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Arteriovenous fistulas and digital hypoperfusion ischemic syndrome in patients on hemodialysis

World Journal of Nephrology 2013年第2期2卷 26-30页

作者： Radojica V stolic Goran Z Trajkovic Dijana J Miric Bojana Kisic Zorana Djordje Goran Lj Azanjac marijana s stanojevic Dragica Z stolic Medical Faculty University of Pristina Clinical Center Kragujevac Faculty of Medicine University of Kragujevac Health Center Pristina

AIM： To determine survival parameters as well as char-acteristics of patients with this syndrome. METHODs： The investigation was conducted over a period of eight years, as a prospective, non-random-ized, clinical study which included 204 patients, treated by chronic hemodialysis. Most patients received hemo-dialysis 12 h per week. As vascular access for hemodi-alysis all subjects had an arteriovenous fstulae. Based on surveys the respondents were divided into groups of patients with and without digital hypoperfusion isch-emic syndrome. Gender, demographic and anthropo-metric characteristics, together with comorbidity and certain habits, were recorded. During this period 34.8% patients ***： Patients with digital hypoperfusion ischemic syndrome were older than those without ischemia （P = 0.01）. Hemodialysis treatment lasted signifcantly lon-ger in the patients with digital hypoperfusion ischemic syndrome （P = 0.02）. The incidence of cardiovascular disease （P 〈 0.001） and diabetes mellitus （P = 0.01）, as well as blood fow through the arteriovenous fstula （ P = 0.036）, were higher in patients with digital hypoper-fusion ischemic syndrome. statistically significant dif-ferences also existed in relation to oxygen saturation （P = 0.04）. Predictive parameters of survival for patients with digital hypoperfusion ischemic syndrome were： adequacy of hemodialysis （B = -3.604, P 〈 0.001）, hypertension （B = -0.920, P = 0.018）, smoking （B = -0.901, P = 0.049）, diabetes mellitus （B = 1.227, P = 0.005）, erythropoietin therapy （B = 1.274, P = 0.002） and hemodiafltration （B = -1.242, P = 0.033）. Kaplan-Meier survival analysis indicated that subjects with and without digital hypoperfusion ischemic syndrome dif-fered regarding the length of survival （P 〈 0.001）, i.e. , patients with confrmed digital hypoperfusion ischemic syndrome died ***： survival was signifcantly longer in the patients without digital hypoperfusion ischemic syn-drome.

关键词： Digital hypoperfusion ischemic syndrome Predictive parameters survival Arteriovenous fistula Hemodialysis

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena stanojevic Ivana stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Prediction of the surface roughness of wood for machining

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Journal of Forestry Research 2017年第6期28卷 1271-1273页

作者： Damjan stanojevic Marija Mandic Gradimir Danon srdjan svrzic High school Applied Professional Studies Filipa Filipovica 20 Vranje 17500 Serbia Faculty of Forestry University of Belgrade Kneza Viseslava 1 Belgrade 11000 Serbia

The surface quality of solid wood is very important for its effective response in manufacturing processes. The effects of feed rate, cutting depth and rake angle on surface roughness and power consumption were investigated and modeled. Neuro-fuzzy methodology was applied and shown that it could be useful, reliable and an effective tool for modeling the surface roughness of ***, the results of the present research can be successfully applied in the wood industry to reduce time, energy and high experimental costs.

关键词： Neuro-fuzzy Forecasting surface roughness Wood Prediction

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Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection

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World Journal of Gastroenterology 2010年第1期16卷 119-122页

作者： Miroslav P stojanovic Milan Radojkovic Ljiljana M Jeremic Aleksandar V Zlatic Goran Z stanojevic Milan A Jovanovic Milos s Kostov Vuka P Katic Department of Hepato-bilio-pancreatic Surgical ClinicClinical Center Nis

Pancreatic schwannoma is a very uncommon tumor of the pancreas,with only 27 cases *** pancreatic schwannomas are benign,with only four malignant tumors *** describe a case of giant malignant schwannoma of the pancreatic body and tail,which involved the transverse *** tumor was treated successfully with en bloc distal splenopancreatectomy and colon *** is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body,with infiltration of the transverse colon,with excellent longterm *** patient is alive and well 28 mo after the *** authors conclude that pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms of the pancreas,although the diagnosis can only be confirmed by microscopic *** the case of the benign tumors,local excision is adequate,but in the case of malignant schwannoma,oncological standards must be fulfilled.

关键词： Pancreatic neoplasms schwannoma Colonic neoplasms surgery

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