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B7 homolog 3 in pancreatic cancer

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World Journal of Gastroenterology 2024年第31期30卷 3654-3667页

作者： Dijana Perovic marija Dusanovic Pjevic Vladimir Perovic Milka Grk Milica Rasic Maja Milickovic Tanja Mijovic Petar Rasic Institute of Human Genetics Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Institute of Microbiology and Immunology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite advances in cancer treatment,pancreatic cancer(PC)remains a disease with high mortality rates and poor survival *** B7 homolog 3(B7-H3)checkpoint molecule is overexpressed among many malignant tumors,including PC,with low or absent expression in healthy *** modulating various immunological and nonimmunological molecular mechanisms,B7-H3 may influence the progression of ***,the impact of B7-H3 on the survival of patients with PC remains a subject of ***,most available scientific data recognize this molecule as a suppressive factor to antitumor immunity in ***,it has been demonstrated that B7-H3 stimulates the migration,invasion,and metastasis of PC cells,and enhances resistance to *** preclinical models of PC,B7-H3-targeting monoclonal antibodies have exerted profound antitumor effects by increasing natural killer cell-mediated antibodydependent cellular cytotoxicity and delivering radioisotopes and cytotoxic drugs to the tumor ***,PC treatment with B7-H3-targeting antibody-drug conjugates and chimeric antigen receptor T cells is being tested in clinical *** review provides a comprehensive analysis of all PC-related studies in the context of B7-H3 and points to deficiencies in the current data that should be overcome by future research.

关键词： B7 homolog 3 Pancreatic cancer Prognosis Signaling pathways Immunotherapy

转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化

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Engineering 2024年第1期32卷 57-68页

作者： Vedrana Vicic Bockor Nika Foglar Goran Josipovic marija Klasic Ana Vujic Branimir Plavsa Toma Keser Samira Smajlovic Aleksandar Vojta Vlatka Zoldos Laboratory for Epigenetics Department of BiologyFaculty of ScienceUniversity of ZagrebZagreb 10000Croatia Genos Glycoscience Research Laboratory Zagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulatory transcriptional *** Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase *** in silico analysis of HNF1A,*** FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrich-ment of these transcription factors specifically in the *** previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma ***,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan *** used the state-of-the-art clus-tered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9)molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell *** results show that the downregulation of all three genes individually and in pairs affects the transcrip-tional activity of many glyco-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan *** effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantennary *** propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan *** also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

关键词： Clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha(HNF1A) Hepatocyte nuclear factor 4 alpha(HNF4A) Forkhead box protein A2(FOXA2) N-glycosylation HepG2 cells

Global warming scenarios for the Eastern Adriatic Sea indicate a higher risk of invasiveness of non-native marine organisms relative to current climate conditions

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Marine Life Science & Technology 2024年第1期6卷 143-154页

作者： Branko Glamuzina Lorenzo Vilizzi Marina Piria Ante Zuljevic Ana Bratos Cetinic Ana Pesic Branko Dragicevic Lovrenc Lipej marijana Pecarevic Vlasta Bartulovic Sanja Grđan Ivan Cvitkovic Tatjana Dobroslavic Ana Fortic Luka Glamuzina Borut Mavric Jovana Tomanic marija Despalatovic Domen Trkov Marina Brailo Scepanovic Zoran Vidovic Predrag Simonovic Sanja Matic-Skoko Pero Tutman Department of Applied Ecology University of DubrovnikDubrovnikCroatia Department of Ecology and Vertebrate Zoology Faculty of Biology and Environmental ProtectionUniversity of LodzLodzPoland Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebZagrebCroatia Institute of Oceanography and Fisheries SplitCroatia Institute of Marine Biology University of MontenegroKotorMontenegro National Institute of Biology Marine Biology Station PiranPiranSlovenia Teacher Education Faculty University of BelgradeBelgradeSerbia Faculty of Biology University of BelgradeBelgradeSerbia

Globally,marine bioinvasions threaten marine ecosystem structure and function,with the Mediterranean Sea being one of the most affected *** invasions are expected to increase due to climate *** conducted a risk screening of marine organisms(37 fishes,38 invertebrates,and 9 plants),both extant and‘horizon’(i.e.,not present in the area but likely to enter it).Based on expert knowledge for the Eastern Adriatic Sea coasts of Slovenia,Croatia,and Montenegro,screenings were conducted under both current and predicted climate conditions indicating with an increase in sea surface temperature and salinity of the Adriatic Sea together with changes in precipitation *** aims were to:(1)identify non-native extant and horizon marine species that may pose threats to native biodiversity and(2)evaluate the risk of invasiveness of the selected species under current and predicted climate *** the 84 species screened,there was an increase in those ranked as‘high risk’from 33(39.3%)under current climate conditions and to 47(56.0%)under global warming *** those ranked as‘very high’risk,the increase was from 6(7.1%)to 21(25.0%).Amongst the screened species,the already established high-risk species Pacific oyster Magallana gigas and Atlantic blue crab Callinectes sapidus represent a threat to ecosystem *** the under-representation of marine species in the current European Union List,the species we have ranked as high to very high risk should be included.

关键词： AS-ISK Early detection Introduction vectors/pathways Invasive species Rapid response

转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化（英文）

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Engineering 2024年第1期 57-68页

作者： Vedrana Vi?i? Bo?kor Nika Foglar Goran Josipovi? marija Klasi? Ana Vuji? Branimir Plav?a Toma Keser Samira Smajlovi? Aleksandar Vojta Vlatka Zoldo? Laboratory for Epigenetics Department of Biology Faculty of Science University of Zagreb Genos Glycoscience Research Laboratory Faculty of Pharmacy and Biochemistry University of Zagreb

Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2) are key transcription factors that regulate a complex gene network in the liver,creating a regulatory transcriptional *** Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase *** in silico analysis of HNF1A,HNF4A,and FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the *** previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma ***,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan *** used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell *** results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many gly co-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan *** effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantenna ry *** propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan *** also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

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Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

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Neural Regeneration Research 2022年第11期17卷 2325-2334页

作者： Milena Stevanovic Danijela Stanisavljevic Ninkovic marija Mojsin Danijela Drakulic marija Schwirtlich Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgradeSerbia University of Belgrade Faculty of BiologyBelgradeSerbia Serbian Academy of Sciences and Arts BelgradeSerbia

Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain *** SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial *** represent a class of small non-coding RNAs that play important roles in the regulation of gene *** with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for *** emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult *** SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and *** strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of *** in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological *** focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.

关键词： dysregulation of miRNA expression glioblastoma gliogenesis glioma stem cells ischemic stroke neural stem cells neural tissue regeneration neurodegenerative diseases neurodevelopment neurogenesis SOX/miRNA interplay traumatic brain injury

Removal of humic substances by biosorption

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Journal of Environmental Sciences 2008年第12期20卷 1423-1428页

作者： VUKOVI marija DOMANOVAC Tomislav BRIKI Felicita Division of Industrial Ecology Faculty of Chemical Engineering and TechnologyUniversity of ZagrebMaruliev trg 19HR 10000 ZagrebCroatia IPZ Uniprojekt Terra Babonieva 32HR 10000 ZagrebCroatia

Fungal pellets of Aspergillus niger 405,Aspergillus ustus 326,and Stachybotrys sp.1103 were used for the removal of humic substances from aqueous *** biosorption,carried out at pH 6 and 25°C,was monitored spectrophotometrically and the process described with Freundlich’s *** sorption coeffcients Kf and n showed that *** exhibited the highest effciency.A good match between the model and experimental data and a high correlation coeffcient(R2)pointed out to judicious choice of ...

关键词： biosorption humic substances fungal pellets aqueous solution desorption

Short-circuit Analysis in Large-scale Distribution Systems With High Penetration of Distributed Generators

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IEEE/CAA Journal of Automatica Sinica 2017年第2期4卷 243-251页

作者： Luka V.Strezoski marija D.Prica IEEE Case School of Engineering Case Western Reserve University

In this paper a short-circuit computation(SCC) procedure for large-scale distribution systems with high penetration of distributed generators based on contemporary technologies is proposed. The procedure is suitable for real-time *** of modern distributed generators differs from the modeling of traditional synchronous and induction ***, SCC procedures found on the presumption of distribution systems with only traditional generators are not suitable in nowadays systems. In the work presented in this paper, for computation of the state of the system with short-circuit, the improved backward/forward sweep(IBFS) procedure is *** results show that the IBFS procedure is much more robust than previous SCC procedures, as it takes into account all distribution system elements, including modern distributed generators.

关键词： Distributed generation(DG) distribution system distribution management system(DMS) short-circuit computation

Deriving striatal projection neurons from human pluripotent stem cells with Activin A

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Neural Regeneration Research 2015年第12期10卷 1914-1916页

作者： Zoe Noakes marija Fjodorova Meng Li Stem Cell Neurogenesis Group Neuroscience and Mental Health Research InstituteSchool of Medicine and School of BioscienceCardiff University

The striatum is the main input structure of the basal ganglia and is involved in voluntary motor control,habit learning and reward *** spiny neurons（MSNs）comprise80%and 95%of striatal neurons in primates and rodents... 详细信息

关键词： cell MSNs PSCs Deriving striatal projection neurons from human pluripotent stem cells with Activin A stem

EFFECTS OF SPECTRAL DEPENDENCE IN PASS-THROUGH PHOTON-BASED BIOMEDICAL TRANSILLUMINATION

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 235-244页

作者： PAULINO VACAS-JACQUES marija STROJNIK GONZALO PAEZ Centro de Investigaciones en Optica Apartado Postal 1-94837000LeonGuanajuatoMexico

We have proposed an interferometric setup for biomedical analysis in transillumination *** dependence of optical properties must be considered for selecting source and sam*** expansion of the sample optical properties,around the central wavelength of emission,serves to account for spectral *** spectral values depend on the central moments of the source,and specific constants associated to the optical properties of the *** matching wavelength characteristics of source and sample,a first-order approximation is *** such case,the expected values are exactly the optical properties evaluated at the central ***,in the first-order approximation,the transillumination interferometer yields the integrated attenuation of the sample at the central wavelength of *** verify the latter assertion by performing a wavelength-dependent Monte Carlo analysis to calculate the response of the transillumination *** attenuation coefficients,for imaging and characterization scenarios,are in agreement with the value computed at the central wavelength of the source.

关键词： Transillumination wavelength-dependent Monte Carlo tissue characterization tissue imaging.