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Join us on an amazing journey towards next-generation treatments for CNS disorders:Launch of Neuroprotection,a new high-quality journal in translational neuroscience

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Neuroprotection 2023年第1期1卷 5-8页

作者： Xunming Ji Piotr Walczak Heleen M.M.van Beusekom Ana I.Casas Andrew Clarkson Tracy Farr Jukka Jolkkonen Yajie Liang Michel M.Modo Paulo H.Rosado-de-Castro Karsten Ruscher Yan-Jiang Wang Haitao Wu marietta zille Shen Li Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine Center for Advanced Imaging ResearchUniversity of MarylandBaltimoreMarylandUSA Department of Cardiology Erasmus MC RotterdamUniversity Medical Center RotterdamRotterdamThe Netherlands Department of Neurology Center for Translational Neuro‐and Behavioral Sciences(C‐TNBS)University Clinics EssenEssenGermany Department of Anatomy Brain Health Research Center and Brain Research New ZealandDunedinNew Zealand Medical School Queen's Medical CentreUniversity of NottinghamNottinghamUK A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Anatomy and Department of Radiology School of MedicineInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratory for Experimental Brain Research University of LundLundSweden Department of Neurology Daping HospitalCenter for Clinical NeuroscienceChongqingChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of WarwickCoventryUK

Translational medicine in neurodegenerative and neurovascular diseases is approaching a breakthrough point.Recent years have led to dramatic progress in both experimental and clinical research.Based on a much better and continuously increasing understanding of disease mechanisms,progression and pathophysiology,new therapies with an improved translational potential to protect tissue either against acute or chronic degeneration and even approaches potentially capable of repairing damaged brain tissue are emerging.

关键词： cytoprotection nervous system repair neurodegeneration neuroprotection neurovasculardiseases translational research

Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou marietta zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic burdens.Abnormal metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβantibodies.Nonetheless,the cognitive benefits of the current treatments are limited.The etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive impairment.Hence,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve cognition.To attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients.The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD.The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

An Ontology-Based Framework for Semi-Automatic Schema Integration

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Journal of Computer Science & Technology 2005年第6期20卷 788-796页

作者： zille Huma Muhammad Jaffar-Ur Rehman Nadeem Iftikhar Muhammad Ali dinnah University Islamabad Pakistan

Currently, schema integration frameworks use approaches like rule-based, machine learning, etc. This paper presents an ontology-based wrapper-mediator framework that uses both the rule-based and machine learning strategies at the same time. The proposed framework uses global and local ontologies for resolving syntactic and semantic heterogeneity, and XML for interoperability. The concepts in the candidate schemas are merged on the basis of the similarity coefficient, which is calculated using the defined rules and the prior mappings stored in the case-base.

关键词： heterogeneous databases database integration database semantics rule-based processing machine learning

Laccases stabilization with phosphatidylcholine liposomes

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Journal of Biophysical Chemistry 2012年第1期3卷 81-87页

作者： Meritxell Martí Andrea zille Artur Cavaco-Paulo José Luís Parra Luisa Coderch Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) Barcelona Spain

In recent years, there has been an upsurge of interest in enzyme treatment of textile fibres. Enzymes are globular proteins whose catalytic function is due to their three dimensional structure. For this reason, stability strategies make use of compounds that avoid dismantling or distorting protein 3D structures. This study is concerned with the use of microencapsulation techniques to optimize enzyme stabilization. Laccases were embedded in phophatidylcholine liposomes and their encapsulation capacity was assessed. Their enzymatic activity and stability were analyzed, comparing free-enzymes, enzymes in liposomes, and the lipid fraction separated from the aqueous fraction. An increase in their encapsulation efficiency was found at higher lipid/laccase ratios. Relative activity of enzyme-containing vesicles has also been shown to be retained much more than that of free native enzymes. The loss of activity of laccases entrapped in the vesicles in the total stability process is lower than 10% compared with 40% to 60% of loss of free-laccases after heating the samples for 3 days. Laccase stabilization could be of interest to future textile or cosmetic applications because of their potential for environmentally friendly oxidation technologies.

关键词： MLV Liposome Enzymes Laccases Encapsulation Stability

深度学习在膝关节MRI前交叉韧带撕裂检测中的价值:多中心验证研究

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国际医学放射学杂志 2023年第1期46卷 122-122页

作者： A.Tran L.Lassalle P.zille R.Guillin E.Pluot C.Adam 沈晶

摘要目的开发一种用于前交叉韧带(ACL)撕裂检测的深度学习算法,并采用2个外部数据集验证其准确性。方法收集来自不同厂家和不同场强的19 765例膝关节MRI

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Multi-scale coarse-to-fine approach for the study of turbulent motion from 2D images

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Multi-scale coarse-to-fine approach for the study of turbule...