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Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： Riccardo Brandiele Andrea Guadagnini Mattia Parnigotto Federico Pini Vito Coviello Denis Badocco Paolo Pastore Gian Andrea Rizzi Andrea Vittadini Daniel Forrer Vincenzo Amendola Christian durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday *** nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating *** this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ***_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in *** novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y LAL LFL Oxide support Pto Nanoalloys

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

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World Journal of Gastroenterology 2024年第9期30卷 1132-1142页

作者： Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Hepatogastroenterology Division Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Pathology Division Department of Mental and Physical Health and Preventive MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Experimental Medicine Division of PharmacologyUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Advanced Medical and Surgical Sciences(DAMSS) University of Campania Luigi VanvitelliNaples 80138Italy Department of Pharmacy University of Naples Federico IINaples 80131Italy

BACKGROUND Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin ***,data regarding their role in inflammatory bowel diseases(IBD)are currently *** This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(CD)and ulcerative colitis(UC),aligning them with IBD disease endoscopic and histologic *** Colonic mucosal biopsies from CD/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and *** sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and CD endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both CD and UC inflamed mucosa,MC3R(CD:+7.7 fold vs normal mucosa,P<0.01;UC:+12 fold vs normal mucosa,P<0.01)and MC5R(CD:+5.5 fold vs normal mucosa,P<0.01;UC:+8.1 fold vs normal mucosa,P<0.01)were significantly more expressed compared to normal *** MC3R and MC5R are expressed in the colon of IBD ***,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both CD and UC,suggesting a potential use of these receptors in IBD pharmacology.

关键词： Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's disease Inflammatory bowel disease

Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement

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World Journal of Gastroenterology 2014年第40期20卷 14642-14651页

作者： Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti marilena durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro Regional Alcohologic Centre Liguria Region Alcohol Unit and Related Diseases Department of Internal and Specialist Medicine IRCCS AOU San Martino-IST National Institute for Cancer Research 16100 Genova Italy Gastroenterology Department of Surgical and Gastroenterological Sciences University Hospital of Padova Veneto Region 35100 Padova Italy Internal Medicine University of Pisa 56100 Pisa Italy Department of DependenceASS4 Medio Friuli Regione Autonoma Friuli Venezia Giulia34100 Trieste Italy Regional Transplantation Centre Autonomous Region of Friuli Venezia Giulia 33100 Udine Italy Regional Transplantation Centre Liguria Region 16100 Genova Italy Regional AlcohologicCentre Toscana Region Alcohol Unit Careggi Hospital University of Firenze 50100 Firenze Italy Department of Dependence Molise Region 86100 Campobasso Italy Alcohol Unit Department of Dependence Molise Region 86100 Campobasso Italy Alcohol Unit ASL di Ravenna Emilia Romagna Region 48100 Ravenna Italy Alcohol Unit ASL 4 di Terni Umbria Region05100 Terni Italy Hepatology Unit Santa Maria Hospital 05100 Terni Italy Gastroenterology Ordine Mauriziano Hospital Piemonte Region 10100 Torino Italy Italian Clubs of Alcoholics in Treatment 84134 Salerno Italy Department of Toxicology University of Genova 16100 Genova Italy World Health Organization Collaborating Centre for Research and Health Promotion on Alcohol and Alcohol-related Health Problems Europe Region Istituto Superiore di Sanità 00100 Roma Italy

Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular ***-four per cent of all deaths from cirrhosis are attributed to *** liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the"6-mo rule".Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety *** is necessary to identify other risk factors that could be associated with the resumption of alcohol ***"Group of Italian Regions"suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving *** multidisciplinary transplant team must include an addiction specialist/*** have to participate in self-help groups.

关键词： Alcohol Alcoholic hepatitis Cirrhosis Hepatocellul

Prognostics for Lithium-ion batteries for electric Vertical Take-off andLanding aircraft using data-driven machine learning

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能源与人工智能(英文) 2023年第2期12卷 145-162页

作者： Mihaela Mitici Birgitte Hennink marilena Pavel Jianning Dong Faculty of Science Utrecht UniversityHeidelberglaan 83584 CSUtrechtThe Netherlands Faculty of Aerospace Engineering Delft University of TechnologyKluyverweg 1HS 2926DelftThe Netherlands Electrical Engineering Mathematics and Computer Science FacultyTU Delft2628 CDDelftThe Netherlands

The health management of batteries is a key enabler for the adoption of Electric Vertical Take-off and Landingvehicles (eVTOLs). Currently, few studies consider the health management of eVTOL batteries. One distinctcharacteristic of batteries for eVTOLs is that the discharge rates are significantly larger during take-off andlanding, compared with the battery discharge rates needed for automotives. Such discharge protocols areexpected to impact the long-run health of batteries. This paper proposes a data-driven machine learningframework to estimate the state-of-health and remaining-useful-lifetime of eVTOL batteries under varying flightconditions and taking into account the entire flight profile of the eVTOLs. Three main features are consideredfor the assessment of the health of the batteries: charge, discharge and temperature. The importance of thesefeatures is also quantified. Considering battery charging before flight, a selection of missions for state-ofhealth and remaining-useful-lifetime prediction is performed. The results show that indeed, discharge-relatedfeatures have the highest importance when predicting battery state-of-health and *** several machine learning algorithms, it is shown that the battery state-of-health and remaining-useful-lifeare well estimated using Random Forest regression and Extreme Gradient Boosting, respectively.

关键词： Electric Vertical Take-off and Landing vehicles Lithium-ion battery State-of-health Machine learning Remaining-useful-life

The challenges on operating a zero net energy building facing global warming conditions

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Building Simulation 2022年第3期15卷 435-451页

作者： Alberto Hernandez Neto Luciane Cleonice durante Ivan Julio Apolonio Callejas Emeli Lalesca Aparecida da Guarda JoséVinnicius Ranieri Moreira Escola Politécnica University of São PauloBrazil Federal University of Mato Grosso Brazil Federal University of Santa Catarina Brazil

This study proposes a methodology to evaluate the energy performance of existing Zero Energy Buildings and to prospect retrofit strategies in a Savannah climate,concerning the A2 scenario of emissions from the Fourth Report of the Intergovernmental Panel on Climate *** selected building to study is recognized for its high energy performance,named Centro SEBRAE de Sustentabilidade(CSS).Two efficient measures were considered:(i)improvement in the air conditioning system coefficient of performance(COP)and(ii)in the energy efficiency of the photovoltaic plates of generation *** methodology is grounded in the potential bioclimatic concept and the employed steps applied were:preparation of climate archives in the 2020,2050 and 2080 time-slices;calibration of the computational model;evaluation of the retrofit strategies on its energy consumption efficiency through computer *** the CSS has already attended mostly the bioclimatic strategies for the local climate and has high efficiency measures in its systems,the retrofit focused the air conditioning and PV *** isolated retrofit of the air conditioning system was unable to guarantees the NZEB condition despite providing an adequate level of energy efficiency until *** retrofit of the PV system was the only one that provides the NZEB condition for climate change *** contribution of this paper is to provide a guide to be used in NZEBs,with measures of optimization that provide high potential bioclimatic face to the local where it is built,making it possible to maintain this condition in scenarios of global warming.

关键词： sustainable constructions potential bioclimatic building energy consumption weather scenarios

Physiological cellular responses and adaptations of Rhodococcus erythropolis IBB_(Po1) to toxic organic solvents

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Journal of Environmental Sciences 2014年第10期26卷 2065-2075页

作者： Mihaela marilena Stancu Institute of Biology Bucharest of Romanian Academy Bucharest 060031 P.O. Box 56-53 Romania

A new Gram-positive bacterium, Rhodococcus erythropolis IBBPo1（KF059972.1） was isolated from a crude oil-contaminated soil sample by enrichment culture method. R. erythropolis IBBPo1 was able to tolerate a wide range of toxic compounds, such as antibiotics（800–1000 μg/mL）,synthetic surfactants（50–200 μg/mL）, and organic solvents（40%–100%）. R. erythropolis IBBPo1 showed good tolerance to both alkanes（cyclohexane, n-hexane, n-decane） and aromatics（toluene, styrene, ethylbenzene） with logPOW（logarithm of the partition coefficient of the solvent in octanol–water mixture） values between 2.64 and 5.98. However, alkanes were less toxic for R. erythropolis IBBPo1 cells, compared with aromatics. The high organic solvent tolerance of R. erythropolis IBBPo1 could be due to the presence in their large genome of some catabolic（alkB, alkB1, todC1, todM, xylM）, transporter（HAE1） and trehalose-6-phosphate synthase（otsA1, KF059973.1） genes. Numerous and complex physiological cellular responses and adaptations involved in organic solvent tolerance were revealed in R. erythropolis IBBPo1 cells exposed 1 and 24 hr to 1% organic solvents. R. erythropolis IBBPo1 cells adapt to 1% organic solvents by changing surface hydrophobicity, morphology and their metabolic *** modifications in otsA1 gene sequence were also observed in cells exposed to organic solvents（except ethylbenzene）.

关键词： Rhodococcus erythropolis Adaptation Organic solvents

Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications

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World Journal of Stem Cells 2022年第1期14卷 54-75页

作者： Carla Vicinanza Elisabetta Lombardi Francesco Da Ros Miriam Marangon Cristina durante Mario Mazzucato Francesco Agostini Stem Cell Unit Centro di Riferimento Oncologico di AvianoIRCCSAviano 33081Italy

Mesenchymal stem stromal cells(MSC)are characterized by the intriguing capacity to home toward cancer cells after systemic ***,MSC can be harnessed as targeted delivery vehicles of cytotoxic agents against *** cancer patients,MSC based advanced cellular therapies were shown to be safe but their clinical efficacy was ***,the amount of systemically infused MSC actually homing to human cancer masses is insufficient to reduce tumor ***,induction of an unequivocal anticancer cytotoxic phenotype in expanded MSC is necessary to achieve significant therapeutic *** vivo cell modifications are,thus,required to improve anti-cancer properties of *** based cellular therapy products must be handled in compliance with good manufacturing practice(GMP)*** the present review we include MSCimproving manipulation approaches that,even though actually tested at preclinical level,could be compatible with GMP *** particular,we describe possible approaches to improve MSC homing on cancer,including genetic engineering,membrane modification and cytokine ***,we discuss appropriate modalities aimed at inducing a marked cytotoxic phenotype in expanded MSC by direct chemotherapeutic drug loading or by genetic *** conclusion,we suggest that,to configure MSC as a powerful weapon against cancer,combinations of clinical grade compatible modification protocols that are currently selected,should be introduced in the final *** standardized cancer clinical trials are required to test the efficacy of ameliorated MSC based cell therapies.

关键词： Cancer Mesenchymal stem stromal cells Good manufacturing practice Homing Targeted therapy Ex vivo cell modification

Analysis of predictor equations for determining the blast-induced vibration in rock blasting

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International Journal of Mining Science and Technology 2019年第6期29卷 905-915页

作者： marilena Cardu Dario Coragliotto Pierpaolo Oreste DIATI Politecnico di Torino 10129 TorinoItaly IGG-CNR Torino 10129Italy Lochaline Quartz Sand Ltd. Lochaline MinePA805LQ MorvernScotlandUnited Kingdom

The paper proposes a new empirical correlation designed to complement the‘‘site laws"currently used to evaluate the attenuation in the rock masses of vibrations induced by rock *** formula contains a deformed exponential known as the K-exponential,which seems to well represent a large number of both natural and artificial phenomena ranging from astrophysics to quantum mechanics,with some extension in the field of economics and *** validation of the formula was performed via the analysis of vibration data covering a number of case studies,which differed in terms of both operation and rock type.A total of 12 experimental cases were analysed and the proposed formulation exhibited a good performance in 11 of *** particular,the proposed law,which was built using blast test data,produced very good approximations of the points representing the vibration measurements and would thus be useful in organising production ***,the developed formula was found to work less well when a correlation obtained for a given site was applied to another presenting similar types of rocks and operations,and thus should not be employed in the absence of measurements from test data.

关键词： Rock blasting Vibrations Predictor equation Site law K-statistics K-exponential

Squarefree Monomial Modules and Extremal Betti Numbers

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Algebra Colloquium 2016年第3期23卷 519-530页

作者： marilena Crupi Carmela Ferro University of Messina Department of Mathematics and Computer Science Viale Ferdinando Stagno d'Alcontres 31 Messina 98166 Italy

Let K be a field and let S = K[x1,...,xn] be a polynomial ring over K. Let F = ir=1 Sei be a finitely generated graded free S-module with basis {e1,..., er} in degrees f1,..., fr such that f1≤ f2 ~≤……≤ fr. We examine some classes of squarefree monomial submodules of F. Hence, we focalize our attention on the Betti table of such classes in order to analyze the behavior of their extremal Betti numbers.

关键词： graded modules squarefree monomial modules minimal graded resolutions

Biodegradable Mg alloys for orthopedic implants——A review

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Journal of Magnesium and Alloys 2021年第6期9卷 1884-1905页

作者： Violeta Tsakiris Christu Tardei Florentina marilena Clicinschi Department of Metallic Composite and Polymeric MaterialsNational Institute for Research and Development in Electrical Engineering(ICPE–Advanced Researches)313 Splaiul UniriiDistrict 3030138 BucharestRomania

The last decade has seen a significant growth in the market for alloys used for implants,especially for those intended for orthopedic *** into biodegradable magnesium-based alloys has made great strides in this period,so huge progress has been made in their use in the medical *** important factors that led to the intensification of research in this regard,were social but also economic,wanting to improve the quality of life,by reducing the use of conventionally permanent metallic implants(stainless steel,cobalt-based alloys,and titanium alloys)which involve the second implant removal surgery and other undesirable effects(stress shielding and metal ion releases),with a negative impact on the emotional and physical condition of patients,and by significantly reducing the costs for both the patient and the health system in the field of *** paper refers to the impact and importance of biodegradable Mg alloys,reviewing the beginning of their development,the significant characteristics that make them so desirable for such applications(orthopedic implants)but also the characteristics that must be modulated(corrosion rate and mechanical properties)to arrive at the ideal product for the targeted *** highlights,in detail,the mechanism and aspects related to the corrosion behaviour of Mg alloys,electrochemical characterization techniques/methods,as well as strategies to improve the corrosion behaviour and mechanical properties of these types of biodegradable *** means of optimization,the category and the effect of the alloying elements,the design criteria,the requirements that the implants of biodegradable alloys Mg-based must meet and the aspects related to their efficiency are also ***,the potential applications in the specialized clinics,as well as the final products currently used and made by important prestigious companies in the world are approached.

关键词： Mg alloys Biodegradable Orthopedic implants Corrosion Degradation Biomedical applications