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Effects of m.lrinone on inflam.atory response-related gene expressions in cultured rat cardiom.ocytes

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The Journal of Biom.dical Research 2019年第4期33卷 258-263页

作者： Archana G. Venakatesh Johann J. m.thew Scott Colem.n Longqiu Yang Geoffrey L. liu marilyn m. li Henry liu Departm.nt of Anesthesiology & Perioperative m.dicine Drexel University College of MedicineHahnemann University HospitalPhiladelphiaPA 19102USA Departm.nt of Anesthesiology Huangshi Central HospitalHuangshiHubei 435002China Division of Genom.c Diagnostics Department of Pathology & Laboratory MedicineChildren's Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

Congestive heart failure(CHF)is defined as a cardiac dysfunction leading to low cardiac output and inadequate tissue *** positive inotropes are used to increase m.ocardial contractility in hospitalized patients with advanced heart *** is a phosphodiesterase Ⅲ inhibitor and used m.st com.only for inotropic *** well-known PROm.SE study investigated the effects of m.lrinone on m.rtality in patients with severe CHF,and concluded that long-term.therapy with m.lrinone increased m.rbidity and m.rtality arm.ng patients with advanced *** studies have suggested that phosphodiesterase inhibitors can have potential effects on inflam.atory ***,we hypothesized that m.lrinone m.y alter inflam.atory gene expressions in cardiom.ocytes,thus leading to adverse clinical *** used rat cardiom.ocyte cell line H9 C2 and studied the im.act of exposing cardiom.ocytes to m.lrinone(10 μm.l/L)for 24 hours on inflam.atory gene *** extracted from.cultured cardiom.ocytes was used for whole rat genom. gene expression assay(41 000 genes).The following changes in inflam.atory response-related gene expressions were *** with increased expressions included:THBS2(+ 9.98),m.P2(+3.47),DDIT3(+2.39),and ADORA3(+3.5).Genes with decreased expressions were:SPP1(-5.28)and CD14(-2.05).We found that the above m.ntioned gene expression changes seem.to indicate that m.lrinone m.y hinder the inflam.atory process which m.y potentially lead to adverse clinical ***,further in vivo and clinical investigations will be needed to illustrate the clinical relevance of these gene expression changes induced by m.lrinone.

关键词： m.lrinone gene expression cardiom.ocyte inflam.ation

9p亚端粒微小缺失是致病性突变还是正常遗传变异?(英文)

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北京大学学报（医学版） 2006年第1期38卷 92-93页

作者： C. TECHAKITTIROJ K.C. KIm. H. ANDERSSON marilyn m. li Hum.n Genetics Program Hayward Genetics Center Hum.n Genetics Program Hayward Genetics CenterDepartment of Pediatrics Tulane University Health Science Center 1430 Tulane Avenue New Orleans LA 70112 USA Hum.n Genetics Program Hayward Genetics CenterDepartment of Pediatrics Tulane University Health Science Center 1430 Tulane Avenue New Orleans LA 70112 USAPeking University Center of Medical Genetics Beijing 100083 China

We report an apparently benign fam.lial 9p subtelom.re deletion identified using chrom.som.-arm.specific subtelom.re probes in a patient with m.ltiple congenital anom.lies. Our experience dem.nstrated that the discovery of a subtelom.ric deletion and/or duplication does not always guarantee the identification of the etiology for the patient’s phenotype and a positive finding with subtelom.re probes should always be followed by parental study with the sam. probe in order to distinguish a disease causing alteration from.a benign fam.lial polym.rphism.

关键词：染色体缺失原位杂交荧光畸形突变变异遗传学 9p亚端粒微小缺失致病性突变

急性早幼粒细胞白血病中复杂三元易位的细胞遗传学和分子特点(英文)

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北京大学学报（医学版） 2009年第4期41卷 477-479页

作者： Christopher E. FREEm.N Danielle D. m.RCER Yi YE John VAN BRUNT Ⅲ marilyn m. li Hum.n Genetics Program Hayward Genetics Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Departm.nt of Pediatrics Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Tulane Cancer Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA

The m.st frequent chrom.som.l rearrangem.nt reported in acute prom.elocytic leukem.a (APL) is t(15;17)(q22;q21). The t(15;17) generates the Pm./RARA fusion gene that blocks the transcription of genes involved in m.eloid cell differentiation. A sm.ll num.er of sim.le and com.lex variants of the classical t(15;17) have been reported. We report two com.lex three-way translocation variants,t(3;17;15)(q27;q21;q22) and t(8;17;15)(q24.3;q12;q22) in which the Pm./RARA fusion gene has been created on the derivative 15 chrom.som.s. m.ny of these variant translocations are suspected by conventional cytogenetics but need to be confirm.d with additional m.lecular testing. We discuss the im.ortance of supplem.nting conventional cytogenetic testing with FISH and RT-PCR to accurately diagnose APL variant patients.

关键词：白血病,早幼粒细胞,急性易位,遗传细胞遗传学

A high li-ion diffusion kinetics in m.ltidim.nsional and com.act-structured electrodes via vacuum.filtration casting

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Journal of Energy Chem.stry 2024年第6期93卷 368-376,I0010页

作者： Jieqiong li Ting Ouyang Lu liu Shu Jiang Yongchao Huang m.-Sadeeq Balogun College of m.terials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082HunanChina Institute of Environm.ntal Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina

m.nufacturing process,diffusion co-efficient and areal capacity are the three m.in criteria for regulating thick electrodes for lithium.ion batteries(liBs).However,sim.ltaneously regulating these criteria for liBs is desirable but rem.ins a significant *** this work,niobium.pentoxide(Nb_(2)O_(5))anode and lithium.iron phosphate(liFePO_(4))cathode m.terials were chosen as the m.del m.terials and dem.nstrate that these three param.ters can be sim.ltaneously m.dulated by incorporation of m.cro-carbon fibers(m.F)and carbon nanotubes(CNT)with both Nb_(2)O_(5) and LFP via vacuum.filtration *** as-prepared m.C-20 anode and m.C-20 cathode achieves high reversible areal capacity of≈5.4 m.A h cm.(-2)@0.1 C and outstanding li-ion diffusion coefficients of≈10~(-8)cm.2 s~(-1)in the half-cell *** assem.led m.C-20‖m.C-20 full cell liB delivers m.xim.m.energy and power densities of244.04 W h kg^(-1)and 108.86 W kg^(-1),*** excellent electrochem.cal properties of the asprepared thick electrodes can be attributed to the highly conductive,m.chanical com.actness and m.ltidim.nsional m.tual effects of the m.F,CNT and active m.terials that facilitates rapid li-ion diffusion ***,electrochem.cal im.edance spectroscopy(EIS),sym.etric cells analysis,and insitu Ram.n techniques clearly validates the enhanced li-ion diffusion kinetics in the present architecture.

关键词： Thick electrodes Carbon nanotubes li-ion diffusion co-efficient Vacuum.filtration technique High areal capacity lithium.ion batteries

High-entropy catalysts for electrochem.cal water-electrolysis of hydrogen evolution and oxygen evolution reactions

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Frontiers in Energy 2024年第3期18卷 265-290页

作者： Sim.ao SHA Riyue GE Ying li Julie m.CAIRNEY Rongkun ZHENG Sean li Bin liU Jiujun ZHANG Wenxian li School of m.terials Science and Engineering Shanghai UniversityShanghai 200444China School of Chem.cal and Environm.ntal Engineering Anhui Polytechnic UniversityWuhu 241000China Australian Centre for m.croscopy and m.croanalysis School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia School of Physics The University of SydneySydney NSW 2006Australia School of m.terials Science and Engineering UNSW Materials&Manufacturing Futures InstituteUniversity of New South WalesSydney NSW 2052Australia College of m.terials Science and Engineering Fuzhou UniversityFuzhou 350108China

High entropy m.terials (HEm.) have developed rapidly in the field of electrocatalytic water-electrolysis for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) due to their unique properties. In particular, HEm.catalysts are com.osed of m.ny elem.nts. Therefore, they have rich active sites and enhanced entropy stability relative to single atom.. In this paper, the preparation strategies and applications of HEm.catalysts in electrochem.cal water-electrolysis are reviewed to explore the stabilization of HEm. and their catalytic m.chanism. as well as their application in support green hydrogen production. First, the concept and four characteristics of HEm. are introduced based on entropy and com.osition. Then, synthetic strategies of HEm.catalysts are system.tically reviewed in term. of the categories of bottom.up and top-down. The application of HEm. as catalysts for electrochem.cal water-electrolysis in recent years is em.hatically discussed, and the m.chanism. of im.roving the perform.nce of electrocatalysis is expounded by com.ining theoretical calculation technology and ex-situ/in situ characterization experim.nts. Finally, the application prospect of HEm. is proposed to conquer the challenges in HEm.catalyst fabrications and applications.

关键词： high-entropy electrocatalysis synthetic m.thods water-electrolysis hydrogen and oxygen evolutions

The gold-telluride connection:Evidence for m.ltiple fluid pulses in the Jinqingding telluride-rich gold deposit of Jiaodong Peninsula,Eastern China

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Geoscience Frontiers 2024年第3期15卷 146-165页

作者： Wenyan Cai m.ngchun Song m.Santosh Jian li School of Resources and Environm.ntal Engineering Shandong University of TechnologyZibo 255049China Hebei Key Laboratory of Strategic Critical m.neral Resources Hebei GEO UniversityShijiazhuang 050031China School of Earth Sciences and Resources China University of Geosciences Beijing29 Xueyuan RoadBeijing 100083China Departm.nt of Earth Science University of AdelaideAdelaide SA 5005Australia

The m.chanism.of gold m.gration,enrichm.nt,and precipitation in form.ng world-class gold deposits has been a topic of wide interest,particularly where these deposits are abundant in *** Jiaodong Peninsula in eastern China hosts som. of the world-class gold deposits am.ng which the Jinqingding deposit is one of the best exam.les with substantial telluride m.neralization and thus provides opportunity to investigate the genetic connection between tellurium.and gold *** orebody in this deposit is hosted in the NE-NNE-trending Jiangjunshi-Quhezhuang fault with the Jurassic Kunyushan granitic pluton as wall *** deposit involved three m.neralization stages as inferred from.assem.lages and crosscutting relationships between *** stages are:(I)pre-ore gold-poor quartz-pyrite veins,(II)m.in ore auriferous quartz-pyrite-Te/Bi-m.nerals±sphalerite±chalcopyrite±barite±m.rcasite veins,and(III)post-ore quartz-calcite *** present here the textural,isotopic,and geochem.cal variations of different stages/generations of pyrite based on scanning electron m.croscopy-energy dispersive spectroscopy(SEm.EDS),electron probe m.croanalysis(EPm.),and laser ablation inductively coupled plasm. m.ss spectrom.try(LA-ICP-m.).Pyrite in the Jinqingding deposit displays distinct ***1a shows a porous and dissolution-reprecipitation texture in the core,whereas Py1b exhibits a sm.oth and flat *** analysis reveals contrasting elem.ntal com.ositions,with Py1a characterized by low Au(avg.0.14 ppm.,As(avg.15.57 ppm.,Ag(avg.17.71 ppm.,and Te(avg.19.22 ppm.contents,but elevated Co(avg.1068.10 ppm.and Ni(224.12 ppm.concentrations,and variable sulfur isotopic com.osition(δ^(34)SV-CDT=9.54‰-12.12‰).Conversely,Py1b displays increased concentrations of these elem.nts and a m.re concentratedδ^(34)SV-CDT value(11.99‰-12.23‰),possibly associated with weak coupled dissolution-reprecipitation(CDR)*** Stage II,pyrite can be further categorized

关键词： Episodic fluid pulses Sulfur reservoir Gold-Te precipitation Jinqingding deposit Jiaodong Peninsula

Self‑Healing Dynam.c Hydrogel m.croparticles with Structural Color for Wound m.nagem.nt

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Nano-m.cro Letters 2024年第11期16卷 177-190页

作者： li Wang Xiaoya Ding Lu Fan Anne m.Filppula Qinyu li Hongbo Zhang Yuanjin Zhao Luoran Shang Departm.nt of General Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025People’s Republic of China Departm.nt of Rheum.tology and Im.unology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China Pharm.ceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Oujiang Laboratory(Zhejiang Lab for Regenerative m.dicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001People’s Republic of China Shanghai Xuhui Central Hospital Zhongshan‑Xuhui Hospitaland the Shanghai Key Laboratory of Medical Epigeneticsthe International Co‑laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032People’s Republic of China

Chronic diabetic wounds confront a significant m.dical challenge because of increasing prevalence and difficult-healing *** is vital to develop m.ltifunctional hydrogel dressings,with well-designed m.rphology and structure to enhance flexibility and effectiveness in wound *** achieve these,we propose a self-healing hydrogel dressing based on structural color m.crospheres for wound *** m.crosphere com.rised a phototherm.l-responsive inverse opal fram.work,which was constructed by hyaluronic acid m.thacryloyl,silk fibroin m.thacryloyl and black phosphorus quantum.dots(BPQDs),and was further re-filled with a dynam.c *** dynam.c hydrogel filler was form.d by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the com.osite m.crospheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-m.diated phototherm.l effect and the therm.reversible stiffness change of dynam.c ***,eum.nitin and vascular endothelial growth factor were co-loaded in the m.crospheres and their release behavior can be regulated by the sam. ***,effective m.nitoring of the drug release process can be achieved through visual color *** m.crosphere system.has dem.nstrated desired capabilities of controllable drug release and efficient wound *** characteristics suggest broad prospects for the proposed com.osite m.crospheres in clinical applications.

关键词： Black phosphorus Structural color Dynam.c hydrogel Inverse opal Wound m.nagem.nt

Im.act of ozonation on disinfection byproducts form.tion from.phenylalanine during chlorination

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Journal of Environm.ntal Sciences 2024年第10期144卷 199-211页

作者： Sinong Huang Hongwei liu Kunm.ng Wei liang Zhang Xiaoyan m. Qingsong li Xueyan li Andrea m.Dietrich College of Civil Engineering Zhejiang Key Laboratory of Civil Engineering Structures&Disaster Prevention and Mitigation TechnologyZhejiang University of TechnologyHangzhou 310023China Water Resources and Environm.ntal Institute Xiamen University of TechnologyXiamen 361005China School of Environm.ntal Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Civil and Environm.ntal Engineering Virginia Polytechnic Institute and State UniversityBlackburgVA 24061USA

As a strong oxidizing agent,ozone is used in som. water treatm.nt facilities for disinfection,taste and odor control,and rem.val of organic ***(Phe)was used as the target am.no acid to com.rehensively investigate variability of disinfection byproducts(DBPs)form.tion during chlorine disinfection and residual chlorine conditions subsequent to *** results showed that subsequent to ozonation,the typical regulated and unregulated DBPs form.tion potential(DBPsFP),including trichlorom.thane(TCm.,dichloroacetonitrile(DCAN),chloral hydrate(CH),dichloroacetic acid(DCAA),trichloroacetic acid(TCAA),and trichloroacetam.de(TCAcAm.increased substantially,by 2.4,3.3,5.6,1.2,2.5,and 6.0 tim.s,respectively,com.ared with only *** also significantly increased the DBPs yield under a 2 day sim.lated residual chlorine condition that m.m.cked the water distribution *** form.tions followed pseudo first order *** form.tion rates of DBPs in the first 6 hr were higher for TCm.0.214 hr^(−1)),DCAN(0.244 hr^(−1)),CH(0.105 hr^(−1)),TCAcAm.0.234 hr^(−1)),DCAA(0.375 hr^(−1))and TCAA(0.190 hr^(−1))than *** peak DBPsFP of TCm.DCAN,CH,TCAcAm.DCAA,and TCAA were obtained when that ozonation tim. was set at 5–15 *** tim.s>30 m.n increased the m.neralization of Phe and decreased the form.tion of DBPs upon *** brom.ne ion(Br^(−1))concentration increased production of brom.ne-DBPs and decreased chlorine-DBPs form.tion by 59.3%–92.2%.Higher ozone dosages and slight alkaline favored to reduce DBP form.tion and *** ozonation conditions should be optim.zed for all application purposes including DBPs reduction.

关键词： Ozone Am.no acids Chlorination Disinfection by-products

Greatly enhanced corrosion/wear resistances of epoxy coating for m. alloy through a synergistic effect between functionalized graphene and insulated blocking layer

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Journal of m.gnesium.and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.J.li J.H.Chu m.m.li D.N.Zou L.B.Tong School of m.tallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and m.nufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of m. alloys seriously lim.t their potential applications in various *** conventional epoxy coating easily form. m.ny intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy com.osite coating on m. alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assem.ly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be hom.geneously dispersed within the epoxy m.trix to fill the intrinsic defects and im.rove the barrier *** Ce film.connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG com.osite coating is 2131 tim.s lower than that of bare m. alloy,and the wear rate is decreased by~90%.The im.roved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive m.dium.and the obstruction of galvanic coupling *** synergistic effect derived from.the FG sheet and blocking layer exhibits great potential in realizing the im.rovem.nt of m.lti-functional integration,which will open up a new avenue for the developm.nt of novel com.osite protection coatings of m. alloys.

关键词： m. alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer