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Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants

World Journal of Gastroenterology 2018年第14期24卷 1540-1549页

作者： Naohiro Yanagisawa Naoyoshi Nagata Kazuhiro Watanabe Tatsuhiro Iida mariko hamada Sakurako Kobayashi Takuro Shimbo Junichi Akiyama Naomi Uemura Department of Gastroenterology and Hepatology National Center for Global Health and MedicineTokyo 162-8655Japan Ohta Nishinouchi Hospital Fukushima 963-8022Japan Department of Gastroenterology and Hepatology National Center for Global Health and MedicineKohnodai HospitalChiba 272-8516Japan

AIM To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants(DOAC).METHODS We collected data from 218 patients receiving oral anticoagulants(73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics(age-and sexmatched controls) who underwent polypectomy.(1) We evaluated post-polypectomy bleeding(PPB) risk in patients receiving warfarin or DOAC compared with controls;(2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge(HPB)(endoscopy guideline recommendation), continuing AC, and discontinuing AC without *** PPB rate was significantly higher in warfarin users and DOAC users compared with controls(13.7% and 13.7% vs 0.9%, P < 0.001), but was not significantly different between rivaroxaban(13.2%), dabigatran(11.1%), and apixaban(13.3%) users. Two thromboembolic events occurred in warfarin users, but none in DOAC users. Compared with the continuing anticoagulant group, the discontinuing anticoagulant with HPB group(guideline recommendation) had a higher PPB rate(10.8% vs 19.6%, P = 0.087). These findings were significantly evident in warfarin but not DOAC users. One thrombotic event occurred in the discontinuing anticoagulant with HPB group and the discontinuing anticoagulant without HPB group; none occurred in the continuing anticoagulant *** PPB risk was similar between patients taking warfarin and DOAC. Thromboembolism was observed in warfarin users only. The guideline recommendations for HPB should be re-considered.

关键词： High-risk endoscopic procedures Novel oral anticoagulants Endoscopic guideline validation Postprocedure gastrointestinal bleeding

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NANOPOROUS MATERIALS BASED ON SPIROKETAL AND SPIROTHIOKETAL POLYMERS FOR SEPARATING METHANOL-TOLUENE MIXTURE

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Chinese Journal of Polymer Science 2011年第4期29卷 450-455页

作者： hamada hamada Abdel-Razik Zeinhom Mohamed El-Bahy Chemistry Department Faculty of Science and Education(Alkhurma Branch)Taif UniversitySaudi Arabia

Organic microporous materials based on spiroketal and spirothioketal polymers were synthesized through 1,3- dioxol-forming polymerization reaction between pentaerythritol or pentaerythritol tetrathiol and different types of cyclohexa- 1,4-dione derivatives. The structure of the prepared polymers was confirmed by NMR spectroscopy and molecular mass measurements. Nitrogen adsorption/desorption isotherms of the prepared polymers show a large amount of nitrogen adsorbed at low relative pressure indicating microporosity. These polymers have Brunauer Emmitt and Teller （BET） surface areas in the range from 492 （m^2g^-1） to 685 （m^2 g^-1）. The prepared polymers were found to be useful for pervaporation separation of methanol-toluene mixture with a separation factor up to 12.5 and fluxes, varying between 6.7×10-3 kg/（m^2 h） and 13.4 × 10^-3 kg/（m^2 h）.

关键词： Spiroketal polymers Nanoporous materials Separation membranes.

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Bloch-type spaces and extended Cesàro operators in the unit ball of a complex Banach space

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Science China Mathematics 2019年第4期62卷 617-628页

作者： Hidetaka hamada Faculty of Science and Engineering Kyushu Sangyo University

Let B be the unit ball of a complex Banach space X. In this paper, we generalize the Bloch-type spaces and the little Bloch-type spaces to the open unit ball B by using the radial derivative. Next, we de?ne an extended Ces`aro operator T_φ with the holomorphic symbol φ and characterize those φ for which T_φ is bounded between the Bloch-type spaces and the little Bloch-type spaces. We also characterize those φ for which T_φ is compact between the Bloch-type spaces and the little Bloch-type spaces under some additional assumption on the symbol φ. When B is the open unit ball of a ?nite dimensional complex Banach space X, this additional assumption is automatically satis?ed.

关键词： Bloch-type space complex Banach space extended Cesaro operator little Bloch-type space

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Support points for families of univalent mappings on bounded symmetric domains

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Science China Mathematics 2020年第12期63卷 2379-2398页

作者： Hidetaka hamada Gabriela Kohr Faculty of Science and Engineering Kyushu Sangyo UniversityFukuoka 813-8503Japan Faculty of Mathematics and Computer Science Babecs-Bolyai UniversityCluj-Napoca 400084Romania

In this paper,we study some extremal problems for the family Sg^0(BX)of normalized univalent mappings with g-parametric representation on the unit ball BX of an n-dimensional JB*-triple X with r≥2,where r is the rank of X and g is a convex(univalent)function on the unit disc U,which satisfies some natural *** obtain sharp coefficient bounds for the family Sg^0(BX),and examples of bounded support points for various subsets of Sg^0(BX).Our results are generalizations to bounded symmetric domains of known recent results related to support points for families of univalent mappings on the Euclidean unit ball B^n and the unit polydisc U^n in C^*** questions will be also ***,we point out sharp coefficient bounds and bounded support points for the family Sg^0(B^n)and for special compact subsets of Sg^0(B^n),in the case n≥2.

关键词： bounded symmetric domain Carathéodory family g-Loewner chain parametric representation starlike mapping support point

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Sex differences in estrogen receptor promoter expression in the area postrema

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Neural Regeneration Research 2013年第2期8卷 149-155页

作者： Chunxiao Zhang Tomohiro hamada Department of Physiology Norman Bethune College of Medicine Jilin University Department of Physiology Nippon Medical School

Estrogen receptor a is widely distributed in the rat brain, but the tissue- or target-specificity of the estrogen receptor a gene promoters remains unknown. In the present study, we used transgenic rats expressing enhanced green fluorescent protein under the control of the estrogen receptor a 0/B promoter to examine expression driven by this promoter in two significant nuclei that regulate cardiovascular activity, the area postrema and the nucleus tractus solitarius. Immunohistochemistry showed that enhanced green fluorescent protein-labeled cells were distributed in the area postrema and the nucleus tractus solitarius of both female and male transgenic rats, and a neural network of enhanced green fluorescent protein-positive fibers was seen between the area postrema and the nucleus tractus solitarius. The number of enhanced green fluorescent protein-labeled cells in the area postrema of female rats was significantly higher than in the males, but no significant difference was found in the number of enhanced green fluorescent protein-labeled cells in the nucleus tractus solitarius. The sex differences in the number of enhanced green fluorescent protein-labeled cells in the area postrema was not affected after ovariectomy or 1713-estradiol benzoate treatment in adult rats. Our results suggest that the effects of estrogen in the area postrema are related to the expression of estrogen receptor a under the control of the 0/B promoter, and changes in the sex hormone environment in the adult period do not affect estrogen receptor a expression in the area postrema or the nucleus tractus solitarius.

关键词： neural regeneration basic research estrogen receptor a promoter green fluorescent protein sexdifferences area postrema nucleus tractus solitarius medulla estrogen rats grant-supportedpaper photographs-containing paper neuroregeneration

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Sharp Growth Theorems and Coefficient Bounds for Starlike Mappings in Several Complex Variables

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Chinese Annals of Mathematics,Series B 2008年第4期29卷 353-368页

作者： Hidetaka hamada Tatsuhiro HONDA Faculty of Engineering Kyushu Sangyo University Department of Architectural Engineering Hiroshima Institute of Technology

Let B be the unit ball in a complex Banach space. Let S^＊k＋1（B） be the family of normalized starlike mappings f on B such that z = 0 is a zero of order k ＋ 1 of f（z） - z. The authors obtain sharp growth and cov... 详细信息

关键词： Sharp coefficient bound Sharp covering theorem Sharp growth theorem Starlike mapping Zero of order k

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Developed correlations between sound wave velocity and porosity, permeability and mechanical properties of sandstone core samples

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Petroleum Research 2020年第4期5卷 326-338页

作者： Ghareb hamada Veronique Joseph Petroleum Engineering depuroment College of Engineering American University of KurdistanKurdistanlrag Petroleurm Enginering Department Faculty of Engineering University Teknologi PetronasMalaysia

In the evaluation of a petroleum reserve,it is necessary to accurately determine certain petrophysical properties such as porosity and permeability of the reservoir rocks and rock mechanical *** properties are key factors in the reservoir descniption and geomechanical properties are determining parameters in drilling operations and in stimulation and hydraulic fracturing jobs and also the development plans for given *** is more convenient to use homogenous rock samples with nearly constant initial permeability;however,obtaining such cores is very *** this paper a simulated natural and homogeneous compacted sandstone rock with known physical and petrophysical propertie were *** properties of reservoir rocks incude pore size distribution;grain size,cementing material concentration,and confining pressure affect rock porosity and *** wave velocity was measured using an ultra sound tool on different sandstone core *** cor-relations have been developed between sound wave velocity(Vp and Vs)the petrophysical properties mainly porosity and *** correlations have been found between seismic wave ve-locity(Vp,Vs and VpVs)and mechanical parameters namely Young's modulus,shear modulus,bulk modulus and Poison's atio for sandstone core *** study has been carried out on dry core samples and core samples with different water saturations and results showed that there are changes in the correlation between seismic wave velocity and mechanical and ptrophysical properties as function of water saturation change from dry rock to water wet rock.

关键词： Seismic wave Porosity Permeability Mechanical parameters Sand core Samples Water saturation

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Linear Gyro-Kinetic Response Function for Zonal Flows

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Plasma Science and Technology 2011年第2期13卷 157-161页

作者： T.WATARI Y.hamada National Institute for Fusion Science

A linear response function for zonal flows is obtained by solving the gyro-kinetic equation. This is an extension of a previous work which adopted the method of ＂integrating along particle orbit＂ to solve the drift kinetic equation. The formula derived in this paper is used to calculate the dispersion relation of geodesic acoustic mode, which is then compared with that of the gyro-kinetic analytic formula.

关键词： zonal flow geodesic acoustic mode integrating along particle orbits

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Governance and Expertise in the Teaching Profession:An Analysis of Contemporary Japanese Educational Reforms

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ECNU Review of Education 2019年第2期2卷 166-177页

作者： Hirofumi hamada University of Tsukuba

Purpose:This article examines the Japanese teaching profession’s position on current school governance reforms in Japan and the difficulties teachers are facing as the reforms ***/Approach/Methods:This article describes how a policy for developing teacher quality standards tends to suppress teacher independence while increasing the heteronomy of the teaching *** article discusses how Japan can meet its goal of ensuring“expertise in the teaching profession”by referring to the relationship between“professionalism”and“publicness”in the theories of occupational ***:Expertise in the teaching profession is based on a mixture of academic and practical *** term“educational professionals”should be interpreted to include both“researchers”and“practitioners.”A sustainable governance mechanism for the Japanese teaching profession should be built on a four-way relationship among researchers,practitioners,citizens,and government ***/Value:This study provides a critical review of a broad-reaching educational policy and proposes a new approach for restructuring the governance of the Japanese teaching profession.

关键词： Autonomy Japanese education reform shared governance teaching profession

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Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey

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World Journal of Gastroenterology 2017年第16期23卷 2826-2831页

作者： Shin hamada Atsushi Masamune Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

Treatment of acute pancreatitis(AP) is one of the critical challenges to the field of gastroenterology because of its high mortality rate and high medical costs associated with the treatment of severe cases. Early-phase treatments for AP have been optimized in Japan, and clinical guidelines have been provided. However, changes in early-phase treatments and the relationship between treatment strategy and clinical outcome remain unclear. Retrospective analysis of nationwide epidemiological data shows that time for AP diagnosis has shortened, and the amount of initial fluid resuscitation has increased over time, indicating the compliance with guidelines. In contrast, prophylactic use of broad-spectrum antibiotics has emerged. Despite the potential benefits of early enteral nutrition, its use is still limited. The roles of continuous regional arterial infusion in the improvement of prognosis and the prevention of late complications are uncertain. Furthermore, early-phase treatments have had little impact on late-phase complications, such as walledoff necrosis, surgery requirements and late(> 4 w) AP-related death. Based on these observations, earlyphase treatments for AP in Japan have approached the optimal level, but late-phase complications have become concerning issues. Early-phase treatments and the therapeutic strategy for late-phase complications both need to be optimized based on firm clinical evidence and cost-effectiveness.

关键词： Diagnostic time Fluid resuscitation Enteral nutrition Continuous regional arterial infusion Walledoff necrosis

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