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Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第28期11卷 4382-4389页

作者： Hiroaki Yokomori Masaya Oda mariko ogi Go Wakabayashi Shigeyuki Kawachi Kazunori Yoshimura Toshihiro Nagai Masaki Kitajima Masahiko Nomura Toshifumi Hibi Department of Internal Medicine Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Organized Center of Clinical Medicine International University of Health and Welfare Tokyo 107-0052Japan Laboratory of Pathology Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Department of Surgery School of Medicine Keio UniversityTokyo 160-0016Japan Physiology Saitama Medical School Saitama 350-0495Japan Electron Microscopy Laboratory School of Medicine Keio UniversityTokyo 160-0016Japan Department of Internal Medicine School of Medicine Keio UniversityTokyo 160-0016Japan

AIM：To examine the expression of intercellular adhesion molecule-1 （ICAM-1） and lymphocyte function-associated antigen-1（LFA-1）expression on canals of Hering （COH）and bile ductules associated with the autoimmune process of bile duct destruction in primary biliary cirrhosis（PBC）．METHODS：Ten wedged liver biopsies of PBC（five cases each of stages 2 and 3）were studied. The liver specimens were processed for transmission electron microscopy. Immunohistochemistry was performed using anti-ICAM-1 and anti-LFA-1 mouse *** situ hybridization was done to examine the messenger RNA expression of ICAM-1 in ***-embedded sections using peptide nucleic acid probes and the catalyzed signal amplification （CSA）***-silver staining for electron microscopy was Derrormed using anti-ICAM and anti-LFA-1 mouse *** immunogold particles on epithelial cells of bileductules and cholangiocytes of CoH cells were counted and analyzed *** blotting was performed to confirm ICAM-1 protein expression．RESULTS：In liver tissues of PBC ***-stochemistry showed aberrant ICAM-1 expression on the plasma membrane of epithelial cells lining bile ductules，and also on mature cholangiocytes but not on hepatocytes in ***-1-positive lymphocytes were closely associated with epithelial cells in bile ***-1 expression at protein level was confirmed by Western *** situ hybridization demonstrated ICAM-1 mRNA expression in bile ductules and LFA-1 mRNA in lymphocytes infiltrating the *** immunoelectron microscopy，ICAM-1 was demonstrated on the basal suface of epithelial cells in bile ductules and on the luminal surfaces of cholangiocytes in damaged *** with intermediate morphology resembling progenitor cells in Coil were not labeled with ICAM-1 and LFA-1．CONCLUSION：De novo expression of ICAM-1 both on mature cholangiocytes in COH and epithelial cells in bile ductules in PBC implies that lymphocyte-indu

关键词： Primary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopyPrimary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopy

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Effect of visual attention guidance by camera work in visualization using dome display

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 42-54页

作者： Tetsuro ogi Takeshi Yokota Graduate School of System Design and Management Keio University Japan

Dome display is expected to be used as effective visualization environment for modeling and simulation due to the features of frameless and high immersive ***,since the users in the dome display can see the projected image in arbitrary direction freely,it is difficult to share information among the *** this research,in order to solve such a problem,the effect of visual attention guidance in the dome environment due to the effect of camera work was *** a visualization system,DomePlayer that can express the effect of camera work based on the camera work description language was *** the result of evaluation experiments using this system,the constraint condition of the camera work in the dome environment was derived and the effect of visual attention guidance by the camera work was evaluated.

关键词： Visual attention guidance dome display 360◦image camera work VR sickness

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Forecasting of Asian dust storm that occurred on May 10-13, 2011, using an ensemble-based data assimilation system

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Particuology 2016年第5期14卷 121-130页

作者： Keiya Yumimoto Hiroshi Murakami Taichu Y. Tanaka Tsuyoshi T. Sekiyama Akinori ogi Takashi Maki Meteorological Research Institute 1-1 Nagamine Tsukuba Ibaraki 305-0052 Japan Earth Observation Research Center Japan Aerospace Exploration Agency 2-1-1 Sengen Tsukuba Ibaraki 305-8505Japan Japan MeteorologicalAgency 1-3-40temachi Chiyoda-ku Tokyo lO0-8122Japan

An ensemble-based assimilation system that used the MASINGAR ink-2 （Model of Aerosol Species IN the Global AtmospheRe Mark 2） dust forecasting model and satellite-derived aerosol optical thickness （AOT） data. processed in the JAXA （Japan Aerospace Exploration Agency） Satellite Monitoring for Environmental Studies （JASMES） system with MODIS （Moderate Resolution Imaging Spectroradiometer） observations. was used to quantify the impact of assimilation on forecasts of a severe Asian dust storm during May 10-13. 2011. The modeled bidirectional reflectance function and observed vegetation index employed in JASMES enable AOT retrievals in areas of high surface reflectance, making JASMES effective for dust forecasting and early warning by enabling assimilations in dust storm source regions. Forecasts both with and without assimilation were validated using PM^0 observations from China, Korea, and Japan in the TEMM WG1 dataset. Only the forecast with assimilation successfully captured the contrast between the core and tail of the dust storm by increasing the AOT around the core by 70-150% and decreasing it around the tail by 20-30% in the 18-h forecast. The forecast with assimilation improved the agreement with observed PMlo concentrations, but the effect was limited at downwind sites in Korea and Japan because of the lack of observational constraints for a mis-forecasted dust storm due to cloud.

关键词： Data assimilation Aerosol transport model Ensemble Kalman filter Satellite observation Aerosol optical thickness Asian dust

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New insight into pyrrolic-N site effect towards the first NIR window absorption of pyrrolic-N-rich carbon dots

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Nano Research 2023年第4期16卷 6001-6009页

作者： Fitri Aulia Permatasari Reza Umami Citra Deliana Dewi Sundari Tirta Rona Mayangsari Atthar Luqman Ivansyah Fahdzi Muttaqien Takashi ogi Ferry Iskandar Department of Physics Faculty Mathematics and Natural SciencesInstitut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Collaboration Research Center for Advanced Energy Materials National Research and Innovation Agency-Institut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Department of Chemistry Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10BandungWest Java 40132Indonesia Department of Chemistry Education UIN Sunan Gunung Djati BandungJl.CimincrangBandungWest Java 40292Indonesia Department of Chemistry Universitas PertaminaJakarta 12220Indonesia Master Program in Computational Science Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10BandungWest Java 40132Indonesia Instrumentation and Computational Physics Research Group Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10Bandung 40132Indonesia Research Center for Nanoscience and Nanotechnology Institut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Chemical Engineering Program Department of Advanced Science and EngineeringGraduate School of Advanced Science and EngineeringHiroshima UniversityHigashi-Hiroshima 739-8527Japan

Controlled C-N configurations,i.e.,pyrrolic-N,pyridinic-N,and graphitic-N,are promising strategies to tailor the carbon dots’(CDs)optical properties into the first near infrared(NIR)window(650-900 nm),a responsive range for biomedical ***,a deep understanding of the role of the C-N configuration in the CDs’properties is still challenging and thoughtprovoking owing to their complex ***,an underlying pyrrolic-N concentration and position effect on the pyrrolic-N-rich CDs’absorption was comprehensively elucidated based on the integrated experimental and computational *** assynthesized pyrrolic-N-rich CDs exhibit a first NIR window absorption centered at 650 nm with high photothermal ***-N concentrations from 1.4%to 11.3%and positions(edge and mid-site)were systematically investigated.A mid-site pyrrolic-N was subsequently generated after the pyrrolic-N concentration more than 10%.Edge-site pyrrolic-N induces a frontier orbital hybridization,reducing bandgap energy,while mid-site pyrrolic-N plays a critical role in inducing a first NIR window absorption owing to their high charge ***,pyrrolic-N-rich CDs inherit a bowl-like topological feature,elevating the CDs’layer thickness as much as 0.71 *** study shed light on the design and optimization of pyrrolic-N on CDs for the first NIR window responsive materials in any biomedical application.

关键词： absorption carbon dots charge transfer first near infrared(NIR)window frontier orbital hybridization mid-site pyrrolic-N

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Fatigue Behavior of Open-Holed CFRP Laminates with Initially Cut Fibers

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Open Journal of Composite Materials 2017年第1期7卷 49-62页

作者： Sudarsono Sudarsono Keiji ogi Graduate School of Science and Engineering Ehime University Ehime Japan Department of Mechanical Engineering Halu Oleo University Kendari Indonesia

Carbon fiber-reinforced plastic (CFRP) laminates with initially cut fibers (ICFs) have good formability without large degradation of static strength;however, their fatigue behavior has not been investigated thus far. In this paper, we investigated fatigue behavior and damage progress of open-holed CFRP laminates with ICFs having interlayers. Three types of CFRP laminates were employed: a laminate without ICF fabricated using an autoclave (Continuous-A), a laminate with ICF fabricated using an autoclave (ICF-A) and a laminate with ICF fabricated using press molding (ICF-P). First, fatigue test was conducted to obtain S (maximum stress)-N (the number of cycles to failure) curves in order to reveal fatigue strength. The fatigue tests for several specimens were interrupted at three prescribed numbers of cycles to observe damage progress. It is found that the Continuous-A laminate shows little strength degradation in the S-N curve while fatigue strength in both ICF laminates is decreased by approximately 30% at N of 106. In contrast, the damage progress of the ICF-P laminate is the least among the three laminates while the delamination progress at both edges and around the hole in the Continuous-A laminate is the most prominent.

关键词： Carbon Fiber-Reinforced Plastic Fatigue Initially Cut Fibers Open-Holed Interlayer

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Microstructural Evolution in Directionally Solidified Ni-Base Superalloy IN792+Hf

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Journal of Materials Science & Technology 2008年第1期24卷 110-114页

作者： S.M.Seo I.S.Kim J.H.Lee C.Y.Jo H.Miyahara K.ogi High Temperature Materials Research Group KIMS Changwon641-010Korea Dept.of Metall.& Mater.Eng. Changwon Univ. Changwon641-773Korea Dept.of Mater.Sci.& Eng. Kyushu Univ. Fukuoka819-0395Japan Oita National College of Technology Oita 870-0152Japan

Microstructural evolution during directional solidification （DS） of Ni-base superalloy IN792＋Hf has been investigated with an emphasis on theγ′precipitates and MC-type *** quantitative image analyses revealed that the increase in the solidification rate up to 100μm/s at constant thermal gradient of 178 K/cm resulted in a fine and uniform distribution ofγ′*** relationship between the as-castγ′size and cooling rate was also determined for DS IN792＋*** the mean time,the MC carbide size was found to be dependent both on the solidification rate and the S/L interface morphology while the area fraction of MC carbide was significantly influenced by the S/L interface morphology.

关键词： IN792 MC corbide Gamma prime Solidification rate

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The leaf extract of Mallotus japonicus and its major active constituent, rutin,suppressed on melanin production in murine B16F1 melanoma

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Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 819-823页

作者： Junsei Taira Eito Tsuchida Masatsugu Uehara Natsuko Ohhama Wakana Ohmine Takayuki ogi Department of Bioresource Technology Okinawa National College of Technology Okinawa Industrial Technology Center

Objective: To find anti-melanogenesis materials used in whitening ***: The ethanolic leaf extract of Mallotus japonicus(M. japonicus) having an anti-melanogenesis activity was separated by a sephadex LH-20 chromatography. Each fraction was measured for its tyrosinase inhibitory activity together with its polyphenol content using the Folin–Ciocalteu method. The anti-melanogenesis activity of the active fractions was determined by the melanin content in the murine B16F1 melanoma. The active fractions were put together due to similar constituents, and then separated by high performance liquid chromatography using a C-18 ODS column. The major antimelanogenesis compound was identified using1 H and13C-NMR and liquid chromatography-mass ***: The ethanolic leaf extract of M. japonicus showed an anti-tyrosinase activity with a high polyphenol content, resulting in suppression of melanin production in the B16F1 melanoma. The extract was separated and the active compound was identical as rutin based on the1 H,13C-NMR and liquid chromatography-mass spectrometry analysis data. In addition, the rutin treatment with cells reduced the melanin content in a concentration dependent manner without any cell toxicity. The leaf extract of M. japonicus containing rutin would be useful in whitening cosmetics for protection from UV-light exposure to be limiting the accumulation of melanin in ***: The leaf extract of M. japonicus and/or rutin isolated from the extract as a key whitening agent would be useful as a whitening cosmetic material for protecting against disorder skin due to melanin accumulation.

关键词： melanin rutin melanoma cosmetics constituent suppr

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Estimation of mineral and trace element intake in vegans living in Japan by chemical analysis of duplicate diets

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Health 2011年第11期3卷 672-676页

作者： Munehiro Yoshida Noriko ogi Yuki Iwashita Laboratory of Food and Nutritional Sciences Faculty of ChemistryMaterials and BioengineeringKansai UniversitySuitaJapan

Thirty-six daily duplicate diet samples were collected from 12 healthy female Japanese vegans and sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper, manganese, iodine, selenium, chromium and molybdenum in the diets were measured to estimate mineral and trace element intake by Japanese vegans. Significantly higher intake of potassium, magnesium, phosphorus, iron, copper, manganese and molybdenum was observed in vegans than in general Japanese women, but no difference was observed in sodium, iodine, selenium and chromium intake. Vegan calcium intake tended to be low compared to that of general women but the difference was not significant. Since high potassium, magnesium and iron intakes cannot be achieved by general Japanese diets and high intake of potassium and magnesium may prevent hyperextension and cardiovascular disease in vegans, there are few problems with Japanese vegan diets regarding mineral and trace element intake, except for calcium intake, which is low as it is in the general Japanese people.

关键词： Vegan Mineral intake Trace Element Intake Duplicate Diets Japan

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2-Octyl-Cyanoacrylate Skin Adhesive Used as a Splinting Material in Auricular Surgery

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Modern Plastic Surgery 2016年第4期6卷 21-26页

作者： Naoto Yamamoto Satoshi Yanagibayashi Ryuichi Yoshida Hiroyuki ogi Megumi Takikawa Akio Nishijima Eri Maruyama Department of Plastic and Reconstructive Surgery New Tokyo Hospital Chiba Japan Department of Plastic and Reconstructive Surgery Asakadai Central General Hospital Saitama Japan

In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.

关键词： Auricular Surgery Postoperative Dressings Splinting Material 2-Octyl-Cyanoacrylate Skin Adhesive

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铝合金基石墨复合材料的阻尼行为

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复合材料学报 1994年第4期11卷 39-43页

作者：谭启陈锋何德坪 Hrofumi Migahara Keiseku ogi Michiru Sakamoto 中国科学技术大学内耗与固体缺陷开放实验室东南大学材料科学与工程系日本九州大学材料科学与工程系日本九州工业试验所

用内耗技术研究了石墨颗粒／铝硅复合材料的低频阻尼行为，考查了阻尼对石墨含量、测量频率、温度和应变振帽的依赖关系以及相应的弹性模量的变化，比较了铸态和挤压变形复合材料的阻尼特征。对其阻尼机制作了初步的探讨。

关键词：复合材料石墨阻尼位错应变振幅效应

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