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The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis

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Molecular Plant 2019年第7期12卷 935-950页

作者： Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal marielle vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical Garden Shanghai Chenshan Plant Science Research Center Chinese Academy of Sciences Shanghai China State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai China Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Fudan University Shanghai China Novogene Bioinformatics Institute Beijing China Whitehead Institute for Biomedical Research 455 Main Street Cambridge MA 02142 USA Department of Biology Massachusetts Institute of Technology Cambridge MA 02139 USA John Innes Centre Norwich NR4 7UH UK

Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,"Huang Qin," are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants.

关键词： genome skullcap 4’-deoxyflavone traditional Chinese medicine Huang Qin:evolution specialized metabolism

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Functional responses to deforestation in fish communities inhabiting neotropical streams and rivers

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Ecological Processes 2023年第1期12卷 716-732页

作者： Isabel Cantera Céline Jézéquel Tony Dejean Jérôme Murienne Régis vigouroux Alice Valentini Sébastien Brosse Department of Environmental Science and Policy Universitàdegli Studi di MilanoVia Celoria 2620133 MilanItaly Laboratoire Evolution et DiversitéBiologique UMR5174-UniversitéPaul SabatierCNRSIRD118 Route de Narbonne31062 ToulouseFrance SPYGEN Savoie Technolac-BP 27417 Rue du Lac Saint-André73375 Le Bourget-du-Lac CedexFrance HYDRECO Laboratoire Environnement de Petit SautB.P 82397388 Kourou CedexFrench GuianaFrance

Background Deforestation is a widespread disturbance for neotropical freshwater *** biodiversity declines have been associated with deforestation,its functional consequences for stream and river fish faunas remain poorly *** this study,we explored how deforestation affects the different facets of the functional structure of fish communities inventoried using environmental DNA metabarcoding in 64 river and 35 stream sites of French ***,we investigated how functional richness,divergence,evenness and identity of fish faunas are affected by *** We showed that anthropogenic disturbances in French Guiana are modifying the functional diversity of freshwater fish *** disturbances not only affected the amount of functional traits held by the communities but also the identity of the traits and the internal structure of the functional ***,different facets of the functional diversity supported by fish assemblages were *** streams,deforestation did not affect the overall diversity of traits but reduced functional redundancy,underlined by a shift in functional identity towards assemblages dominated by pelagic *** contrast,river fish faunas experienced a decline in functional richness,paired with shifts in functional identity and a loss of fish species with extreme *** The response to deforestation differed between streams and rivers,but it supports the hypothesis that deforestation is linked to functional changes in fish *** diminishing the range of the functions in rivers or by jeopardizing the redundancy of functions in streams,deforestation could severely hamper the functioning and stability of neotropical freshwater ecosystems.

关键词： eDNA Traits Functional space Richness Divergence Evenness Identity Gold mining

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Performance of a New Method of Multicomponent Images Segmentation in the Presence of Noise

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Engineering（科研） 2011年第11期3卷 1082-1089页

作者： Sié Ouattara Olivier Asseu Alain Clément Bertrand vigouroux 不详

Any undesirable signal limiting to a degree or another the integrity and the intelligibility of a useful signal can be considered as noise. In the general rule, the good performance of a system is assured only if the level of power of the useful signal exceeds by several orders of magnitude that of the noise (signal to noise of a several tens of decibels). However certain elaborate methods of treatment allow working with very low signal to noise ratio in an optimal way any a priori knowledge available on the signal useful to interpret. In this work, we evaluate the robustness of the noise on a new method of multicomponent image segmentation developed recently. Two types of additional noises are considered, which are the Gaussian noise and the uniform noise, with varying correlation between the different components (or planes) of the image. Quantitative results show the influence of the noise level on the segmentation method.

关键词： Multicomponent Images Segmentation n-D Compact Histogram Additional Noise Gaussian Noise Uniform Noise Correlated Noise

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Analysis of the Relevance of Evaluation Criteria for Multicomponent Image Segmentation

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Journal of Software Engineering and Applications 2011年第6期4卷 371-378页

作者： Sié Ouattara Georges Laussane Loum Alain Clément Bertrant vigouroux 不详

Image segmentation is an important stage in many applications such as image, video and computer processing. Generally image interpretation depends on it. The materials and methods used to demonstrate are described. The results are presented and analyzed. Several approaches and algorithms for image segmentation have been developed, but it is difficult to evaluate the efficiency and to make an objective comparison of different segmentation methods. This general problem has been addressed for the evaluation of a segmentation result and the results are available in the literature. In this work, we first presented some criteria of evaluation of segmentation commonly used in image processing with reviews of their models. Then multicomponent synthetic images of known composition are applied to these criteria to explore the operation and evaluate its relevance. The results show that choosing an assessment method depends on the purpose, however the criterion of Zeboudj appears powerful for the evaluation of region segmentations for properly separated classes, on the contrary the criteria of Levine-Nazif and Borsotti are adapted to the methods of classification and permit to build homogeneous regions or classes. The values of the Rosenbeger criterion are generally low and similar, so hard to make a comparison of segmentations with this criterion.

关键词： Quality of Segmentation Multicomponent Images Supervised and Unsupervised Evaluation Synthetic Images Metric

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轻盈光盒

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建筑实践 2015年第9期 16-23页

作者：李莹 Iwan Baan Francis vigouroux

今年5月刚刚开放的波尔多新体育场,由瑞士著名建筑师事务所赫尔佐格和德梅隆建筑事务所设计,是翠绿的风景中一座神殿般的空灵结构。波尔多LAC区的新体育场,位于人工湖和北波尔多加隆河之间,是座明亮的五层结构。项目设计统一了三个关键... 详细信息

今年5月刚刚开放的波尔多新体育场,由瑞士著名建筑师事务所赫尔佐格和德梅隆建筑事务所设计,是翠绿的风景中一座神殿般的空灵结构。波尔多LAC区的新体育场,位于人工湖和北波尔多加隆河之间,是座明亮的五层结构。项目设计统一了三个关键要素:包围运动场的看台作为比赛场地和外部环境之间过渡地带的宽敞大厅,以及体育场的整体外观。作为明年欧锦赛的主要场馆之一,这里除了用于波尔多足球俱乐部的主场,还将举办一系列文化活动。

关键词：建筑师赫尔佐格德梅隆波尔多

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法国国营铁路隧道的加固技术

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铁道建筑 1982年第2期 35-38页

作者： M.DENIS ,H.vigouroux ,焦新卿

为了加固一个多世纪以前修建的隧道,法国国营铁路采用了传统的压注水泥浆技术,解决下面两个问题: 一、填充围岩和衬砌之间的空隙,如在施工时拱部和围岩之间的回填受到水流冲刷而形成的空隙,及在其它情况下溶蚀的空隙等;

关键词：国营铁路水泥浆边墙压注砖衬砌压浆泵法国法兰西共和国

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重庆江北国际机场T3A航站楼

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建筑学报 2019年第9期 64-68页

作者：邱小勇钱方陈荣锋闫雪潘磊张洁(西南院) Jean-Francois vigouroux Philippe Boucher 中国建筑西南设计研究院有限公司 ADPI 中国民航机场建设集团有限公司

Yubei District, Chongqing地点/重庆渝北设计/2009-2014年/竣工/2017年Design Stage 2009-2014Completion 2017业主重庆机场集团有限公司建筑设计方案设计:中国建筑西南设计研究院有限公司(设计牵头方)、ADPI (方案参与)初步设计和施... 详细信息

Yubei District, Chongqing地点/重庆渝北设计/2009-2014年/竣工/2017年Design Stage 2009-2014Completion 2017业主重庆机场集团有限公司建筑设计方案设计:中国建筑西南设计研究院有限公司(设计牵头方)、ADPI (方案参与)初步设计和施工图设计:中国建筑西南设计研究院有限公司(设计牵头方)。

关键词：重庆江北国际机场 T3A 建筑专业

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