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21世纪经济和产业政策面临的挑战与前景——建立一个充满竞争的参与型社会

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经济资料译丛 2001年第3期 30-36页

作者： hattori Keiji 薛勇厦门大学国际贸易系 361005

——在全球市场一体化和国内社会快速老龄化的趋势下,日本的可持续发展将取决于是否能够成为一个充满竞争的参与型社会。在过去的五十年中,支撵日本发展的是建立在自给自足基础上的社会经济体制,它将被一个更加开放、与外界联系更加紧... 详细信息

——在全球市场一体化和国内社会快速老龄化的趋势下,日本的可持续发展将取决于是否能够成为一个充满竞争的参与型社会。在过去的五十年中,支撵日本发展的是建立在自给自足基础上的社会经济体制,它将被一个更加开放、与外界联系更加紧密的结构所取代。 ——为了实现这一目标,未来的经济和产业政策必须相互协调,为促进供求平衡创造各种必备的基本条件。 ——更具体地说,我们应主要通过技术创新来不断增强经济体制的竞争力。作为较早进入老龄化社会的国家,日本需要从制度上为社会的每位成员(包括老年人)创造广泛的就业机会和社会参与机会,使其通过一生的追求和激励,实现其价值、发现其才智、激发其潜能。

关键词： 21世纪经济发展产业政策日本技术创新

A case of recurrent rhabdomyolysis associated with childhood Sjogren’s syndrome

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Open Journal of Pediatrics 2013年第3期3卷 276-278页

作者： Shuntaro Morikawa Ichiro Kobayashi Yutaka Uzuki Masahiro Ueki Tetsuo hattori Hayato Aoyagi Department of Pediatrics Obihiro Kyokai HospitalObihiroJapan Department of Pediatrics Hokkaido University Graduate School of MedicineSapporoJapan Department of Pediatrics Sapporo City General HospitalSapporoJapan

We report a 9-year-old Japanese girl who presented with muscle weakness and elevated serum levels of muscle-derived enzymes following mycoplasma infection. Rhabdomyolysis or myositis was suggested by magnetic resonance imaging and repeated four times within 4 years. Each episode developed following respiratory infection and spontaneously recovered. The diagnosis of Sjogren’s syndrome was made by decreased salivary secretion, MR sialography, lip biopsy, and positive anti-SSA/Ro antibody. Given the rarity of rhabdomyolysis/myositis, recurrent episode could be induced by infectious disease on the basis of underlying Sjogren’s syndrome. Conclusion: Sjogren’s syndrome should be considered as an underlying disease of recurrent infection-induced rhabdomyolysis/ myositis.

关键词： Childhood Infection Myositis Mycoplasma Pneumoniae Sjogren’s Syndrome

Five-Year Outcomes of Bilateral Subthalamic Nucleus Stimulation in Japanese Patients with Parkinson’s Disease

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Advances in Parkinson's Disease 2015年第2期4卷 21-27页

作者： Atsushi Umemura Miwako Miyata Yuichi Oka Kenji Okita Genko Oyama Yasushi Shimo Nobutaka hattori Department of Research and Therapeutics for Movement Disorders Juntendo University Graduate School of Medicine Tokyo Japan Department of Neurosurgery Juntendo University Graduate School of Medicine Tokyo Japan Health Assistant Information Technology Course Department of Human Care Engineering Faculty of Health Science Nihon Fukushi University Aichi Japan Department of Neurosurgery Nagoya City University Graduate School of Medicine Nagoya Japan Department of Neurology Nagoya City University Graduate School of Medicine Nagoya Japan Department of Neurology Juntendo University Graduate School of Medicine Tokyo Japan

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely performed for medically refractory Parkinson’s disease (PD). Several western studies have examined the long-term outcomes of STN DBS. However, the long-term outcomes in Japanese patients have not been reported. Methods: We studied the long-term outcomes of STN DBS in Japanese patients with PD. Fifty-five consecutive patients treated with bilateral STN DBS were followed for 5 years after surgery. Each patient underwent Unified Parkinson’s Disease Rating Scale assessments preoperatively and 1 and 5 years after surgery. Results: Twelve patients (22%) were lost to follow up within 5 years. Among them, 7 died and 5 became bed ridden because of PD deterioration. In the 43 patients followed for 5 years, STN DBS significantly improved motor function. The cardinal motor symptoms of tremor, rigidity, and bradykinesia in medication-on periods were significantly better than baseline 5 years after DBS. However, axial motor symptoms of speech, gait and postural stability gradually deteriorated and significantly worsened 5 years after DBS. Motor complications, including dyskinesia and motor fluctuations, significantly improved after DBS with a marked reduction in dopaminergic medication. These effects were maintained 5 years after DBS. Frequently, persisting adverse effects included apraxia of eyelid opening and dysarthria. Conclusions: STN DBS significantly improved motor symptoms in patients with advanced PD. These effects were maintained over 5 years in most patients. However, some showed rapid PD progression even after STN DBS. Other treatments for the axial symptoms and disease progression are needed in long-term PD treatment.

关键词： Deep Brain Stimulation Subthalamic Nucleus Parkinson’s Disease Long-Term Outcome Adverse Effect

Optimization of siRNA Delivery Method into the Liver by Sequential Injection of Polyglutamic Acid and Cationic Lipoplex

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Pharmacology & Pharmacy 2015年第7期6卷 302-310页

作者： Yoshiyuki hattori Shohei Arai Takuto Kikuchi Megumi Hamada Ryou Okamoto Yoko Machida Kumi Kawano Department of Drug Delivery Research Hoshi University Tokyo Japan

Previously, we developed a novel siRNA transfer method to the liver by sequential intravenous injection of poly-L-glutamic acid (PGA) and cationic liposome/siRNA complex (cationic lipoplex). In this study, we examined the effects of the charge ratio (+/-) of cationic liposome/siRNA, molecular weight of PGA and cationic lipid of cationic liposome on the biodistribution of siRNA after sequential injection of PGA plus cationic lipoplex. When 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)/cholesterol (Chol) lipoplex was intravenously injected into mice, the accumulation of siRNA was mainly observed in the lungs. In contrast, when DOTAP/Chol lipoplex was intravenously injected at 1 min after intravenous injection of PGA, siRNA was largely accumulated in the liver. The charge ratio (+/-) of DOTAP/Chol liposome/siRNA did not affect the biodistribution of siRNA after sequential injection. As regards the molecular weight of PGA, the accumulation of siRNA was observed mainly in the liver after the sequential injection of PGA of 20.5, 38, 64 or 200 kDa plus DOTAP/Chol lipoplex. Furthermore, to examine the effect of cationic lipid of cationic liposome on the biodistribution of siRNA, we prepared other cationic liposomes composed of 1,2-di-O-octadecenyl-3-trimethylammonium propane chloride (DOTMA)/Chol, dimethyldioctade-cylammonium bromide (DDAB)/Chol and O,O’-ditetradecanoyl-N-(α-trimethylammonioacetyl)di-ethanolamine chloride (DC-6-14)/Chol. For the cationic liposomes, the accumulation of siRNA was observed mainly in the liver when their cationic lipoplexes were sequentially injected after injection of PGA into mice. From these findings, sequential injection of PGA plus cationic lipoplex could deliver siRNA efficiently into the liver regardless of the charge ratio (+/-) of lipoplex, lengths of PGA and cationic lipid of liposome.

关键词： Cationic Liposome siRNA Delivery Polyglutamic Acid Liver Targeting Sequential Injection

ULF Geomagnetic Anomalies Possibly Due to Crustal Activities in Boso and Izu Peninsula,Japan

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ULF Geomagnetic Anomalies Possibly Due to Crustal Activities...

Oxidation Condition and Metal Fertility of Granitic Magmas:Zircon Trace-Element Data from Porphyry Cu Deposits in the Central Asian Orogenic Belt

中国地球物理学会第二十六届年会、中国地震学会第十三次学术大会

作者： Katsumi hattori Takuya Hirano Hisashi Ishikawa Chie Yoshino Yuki Ishiguro Graduate School of Science Chiba UniversityJapan

*** A number of case studies have shown convincing evidence of ULF(Ultra Low Frequency) magnetic signatures before large earthquakes(Johnston 1997;Hayakawa et al.,2008 ).Different from those early studies,this researc... 详细信息

关键词： ULF Geomagnetic Anomalies Possibly Due to Crustal Activities in Boso and Izu Peninsula,Japan

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Oxidation Condition and Metal Fertility of Granitic Magmas:Z...

中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： Ping Shen Keiko hattori Hongdi Pan Simon Jackson Eleonora Seitmuratova Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Department of Earth Sciences University of Ottawa College of Earth Sciences Chang'an University Geological Survey of Canada

The Central Asian Orogenic Belt(CAOB)hosts a number of porphyry Cu deposits,all associated with calcalkaline granitic rocks and ranging in size from giant to ***-and trace-element compositions of whole rocks and zircons grains were measured from 13 ore-bearing intrusions in nine porphyry Cu deposits(with 0.6to 12 Mt Cu),including Bozshakol,Nurkazghan,Kounrad,Borly,Aktogai,and Koksai in Kazakhstan,Baogutu,and Tuwu-Yandong in China,and Erdenet in *** zircon grains show high Ce/Ceratios,ranging from 29 to *** Ce/Ceratios are recorded at a given crystallization temperature from deposits with larger Cu ***(>4 Mt Cu)and intermediate(1.5–4 Mt Cu)size porphyry Cu deposits are associated with granitic intrusions that have zircons with Ce/Ceratios greater than *** is also a clear relationship between calculated log(f O)values and the size of deposits,with NNO+2 values separating large and intermediate porphyry deposits from small *** data of zircon Ce/Ceratios and associated oxygen fugacity values in magma from ore-bearing intrusions indicate that more oxidized magmas are associated with the formation of larger porphyry Cu *** a conclusion may potentially be used in regional exploration for porphyry Cu deposits in the CAOB.

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掺入三氯乙烯对1200℃下硅热氧化的影响

微纳电子技术 1979年第3期 72-76页

作者： Takeshi hattori 魏淑清

研究了在1200℃下掺入少量三氟乙烯（TCE）时硅的热氧化动力学。这种条件下的抛物线（B）和直线（B/A）速率常数大于无TCE时标准氧化的数值。常数B/A增加到一最大值,然后随TCE浓度的提高而下降,B却直线上升。研究了掺入TCE后对形成的SiO... 详细信息

研究了在1200℃下掺入少量三氟乙烯（TCE）时硅的热氧化动力学。这种条件下的抛物线（B）和直线（B/A）速率常数大于无TCE时标准氧化的数值。常数B/A增加到一最大值,然后随TCE浓度的提高而下降,B却直线上升。研究了掺入TCE后对形成的SiO2膜介质强度的影响。观察到的击穿统计数值是因掺入TCE后获得的重大改进。

关键词： TCE 抛物线速率常数三氯乙烯氯代烃氧化膜掺入热氧化

Effect of inoculation with arbuscular mycorrhizal fungi on growth, nutrient uptake and curcumin production of turmeric (<i>Curcuma longa </i>L.)

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Agricultural Sciences 2013年第2期4卷 66-71页

作者： Kenji Yamawaki Atsushi Matsumura Rintaro hattori Arata Tarui Mohammad Amzad Hossain Yoshiyuki Ohashi Hiroyuki Daimon Faculty of Agriculture University of the Ryukyus Okinawa Japan Graduate School of Life and Environmental Sciences Osaka Prefecture University Osaka Japan

Profitable turmeric (Curcuma longa L.) production requires adequate nutrients. We have investigated the effect of inoculation with arbus cular mycorrhizal fungi (AMF) on growth, nutrient uptake, yield and curcumin production of turmeric under field and glasshouse conditions. Although AMF inoculation slightly increased plant height, leaf number and shoot N content, no statistical differences were observed in vegetative growth parameters, biomass production, nutrient uptake and curcumin content compared to control plants under field conditions. It was difficult to determine the exact effect of inoculated AMF on turmeric growth because of indigenous AMF. On the other hand, turmeric showed better response to AMF inoculation under greenhouse conditions. AMF inoculation resulted in higher biomass production and nutrient uptake of turmeric. Moreover the concen tration of curcumin, contained in the rhizome of turmeric, increased in AMF treatment. These results indicate that AMF inoculation has beneficial effects on turmeric growth and curcumin production. AMF inoculation to turmeric field would be effective when indigenous soil populations of AMF are low or native AMF are no longer effective.

关键词： Arbuscular Mycorrhizal Fungi Curcumin Rhizome Turmeric

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蓝牙技术开发商开创无线新时代

英语自学 2006年第6期 23-25页

作者： James hattori 陈健