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Normal Range of Neutrophile to Lymphocyte Ratio in Healthy, Chronic Kidney Disease Stage 4 - 5 and Hemodialysis Participant in a Sub-Saharan African Context

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Open Journal of Nephrology 2024年第1期14卷 104-114页

作者： Fouda Menye Epse Ebana Hermine Danielle Elimby Lionel Thierry Sevele Deussi De ngaha Bogne Takam Yvan Halle marie-Patrice Eveline Ngouadjeu Dongho Department of Medicine and Specialties General Hospital of Douala Douala Cameroon Department of internal Medicine and specialties Faculty of Medicine and Biomedical Sciences of Yaounde Yaounde Cameroon Department of internal Medicine and specialties Faculty of Medicine and Pharmaceutic Sciences of Douala Douala Cameroon

Background: Neutrophile to lymphocyte ratio (NLR) is a well-established marker of inflammation. it has been reported to be high in chronic kidney disease (CKD) and it is described as a prognosis factor in hemodialysis patients. However, limited data are available about the normal range of NLR in healthy adults as well as CKD patients including hemodialysis black Africans in Sub-Saharan countries. We sought to study NLR in healthy and advanced CKD in a single Cameroonian health facility. Methods: Blood samples were obtained from blood donors, CKD stage 4 and non-dialysis stage 5, and hemodialysis patients for more than 6 months. Patients with confounding factors such as positive CRP, infection, and recent use of steroids were excluded. RNL means standard deviations (SDs), and 95% confidence intervals (95% Ci) were determined. RNL range was defined as percentiles P2.5 to P97.5. Results: A total of 102 participants were included. Mean age was 40.45 ± 9.97 years and 58.8% were male. Age and sex distribution were similar in the three groups. Leucopenia and neutropenia were common in all the groups. Means NLR was 1.29 ± 0.57 (95% Ci 1.08 - 1.49) range between 0.55 to 2.67;2.31 ± 1.3 (95% Ci 1.75 - 2.88) with range between 0.69 to 4.31 and 2.14 ± 0.98 (95% Ci 1.85 - 2.44) with range between 0.77 to 4.32 respectively in controls, CKD, and hemodialysis participants. NLR was comparable in CKD and hemodialysis patients (p = 0.99). Compared to controls, NLR was significantly elevated in CKD (p = 0.043) and hemodialysis patients (p Conclusion: Our data suggest that the normal range for NLR in adult nongeriatric healthy and advanced CKD patients including those on chronic hemodialysis may vary between 0.55 to 2.67 and 0.69 to 4.32 respectively.

关键词： NLR CKD Hemodialysis Cameroon

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Normal Range of Neutrophile to Lymphocyte Ratio in Healthy, Chronic Kidney Disease Stage 4 - 5 and Hemodialysis Participant in a Sub-Saharan African Context

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Open Journal of Nephrology（肾脏病） 2024年第1期 104页

作者： Fouda Menye Epse Ebana Hermine Danielle Elimby Lionel Thierry Sevele Deussi De ngaha Bogne Takam Yvan Halle marie-Patrice Eveline Ngouadjeu Dongho

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Effect of the Aqueous Extract of Schumanniophyton magnificumHarms on Sexual Maturation and Fertility of immature (K. schum) Female Rat

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Pharmacology & Pharmacy 2018年第10期9卷 415-427页

作者： Emma F. Bend Pierre C. Oundoum Oundoum marie.i. ngaha njila Brice L. Koloko Camille D. Nyonseu Samuel H. Mandengue Paul Moundipa Theophile Dimo Dieudonne Massoma Lembè Department of Animal Sciences Faculty of Science University of Douala Douala Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

The aim of the study was to bring scientific evidence of the curative action of the stem bark aqueous extract of Schumanniophyton magnificum (ASMa) on the sexual maturation and fertility of the immature female Wistar rat. Forty immature female rats were randomized and divided into 4 groups of ten animals each and orally treated with the ASMa at doses of 0 (distilled water), 200 mg/kg, 400 mg/kg and 800 mg/kg /BW/day for 30 consecutive days. Body weight and food intake were recorded throughout the experimental period. The precocity of the puberty onset in treated animals was evaluated through the determination of their age at vaginal opening. At the end of the experimental period, 5 animals in each group were sacrificed and blood samples were collected for hormonal assay. Their ovaries and uteri were removed, blotted, weighted and prepared for biochemical analysis. The remaining rats (5 per group) were crossed with males of proven fertility. After laparotomy (ten days after mating) and delivery, fertility and gestational parameters were recorded. it was noticed that, body weight gain increased significantly at all doses although there was no significant difference in food intake. The sexual maturation of treated animal was reduced to 5 days when compared to control. This was associated with the simultaneous elevation of FSH and LH (p ian cholesterol significantly decreased (p ile the uterine protein significantly increased (p imal treated at doses of 400 mg/kg and 800 mg/kg exhibited an early fertilization (2 - 3 days) when compared to the control one (9 - 14 days). The number of implantation site significantly increased (p ive fetuses after delivery and gestational rate (80% and 100%) respectively. These results provide the strong evidence on the induction of the

关键词： Schumanniophyton magnificum Sexual Maturation Hormone Level Fertility

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Effect of the Aqueous Stem Bark Extract of Schumanniophyton magnificum on Reproductive Functions on Wistar Strain Mature Female Rats

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Pharmacology & Pharmacy 2022年第9期13卷 340-354页

作者： Emma F. Bend Brice L. Koloko Sylvin B. Ateba Modeste Wankeu-Nya marie.i. ngaha njila Zacharie Nde Paul V. Mboumwa marie C. Tchamadeu Samuel H. Mandengue Paul Moundipa Theophile Dimo Dieudonné Massoma Lembè Department of Animal Production Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Animal Sciences Faculty of Science University of Douala Douala Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

in recent years, the rate of infertility has not stopped increasing in the world. The aim of the present study was to evaluate the effects of the aqueous extract of Schumanniophyton magnificum (Rubiaceae) on cyclicity, ovulation and gestation in mature rats. Methods: After a qualitative phytochemical analysis of these aqueous extracts, the experimental studies carried out were based on the evaluation of the pro-fertility effects of this extract in mature rats. For this purpose, 35 rats were used for the estrous cyclicity test and treated for 21 days at the end of which vaginal smears were taken and the duration, as well as the frequency of the appearance of the phases of the cycle, were evaluated. The ovulation test was performed on 80 female rats, which were divided into two groups of 40 animals and treated respectively in the morning and evening with distilled water, β-oestradiol or plant extract at doses of 200, 400 and 800 mg/kg. At the end of estrus, the rats were sacrificed, the ovaries were removed and weighed, the hemorrhagic points counted and the blood samples were taken for hormonal studies. The last phase of the study consisted in evaluating the effects of these plant extracts on the evolution of gestation. Thus, 42 mature rats were treated during the periods from the 1st to the 10th day (1st stage), and from the 11th to the 17th day (2nd stage). At the end of these two phases, a laparotomy was performed and the number of implantation sites and corpus luteum was counted. And finally, at parturition, from the 18th to the 22nd day (3rd stage), the number of living pups was performed and the gestational parameters were calculated. Results: Administration at the beginning of prœstrus allowed a significant increase (p S. magnificum extract. On the other hand, a significant decrease in progesterone levels (p S. magnificum at doses of 200, 800 mg/kg (p S. magnificum when compared to the control (23 ± 0.16 d). Conclusion: it appears from all these investig

关键词： Estrous Cycle Ovulation Fertility Schumanniophyton magnificum

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Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon

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Open Journal of Epidemiology 2023年第4期13卷 436-448页

作者： Paul V. Mboumwa Modeste Wankeu-Nya Théodore Sala Béyemé Zacharie Nde Emma F. Bend Frantz Ngalle Epoupa Brice L. Koloko Sylvin B. Ateba marie.i. ngaha njila Paul Moundipa Théophile Dimo Dieudonné Massoma Lembè Department of Biology of Animal Organisms Faculty of Science University of Douala Douala Cameroon Department of Animal Production Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Urology of Laquintinie Hospital of Douala Douala Cameroon Department of Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

Sexual dysfunction is a group of diseases, disorders or difficulties experienced by men or women during any stage of normal sexual activity. in Africa in general and Cameroon in particular, statistical data concerning the prevelance and the main causes of male sexual dysfunction are rare due to socio-cultural and religious burdens and sometimes self-medication. The objective of this work was to determine the prevalences, comorbidities and the risk factors of the main sexual dysfunction in some hospitals in city of Douala. Through a descriptive retrospective study carried out from Novembre 2019 to June 2021, sociodemographic parameter, reasons of consultation, risk factors and type of male sexual dysfunction (erectile dysfunction or erectile dysfunction (ED), ejaculation disorders (EjD), libido disorders (LD) and disorders of sexual activity with pain or painful sexual intercourse (PSi)) were collected in the medical files of patients who have made urological consultation between 2016 and 2020 at the Deido District hospital, Laquintinie Douala Hospital and Douala General hospital respectively. At the end of our data collection, out of a total of 24995 consultations, 2743 (10.98%) patients were suffering from at least one male sexual dysfunction. Moreover, sexual disorders were the 2nd reason of urological consultation (13.69%) after urinary disorders (33.85%). Among sexual disorders, erectile (76%) and ejaculatory (20%) disorders were the predominant pathologies recorded with the prevalences of 9.79 et 2.62% respectively, and were mostly represented in patients from [41 - 50] for erectile dysfunction, and [18 - 30] years old for ejaculative dysfunction. in addition, the number of patients with ejaculatory and erectile dysfunctions was more important in patients from [18 - 30] and [31 - 40] years old respectively. Among patients presenting sexual disorders, several risk factors or pathologies were associated with the dysfunction: benign prostatic hyperplasi

关键词： Male Sexual Dysfunction Patient Urologist Prevalence

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Antifertility Effects of Aqueous Roots Extract of Alchornea cordifolia(Euphorbiaceae) on Female Albino Rats

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Pharmacology & Pharmacy 2014年第8期5卷 838-845页

作者： Dieudonne Massoma Lembè Larice E. Njoh Njoh Emma F. Bend Brice L. Koloko Pierre C. Oundoum Oundoum marie.i. ngaha njila Hubert Kenmogne Cyprien M. Hambe marie C. Tchamadeu Judith Domkam Theophile Dimo Gustavo F. Gonzales Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon Department of Animal Sciences Faculty of Science University of Douala Douala Cameroon Laboratory of Endocrinology and Reproduction Faculty of Sciences and Philosophy Alberto Cazorla Talleri Universidad Peruana Cayetano Heredia Lima Peru

Aqueous roots extract of Alchornea cordifolia was studied to evaluate its traditional antifertility claim. Antifertility effect of Alchornea cordifolia was evaluated according to the stages of pregnancy of female rats. in the first stage, forty female rats were randomly divided into four groups (10 rats/group) and respectively treated with 1 ml distilled water (control), 100, 200 and 400 mg/kg body weight (BW) per day of Alchornea cordifolia. After laparotomy and at parturition, sites of implantation and resorption on the uterine horns were determined. The ovaries and uterus were collected and weighed. Blood samples were collected for hormonal assay. in the second and third stage of pregnancy, treatment schedule and antifertility parameters were assessed as above for the first stage. Treated groups received daily 400 mg/kg bw of extract of Alchornea cordifolia while Control group received distilled water. it was observed in the first stage of pregnancy that, the number of resorption sites significantly (p implantation site was observed at dose 400 mg/kg after laparotomy as well as the number of pups at parturition at all doses. The body weight of ovaries and uterine horns at dose 400 mg/kg significantly (p ignificantly the concentrations of serum progesterone. in the second stage of pregnancy after laparotomy and at parturition, the number of live fetus and the survival ratio significantly (p iated with the vaginal discharge and bleeding of animals. in the third stage of pregnancy, the extract caused an early parturition associated with a decreased number of live fetus and the survival ratio with p The results indicate that aqueous roots extract of Alchornea cordifolia could induce inhibitory effects on reproductive functions in female albino rats.

关键词： implantation Embryo Development Abortion Hormone Level

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Acute and Reproductive Toxicity of the Aqueous Extract of the Dry Seeds of Aframomum daniellii on the Female Wistar Rat Strain

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Pharmacology & Pharmacy 2021年第7期12卷 141-153页

作者： Zacharie Nde Modeste Wankeu-Nya Brice L. Koloko Sylvin B. Ateba marie.i. ngaha Emma F. Bend Paul V. G. Mboumwa Doriane C. Nyonseu Nzeubang Dieudonné Massoma Lembè Laboratory of Biology and Physiology of Animal Organisms Faculty of Sciences of Douala University Douala Cameroon

This work was designed to investigate the acute and reproductive toxicity activity of the aqueous extract of the dry seeds of Aframomum daniellii on the female rats. The acute toxicity of the aqueous extract of Aframo... 详细信息

This work was designed to investigate the acute and reproductive toxicity activity of the aqueous extract of the dry seeds of i>Aframomumi> i>danielliii> on the female rats. The acute toxicity of the aqueous extract of i>Aframomumi> i>danielliii> (i>A.i> i>danielliii>) was evaluated with 6 female rats which were divided into 2 groups (1 Test group and the Control group) of 3 female rats each. The control group received distilled water (10 mL/kg/i>poi>) and the test group received a single dose of extract of i>A.i> i>danielliii> at the dose of 2000 mg/kg. The reproductive toxicity was evaluated using 45 adult female rats which were divided into 5 groups. Group i, received distilled water (1 mL/100 g/i>poi>, neutral control);group ii, received Clomiphene citrate (600 μg/kg/i>poi>, positive control);Groups iii, iV and V (trials) received aqueous extract of i>A.i> i>danielliii> at doses of 100, 200 and 400 mg/kg/i>poi> respectively. The animals were treated daily for 14 days. From the 6th day of treatment, the rats were mated with males of proven fertility for 8 days. On day 22, after laparotomy and delivery, the number of implantation sites, corpora lutea, resorption sites and pups were recorded. Concerning the acute toxicity, it was observed that, after the single dose of 2000 mg/kg administration of the aqueous extract of the dry seeds of i>A.i> i>danielliii>, no deaths were recorded. Concerning the reproductive toxicity, no implantation and gestation were observed when compared to the control. However, the aqueous extract of i>A.i> i>danielliii> caused a significant (p increase in serum estrogen levels in all treated rats when compared to the control. These results indicate that, the aqueous extract of the dry seeds of i>Ai> i>danielliii> is weakly toxic, but could negatively affect some reproductive parameters.

关键词： Acute Toxicity Reproductive Toxicity Female Rats Aframomum daniellii

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Consultation, Diagnosis and Treatment Delays for Breast Cancer among Patients Followed up at the YaoundéGeneral Hospital, Cameroon

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Open Journal of Obstetrics and Gynecology 2020年第11期10卷 1580-1589页

作者： Jean Dupont Kemfang Ngowa Angèle Kabeyene Richard Ngarvounsia Etienne Atenguena Yvan Sinclair ngaha Tchawe Anny Ngassam Christiane Nsahlai Junie Metogo Jovanny Fouogue Tsuala Pierre marie Tebeu Department of Obstetrics/Gynecology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaoundé General Hospital Obstetrics/Gynecology Unit Yaoundé Cameroon Department of Pathology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaoundé General Hospital Medical Oncology Unit Yaoundé Cameroon Department of Obstetrics/Gynecology Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

introduction: Breast cancer is often diagnosed at an advanced stage in Cameroon. The objective was to analyse consultation, diagnosis and treatment delays for breast cancer among patients followed up at the Yaoundé General Hospital (YGH) in Cameroon. Materials and Methods: This was a cross-sectional study carried out from the files of patients followed up for breast cancer at the YGH from January 1, 2014 to April 30, 2018. A total of 183 patients were included. We measured time elapsed between the awareness of first signs of disease and the initial consultation (consultation delays), time lapse between the initial consultation and pathological diagnosis of breast cancer (diagnosis delays), interval between pathological diagnosis and treatment onset (treatment delays), time elapsed between the initial consultation and management (health system delays) and time elapsed from awareness of first signs of disease to treatment onset (overall delays). Resultsily:Verdana;">ily:Verdana;">

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Effect of the Aqueous Stem Bark Extract of Schumanniophyton magnificum on Reproductive Functions on Wistar Strain Mature Female Rats

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Pharmacology & Pharmacy（药理与制药） 2022年第9期

作者： emma f.bend brice l.koloko sylvin b.ateba modeste wankeu-nya marie.i.ngaha njila zacharie nde paul v.mboumwa marie c.tchamadeu samuel h.mandengue paul moundipa theophile dimo dieudonné massoma lembè

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Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon

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Open Journal of Epidemiology（流行病学期刊） 2023年第4期

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