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Falls and health-related quality of life (SF-36) in elderly people—ISACAMP 2008

Health 2013年第12期5卷 49-57页

作者： Iara Guimaraes Rodrigues Margareth Guimaraes Lima marilisa Berti de Azevedo Barros Faculty of Medical Sciences Department of Public HealthState University of CampinasCampinasBrazil

Falls are accidental events and harmful to the healthy elderly. Its consequence can lead to the disability and the death. Accordingly, it becomes important to assess the relation between falls and quality of life. This theme is little studied in Brazil and internationally, especially in areas with large population bases. Objective: To identify the association between occurrence of fall and health-related quality of life (HRQL) using the SF-36 according to gender, age and schooling, among the elderly population of Campinas/Brazil. Methods: A cross-sectional, population-based study, using data from ISACAMP 2008. The present study analyzed only the population with 60 years old or more, totaling 1432 elderly individuals. The dependent variables were the eight SF-36 scale, version 2. The main independent variables were the falls occurred in the last 12 months and the limitation in activities daily living due to the falls. Analysis were carried out with the simple and multiple linear regression model in order to determine the associations between the dependent and main independent variables, using svy commands of STATA 11.0. Results: The prevalence of falls in the last year was 6.3%. The elderly individuals who referred to fall in the last 12 months exhibited the lowest score in seven of eight SF-36 scales, comparing with non-fallers. The association between fall and HRQL was greater in the male population. The elderly individuals who are older (75 or more) and located in the lower schooling stratum, and experienced falls also exhibited the lowest SF-36 scale scores, in physical and social functioning. Stratifying falls, considering those who cause limitations and those who do not, can be observed with the lowest scores in physical functioning, role physical, role emotion and social functioning, and only in the stratum of people who have limitations in daily living. Conclusion: The occurrence of falls can cause important limitations in the elderly individuals, and the lim

关键词： Falls Elderly Quality of Life

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Impedancemetry of multiplexed quantum devices using an on-chip cryogenic complementary metal-oxide-semiconductor active inductor

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Chip 2023年第4期2卷 133-141页

作者： L.Le Guevel G.Billiot S.De franceschi A.Morel X.Jehl A.G.M.Jansen *** UniversitéGrenoble Alpes CEALETIGrenoble F-38000France UniversitéGrenoble Alpes CEAGrenoble INPIRIGPHELIQSGrenoble F-38000France Department of Electrical and Computer Engineering University ofMassachusetts-AmherstMA 01003USA UniversitéSavoie Mont Blanc SYMMEAnnecy F-74000France

In the pursuit for scalable quantum processors,significanteffort has been devoted to the development of cryogenic classical hardware for the control and readout of a growingnumber of *** current work presented a novelapproach called impedancemetry that is suitable for measuringthe quantum capacitance of semiconductor qubits connected toa resonant *** impedancemetry circuit exploits theintegration of a complementary metal-oxide-semiconductor(CMOS)active inductor in the resonator with tunable resonance frequency and quality factor,enabling the optimizationof readout sensitivity for quantum *** realized cryogenic circuit allows fast impedance detection with a measuredcapacitance resolution down to 10 aF and an input-referrednoise of 3.7 aF/Hz *** 4.2 K,the power consumption of theactive inductor amounts to 120μW,with an additional dissipation for on-chip current excitation(0.15μW)and voltageamplification(2.9 mW)of the impedance *** to the commonly used schemes based on dispersiveRF reflectometry which require millimeter-scale passive inductors,the circuit exhibits a notably reduced footprint(50μm360μm),facilitating its integration in a scalable quantumclassical *** impedancemetry method has been applied at 4.2 K to the detection of quantum effects in the gatecapacitance of on-chip nanometric CMOS transistors that areindividually addressed via multiplexing.

关键词： Impedancemetry Qubit readout Cryogenic circuit Activeinductor CMOS

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The collagen receptor,discoidin domain receptor 2,functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development

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Bone Research 2022年第1期10卷 178-194页

作者： Fatma F.Mohamed Chunxi Ge Randy T.Cowling Daniel Lucas Shawn A.Hallett Noriaki Ono Abdul-Aziz Binrayes Barry Greenberg Renny T.franceschi Department of Periodontics&Oral Medicine University of MichiganAnn ArborMIUSA Division of Cardiovascular Medicine University of California at San DiegoSan DiegoCAUSA Division of Experimental Hematology and Cancer Biology Cincinnati Children’s Medical CenterCincinnatiOHUSA Department of Pediatrics Cincinnati Children’s HospitalCincinnatiOHUSA Department of Orthodontics&Pediatric Dentistry University of MichiganAnn ArborMIUSA Department of Prosthetic Dental Sciences College of DentistryKing Saud UniversityRiyadhSaudi Arabia Department of Biological Chemistry School of MedicineUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering University of MichiganAnn ArborMIUSA

Discoidin Domain Receptor 2(DDR2)is a collagen-activated receptor kinase that,together with integrins,is required for cells to respond to the extracellular ***2 loss-of-function mutations in humans and mice cause severe defects in skeletal growth and ***,the cellular functions of Ddr2 in bone are not *** and lineage analysis showed selective expression of Ddr2 at early stages of bone formation in the resting zone and proliferating chondrocytes and *** with these findings,Ddr2^(+)cells could differentiate into hypertrophic chondrocytes,osteoblasts,and osteocytes and showed a high degree of colocalization with the skeletal progenitor marker,Gli1.A conditional deletion approach showed a requirement for Ddr2 in Gli1-positive skeletal progenitors and chondrocytes but not mature ***,Ddr2 knockout in limb bud chondroprogenitors or purified marrow-derived skeletal progenitors inhibited chondrogenic or osteogenic differentiation,*** work establishes a cell-autonomous function for Ddr2 in skeletal progenitors and cartilage and emphasizes the critical role of this collagen receptor in bone development.

关键词： Gli1 progenitor skeletal

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Role of Helicobacter pylori infection on nutrition and metabolism

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World Journal of Gastroenterology 2014年第36期20卷 12809-12817页

作者： Francesco franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio Department of Emergency Internal Medicine Institute Catholic University of Sacred Heart 00168 Rome Italy Department of Medicine Internal Medicine and Gastroenterology Catholic University of Sacred Heart 00168 Rome Italy

Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world’s population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome.

关键词： Helicobacter pylori Malabsorption Metabolic syndrome Gastrointestinal hormones

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Impact of COVID-19 in individuals with and without pre-existent digestive disorders with a particular focus on elderly patients

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World Journal of Gastroenterology 2023年第26期29卷 4099-4119页

作者： Alfredo Papa Marcello Covino Sara Sofia De Lucia Angelo Del Gaudio Marcello Fiorani Giorgia Polito Carlo Romano Settanni Andrea Piccioni Francesco franceschi Antonio Gasbarrini CEMAD Center for Diagnosis and Treatment of Digestive DiseasesFondazione Policlinico Universitario A.GemelliIRCCSRoma 00168Italy CEMAD UniversitàCattolica del Sacro CuoreRoma 00168Italy Department of Emergency UniversitàCattolica del Sacro Cuore-Fondazione Policlinico Universitario A.GemelliIRCCSRome 00168Italy Emergency Medicine UniversitàCattolica del Sacro CuoreRoma 00168Italy Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Emergency Fondazione Policlinico Universitario A.GemelliIRCCSRoma 00168Italy Department of Emergency UniversitàCattolica del Sacro CuoreRoma 00168Italy

Coronavirus disease 2019(COVID-19)has several extrapulmonary ***(GI)symptoms are among the most frequent clinical manifestations of COVID-19,with severe consequences reported in elderly ***,the impact of COVID-19 on patients with pre-existing digestive diseases still needs to be fully elucidated,particularly in the older *** review aimed to investigate the impact of COVID-19 on the GI tract,liver,and pancreas in individuals with and without previous digestive diseases,with a particular focus on the elderly,highlighting the distinctive characteristics observed in this ***,the effectiveness and adverse events of the anti-COVID-19 vaccination in patients with digestive disorders and the peculiarities found in the elderly are discussed.

关键词： COVID-19 Elderly Inflammatory bowel disease Liver disease Cirrhosis Pancreatic disease

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Smoking and Health-Related Quality of Life(SF-36).A Population-Based Study in Campinas,SP,Brazil

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Health 2014年第12期6卷 1539-1548页

作者： Margareth Guimaraes Lima Flávia Silva Arbex Borim marilisa Berti de Azevedo Barros Faculty of Medical Sciences Department of Public HealthState University of CampinasCampinasBrazil

Introduction: Smoking persists as a global and relevant health problem being one of the major risk factors to non-communicable diseases and early death. Studies on the association between smoking and health related quality of life (HRQL) are scarce in Brazil and Latin America. The aim of this study was to analyze the HRQL according to smoking status on adults aged 20 to 59 years, living in Campinas, Brazil. Method: It is a population-based cross-sectional study, carried out with data from the Campinas Health Survey developed in 2008/2009. The dependent variables were the eight scales and the two components—physical (PCS) and mental component summary (MCS) of the instrument SF-36, version 2. Means and confidence intervals of the SF-36 scale scores and components were estimated according to smoking (never smokers, former smokers, current smokers) and nicotine dependence (mild, moderate, heavy). Results: The sample comprised 957 individuals (mean age of 37.5 years). Comparing with never smokers, smokers had lower score means in all SF-36 scales, except in physical functioning and role-physical;among the former smokers, lower scores were observed in vitality and mental health. A reduction of the MCS score was observed among smokers and former smokers among men;but in the female population, this reduction was observed only in smokers compared with never smokers. According to the nicotine dependence, it was observed an increasing reduction in MCS scores from mild, to moderate and heavy smokers. Conclusion: Smoking is significantly and negatively associated with HRQL in the studied population. The results point out the importance of the strategic policies against smoking, to reduce morbidity and premature death, but also to increase the quality of life and well-being. It is also important to consider the mental health dimension, since that best mental health can be relevant to promote healthier behaviors.

关键词： Smoking Quality of Life Health Status SF-36 Survey

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Gut microbiota in autism and mood disorders

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World Journal of Gastroenterology 2016年第1期22卷 361-368页

作者： Francesca Mangiola Gianluca Ianiro Francesco franceschi Stefano Fagiuoli Giovanni Gasbarrini Antonio Gasbarrini Catholic University School of Medicine00168 RomeItaly Department of Internal Medicine Division of Internal MedicineGastroenterology and Liver Disease “A.Gemelli”University Hospital 00168 RomeItaly Gastroenterology and Transplant Hepatology Papa Giovanni XXIII Hospital24127 BergamoItaly “Ricerca in Medicina”ONLUS Foundation 40121 BolognaItaly

The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal(GI)system is supported by several studies that have shown a qualitative and quantitative alteration of the intestinal flora in a number of gastrointestinal and extra-gastrointestinal *** the last few years,the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism,dementia and mood disorder,has been *** evidence of the inflammatory state alteration,highlighted in disorders such as schizophrenia,major depressive disorder and bipolar disorder,strongly recalls the microbiota alteration,highly suggesting an important role of the alteration of GI system also in neuropsychiatric *** to now,available evidences display that the impairment of gut microbiota plays a key role in the development of autism and mood *** application of therapeutic modulators of gut microbiota to autism and mood disorders has been experienced only in experimental settings to date,with few but promising results.A deeper assessment of the role of gut microbiota in the development of autism spectrum disorder(ASD),as well as the advancement of the therapeutic armamentarium for the modulation of gut microbiota is warranted for a better management of ASD and mood disorders.

关键词： Gut microbiota Mood disorders Autism Depression Gut microbiota modulation Fecal microbiotatransplantation

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Chromium-Containing Organic Fertilizers from Tanned Hides and Skins: A Review on Chemical, Environmental, Agronomical and Legislative Aspects

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Journal of Environmental Protection 2012年第11期3卷 1532-1541页

作者： Claudio Ciavatta Chiara Manoli Luciano Cavani Clizia franceschi Paolo Sequi Agricultural Research Council Research Center for the Soil-Plant System Roma Italy Department of Agro-Environmental Science and Technology University of Bologna Bologna Italy ILSA SpA Arzignano Italy

A category of chromium (Cr)-containing fertilizers is represented by the fertilizers deriving from byproducts of tanning process. Their use is widespread because of their good agronomic response due to the high content of slow release or- ganic nitrogen (N) and carbon (C). They do not represent an environmental hazard because only the non-toxic form of Cr(III) is present. Productive processes may involve chemical, enzymatic or thermal hydrolysis. The final product is characterized by different contents of peptides and free amino acids depending on the type of hydrolysis. Legislation concerning Cr-containing fertilizers is controversial because often do not consider any scientific evidences;nevertheless, the European Union, the United States and countries as Italy, do not set the restriction to Cr(III) and generally only the presence of the toxic form, Cr(VI), is limited. Depending on its two main oxidation forms, Cr issue has been studied for many years. Several authors confirmed that Cr(VI) is carcinogenic, while Cr(III) is an essential trace element in human and animal diet. In soil Cr(III) has low mobility, whereas Cr(VI) is highly water soluble. However Cr(VI) in soil is quickly reduced to Cr(III);on the contrary oxidation of Cr(III) to Cr(VI) is rarely possible because particular conditions must occur. Only a very small fraction of Cr in soil is available to plant uptake and its translocation in edible parts is limited because it is immobilized in roots as Cr(III). Therefore risks of environmental pollution using these fertilizers are negligible;on the contrary they have positive environmental and agronomical effects. The aim of this review is to deal with the category of the organic fertilizers containing Cr derived from tannery processes focusing on its chemical, productive, legislative, environmental and agronomical aspects. Special attention is given to the ambiguous issue of Cr briefly summarizing the most important studies of the last forty years.

关键词： Organic Fertilizers Tanned Hides and Skins Hydrolyzed Leather Trivalent Chromium Hexavalent Chromium Soil

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Effects of functional foods, nutraceuticals, and herbal products on pancreas

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Chinese Medical Journal 2023年第5期136卷 619-620页

作者： Angela Saviano Christian Zanza Yaroslava Longhitano Enrico Celestino Nista Francesco franceschi Veronica Ojetti Department of Emergency Medicine Fondazione Policlinico Universitario Agostino GemelliIRCCSRomeItaly Foundation“Ospedale Alba-Bra”and Department of Anesthesia Critical Care and Emergency MedicineMichele and Pietro Ferrero HospitalVerdunoItaly Department of Anesthesiology and Perioperative Medicine University of PittsburghPittsburghPAUSA Department of Gastroenterology Fondazione Policlinico Universitario Agostino GemelliIRCCSRomeItaly.

To the Editor:Today functional foods,nutraceuticals,and herbal products are becoming a part of human daily *** patient’s interest and demand for them are ***,healthcare systems and people have shown an increased desire to prevent some diseases and to improve their *** data about the properties and side effects of these products on the pancreas are still lacking,and more studies are required to provide a definitive opinion on their clinical benefits and *** industry of functional foods,nutraceuticals,and herbal products is gaining popularity.

关键词： herbal functional becoming

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Molecular alterations in pancreatic tumors

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World Journal of Gastroenterology 2021年第21期27卷 2710-2726页

作者： Michela Visani Giorgia Acquaviva Antonio De Leo Viviana Sanza Lidia Merlo Thais Maloberti Alba ABrandes Enrico franceschi Monica Di Battista Michele Masetti Elio Jovine Sirio Fiorino Annalisa Pession Giovanni Tallini Dario de Biase Department of Experimental Diagnostic and Specialty MedicineUniversity of Bologna–Molecular Diagnostic UnitAzienda USL di BolognaBologna 40138Italy Division of Molecular Pathology Laboratory IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Medical Oncology Department Azienda USL/IRCCS Istituto Delle Scienze Neurologiche di BolognaBologna 40139Italy Division of Surgery IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40133Italy Internal Medicine Unit Budrio Hospital Azienda USLBologna 40133Italy Department of Pharmacy and Biotechnology University of BolognaBologna 40138Italy

Genetic alterations in pancreatic tumors can usually be classified in:(1)Mutational activation of oncogenes;(2)Inactivation of tumor suppressor genes;and(3)Inactivation of genome maintenance genes controlling the repair of DNA *** ultrasound-guided fine-needle aspiration has improved preoperative diagnosis,but the management of patients with a pancreatic lesion is still *** testing could help mainly in solving these“inconclusive”*** introduction of multi-gene analysis approaches,such as next-generation sequencing,has provided a lot of useful information on the molecular characterization of pancreatic *** types of pancreatic tumors(e.g.,pancreatic ductal adenocarcinomas,intraductal papillary mucinous neoplasms,solid pseudopapillary tumors)are characterized by specific molecular *** aim of this review is to summarize the main molecular alterations found in pancreatic tumors.

关键词： Pancreatic tumors Molecular alterations Pancreatic ductal adenocarcinomas Intraductal papillary mucinous neoplasm Mutations Molecular markers

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