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Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 19-29页

作者： Daniel Heise Jan Bednarsch Andreas Kroh Sandra Schipper Roman Eickhoff marielle coolsen.ron.ld van.dam Sven Lang Ulf Neumann Florian Ulmer Department of Surgery and Transplantation University Hospital RWTH AachenAachen 52074Germany Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

BACKGROUND Laparoscopic liver surgery is currently considered the standard of care for various liver ***,studies focusing on perioperative outcome after laparoscopic hepatectomy(LH)in overweight patients are still sparse and its benefit compared to open hepatectomy(OH)is a matter of *** To analyze postoperative outcomes in overweight[body mass index(BMI)over 25 kg/m²]and obese(BMI over 30 kg/m²)patients undergoing LH and compare postoperative outcome with patients undergoing *** Perioperative data of 68 overweight(BMI over 25 kg/m²)including a subcohort of obese(BMI over 30 kg/m²)patients(n=27)who underwent LH at our institution between 2015 and 2019 were retrospectively analyzed regarding surgical outcome and compared to an equal number of patients undergoing *** The mean BMI was 29.8±4.9 kg/m2 in the LH group and 29.7±3.6 kg/m2 in the OH group with major resections performed in 20.6%(LH)and 26.5%(OH)of cases,*** time(194±88 min vs 275±131 min;P<0.001)as well as intensive care(0.8±0.7 d vs 1.1±0.8 d;P=0.031)and hospital stay(7.3±3.6 d vs 15.7±13.5 d;P<0.001)were significant shorter in the LH ***,overall complications(20.6%vs 45.6%;P=0.005)and major complications(1.5%vs 14.7%,P=0.002)were observed less frequently after *** additional investigation analyzing the subgroup of obese patients who underwent LH(n=27)and OH(n=29)showed a shorter operative time(194±81 min vs 260±137 min;P=0.009)and a reduced length of hospitalization(7.7±4.3 d vs 17.2±17 d;P<0.001)but no difference in postoperative complications or overall *** LH is safe and cost-effective in overweight and obese ***,LH is significantly associated with fewer postoperative complications and reduced hospital stay compared to OH in these patients.

关键词： Laparoscopic hepatectomy Obesity Overweight Morbidity Postoperative outcome Cost

Balanced Monitoring of Flow Phenomena in Moving Mesh Methods

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Communications in Computational Physics 2010年第1期7卷 138-170页

作者： A.van.dam P.A.Zegeling Department of Mathematics Utrecht UniversityP.O.Box 80.0103508 TA UtrechtThe Netherlands

Adaptive moving mesh research usually focuses either on analytical deriva-tions for prescribed solutions or on pragmatic solvers with challenging physical appli-cations. In the latter case, the monitor functions that steer mesh adaptation are oftendefined in an ad-hoc way. In this paper we generalize our previously used moni-tor function to a balanced sum of any number of monitor components. This avoidsthe trial-and-error parameter fine-tuning that is often used in monitor functions. Thekey reason for the new balancing method is that the ratio between the maximum andaverage value of a monitor component should ideally be equal for all *** as a monitor component is a good motivating example for this. Entropy alsoturns out to be a very informative monitor component. We incorporate the monitorfunction in an adaptive moving mesh higher-order finite volume solver with HLLCfluxes, which is suitable for nonlinear hyperbolic systems of conservation laws. Whenapplied to compressible gas flow it produces very sharp results for shocks and otherdiscontinuities. Moreover, it captures small instabilities (Richtmyer-Meshkov, Kelvin-Helmholtz). Thus showing the rich nature of the example problems and the effective-ness of the new monitor balancing.

关键词： Moving mesh method conservative interpolation balanced monitor function direc-tional adaptation hydrodynamics implosion problem

Effects of turbulence on carbon emission in shallow lakes

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Journal of Environmental Sciences 2018年第7期30卷 166-172页

作者： Lin Zhu Boqiang Qin Jian Zhou Bryce van.dam Wenqing Shi Taihu Lake Laboratory Ecosystem Station State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Institute of Marine Sciences University of North Carolina at Chapel Hill Center for Eco-Environmental Research Nanjing Hydraulics Research Institute

Turbulent mixing is enhanced in shallow lakes. As a result, exchanges across the air–water and sediment–water interfaces are increased, causing these systems to be large sources of greenhouse gases. This study investigated the effects of turbulence on carbon dioxide（CO2）and methane（CH4） emissions in shallow lakes using simulated mesocosm *** demonstrated that turbulence increased CO2 emissions, while simultaneously decreasing CH4 emissions by altering microbial processes. Under turbulent conditions, a greater fraction of organic carbon was recycled as CO2 instead of CH4, potentially reducing the net global warming effect because of the lower global warming potential of CO2 relative to CH4. The CH4/CO2 flux ratio was approximately 0.006 under turbulent conditions, but reached 0.078 in the control. The real-time quantitative PCR analysis indicated that methanogen abundance decreased and methanotroph abundance increased under turbulent conditions, inhibiting CH4 production and favoring the oxidation of CH4 to *** findings suggest that turbulence may play an important role in the global carbon cycle by limiting CH4 emissions, thereby reducing the net global warming effect of shallow lakes.

关键词： Turbulence Carbon dioxide Methane Methanogen Methanotroph

A review on the best practices in concrete pavement design and materials in wet-freeze climates similar to Michigan

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第3期6卷 245-255页

作者： Naser P. Sharifi Siyu Chen Zhanping You Thomas van.dam Christopher Gilbertson Department of Civil and Environmental Engineering Michigan Technological University Houghton MI 49931 USA Nichols Consulting Engineers Chtd. Reno NV 89509 USA

The research presented in this paper aims to identify best practices of design and materials for concrete pavements in wet-freeze climates similar to the Michigan State. For the purposes of this paper, a best practice is a procedure that has been shown by field-validated research or experience to produce improved results and that is established or proposed as a standard suitable for widespread implementation. The local wet-freeze climate makes the requirements for Michigan's pavement system different from many other regions. Wetfreeze climates can result in various concrete pavement distress mechanisms such as thermally-induced cracking, freeze-thaw deterioration, accelerated cracking due to loss of support, frost heave, and material degradation. Therefore, appropriate procedures for design and material selection need to be selected to withstand high precipitation and freezing winter temperatures. Failure to take into account the climatic conditions may lead to inadequate or reduced pavement performance. However, utilizing appropriate techniques and materials could potentially improve the quality and increase the service life of the concrete pavement. Three design methods and five materials have been identified, and examples of their successful performance in wet-freeze climates are provided. In addition, the reasons that give them the superior performance in wet-freeze climates are discussed in detail.

关键词： Concrete pavements Pavement design Pavement materials Best practice Wet-freeze climate

;he regulation of TGF-β/SMAD signaling by protein deubiquitination

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Protein & Cell 2014年第7期5卷 503-517页

作者： Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van.dam Long Zhang Fangfang Zhou Life Sciences Institute Zhejiang University Hangzhou 310058 China Department of Molecular Cell Biology Cancer Genomics Centre Netherlands and Centre of Biomedical Genetics Leiden University Medical Center Postbus 9600 2300 RC Leiden The Netherlands

Transforming growth factor-β （TGF-β） members are key cytokines that control embryogenesis and tissue homeostasis via transmembrane TGF-β type II （TβR II） and type I （TβRI） and serine/threonine kinases receptors. Aberrant activation of TGF-β signaling leads to diseases, including cancer. In advanced cancer, the TGF-β/SMAD pathway can act as an oncogenic factor driving tumor cell invasion and metastasis, and thus is considered to be a therapeutic target. The activity of TGF-β/SMAD pathway is known to be regulated by ubiquitination at multiple levels. As ubiquitination is reversible, emerging studies have uncovered key roles for ubiquitin-removals on TGF-β signaling components by deubiquitinating enzymes （DUBs）. In this paper, we summarize the latest findings on the DUBs that control the activity of the TGF-β signaling pathway. The regula- tory roles of these DUBs as a driving force for cancer progression as well as their underlying working mech- anisms are also discussed.

关键词： TGF-β TβRI SMAD DUB ubiquitin deubiquitination

VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation

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Journal of Molecular Cell Biology 2020年第2期12卷 138-151页

作者： Yihao Li Chao Cui Feng Xie Szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van.dam Andreas Bauer Long Zhang Peterten Dijke Department of Cell and Chemical Biology and Oncode Institute Leiden University Medical Center2300RC LeidenThe Netherlands MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China Department of Human Genetics Leiden Genome Technology CentreLeiden University Medical Center2300RC LeidenThe Netherlands Sequence Analysis Support Core Leiden University Medical Center2300RC LeidenThe Netherlands Novartis Institutes for BioMedical Research Inc.Novartis CampusForum 2.5.01.30CH-4056BaselSwitzerland

The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue ***,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well ***(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of ***-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene *** was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 *** multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced *** the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish *** findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction.

关键词： Smurfl TGF-βtype I receptor ubiquitination Activin mesoderm induction

Electromagnetic emanation exploration in FPGA-based digital design

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Journal of Central South University 2019年第1期26卷 158-167页

作者： van Toan NGUYEN Minh Tung dam Jeong-Gun LEE E-SoC Laboratory/Smart Computing Laboratory Department of Computer Engineering Hallym University

As semiconductor technologies have been shrinking,the speed of circuits,integration density,and the number of I/O interfaces have been significantly *** a consequence,electromagnetic emanation(EME)becomes a critical issue in digital system *** devices must meet electromagnetic compatibility(EMC)requirements to ensure that they operate properly,and safely without interference.I/O buffers consume high currents when they *** bonding wires,and lead frames are long enough to play as efficient antennas to radiate electromagnetic interference(EMI).Therefore,I/O switching activities significantly contribute to the *** this paper,we evaluate and analyze the impact of I/O switching activities on the *** will change the circuit configurations such as the supply voltage for I/O banks,their switching frequency,driving current,and slew ***,a trade-off between the switching frequencies and the number of simultaneous switching outputs(SSOs)is also considered in terms of ***,we evaluate the electromagnetic emissions that are associated with the different I/O switching *** results show that the electromagnetic emissions associated I/O switching activities depend strongly on their operating parameters and *** the circuit implementations and measurements are carried out on a Xilinx Spartan-3 FPGA.

关键词： electromagnetic interference electromagnetic emanation near field emissions field programmable gate array slew rate

Prediction of falling weight deflectometer parameters using hybrid model of genetic algorithm and adaptive neuro-fuzzy inference system

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Frontiers of Structural and Civil Engineering 2023年第5期17卷 812-826页

作者： Long Hoang NGUYEN Dung Quang VU Duc dam NGUYEN Fazal E.JALAL Mudassir IQBAL Vinh The DANG Hiep van LE Indra PRAKASH Binh Thai PHAM Faculty of Civil Engineering University of Transport TechnologyHanoi 10000Vietnam Department of Civil Engineering State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200025China Department of Civil Engineering University of Engineering and TechnologyPeshawar 25120Pakistan DDG(R)Geological Survey of India Gandhinagar 382010India

A falling weight deflectometer is a testing device used in civil engineering to measure and evaluate the physical properties of pavements,such as the modulus of the subgrade reaction(Y1)and the elastic modulus of the slab(Y2),which are crucial for assessing the structural strength of *** this study,we developed a novel hybrid artificial intelligence model,i.e.,a genetic algorithm(GA)-optimized adaptive neuro-fuzzy inference system(ANFIS-GA),to predict Y1 and Y2 based on easily determined 13 parameters of rigid *** performance of the novel ANFIS-GA model was compared to that of other benchmark models,namely logistic regression(LR)and radial basis function regression(RBFR)*** models were validated using standard statistical measures,namely,the coefficient of correlation(R),mean absolute error(MAE),and root mean square error(RMSE).The results indicated that the ANFIS-GA model was the best at predicting Y1(R=0.945)and Y2(R=0.887)compared to the LR and RBFR ***,the ANFIS-GA model can be used to accurately predict Y1 and Y2 based on easily measured parameters for the appropriate and rapid assessment of the quality and strength of pavements.

关键词： falling weight deflectometer modulus of subgrade reaction elastic modulus metaheuristic algorithms

Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies

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Infectious Diseases of Poverty 2017年第1期6卷 1379-1391页

作者： Paul L.A.M.Corstjens Pytsje T.Hoekstra Claudia J.de Dood Govert J.van.dam Department of Molecular Cell Biology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands Department of Parasitology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands

Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling *** relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and ***:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay *** test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%*** facilitates testing large urine pools from many individuals with minimal loss of sensitivity and *** test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and *** requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of ***:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced *** low endemic settings as the pool size can be increased as opposed to prevalence ***:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm *** strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sens

关键词： Schistosomiasis Diagnostics Sample pooling Mass drug administration Circulating anodic antigen Lateral flow Strip test Up-converting reporter particle UCP-LF CAA