviews mobility models, ad-hoc network architectures, routing protocols and network simulators. Our aim is to provide guidelines for software developers with regards to the performance evaluation of their applications by means of simulation.

关键词： mobile ad-hoc communication simulation disaster scenario mobility model

Generating native user interfaces for multiple devices by means of model transformation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2015年第12期16卷 995-1017页

作者： Ignacio marin Francisco ORTIN German PEDROSA Javier RODRIGUEZ Department of Research and Development CTIC Foundation Department of Computer Science University of Oviedo

In the last years, the types of devices used to access information systems have notably increased using different operating systems, screen sizes, interaction mechanisms, and software features. This device fragmentation is an important issue to tackle when developing native mobile service front-end applications. To address this issue,we propose the generation of native user interfaces(UIs) by means of model transformations, following the modelbased user interface(MBUI) paradigm. The resulting MBUI framework, called LIZARD, generates applications for multiple target platforms. LIZARD allows the definition of applications at a high level of abstraction, and applies model transformations to generate the target native UI considering the specific features of target platforms. The generated applications follow the UI design guidelines and the architectural and design patterns specified by the corresponding operating system manufacturer. The objective is not to generate generic applications following the lowest-common-denominator approach, but to follow the particular guidelines specified for each target device. We present an example application modeled in LIZARD, generating different UIs for Windows Phone and two types of Android devices(smartphones and tablets).

关键词： Model-to-model transformation Native user interfaces Model-based user interfaces Model-driven engineering

Less is more:dimensionality reduction as a general strategy for more precise luminescence thermometry

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第9期11卷 2127-2139页

作者： ERVING XIMENDES RICCARDO marin LUIS DIAS CARLOS DANIEL JAQUE NanoBIG Departamento de Fisica de MaterialesFacultad de CienciasUniversidad Autónoma de MadridC/Francisco Tomás y Valiente 7Madrid 28049Spain NanoBIG Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Ctra.Colmenar km.9.100Madrid 28034Spain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of AveiroAveiro 3810-193Portugal

Thermal resolution(also referred to as temperature uncertainty)establishes the minimum discernible temperature change sensed by luminescent thermometers and is a key figure of merit to rank *** has been done to minimize its value via probe optimization and correction of readout artifacts,but little effort was put into a better exploitation of calibration *** this context,this work aims at providing a new perspective on the definition of luminescence-based thermometric parameters using dimensionality reduction techniques that emerged in the last *** application of linear(Principal Component Analysis)and non-linear(t-distributed Stochastic Neighbor Embedding)transformations to the calibration datasets obtained from rare-earth nanoparticles and semiconductor nanocrystals resulted in an improvement in thermal resolution compared to the more classical intensity-based and ratiometric ***,in turn,enabled precise monitoring of temperature changes smaller than 0.1℃.The methods here presented allow choosing superior thermometric parameters compared to the more classical ones,pushing the performance of luminescent thermometers close to the experimentally achievable limits.

关键词： precise dimensionality luminescence

Targeting Janus tyrosine kinase 3 （JAK3） with an inhibitor induces secretion of TGF-β by CD4＋ T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2012年第4期9卷 350-360页

作者： marina Cetkovic-Cvrlje marin Olson Ketaki Ghate Department of Biological Sciences St. Cloud State University St. Cloud MN USA Laboratory for Immunology St. Cloud State University St. Cloud MN USA

Regulatory T cells （Tregs） are critical for the peripheral maintenance of the autoreactive T cells in autoimmune disorders such as type 1 diabetes （TID）. Pharmacological inhibition of Janus tyrosine kinase 3 （JAK3） has been proposed as a basis for new treatment modalities against autoimmunity and allogeneic responses. Targeting JAK3 with an inhibitor has previously been shown to exhibit protective action against the development of T 1D in non-obese diabetic （NOD） mice. As the mechanism of such preventative action has been unknown, we hypothesized that JAK3 inhibition induces generation of Tregs. Here, we show that the JAK3 inhibitor 4-（4＇-hydroxyphenyl）-amino-6,7-dimethoxyquinazoline （WHI-P131） suppresses proliferation of short-term cultured NOD CD4＋ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It was found that the surviving cells were not of the CD4＋CD25＋FoxP3＋ phenotype. They secreted decreased amounts of IL-IO, IL-4 and interferon （IFN）-y compared to the cells not exposed to the optimal concentrations of JAK3 inhibitor. However, an elevated transforming growth factor （TGF）-β secretion was detected in their supernatants. In vivo treatment of prediabetic NOD mice with WHI-P131 did not affect the frequency and number of splenic and pancreatic lymph node CD4＋FoxP3＋ Tregs, while generating an elevated numbers of CD4＋FoxP3- TGF-β-secreting T cells. In conclusion, our data suggest an induction of TGF-β-secreting CD4＋ T cells as the underlying mechanism for antidiabetogenic effects obtained by the treatment with a JAK3 inhibitor. To our knowledge, this is the first report of the JAK3 inhibitor activity in the context of the murine Tregs.

关键词： FoxP3 Janus tyrosine kinase 3 (JAK3) inhibition regulatory T cells (Tregs) TGF-β type 1 diabetes (TID)