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Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:The“BE-FIT-IBD”study

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World Journal of Gastroenterology 2023年第41期29卷 5668-5682页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Tommaso durante Giovanna Palladino Rossella D’Onofrio Simone Mammone Giusi Arboretto Salvatore Auletta Giuseppe Imperio Andrea Ventura Mario Romeo Alessandro Federico Department of Precision Medicine Hepatogastroenterology UnitUniversity of Campania Luigi VanvitelliNaples 80138Italy Mental Health Department S.Pio HospitalBenevento 82100Italy

BACKGROUND The place regular physical activity(PA)should occupy in managing patients with inflammatory bowel diseases(IBD)is *** To assess PA levels and barriers in a southern Italian IBD *** IBD patients with non-severe disease activity[assessed with partial Mayo score for ulcerative colitis(UC)and Harvey-Bradshaw index for Crohn’s disease]were approached to receive an anonymous online questionnaire to assess PA levels using the International Physical Activity Questionnaire(IPAQ)and to assess disease activity as patient-reported outcomes 2(PRO-2)and finally to assess habits,beliefs and barriers in conducting regular ***,anthropometric and demographic data of patients were also *** was expressed as continuous units of resting metabolic rate(Met)in min/*** PA groups were identified:Inactive(2500 Met min/wk)*** Included patients(219)showed overall PA levels of 834.5 Met min/wk,with a large proportion(94,42.9%)classified as inactive while only a minority(9,4.1%)as health-enhancing *** without dyslipidaemia(P0.05).Active patients expressed the need to discuss PA with their *** barriers(e.g.,diagnosis of IBD and fear of flare-ups after PA)are significantly more reported by inactive *** A significant rate of physical inactivity was recorded in this *** showed good *** should be an element of discussion in IBD visits assessed quickly with non-invasive questionnaires.

关键词： Crohn’s disease Inflammatory bowel disease International Physical Activity Questionnaire Physical activity Ulcerative colitis

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Functional Foods: Can Food Technology Help in the Prevention and Treatment of Diabetes?

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Food and Nutrition Sciences 2013年第8期4卷 827-837页

作者： Rosalba Giacco Beatrice De Giulio marilena Vitale Rosaria Cozzolino Institute of Food Science National Research Council Avellino Italy Institute of Food Science National Research Council Avellino Italy.

Recently, the interest in functional foods is increased dramatically thanks to some scientific evidences demonstrating that, regardless of their nutritional value, some foods components beneficially influence several functions of the body, making them “functional” for the prevention and treatment of degenerative diseases, such as type 2 diabetes and cardiovascular diseases. In particular, the marketplace offers conventional and modified functional foods which acting on intestine, glucose and lipid metabolism are potentially useful for diabetic patients. The field of functional foods, however, presents some criticalities. Up to now, only few functional foods have obtained the statement of a “Health Claim”, either because there are not sufficient scientific evidences based on human intervention studies, that justify a “Health Claim”, or because data are not consistent with the proposed claims. In addition, some functional foods show a low palatability and a lack of variety. Both these issues limit their ordinary intake. This critical aspect also involves the lack of a possible synergistic effect deriving from the contemporary consumption in the diet of different functional foods, as observed with some healthy dietary pattern. Functional foods represent, then, a challenge for the food industry, which needs to implement and/or develop innovative technologies able to create new foods with improved healthy properties, but also with better organoleptic properties suitable for a daily consumption.

关键词： Diabetes Functional Food Glycemic Index Whole Grains Food Technologies

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Total Phenols and Flavonoids Content, Antioxidant Capacity and Lipase Inhibition of Root and Leaf Horseradish (Armoracia rusticana) Extracts

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Food and Nutrition Sciences 2015年第1期6卷 64-74页

作者： Luana Calabrone marilena Larocca Stefania Marzocco Giuseppe Martelli Rocco Rossano Department of Sciences University of Basilicata Potenza Italy Doctoral School of “BioEcoSystems and BioTechnology” Potenza Italy Department of Pharmacy University of Salerno Fisciano Italy

Horseradish (Armoracia rusticana Gaertn) is a perennial crop belonging to the Brassicaceae family, widely used as spice in food and as herbal ingredient in ethno-medicine. This study evaluated the phenolic compounds content, antioxidant capacity and anti-lipase activity of methanol, methanol/water (70/30, v/v) and methanol/water (50/50, v/v) extracts of horseradish roots and leaves. Among the extracts tested, both roots and leaves aqueous methanolic (70/30, v/v and 50/50, v/v) extracts showed higher total phenol and flavonoid contents and antioxidant capacity than the corresponding methanol extracts. But extraction yield was high for methanol/ water (50/50, v/v) extracts, in both roots and leaves. The extracts exhibited anti-lipase activity in dose-dependent manner. The results showed that the extraction yield and the antioxidant capacity were strictly dependent on the solvent polarity. The results suggest that A. rusticana could provide opportunities for the development of functional food and further in vivo studies for obesity treatment.

关键词： Anti-Lipase Activity Antioxidant Leaves Horseradish Roots

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A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

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The Aromatic Plant Satureja horvatiissp. macrophyllaInduces Apoptosis and Cell Death to the A549 Cancer Cell Line

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American Journal of Plant Sciences 2015年第13期6卷 2092-2103页

作者： Paraskevi Yfanti Anna Batistatou Georgios Manos marilena E. Lekka Department of Agricultural Technology Technological Education Institute of Epirus Arta Greece Medical School University of Ioannina Ioannina Greece Chemistry Department University of Ioannina Ioannina Greece

S. horvatii ssp. macrophylla (Lamiaceae) is an endemic aromatic plant of Greece and is used as a culinary herb. In the present study we explored its possible anticancer activity through the induction of apoptosis on cancer cells using A549 cell line as a model. The cytotoxic effects and the type of cell death (apoptosis/necrosis) were evaluated with biochemical and morphological criteria. The total methanol extract of S. horvatii ssp. macrophylla revealed forty two components, of which carvacrol was the major constituent (43.2%). Only a minor portion of them (3.41%) was contained in the active working plant extract solution which was used for cell treatment. This study indicates that extract of S. horvatii spp. macrophylla, which belongs to carvacrol chemotype, can induce both apoptosis and necrosis to A549 cancer cell line.

关键词： Satureja horvatii spp. macrophylla Apoptosis Cytotoxicity A549 GC/MS

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Vibrations and Stresses Induced in the Rock by the Detonating Cord Splitting of Dimension Stone Blocks

Vibrations and Stresses Induced in the Rock by the Detonatin...

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The Seventh International Symposium on Rock Fragmentation by Blasting

作者： Renato MANCINI marilena CARDU Luigi GARIBALDI Alessandro FASANA Dipartimento di Georisorse e Territorio Politecnico di Torino-Italy CNR FIRGET Torino-Italy Dipartimento di Georisorse e Territorio Politecnico di Torino-Italy CNR FIRGET Torino-Italy Dipartimento di Meccanica Politecnico di Torino-Italy Dipartimento di Meccanica Politecnico di Torino-Italy

＜正＞ Detonating cord splitting is a quite common production method for dimension stone blocks, in granite and gneiss quarries, where the blasts are usually designed on the basis of local *** paper relates on a vibrometric test campaign, carried on in a group of gneiss quarries by means of accelerometric measurements at close proximity to the splitting holes rows, both in primary splitting and in recutting operations. Main objectives of the campaign are:- to detect, or to exclude, the possibility of impairment of the commercial stone blocks produced by this method;- to check the validity of the blast design criteria adopted by the quarries;- to obtain experimental data for predicting the friction conditions at the boundaries of the block and its expected displacement.

关键词： Dimension stone blocks Detonating cord Splitting by explosive Vibrations

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A Method for Astral Microtubule Tracking in Fluorescence Images of Cells Doped with Taxol and Nocodazole

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Advances in Molecular Imaging 2019年第4期9卷 60-86页

作者： marilena Varrecchia Joshua Levine Gabriella Olmo Marco Grangetto Marta Gai Ferdinando Di Cunto Department of Automatics and Computer Science Politecnico di Torino Torino Italy

In this paper, we describe an algorithm that performs automatic detection and tracking of astral microtubules in fluorescence confocal images. This sub-population of microtubules only exists during and immediately before mitosis and aids in the spindle orientation by connecting it to the cell cortex. Anomalies in their dynamic behaviour play a causal role in many diseases, such as development disorders and cancer. The main novelty of the proposed algorithm lies in the fact it provides a fully automated estimation of parameters related to microtubule dynamic instability (growth velocity, track length and track lifetime), and helps in understanding the effects of intermediate drug concentrations. Its performance has been objectively assessed using publicly available synthetic data and largely employed metrics. Moreover, we present experiments addressing cell cultures doped with different concentrations of taxol and nocodazole. Such drugs are known to suppress the microtubule dynamic instability, but their effects at intermediate concentrations are not completely assessed. The algorithm has been compared with other state-of-the-art approaches, tested on consistent real datasets. The results are encouraging in terms of performance, robustness and simplicity of use, and the algorithm is now routinely employed in our Department of Molecular Biotechnology.

关键词： Medical Diagnostic Imaging Fluorescence Confocal Microscopy Image Segmentation Microtubules

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非物质文化遗产与抹除:对文化保护与当代博物馆实践的再思考

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文化艺术研究 2013年第3期6卷 154-164页

作者： marilena Alivizatou 高菲伦敦大学学院考古学院南京大学英语系南京210023

非物质文化遗产这一概念在国际遗产保护界的提出,正与文化同质化的担忧以及保护世界多样性的需求相关。联合国教科文组织制定的规范性框架是否会导致文化被当作一套濒临消亡的生活方式而体制化,正是许多批评者提出的疑问。本文联系遗产... 详细信息

非物质文化遗产这一概念在国际遗产保护界的提出,正与文化同质化的担忧以及保护世界多样性的需求相关。联合国教科文组织制定的规范性框架是否会导致文化被当作一套濒临消亡的生活方式而体制化,正是许多批评者提出的疑问。本文联系遗产抹除机制和遗产毁坏与恢复之间的创造性交互作用,回顾了体制化的文化保护办法,再以两个迥异的公共空间即新西兰国家博物馆(蒂帕帕博物馆)与巴黎的凯布朗利博物馆中的原住民身份政治为背景,对这些办法进行了检视。

关键词：非物质文化遗产文化保存话语 UNESCO 博物馆学遗产抹除

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The Hemochromatosis Distribution in Matera Province： A New SNP to Explain the Low Genotype-Phenotype Correlation

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Journal of Life Sciences 2012年第5期6卷 469-475页

作者： Maria Carmela Padula marilena Larocca Rocco Rossano Luigi Milella Domenico Dell'Edera Giuseppe Martelli Department of Biology University of Basilicata Potenza Viale dell 'Ateneo Lucano 85100 Italy

The present study aims to investigate the genotype-phenotype correlation of the hereditary hemochromatosis （HH）, a genetic disorder of iron metabolism, in Matera province （Basilicata, Italy）. Integrating both epidemiological and molecular approaches, the authors studied：（a） the frequency of the HH main mutations; （b） the association between mutations and HH cases. The majority of patients with HH are homozygous for the C282Y mutation of the HFE gene. A second mutation （H63D） is more widely distributed and its connection with HH isn＇t clear, but a low penetrance is attributed to this variant. The population-based study consists of three steps：（1） determination of iron biochemical parameters, （2） genetic test, and （3） sequencing of HFE gene and bioinformatics studies. A case report is presented in a 41-year-old male （genotype： H63D/wt） with biochemical and clinical evidences of HH, in absence of secondary iron overload factors. In the cohort of studied patients （150M：62F）, there are 18 homozygous patients; H63D/H63D genotype is found in 11 cases. In the heterozygous group, H63D/wt is the predominant genotype （61/68 subjects）. All the H63D/wt residents in the same village （Mont.） show altered biochemical parameter levels. In our case study, a substitution localized into the HFE promoter （nt225A 〉 C） is found. Results show that the H63D genotype is responsible for most cases of HH. The peculiar clinical manifestation found in Mont. suggests a founder effect. In our case, the iron overload is related to a presence of an undetected mutation, critical for the transcriptional regulation of the HFE gene.

关键词： Hereditary hemochromatosis HFE gene variants clinical phenotype transcriptional regulation.

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GEOLOGIA E PEDOSTRATIGRAFIA DELLA COLLINA DI CILIVERGHE(Brescia)

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Natural Disaster Reduction in China 1986年第1期 55-78页

作者： CARLO BARONI MAURO CREMASCHI Fasi glaciali pedogenesi e sedimentazione loessica al margine aipino durante il Pleistocene Museo Civico di Scienze Naturali di Brescia:《frequentatore》del Dipartimento di Scienze della Terra dell'Università di Pavia Centro di Studio per la Stratigrafia e la Petrografia delle Alpi Centrali C.N.R..Milano Lavoro Lavoro eseguito nell'ambito del Progetto di Ricerca sui paleosuoli nel margine alpino del Centro C.N.R.per la Stratigrafia e la Petrografia delle Alpi Centrali e del Progetto Nazionale di Ricerca《Morfoncotettonica》 M.P.I.40% responsabile locale P.L.Vercesi eseguito nell'ambito del Progetto di Ricerca sui paleosuoli nel margine alpino del Centro C.N.R.per la Stratigrafia e la Petrografia delle Alpi Centrali e del Progetto Nazionale di Ricerca《Morfoncotettonica》 M.P.I.40% responsabile locale P.L.Vercesi.

Geology and pedo-stratigraphy of the Ciliverghe hill(glacial deposits,pedogenesis,and loess sedi-mentation along the Alpine fringe during the Pleistocene).-Ciliverghe hill consists of Pleistocene *** lowest units(CIL 1 and CIL 2).composed of till and related fluvioglacial *** oldest moraine ridge of the Garda lake moraine *** units are covered with angular unconfor-mity,by glacio-lacustrine marls(CIL 3),by fluviatile gravels supplied from a local source(CIL 4)and by flu-vio-glacial gravels(CIL 5)including Central-Alpine *** the upper unit a rubefied,strongly weatheredpalaeosol is *** the top of the sequence there is a polygenetic cover of loess consisting of at leastthree distinct layers intercalated with pedogenetic *** uppermost loess which includes mouste-rian artifacts dates back to the Late Pleistocene,Five glacial stages are therefore recorded in the Ciliverghesequence,probably spanning the whole glacial *** stratigraphical and morphological develop-ment of the Ciliverghc hill has been tectonicallv controlled due to the activity of buried tectonic structures.

关键词： Pi Pro PI La GEOLOGIA E PEDOSTRATIGRAFIA DELLA COLLINA DI CILIVERGHE Brescia CIL

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