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Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic republic of Congo

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Neuroscience & Medicine 2024年第1期15卷 1-22页

作者： Candide About Kabamba Berry Ikolango Bongenya Jocelyn Ewuti Nonga Lambert Omombo Losenga Noëlla Maketi Dikati thérèse Kasaka Ntumba Grace Ipaya Booto rosalie Djamba Dembo Stéphanie Mauwa selenge Benoit Obel Kabengele Guy Makila Mabe Bumoko marie-thérèse ayan. safi sombo Erick Ntambwe Kamangu Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo “Focus HIV/AIDS” research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine University Clinic of Kinshasa Kinshasa Democratic Republic of Congo Molecular Biochemistry Department Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: the objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) initiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: this is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. the International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. the average age was 40.1 ± 12.1 years. the secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as opportunistic infections. they were alcoholics in (30.2%). their history was heart disease (15.6%), high blood pressure (18.8%);drug abuse (10.4%). the IHDS score was light in 55.2% of cases. the correlation between IHDS/IADL watches asymptomatic neurocognitive impairments (ANI) in 77.1%, almost all of subjects are found with normal overall functioning (94.8%) and a disturbed neurological examination in 53.1% of cases with a predominance of motor impairments in 79.1%. Conclusion: In view of these results, early and systematic screening of NCD and associated factors remains necessary in our context. .

关键词： IHDS Dolutegravir Initiation Kinshasa Neurological Profile PLHIV

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Evolutionary Profile of Opportunistic Infections in People Living with Human Immunodeficiency Virus during Six Months of Dolutegravir Based Antiretroviral Treatment in Kinshasa, Democratic republic of Congo

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World Journal of AIDS 2023年第2期13卷 47-56页

作者： Berry Ikolango Bongenya marie-thérèse ayan. safi sombo Benoit Oben Kabengele Guy Makila Mabe Bumoko Erick Ntambwe Kamangu “HIV/AIDS Focus” research Group Kinshasa Democratic Republic of Congo Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Internal Medicine University Clinic of Kinshasa Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Background: Opportunistic infections (OI), which are still a major problem in the care of People Living with HIV (PLHIV), occur in situations of immunosuppression. the AntiretroViral Treatments (ArT) used allow a spectacular reduction in the frequency of Opportunistic Infections. Objective: the objective of this study is to present the evolution of Opportunistic Infections in People Living with HIV under AntiretroViral Treatment in Kinshasa in the era of Dolutegravir. Methods: the present study is a prospective cohort to present the evolutionary profile of OIs in PLHIV on ArT for 6 months in Outpatient Treatment Centers (OTC) in Kinshasa. Sixteen OTCs had been included. the population of the present work was patients over 18 years of age at inclusion, infected with HIV-1 and initiating ArT in the selected OTC. results: On inclusion, 119 patients were included of which 56.3% were women. Malaria (45.4%), tuberculosis (29.4%) and cutaneous pruritus (23.5%) were the most common Opportunistic Infections (OIs). In the third month of ArT, 37 patients came for the consultation of which 70.3% were women. Non-specific STIs (97.3%), skin pruritus (37.8%) and malaria (24.3%) were the dominant OIs among patients. At the sixth month of ArT, 62 patients came for the medical consultation of which 61.3% were women. Skin pruritus (25.8%), dermatitis (22.6%) and rash (21%) were the most common OIs. Conclusion: the evolutionary profile is marked by the conservation of Opportunistic Infections such as dermatitis (pruritus and rashes) and malaria.

关键词： Opportunistic Infections ArT Initiation PLHIV Kinshasa

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Compliance with First-Line AntiretroViral Treatment (ArT) for HIV Infection in the Era of Dolutegravir in Kinshasa, Democratic republic of the Congo

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World Journal of AIDS 2023年第1期13卷 11-17页

作者： Berry Ikolango Bongenya marie-thérèse ayan.e safi sombo Guy Makila Mabe Bumoko Benoit Obel Kabengele Mariano Manzo Lusakibanza Gauthier Kahunu Mesia Erick Ntambwe Kamangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of the Congo “HIV/AIDS Focus” research Group Kinshasa Democratic Republic of the Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Internal Medicine University Clinic Faculty of Medicine University of Kinshasa Democratic Republic of the Congo Clinical Pharmacology service Department of Pharmacovigilance Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Context: Two years after the transition to Dolutegravir (DTG), at the national level, data on compliance with the execution of this transition and the rational use of the new molecule are not available. Objective: the objective of this study was to determine compliance with first-line ArT prescriptions among People Living with HIV starting AntiretroViral treatment in Kinshasa during the Dolutegravir era. Methods: this study is a descriptive cross-sectional study to determine compliance with first-line ArT prescriptions among people living with HIV during the Dolutegravir era in Kinshasa. Sixteen Outpatients Treatment Centers (OTCs) were included in the study for their expertise in the care of PLHIV, their technical collection platform and their accessibility. the parameters of interest were: age, sex, outpatient treatment centers, and medical prescription. results: One hundred and nineteen (119) patients were included in this work in accordance with the inclusion criteria;67 (56.3%) are female, giving a sex ratio of 1.29 in favor of women. the average age of the patients included is 39.87 ± 12.36 years with extremities of 18 to 69 years. the most represented age group is that of 36 to 45 years with 37 patients (31.9%). One hundred and nineteen (119) patients were received from 16 centers in Kinshasa, according to 6 OTC for the district of Funa, 4 OTC for Tshangu and 3 OTC respectively for Lukunga and Mont-Amba. All the centers respect the new recommendations of the National Program;all patients (100%) are on the Tenofovir (TDF) + Lamivudine (3TC) + Dolutegravir (DTG) combination. Conclusion: Compliance with the prescription of DTG as a first-line ArV in the DrC is effective in the city province of Kinshasa.

关键词： ArT Profile Dolutegravir Kinshasa

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Clinical and Anthropometric Evolution of People Living with Human Immunodeficiency Virus during 6 Months of Dolutegravir Treatment in Kinshasa, Democratic republic of Congo

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World Journal of AIDS 2023年第2期13卷 70-81页

作者： Berry Ikolango Bongenya Lambert Omombo Losenga Stéphanie Mauwa selenge Grace Ipaya Booto Noëlla Makela Dikati thérèse Kaseka Ntumba Benoit Obel Kabengele marie-thérèse ayan. safi sombo Guy Makila Mabe Bumoko Erick Ntambwe Kamangu “HIV/AIDS Focus” research Group Kinshasa Democratic Republic of Congo Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Background: AntiretroViral Treatment (ArT) remains an important tool for reducing morbidity and mortality and improving the quality of life of people living with the Human Immunodeficiency Virus (PLHIV). Under the pressure of ArT, several parameters of PLHIV change and are the subject of different evaluations. Objective: the objective of this work was to study the clinical and anthropometric evolution of PLHIV after 6 months of ArT based on Dolutegravir (DTG). Methods: the present study was a non-interventional prospective cohort to assess the clinical and anthropometric evolution of PLHIV after 6 months of ArT in the Ambulatory Treatment Center (CTA) for HIV in Kinshasa. the patients included were followed for 6 months in compliance with the schedule promulgated by the National Program. the parameters of interest were: Age, sex, Marital Status, Weight, Height, Body Mass Index and Clinical Status. results: On inclusion, 119 patients (56.3% women;43.7% men) were selected. During the consultation appointments, 42 patients (66.7% women;33.3% men) were present at M1, 37 patients (70.3% women;29.7% men) at M3, and 67 patients (61.3% women and 38.7% men) in M6. On inclusion, 41.5% of patients were at Stage 3 and 47.0% had a normal clinical condition. In M1, 48.7% of patients were at Stage 1 and 65.8% had a normal clinical condition. At M3, 41.7% of patients were at Stage 3 and 67.6% had a normal clinical condition. At M6, 61.8% of patients were at Stage 3 and 67.9% had a normal clinical condition. On D0, 45.5% of patients were in the 45 to 55 kg range and 56.5% had a normal Body Mass Index (BMI). At M1, 45.7% were in the 45 to 55 kg range and 50.0% had a normal BMI. At M3, 34.4% were in the 45 to 55 kg range and 64.3% had a normal BMI. At M6, 31.8% were in the range of 45 to 55 kg and, respectively, 37.5% of patients were lean and had a normal BMI. Conclusion: the clinical and anthropometric parameters evolve in saw tooth. Improvements are easily visible up to the third m

关键词： Evolution Clinical Anthropometric PLHIV ArT

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Biological Profile of People Living with Human Immunodeficiency Virus Starting Treatment in Kinshasa, Democratic republic of the Congo

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World Journal of AIDS 2023年第1期13卷 1-10页

作者： Berry Ikolango Bongenya marie-thérèse ayan.e safi sombo Guy Makila Mabe Bumoko Benoit Obel Kabengele Fridolin Kule-Koto Kodondi Baudoin Bu-Tsumbu Buassa richard Lunganza Kalala Erick Ntambwe Kamangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of the Congo “Focus HIV/AIDS” research Group Kinshasa Democratic Republic of the Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo service of Infectious Diseases Department of Internal Medicine University Clinic Faculty of Medicine University of Kinshasa Democratic Republic of the Congo Laboratory of Biochemistry Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Context: the biochemical assessment is a real-time indicator of the state and evolution of an infection. Among other things, it makes it possible to determine the right moment when it becomes necessary to start or change a treatment. Objective: the objective of this study is to present the Biological profile of People Living with HIV starting AntiretroViral treatment in Kinshasa in the era of Dolutegravir. Methods: the present study is a descriptive cross-sectional to determine the biological profile of People Living with HIV (PLHIV) starting AntiretroViral Treatment (ArT). the patient inclusion period was from October 4, 2021 to February 15, 2022. Sixteen centers were included. A sample of 5 ml of blood was taken in a tube with EDTA. Patients were randomly included consecutively in the centers during consultations. the population was made up of adults aged over 18, infected with HIV and starting ArT. the parameters of interest retained for the present study were: sex, age, hemoglobin level, blood sugar, urea, creatinine, transaminases, total cholesterol, triglycerides, proteins total, as well as amylase. results: 119 patients were included in this study in accordance with the inclusion criteria;67 (56.3%) are female, giving a sex ratio of 1.29 in favor of women. the average age of the patients is 39.87 ± 12.36 years. the most represented age group is that of 36 to 45 years with 37 patients (31.9%). the mean values of the biological parameters of the patients at the start of ArT are as follows: 31.61 ± 20.71 IU/L for ALT/SGPT, 25.81 ± 19.96 IU/L for AST/SGOT, 79.35 ± 49.49 IU/L for Amylase, 108.13 ± 62.17 mg/dl for Total Cholesterol, 2.77 ± 1.27 mg/dl for Creatinine, 72.53 ±22.23 mg/dl for Glycaemia, 10.30 ± 2.33 g/dl for Hemoglobin, 7.91 ± 1.75 g/dl for Total Protein, 131.23 ± 68.80 mg/dl for Triglycerides, and 33.61 ± 26.27 mg/dl for Urea. Conclusion: Mean values of PLHIV are, for the most part, within the normal range. the average creatinine is higher than the no

关键词： Biological Profile PLHIV Starting ArT Kinshasa

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