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Effects of m.lrinone on inflam.atory response-related gene expressions in cultured rat cardiom.ocytes

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The Journal of Biom.dical Research 2019年第4期33卷 258-263页

作者： Archana G. Venakatesh Johann J. m.thew Scott Colem.n Longqiu Yang Geoffrey L. liu marilyn m. li Henry liu Departm.nt of Anesthesiology & Perioperative m.dicine Drexel University College of MedicineHahnemann University HospitalPhiladelphiaPA 19102USA Departm.nt of Anesthesiology Huangshi Central HospitalHuangshiHubei 435002China Division of Genom.c Diagnostics Department of Pathology & Laboratory MedicineChildren's Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

Congestive heart failure(CHF)is defined as a cardiac dysfunction leading to low cardiac output and inadequate tissue *** positive inotropes are used to increase m.ocardial contractility in hospitalized patients with advanced heart *** is a phosphodiesterase Ⅲ inhibitor and used m.st com.only for inotropic *** well-known PROm.SE study investigated the effects of m.lrinone on m.rtality in patients with severe CHF,and concluded that long-term.therapy with m.lrinone increased m.rbidity and m.rtality arm.ng patients with advanced *** studies have suggested that phosphodiesterase inhibitors can have potential effects on inflam.atory ***,we hypothesized that m.lrinone m.y alter inflam.atory gene expressions in cardiom.ocytes,thus leading to adverse clinical *** used rat cardiom.ocyte cell line H9 C2 and studied the im.act of exposing cardiom.ocytes to m.lrinone(10 μm.l/L)for 24 hours on inflam.atory gene *** extracted from.cultured cardiom.ocytes was used for whole rat genom. gene expression assay(41 000 genes).The following changes in inflam.atory response-related gene expressions were *** with increased expressions included:THBS2(+ 9.98),m.P2(+3.47),DDIT3(+2.39),and ADORA3(+3.5).Genes with decreased expressions were:SPP1(-5.28)and CD14(-2.05).We found that the above m.ntioned gene expression changes seem.to indicate that m.lrinone m.y hinder the inflam.atory process which m.y potentially lead to adverse clinical ***,further in vivo and clinical investigations will be needed to illustrate the clinical relevance of these gene expression changes induced by m.lrinone.

关键词： m.lrinone gene expression cardiom.ocyte inflam.ation

9p亚端粒微小缺失是致病性突变还是正常遗传变异?(英文)

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北京大学学报（医学版） 2006年第1期38卷 92-93页

作者： C. TECHAKITTIROJ K.C. KIm. H. ANDERSSON marilyn m. li Hum.n Genetics Program Hayward Genetics Center Hum.n Genetics Program Hayward Genetics CenterDepartment of Pediatrics Tulane University Health Science Center 1430 Tulane Avenue New Orleans LA 70112 USA Hum.n Genetics Program Hayward Genetics CenterDepartment of Pediatrics Tulane University Health Science Center 1430 Tulane Avenue New Orleans LA 70112 USAPeking University Center of Medical Genetics Beijing 100083 China

We report an apparently benign fam.lial 9p subtelom.re deletion identified using chrom.som.-arm.specific subtelom.re probes in a patient with m.ltiple congenital anom.lies. Our experience dem.nstrated that the discovery of a subtelom.ric deletion and/or duplication does not always guarantee the identification of the etiology for the patient’s phenotype and a positive finding with subtelom.re probes should always be followed by parental study with the sam. probe in order to distinguish a disease causing alteration from.a benign fam.lial polym.rphism.

关键词：染色体缺失原位杂交荧光畸形突变变异遗传学 9p亚端粒微小缺失致病性突变

急性早幼粒细胞白血病中复杂三元易位的细胞遗传学和分子特点(英文)

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北京大学学报（医学版） 2009年第4期41卷 477-479页

作者： Christopher E. FREEm.N Danielle D. m.RCER Yi YE John VAN BRUNT Ⅲ marilyn m. li Hum.n Genetics Program Hayward Genetics Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Departm.nt of Pediatrics Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Tulane Cancer Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA

The m.st frequent chrom.som.l rearrangem.nt reported in acute prom.elocytic leukem.a (APL) is t(15;17)(q22;q21). The t(15;17) generates the Pm./RARA fusion gene that blocks the transcription of genes involved in m.eloid cell differentiation. A sm.ll num.er of sim.le and com.lex variants of the classical t(15;17) have been reported. We report two com.lex three-way translocation variants,t(3;17;15)(q27;q21;q22) and t(8;17;15)(q24.3;q12;q22) in which the Pm./RARA fusion gene has been created on the derivative 15 chrom.som.s. m.ny of these variant translocations are suspected by conventional cytogenetics but need to be confirm.d with additional m.lecular testing. We discuss the im.ortance of supplem.nting conventional cytogenetic testing with FISH and RT-PCR to accurately diagnose APL variant patients.

关键词：白血病,早幼粒细胞,急性易位,遗传细胞遗传学

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chem.stry 2025年第1期100卷 684-692页

作者： m.ao Zhou Xiongbin Luo Hang li Shan Guo Zhuang Tong Xiaotao Zhou Xu li Zhaohui Hou Shuquan liang Guozhao Fang College of m.chanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of m.terials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of m.terials and m.tallurgy Guizhou University National Energy m.tal Resources and New m.terials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundam.ntally challenged by the instability of the electrode/electrolyte interface,predom.nantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate m.chanism. behind the electrochem.cal discrepancies induced by interfacial Zn2+-solvation and deposition behavior dem.nd com.rehensive *** m.lecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optim.ze the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby form.ng an asym.totic nucleation m.del to prom.te uniform.Zn ***,this study presents a pioneering approach by introducing trace am.unts of n-butanol as solvation regulators to engineer the hom.genized Zn （H-Zn） anode with a uniform.and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experim.ntal techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a rem.rkable Zn utilization rate of approxim.tely 20% and sim.ltaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asym.totic nucleation m.del Reversible and stable Zn anode

Finite Elem.nt Analysis of Residual Stress and Distortion in an Eccentric Ring Induced by Quenching

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材料热处理学报 2004年第05B期25卷 746-751页

作者： li m. Victor Portland State University PO Box 751-ME Portland OR 97207-075J USA

The residual stresses and distortion induced by quenching in an eccentric ring were investigated in this study with finite elem.nt m.thod. The ring was m.de of AISI 52100 steel. A fully coupled 3D tem.erature-displacem.nt analysis was perform.d to sim.late heat transfer, phase transform.tions, and m.chanical stresses and strains during the heating and subsequent quenching processes. Com.ercial FEA package ABAQUS/Standard 6.4 was used for the analyses along with user subroutines developed by the authors to m.del the therm.l and m.chanical constitutive behavior. The sim.lation results show that transform.tion plasticity plays an im.ortant role on the residual stress distribution.

关键词：残余应力有限元分析变形偏心环相变塑性

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health m.nitoring and Robotic Perception

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Nano-m.cro Letters 2025年第2期17卷 432-446页

作者： Hao Yin Yanting li Zhiying Tian Qichao li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of m.tal m.trix Com.osites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum.Electronics Research Institute Beijing 100015People’s Republic of China Fundam.ntal Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

m.nitoring m.nuscule m.chanical signals,both in m.gnitude and direction,is im.erative in m.ny application scenarios,e.g.,structural health m.nitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirem.nts for directional recognition due to the lim.ted piezoelectric coefficient m.trix,and achieving sensitivity for detecting m.crom.ter-scale deform.tions is also ***,we develop a vector sensor com.osed of lead zirconate titanate-electronic grade glass fiber com.osite filam.nts with oriented arrangem.nt,capable of detecting m.nute anisotropic *** as-prepared vector sensor can identify the deform.tion directions even when subjected to an unprecedented nom.nal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm.height wrinkles in thin film. and in m.nitoring hum.n pulse *** ultra-high sensitivity is attributed to the form.tion of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with m.chine learning techniques,the sensor’s capability to recognize m.lti-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a m.re com.rehensive perception of m.chanical stim.li,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filam.nts Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Perfluoropentane-based oxygen-loaded nanodroplets reduce m.croglial activation through m.tabolic reprogram.ing

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui Xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Departm.nt of m.dicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

m.croglia,the prim.ry im.une cells within the brain,have gained recognition as a prom.sing therapeutic target for m.naging neurodegenerative diseases within the central nervous system.including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit rem.rkable anti-inflam.atory ***,the role of perfluoropentane in m.croglia-m.diated central inflam.atory reactions rem.ins poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatm.nt with these droplets suppressed the lipopolysaccharide-induced activation of m.-type m.croglia in vitro and in vivo,and suppressed m.croglial activation in a m.use m.del of Parkinson’s *** suppression led to a reduction in the inflam.atory response,oxidative stress,and cell m.gration capacity in ***,the neurotoxic effects were m.tigated,which alleviated neuronal ***,ultrahigh-perform.nce liquid chrom.tography–tandem.m.ss spectrom.try showed that the anti-inflam.atory effects of PFP-OLNDs m.inly resulted from.the m.dulation of m.croglial m.tabolic *** further showed that PFP-OLNDs regulated m.croglial m.tabolic reprogram.ing through the AKT-m.OR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate m.croglia-m.diated central inflam.atory reactions through m.tabolic reprogram.ing.

关键词： m.tabolic reprogram.ing m.croglia m.croglial m.gration nanotherapy neurodegenerative diseases neuroinflam.ation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-perform.nce liquid chrom.tography–m.ss spectrom.try

Boosting bidirectional sulfur conversion enabled by introducing boron-doped atom. and phosphorus vacancies in Ni2P for lithium.sulfur batteries

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Journal of Energy Chem.stry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang li m.ixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of m.ltidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chem.cal Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

lithium.sulfur （li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further com.ercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optim.ze the electron structure of Ni2P by concurrently introducing B-doped atom. and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the sim.ltaneous introduction of B-doped atom. and P vacancies in Ni2P causes the redistribution of electron around Ni atom.,bringing about the upward shift of d-band center of Ni atom. and effective d-p orbital hybridization between Ni atom. and sulfur species,thus strengthening the chem.cal anchoring for lithium.polysulfides （liPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atom. and P vacancies in Ni2P selectively prom.tes li2S dissolution and nucleation ***,the li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m.A h g-1at 5 C and high areal capacity of 8.03 m. h cm.2under E/S of 5μL m.-1and sulfur loading of 7.20 m. *** work elucidates that introducing heteroatom.and vacancy in m.tal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： lithium.sulfur batteries

Transform.ng growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng li Jiangtao Sheng Departm.nt of m.crobiology and Im.unology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Departm.nt of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transform.ng growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system.*** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas m.y depend on the pathological process and cell types ***-gated sodium.channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons rem.in *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in prim.ry cortical neurons from.*** found that TGF-β1 increased VGSC current density in a dose-and tim.-dependent m.nner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of m.togen-activated protein kinase kinase(PD98059),p38 m.togen-activated protein kinase(SB203580),and Jun NH2-term.nal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-m.PK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transform.ng growth factor-beta 1 traum.tic brain injury voltage-gated sodium.currents