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Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor

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Cellular & Molecular Immunology 2021年第7期18卷 1644-1651页

作者： marie Robert Pierre Miossec Department of Clinical Immunology and Rheumatology and immunogenomics and inflammation research unitUniversity of LyonHôpital Edouard HerriotLyonFrance

Tumor necrosis factor(TNF)inhibitors have improved a lot the treatment of numerous diseases,with the well-known example of rheumatoid arthritis(RA).In the early 2000s,postmarketing data quickly revealed an alarming number of severe tuberculosis(TB)under such *** findings were consistent with previous results in mice where TNF is essential for lymph node formation and granuloma *** effects of TNF inhibition on RA synovium structure are very similar to those on granuloma,with changes in cellular interactions,cytokine,and chemokine *** addition to the role of TNF in granuloma,the interleukin(IL)-12/interferon(IFN)-γpathway is required for an efficient host defense against *** and secondary immunodeficiencies affecting this pathway lead to severe bacillus Calmette-Guérin(BCG)reaction or full *** chronic inflammation as in RA induces a systemic Th1 defect that predisposes to TB through specific downregulation of the IL-12Rß2 *** TNF inhibitors are initiated,this transiently increases this risk of TB,through effects on cellular interactions in a latent TB *** a later stage,when a better control disease activity is obtained,the risk of TB is reduced but not *** the clear benefit from TNF inhibition,latent TB infection screening at baseline is essential for an optimal safety.

关键词： tuberculosis TNF inhibition rheumatoid arthritis cytokines

Density Results in Sobolev Spaces Whose Elements Vanish on a Part of the Boundary

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 823-846页

作者： Jean-marie Emmanuel BERNARD Laboratoire Analyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of Wm＇＂ of functions that vanish on a part γ0 of the boundary. The author gives a crucial estimate of the Poincare constant in balls centered on the boundary of γ0. Then, the convolution-translation method, a variant of the standard mollifier technique, can be used to prove the density of smooth functions that vanish in a neighborhood of γ0, in this subspace. The result is first proved for m = 1, then generalized to the case where m 〉 1, in any dimension, in the framework of Lipschitz-continuous domain. However, as may be expected, it is needed to make additional assumptions on the boundary of γ0, namely that it is locally the graph of some Lipschitz-continuous function.

关键词： Density results Boundary value problems Sobolev spaces

Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean Pierre Majoral Jean marie Francois Richard Fabre Alice Senescau Serge Mignani Anne-marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology

Experimental Study of Aerodynamic Behavior in Wind Tunnels with Ornithopter and Plane Models

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Journal of Thermal Science 2006年第1期15卷 54-58页

作者： marie-Francoise SCIBILIA Jan WOJCIECHOWSKI Centre National de la Recherche Scientiflque France. Institute of Aeronautics and Applied Mechanics Warsaw University of Technology Poland.

There are similarities between planes and birds. In fact aerodynamics bases are the same. In order to make some comparisons, this paper presents two series of experiments ： one in a wind tunnel with an omithopter model for measurements of aerodynamic forces with flapping wings. The wing movement has two degrees of freedom flapping around the longitudinal axis of the model and feathering around the wing axis. Measurements of aerodynamic forces： rift and drag in static case averaging values during many cycles of movement and in dynamic case have been performed. The other part of the paper concerns velocity and turbulence measurements on a metal plane wall jet in a wind tunnel with and without a rough surface, with and without acoustic vibrations in order to simulate a plane wing. Aerodynamic characteristics have been obtained in all cases.

关键词： wind tunnel aerodynamics characteristics ornithopter model plane wall jet.

Covariates of Disability-Profile Transitions in Older People Living at Home

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Journal of Biosciences and Medicines 2014年第3期2卷 25-36页

作者： Michel Raiche Rejean Hebert marie-france Dubois N’Deye Rokhaya Gueye Nicole Dubuc Research Centre on Aging Sherbrooke University Geriatrics InstituteSherbrookeCanada Faculty of Medicine and Health Sciences Universitede SherbrookeSherbrookeCanada Faculty of Arts&Faculty of sciences Universitede Saint-BonifaceWinnipegCanada

The objective of this study was to explore the relationship of sociodemographic, clinical, and health-services use-related variables with transitions between disability-based profiles. In a longitudinal study of 1386 people aged 75 and over living in the community at baseline, disabilities were assessed annually for up to four years with the Functional Autonomy Measurement System (SMAF), which generates 14 Iso-SMAF profiles. These profiles are grouped into 4 disability states, which are predominant alterations in instrumental activities of daily living (IADLs), mobility, mental functions as well as severe and mixed disabilities. Continuous-time, multi-state Markov modeling was used to identify the factors associated with transitions made by older people between these states and to institutionalization and death. Greater age and receiving help for ADL were associated with four transitions, while altered cognitive functions and hospitalization were associated with three, all involving more decline or less recovery. From mild IADL profiles, men have a higher risk of transitioning to intermediate predominantly mental profiles, while women are at higher risk of transitioning to intermediate predominantly mobility profiles. Unmet needs are associated with deterioration, from mild IADL to intermediate predominantly mobility profiles. These results help understanding the complex progression of disabilities in older people.

关键词： Aged Disability Profiles Transitions Covariates Multistate Model Case-Mix Classification Longitudinal

Infectious Pathology of the Scrotum in Abidjan: Ultrasound Features of 80 Cases

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Open Journal of Radiology 2017年第2期7卷 103-111页

作者： N’goran Kouame Fotso Sorel Manewa Amlan marie-france Kouame Anne-marie N’goan-Domoua Roger-Daniel N’gbesso Department of Radiology Yopougon University Hospital Abidjan Cote d’Ivoire

Objectives: The aim of this study was to determine the epidemiological-clinical profile of patients with scrotal infectious pathology in Abidjan and describe the ultrasound features of this scrotal infectious pathology. Methods: This was a prospective study of 80 cases of scrotal infectious pathology objectified by ultrasound at Yopougon University Hospital from 1 January 2015 to 31 December 2015. Ultrasounds were performed using a high-frequency linear probe in B and Color Doppler modes by senior radiologists. The epidemiological-clinical data were recorded from the ultrasound request form and the interrogation of the patient. Results: The average age was 23 years with extreme ranging from 16 to 40 years. Soldiers were the most concerned (40%) followed by students (30%). The painful large bursa was the quasi constant presenting feature (95% of cases) and fever was associated in less than half of the cases (45% of cases). The scrotal involvement was most often unilateral (85% of cases) and the left side was involved in 70% of the cases. Epididymitis was the most frequent pathology (60%) followed by orchiepididymitis (30%) and orchitis (10%). The most commonly encountered accompanying ultrasound findings were envelope thickening (100%), intravaginal fluid effusion (60%), and Doppler Hypervascularization (30%). Conclusion: In Abidjan Scrotal infectious pathology is most often encountered among young soldiers or students most often with a ± febrile large bursa. The most common pathology is left unilateral epididymitis.

关键词： Orchitis Epididymitis Large Bursa Male Genital Infection

Chemical Investigation of the NO_x Detection Mechanisms by Semiconductor Metal Oxide Nanoparticles

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稀有金属材料与工程 2006年第A3期35卷 40-42页

作者： marie-Isabelle Baraton Lhadi Merhari SPCTS-UMR CNRS 6638 Faculty of SciencesF-87060 LimogesFrance CERAMEC R&D F-87000 LimogesFrance

This work reports an FTIR study of the NO_x adsorption/desorption cycles on tin oxide nanosized particles under the operating conditions of real sensors (150℃,in presence of O_2).The chemical reactions are monitored in situ and correlated with the variations of the SnO_2 electrical *** the basis of the FTIR spectra,two contributing mechanisms for the NO_x detection are *** first one presents the formation of bridged nitrate groups bound to the SnO_2 surface via oxygen vacancies acting as electron donor *** second mechanism also involves surface oxygen vacancies in the coordination of NO_x,but this time the formation of NO_x anionic species is *** mechanisms lead to the decrease of the electrical conductivity under NO_x ***,the bridged nitrate groups are not reversible under gas desorption and thus irreversibly contaminate the surface after the first NO_x *** the contrary,the nitrosyl anionic species are reversible and,from the second NO_x adsorption/desorption cycle,ensure the reproducibility of the sensor response.

关键词： NO_x detection surface reactions FTIR spectroscopy Tin oxide SnO2 nanoparticles chemical sensors

Compressive behavior and energy absorption of metal porous polymer composite with interpenetrating network structure

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Transactions of Nonferrous Metals Society of China 2006年第S2期 439-443页

作者： LIU Yu, GONG Xiao-lu Institut Charles Delaunay, CNRS FRE 2848, LASMIS, UTT 12, rue marie Curie, BP 2060, 10010 Troyes, france

Interpenetrating phase composites (IPCs) are a new class of composite materials with improved combinations of mechanical and physical properties. This study was performed on a new type of IPC called metal porous polymer composite (MPPC) with an interpenetrating network structure. Aluminum-polypropylene (AI-PE) and Aluminum-epoxy resin (Al-Ep) composites were produced by infiltrating the polymer in the aluminum foam. The composite microstructures were characterized using SEM observation. The compressive behavior and energy absorption characteristics of MPPC were investigated and compared with the aluminum foams. The compressive modulus of composite was compared with the VOIGT-REUSS bounds and HASHIN-SHTRIKMAN (H-S) bounds models. The experimental modulus of compressive tests falls well within the theoretical models.

关键词： MPPC composite micro structure compressive behavior energy modulus

Advanced Anderson-Fabry disease presenting with left ventricular apical aneurysm and ventricular tachycardia

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World Journal of Clinical Cases 2015年第6期3卷 519-524页

作者： marie-france Poulin Alap Shah Richard G Trohman Christopher Madias Department of Medicine Division of Cardiology Rush University Medical Center

A 54-year-old female with Anderson-Fabry disease(AFD)-R342 Q missense mutation on exon 7 in alphagalactosidase A(GLA) gene- presented with sustained ventricular tachycardia. Imaging confirmed the presence of a new left ventricular apical aneurysm(LVAA) and a significantly reduced intra-cavitary gradient compared to two years prior. AFDcv is an X-linked lysosomal storage disorder caused by GLA enzyme deficiency. The phenotypic expression of AFD in the heart is not well described. Cardiac involvement can include left ventricular hypertrophy(LVH), which is typically symmetric, but can also mimic hypertrophic cardiomyopathy(HCM). Left ventricular apical aneurysm is a rare finding in HCM. We suggest a shared mechanism of LVAA formation in AFD and HCM, independent of the underlying cardiomyopathy. Mechanisms of LVAA formation in HCM include genetic predisposition and long-standing left ventricular wall stress from elevated intra-cavitary systolic pressures due to mid-cavitary obstruction. Both mechanisms are supported in this patient(a brother with AFD also developed a small LVAA). Screening for AFD should be considered in cases of unexplained LVH, particularly in patients with the aneurysmal variant of HCM.

关键词： Anderson-Fabry disease Sustained ventricular tachycardia Left ventricular apical aneurysm Hemodynamic compensation Transthoracic echocardiography Magnetic resonance imaging Hypertrophic cardiomyopathy