检索结果-南通市图书馆

γ-aminobutyric acid B2 receptor:A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus

引用

World Journal of Gastroenterology 2023年第28期29卷 4416-4432页

作者： Charupong Saengboonmee Supannika Sorin Sakkarn Sangkhamanon Surang Chomphoo Somsiri Indramanee Wunchana Seubwai Kanyarat Thithuan Ching-Feng Chiu Seiji Okada marie-claude gingras Sopit Wongkham Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Center for Translational Medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Cholangiocarcinoma Research Institute Khon Kaen UniversityKhon Kaen 40002Thailand Department of Pathology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Forensic Medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031Taiwan Division of Hematopoiesis Joint Research Center for Human Retrovirus InfectionKumamoto UniversityKumamoto 860-0811Japan Human Genome Sequencing Center Department of Human and Molecular GeneticsBaylor College of MedicineHoustonTX 77030United States Michael E.DeBakey Department of Surgery Baylor College of MedicineHoustonTX 77030United States

BACKGROUND The association between diabetes mellitus(DM)and the increased risk and progression of cholangiocarcinoma(CCA)has been reported with unclear underlying *** studies showed thatγ-aminobutyric acid(GABA)B2 receptor(GABBR2)was upregulated in CCA cells cultured in high glucose(HG)*** of GABA receptors in CCA progression have also been studied,but their association with DM and hyperglycemia in CCA remains *** To investigate the effects of hyperglycemia on GABBR2 expression and the potential use of GABBR2 as a CCA therapeutic *** CCA cells,KKU-055 and KKU-213A,were cultured in Dulbecco Modified Eagle’s Medium supplemented with 5.6 mmol/L(normal glucose,NG)or 25 mmol/L(HG)glucose and assigned as NG and HG cells,***2 expression in NG and HG cells was investigated using real-time quantitative polymerase chain reaction and western *** and localization of GABBR2 in CCA cells were determined using ***2 expression in tumor tissues from CCA patients with and without DM was studied using immunohistochemistry,and the correlations of GABBR2 with the clinicopathological characteristics of patients were analyzed using univariate *** of baclofen,a GABA-B receptor agonist,on CCA cell proliferation and clonogenicity were tested using the MTT and clonogenic ***-kinases arrays were used to screen the affected signaling pathways after baclofen treatment,and the candidate signaling molecules were validated using the public transcriptomic data and western *** GABBR2 expression in CCA cells was induced by HG in a dose-and time-dependent *** tissues from patients with DM and hyperglycemia also showed a significantly higher GABBR2 expression compared with tumor tissues from those with euglycemia(P<0.01).High GABBR2 expression was significantly associated with a poorer non-papillary histological subtype but with smaller sizes of CCA tumors(P<0.0

关键词： Baclofen Cholangiocarcinoma Diabetes mellitus Drug repurposing Hyperglycemia Gamma-aminobutyric acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of Corporate Social Responsibility Practices among Apparel Companies and Their Supply Chains

Evaluation of Corporate Social Responsibility Practices amon...

引用

作者： Romy gingras 上海交通大学

学位级别：硕士

Social and environmental issues are particularly relevant to the apparel industry,due mainly to the aggressive competition among firms,the intensive resource use as well as the poor and scandalous working conditions in some ***,the apparel industry is the second most polluted in the world,after oil（Sweeny,2015;Rehman,2016;Conca,2015）,contributing to 10% of global carbon *** it employs more than 60 million people worldwide（Fashion United,2017）,it is therefore imperative to pay special attention to the social and environmental impacts of this industry so as to minimize its adverse effects on the *** thesis elaborates differences and similarities of Corporate Social Responsibility（CSR）practices among thirty-nine large brand name apparel companies and their supply chains,according to three core subjects: labour practices,environment and fair operating practices and demonstrates how CSR practices are implemented and managed through the supply chains in the apparel *** organisations have been divided in two clusters by means of a cluster analysis,after an in-depth study and analysis of their respective CSR reports and sustainability sections of their websites,as well as third-party information provided by NGOs and other relevant *** analysis confirms that CSR practices have to be incorporated along the entire supply chain to be more effective and emphasizes the importance to trace the entire supply *** research can be used as a tool for environmentally friendly customers wishing to make a difference in their consumption habits,as it compares the CSR practices of internationally known companies and helps to understand the concept of CSR among apparel companies and their supply *** can also find this research useful in order to understand the correlation between the five core subjects analysed and the way the companies of each cluster are implementing CSR in their organisations.

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Significance of ichnofossils to genetic stratigraphy——Examples from the Cretaceous of Alberta, Canada

引用

Science China Earth Sciences 2000年第5期43卷 541-560页

作者： S.George Pemberton James A.MacEachern Murray K.gingras 张建平 Department of Earth and Atmospheric Sciences University of AlbertaEdmontonAlbertaCanadaT6G 2E3 Earth Sciences Simon Fraser UniversityBurnabyBritish ColumbiaCanadaV5A 1S6 Department of Earth and Atmospheric Sciences University of AlbertaEdmontonAlbertaCanadaT6G 2E3 Department of GeologyChina University of GeosciencesBeijing 100083China Correspondence should be addressed to zhang Jianping

Trace fossils represent both sedimentological and paleontological entities, representing a unique blending of potential environmental indicators in the rock record. Trace fossils and trace fossil suites can be employed effectively to aid in the recognition of various discontinuity types and to assist in their genetic interpretation. Ichnology may be employed to resolve surfaces of strati-graphic significance in two main ways: 1) through the identification of discontinuities using substrate-controlled ichnofacies, and 2) through careful analysis of vertical softground (penecontem-poraneous) ichnologic successions (analogous to facies successions). Ichnological analysis is a valuable tool in genetic stratigraphic studies. Integrating the data derived from substrate-controlled ichnofacies with paleoecological data from vertical ichnologic successions greatly enhances the recognition and interpretation of a wide variety of stratigraphic surfaces. When this is coupled with conventional facies analysis and sequence stratigraphy, a powerful approach to the interpretation of the rock record is generated.

关键词： trace fossils Glossifungites ichnofacies genetic stratigraphy sequence boundaries Western Canada sedimentary Basin Cretaceous.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

遗迹化石在成因地层学中的意义──以加拿大阿尔伯塔省白垩系为例

引用

中国科学（D辑） 2000年第3期30卷 264-278页

作者： S.G.Pemberton J.A.MacEachern M.K.gingras 张建平 Department of Earth& Atmospheric Sciences University of Alberta Department of Earth Sciences 中国地质大学地球科学与资源学院北京100083

遗迹化石代表沉积学和古生物学两方面的内容，是地层记录中潜在的环境指示者．遗迹化石及其组合可有效地确定地层中各种不连续类型并解释其成因．在地层意义解释方面，遗迹学的应用主要有：（１）利用受基底控制的遗迹相确定不连续面... 详细信息

遗迹化石代表沉积学和古生物学两方面的内容，是地层记录中潜在的环境指示者．遗迹化石及其组合可有效地确定地层中各种不连续类型并解释其成因．在地层意义解释方面，遗迹学的应用主要有：（１）利用受基底控制的遗迹相确定不连续面；（２）通过仔细分析垂向软基底（准同生）遗迹化石序列获取环境变化的证据（与相序列可类比）．在成因地层研究中，把受基底控制的遗迹相资料和遗迹化石序列的生态资料结合起来，可极大地增强对多种地层界面辨认和解释的能力．当这一过程与常规的相分析和层序地层研究结合起来时，将会成为一个强有力的解释地质记录的工具。

关键词：遗迹化石成因地层学西加拿大沉积盆地白垩系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

化学镀镍的废水处理

引用

电镀与环保 1989年第6期9卷 25-28页

作者： R.K.gingras R.S.Capaccio 费树雷

本文概述了化学镀镍达标排放的要求;综述了三废极小化技术,包括减少污染与回收的技术,重点放在清洗水与污泥的传统的与先进的管端处理方法及其在实际应用申的相对效率。

关键词：化学镀镀镍废水处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

重庆晚侏罗世两处兽脚类足迹组合与四川盆地侏罗纪地层(英文)

引用

古脊椎动物学报 2013年第2期51卷 107-130页

作者：邢立达 Martin G. LOCKLEY 陈伟 Gerard D.GIERLINSKI 李建军 W.Scott PERSONS Ⅳ 松川正树叶勇 Murray K.gingras 王昌文中国科学院脊椎动物演化与人类起源重点实验室北京100044 美国科罗拉多大学丹佛分校恐龙足迹博物馆丹佛80217 重庆自然博物馆重庆400013 波兰侏罗纪公园奥斯特罗维茨427-4001 波兰地质研究所华沙400-975 北京自然博物馆科学研究部北京100050 加拿大阿尔伯塔大学生物科学系埃德蒙顿T6G2E9 日本东京学艺大学环境科学系东京184-8501 自贡恐龙博物馆四川自贡643013 加拿大阿尔伯塔大学地球科学系埃德蒙顿T6G2E9 重庆市永川区文物管理所重庆402160

重庆市已报道了4处侏罗纪的恐龙足迹点,包括下侏罗统珍珠冲组的大足化石点,该地点发现了中国迄今最古老的蜥脚类行迹;另外两处化石点(南岸和金鸡)的层位曾被视为中或上侏罗统,这里首次将其确认为上侏罗统上沙溪庙组;第4处化石点(成渝),... 详细信息

重庆市已报道了4处侏罗纪的恐龙足迹点,包括下侏罗统珍珠冲组的大足化石点,该地点发现了中国迄今最古老的蜥脚类行迹;另外两处化石点(南岸和金鸡)的层位曾被视为中或上侏罗统,这里首次将其确认为上侏罗统上沙溪庙组;第4处化石点(成渝), 本文全部作者目前都未曾观察,这里不做描述。南岸化石点是南岸重庆足迹(Chongqingpus nananensis)模式标本的所在地,位于重庆市中心,曾发现过大量兽脚类足迹,如今已消逝在城市化进程中。幸运的是,这批标本被保存于重庆自然博物馆,本文作者曾前后两次对其进行研究,并得出文中的结论。南岸重庆足迹为中型足迹(平均长约29 cm), 最可能被卡岩塔足迹(Kayentapus)所囊括,这批标本中有一些保存着边界不清的拇趾迹。该化石点的其他足迹被归于似异样龙足迹(cf. Anomoepus)。其他较小的、来自重庆市周边中侏罗统中部的足迹此前已被归于跷脚龙足迹(Grallator)。金鸡化石点保存了一条孤立的兽脚类行迹,因其粗壮的特征而被暂时归于似窄足龙足迹(cf. Therangospodus)。金鸡点的行迹也保存了非连续出现的拇趾迹。虽然重庆市和四川盆地及其周边更广泛地区之侏罗纪地层发现的兽脚类足迹日渐增多,但要明确其确切地质年龄及有效的足迹分类依然需要进一步工作。这是因为侏罗纪的恐龙足迹尽管丰富,但显示出连续变化的形态学特征,而保存状况的变化更使其难以在时间与空间上做出定义与鉴别。

关键词：重庆四川盆地晚侏罗世兽脚类足迹足迹分类学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

遗迹相在边缘海相分析中的应用

引用

古地理学报 2000年第2期2卷 54-64页

作者： S.G.Pemberton T.D.A.Saunders M.K.gingras 张建平加拿大阿尔伯塔大学地球和大气科学系

本质上 ,边缘海相储层是由一系列复杂排列的岩相所组成 ,代表几种亚环境结合部位的特征。在边缘海环境中 ,对应于相对海平面变化 ,关键的层序界面之上可被淡水、半咸水和纯海水 (沉积 )所覆盖。因此 ,在对这样的储层进行勘探和开发时 ,... 详细信息

本质上 ,边缘海相储层是由一系列复杂排列的岩相所组成 ,代表几种亚环境结合部位的特征。在边缘海环境中 ,对应于相对海平面变化 ,关键的层序界面之上可被淡水、半咸水和纯海水 (沉积 )所覆盖。因此 ,在对这样的储层进行勘探和开发时 ,区分淡水、半咸水和纯海水沉积就显得格外重要。而遗迹化石组合有助于区分这些环境。总的来说 ,半咸水遗迹化石组合有如下特征 :①低分异度 ;②贫乏的海相组合 ,而不是海相和非海相的混合 ;③由机会物种形成的简单构造组成 ;④遗迹组合常以某个遗迹属为主 ;⑤形态微小 ;

关键词：遗迹相边缘海相遗迹化石海相分析

来源：

维普期刊数据库

同方期刊数据库评论