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Anterior Segment Optical Coherence Tomography Indices and Their Value in Diagnosing Corneal Ectasia

Open Journal of Ophthalmology 2021年第4期11卷 313-324页

作者： Angel atanassov Marieta Konareva-Kostianeva marin atanassov Department of Ophthalmology Faculty of Medicine Medical University Plovdiv Bulgaria

Purpose: To determine the diagnostic value of the anterior segment optical coherence tomography (AS-OCT) indices in differentiating normal from ectatic corneas. Material and Methods: Two groups of patients—with corneal ectasia and normal controls were compared. Each group consists of 80 eyes of 43 age and sex-matched patients. All of them underwent corneal topography with OCULUS Keratograph 5M and corneal pachymetry with AS-OCT with RTVue-100. The indices generated by the AS-OCT pachymetric scans were analyzed. Results: There was a statistically significant difference for all the examined indices between the two groups with p values Conclusion: The anterior segment OCT indices showed excellent capability in differentiating ectatic from normal corneas.

关键词： Keratoconus Corneal Ectasia Marginal Pellucid Degeneration Anterior Segment OCT Pachymetry

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Optical Coherence Tomography Parameters in Preperimetric Open-Angle Glaucoma

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Open Journal of Ophthalmology 2018年第2期8卷 106-119页

作者： Snezhina Stefanova Kostianeva-Zhelinska Marieta Konareva-Kostianeva marin atanassov Department of Ophthalmology Medical University Plovdiv Plovdiv Bulgaria

Purpose: To evaluate the measurements of the peripapillary retinal neurofiber layers (RNFL) and the ganglion cells complex (GCC) obtained by Optical Coherence Tomography (OCT) in eyes with preperimetric open-angle glaucoma. Methods: One hundred and forty eyes of 75 patients (21 male and 54 female), 80 eyes with preperimetric glaucoma (PPG) (45 patients) and 60 normal eyes (30 subjects) were included in this study. Automated visual field examination was done to all participants using Humphrey field analyzer, program 30-2. The GCC thickness and peripapillary RNFL thickness were measured using RTVue-100 (Optivue, Inc., Fremont, CA). The areas under ROC (receiver operating characteristic)—curves (AUCs) were defined for all examined GCC and RNFL parameters. Results: GCC of the eyes with PPG was significantly thinner than GCC of the normal eyes: (89.58 vs 97.82 microns, P < 0.001). There was no significant difference between upper and lower GCC halves in both study groups. We found a reduction of RNFL thickness in glaucomatous eyes (P < 0.001) compared with normals. AUCs for GCC parameters in eyes with PPG were larger than AUCs for RNFL parameters. Conclusion: Our study showed that the peripapillary RNFL and GCC thickness are lower in preperimetric glaucoma than in normal eyes. Despite the fact that GCC measurements (especially GLV) show better AUC than peripapillary measurements, we suggest that two scans (GCC and ONH) put together are superior in detecting early structural glaucomatous damage. Several diagnostic parameters should be considered in the clinical diagnosis of preperimetric glaucoma.

关键词： Optical Coherence Tomography Preperimetric Glaucoma Retinal Nerve Fiber Layer Ganglion Cell Complex

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Aplication of <i>in Vivo</i>Confocal Microscopy in Ophtalmology—Overview

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Open Journal of Ophthalmology 2021年第1期11卷 60-90页

作者： Ralitsa Kermedchieva Marieta Konareva-Kostianeva marin atanassov Vesela Mitkova-Hristova Nina Stoyanova Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria

Confocal microscopy is a method which has been increasingly used over the last decade in the study of the anterior ocular surface. The method allows testing and in vivo high resolution imaging of the structures of the anterior eye segment, at a cellular level, which is close to the histological examination of tissues. The data provided by this method allow for a better understanding of both the functional and pathological processes occurring in the anterior ocular surface not only for scientific purposes but also in clinical practice. The aim of the present work is to summarize the current knowledge and applications of confocal microscopy of the anterior ocular surface.

关键词： Confocal Microscopy Ocular Surface Cornea Corneal Dystrophies Keratitis Trabeculectomy

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