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中国神经科学学会第十二届全国学术会议

作者： Wenting Wang Chenchen Li Qian Chen marie-sophie van der goes James Hawrot Ying Zang Dongqing Wang Xian Gao Annie Y.Yao Katherine Lyman Congyi Lu Baolin Guo Qiangge Zhang Shengxi Wu Charles R.Gerfen Zhanyan Fu Guoping Feng Department of Neurobiology and Collaborative Innovation Center for Brain Science Institute of NeuroscienceSchool of Basic MedicineFourth Military Medical University McGovern Institute for Brain Research Department of Brainand Cognitive SciencesMassachusetts Institute of Technology Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Pain Research Center and Department of Physiology Zhongshan Medical SchoolSun Yat-Sen University Laboratory of System Neuroscience NIMH

Objective SHANK3 is a postsynaptic scaffolding protein critical for the development and function of glutamatergic synapses. Disruption of the Shank3 gene has been strongly implicated as a monogenic cause of autism and Shank3 mutant mice show repetitive grooming and social interaction deficits. Although dysfunction of basal ganglia has been proposed to play a key role in repetitive behaviors, few studies have provided direct evidence supporting this notion and the exact cellular mechanisms are still largely unknown. Methods We investigated how mutation of Shank3 may differentially affect striatonigral（direct pathway） and striatopallidal（indirect pathway） medium spiny neurons（MSNs） and its relevance to repetitive grooming behavior in the Shank3 B mutant mouse model of autism with behavior, electrophysiology, transgenic method and chemogenetics. Results We found that Shank3 deletion preferentially affected synapses onto striatopallidal MSNs. Striatopallidal MSNs showed profound defects including synaptic transmission, synaptic plasticity and spine density. Importantly, the repetitive grooming behavior was rescued by selectively enhancing the striatopallidal MSN activity using Designer Receptors Exclusively Activated by Designer Drugs（DREADDsh M3 Dq） technology. Conclusion Our findings provide direct evidence demonstrating the existence of distinct changes between two striatal pathways in a mouse model of autism, and highlight that the indirect striatal pathway disruption might play a causative role in repetitive behavior of Shank3 B mutant mice.

关键词： Shank3 striatum autism striatonigral striatopallidal repetitive behavior

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Landslide Loss and Damage in Sindhupalchok District, Nepal:Comparing Income Groups with Implications for Compensation and Relief

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International Journal of Disaster Risk Science 2018年第2期9卷 157-166页

作者： Kees van der Geest United Nations University Institute for Environment and Human Security

The 2014 Jure landslide in Sindhupalchok District, Nepal, caused significant loss and damage to ecosystems and livelihoods in the area. In the direct aftermath of the landslide, several disaster loss assessments were conducted, with the aim of counting casualties,injured people, and damaged houses and *** useful and necessary in their own right, such rapid assessments do not reveal the true extent and significance of the losses and damages that people in disaster areas face, including their monetary value. We address this gap, based on a comprehensive household survey(N = 234), as well as other, qualitative research tools. Our results highlight the importance of differentiating between loss and damage in absolute monetary terms as opposed to losses relative to annual income. We find a stark contrast between the high absolute losses incurred by nonpoor households, and the high relative losses—up to 14 times their annual income—experienced by poor *** results have important implications for policy that addresses loss and damage, not only of landslides but also of other disasters. Loss and damage assessments need to take the livelihood characteristics of affected households into account to identify and support those most in need of compensation and relief.

关键词： Compensation and relief Impact assessment Landslides Loss and damage analysis Nepal

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A Review of Self-healing Metals: Fundamentals, Design Principles and Performance

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1167-1179页

作者： Shasha Zhang Niels van Dijk Sybrand van der Zwaag College of Materials and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Materials Preparation and Protection for Harsh Environment(Nanjing University of Aeronautics and Astronautics) Ministry of Industry and Information TechnologyNanjing 211106China Fundamental Aspects of Materials and Energy Group Faculty of Applied SciencesDelft University of TechnologyMekelweg 152629 JB DelftThe Netherlands Novel Aerospace Materials Group Faculty of Aerospace EngineeringDelft University of TechnologyKluyverweg 12629 HS DelftThe Netherlands School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Self-healing metals possess the capability to autonomously repair structural damage during service. While self-healing concepts remain challenging to be realized in metals and metallic systems due to the small atomic volume of the mobile atoms, the slow diffusion unless at high temperatures and the strong isotropic metallic bonds, the scientific interest has increased sharply and promising progress is obtained. This article provides a comprehensive and updated review on the developments and limitations associated with the various modes of potentially healable damage induced in metals and alloys, i.e., stressinduced damage, irradiation-induced damage in bulk materials and contact damage in corrosion protective coatings. The spontaneous intrinsic healing mechanisms not requiring external assistance other than the material operating at the right temperature and an assisted healing mechanism with external intervention are reviewed. Promising strategies to achieve self-healing in metals are identified. Finally, we give some prospects for future research directions in self-healing metals.

关键词： Metal Self-healing Creep behavior Fatigue damage Irradiation Coating

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Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

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World Journal of Gastroenterology 2017年第6期23卷 1018-1029页

作者： Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong Department of Gastroenterology and Hepatology Leiden University Medical Center C.J.Gorter Center Leiden University Medical Center Department of Radiology Leiden University Medical Center Department of Medical Statistics Leiden University Medical Center Center for Inflammatory Bowel Diseases University of California Los Angeles Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Psychiatry Leiden University Medical Center Department of Rheumatology Leiden University Medical Center Department of Neuropsychology Leiden University Medical Center Department of Radiology Leiden University Medical CenterLeiden

To evaluate brain involvement in quiescent Crohn’s disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI).METHODSMultiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study *** glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine (P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow (P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P 1-weighted analysis. In addition, no correlation was found between mental status and MRI *** work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

关键词： Magnetic resonance imaging Systemic inflammation Fatigue Crohn’s disease Cognition

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Toward more reliable stability measurements in stance: recommendations for number of measurements, foot position and feedback——a cross-sectional study among servicemen

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Military Medical Research 2020年第2期7卷 199-208页

作者： Saskia Maria Theresia van der Heijden Maarten Reinders Prins Peter van der Wurff Physical Therapy Sciences Program in Clinical Health SciencesUniversity Medical Center Utrecht3584CX UtrechtThe Netherlands Research and Development Military Rehabilitation Center AardenburgKorte Molenweg 33941PW DoomThe Netherlands Department of Human Movement Sciences Faculty of Behavioural and Movement SciencesVrije Universiteit Amsterdam and Amsterdam Movement Sciences1081BT AmsterdamThe Netherlands Institute for Human Movement Studies HU University of Applied Sciences Utrecht3584CS UtrechtThe Netherlands

Background:In the military,insufficient postural stability is a risk factor for developing lower extremity *** stability training programs are effective in preventing these ***,an objective method for the measurement of postural stability in servicemen is *** primary objective of this study was to assess the influence of the number of repetitions,different foot positions and real-time visual feedback on postural stability,as well as their effects on the intrasession reliability of postural stability measurements in *** secondary objective was to assess the concurrent validity of the ***:Twenty healthy servicemen between 20 and 50 years of age and in active duty were eligible for this quantitative,cross-sectional *** measurements took place on a force plate,measuring the mean velocity of the center of *** participants were asked to stand as still as possible in three different foot positions(wide stance,small stance,and on one leg),five times each for 45 s each time,and the measurements were performed with and without real-time visual ***:We observed a significant main effect of foot position(P<0.001),but not of visual feedback(P=0.119)or repetition number(P=0.915).Postural stability decreased in the more challenging foot *** ICC estimates varied from 0.809(one repetition in wide stance)to 0.985(five repetitions on one leg).The common variance(R2)between different foot positions without feedback varied between 0.008(wide stance)and ***:To yield reliable data,wide-stance measurements should be conducted three times,and small-stance measurements and measurements on one leg should be conducted two *** scores of a measurement in a particular foot position cannot predict the scores of measurements in other foot positions.

关键词： Postural stability Center of Pressure Servicemen Intrasession reliability Concurrent validity

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Tapping the tree-ring archive for studying effects of resin extraction on the growth and climate sensitivity of Scots pine

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Forest Ecosystems 2017年第3期4卷 167-173页

作者： Ernst van der Maaten Annemarie Mehl Martin Wilmking marieke van der Maaten-Theunissen Institute of Botany and Landscape Ecology University of Greifswald

Background： In the German Democratic Republic（GDR）, resin tapping in Scots pine（Pinus sylvestris L.） forests was a major economic activity, and resin-tapped stands are frequently found up until this day. In this study, we investigate how the mechanical damage caused by resin tapping affects the growth and climate sensitivity of Scots pine using a dendroecological ***： Tree-ring samples were collected from resin-tapped and non-tapped trees in two forest areas in northeastern Germany, and tree-growth patterns were analyzed. For elucidating effects of resin tapping on the climate sensitivity of pine growth, climate-growth relationships and pointer years were ***： We observed that resin tapping positively affects tree growth at breast height, likely as wood formation is concentrated on the living part of the bole（i.e. after tapping there is no growth taking place on the tapping face due to the mechanical damage done to the cambium）. We observed no differences in the climate sensitivity of tapped and non-tapped trees, nor in the occurrence of extreme growth ***： Our results highlight that resin extraction is, apart from inflicting mechanical damage, not altering the sensitivity of Scots pine growth to climatic conditions.

关键词： Climate-growth relationships Dendroecology Mechanical damage

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Rank one Eisenstein cohomology of local systems on the moduli space of abelian varieties

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Science China Mathematics 2011年第8期54卷 1621-1634页

作者： van der GEER Gerard Korteweg-de Vries Instituut Universiteit van AmsterdamPostbus 942481090 GE AmsterdamThe Netherlands

We give a formula for the Eisenstein cohomology of local systems on the partial compactification of the moduli of principally polarized abelian varieties given by rank 1 degenerations.

关键词： Eisenstein cohomology BGG complex

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Cost projections for microwave plasma CO production using renewable energy

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Journal of Energy Chemistry 2022年第8期31卷 507-513,I0014页

作者： Remko J.Detz Bob van der Zwaan Netherlands Organisation for Applied Scientific Research(TNO) Amsterdam 1043 NTThe Netherlands Faculty of Science(HIMS and IAS) University of AmsterdamAmsterdam 1090 GDThe Netherlands School of Advanced International Studies(SAIS) Johns Hopkins UniversityBologna 40126Italy

Successful deployment of renewable fuel production requires substantial cost reduction along the entire value chain of the underlying manufacturing *** improve their performance,renewable fuel production technologies should follow a cost-reducing learning *** this article,we adopt recent evidence that learning-by-doing is directly influenced by the technology unit size and explore three scenarios for microwave plasma CO_(2)conversion in which the learning rate varies between 10%,15%,and 20%.Our projections reveal that the total investments required to deploy this CO_(2)conversion technology at an exajoule scale decline from 83 down to 23 billion euros under a 10%increase in the value of the learning *** CO_(2) production costs in 2050 amount to 247–346€(2019)/t CO_(2),in which the range is determined by the value of the learning *** under substantial learning until 2050 the levelized CO production cost is unlikely to become competitive with conventional natural gas-based CO_(2) production processes,except when a CO_(2)tax is applied of up to 150€(2019)/t CO_(2).To optimally exploit effects of learning-by-doing,we recommend developing several CO production technologies simultaneously with multiple unit sizes,so as to improve the chance of ultimately selecting the process with the highest learning rate.

关键词： CO_(2)utilization Synthetic fuels Renewable chemicals Learning curves Unit size

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Microstructure and dislocation structure evolution during creep life of Ni-based single crystal superalloys

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Journal of Materials Science & Technology 2020年第10期42卷 207-214页

作者： Hao Yu Wei Xu Sybrand van der Zwaag Novel Aerospace Materials Group Faculty of Aerospace EngineeringDelft University of Technology2629HSDelftthe Netherlands State Key Laboratory of Rolling and Automation Northeastern University110819ShenyangChina

The high performance of Ni single crystal superalloys during high temperature low stress creep service,is intrinsically determined by the combined effects of microstructural evolution and the dislocation *** the field of the evolution of dislocation network,two main recovery mechanism based on dislocation migration dominate the *** is superdislocations shearing intoγ’rafts through a two-superpartials-assisted *** is the compact dislocations migrating alongγ/γ’*** two mechanisms are similarly climb-rate-controlled *** this work,a model for the minimum creep rate based on thermodynamic and kinetic calculations and using an existing detailed dislocation dynamics model has been built by taking the dislocation migration behaviours as well as the rafted microstructure into consideration,which can well reproduce the([100]tensile)creep properties of existing Ni superalloy grades,without the need to make the dislocation parameter values composition dependent.

关键词： Ni superalloys Microstructure evolution Dislocation behaviour

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Soft metamaterial with programmable ferromagnetism

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Microsystems & Nanoengineering 2022年第6期8卷 217-223页

作者： Kerem Kaya Emre Iseri Wouter van der Wijngaart Division of Micro and Nanosystems KTH Royal Institute of TechnologyStockholm 10044Sweden

Magnetopolymers are of interest in smart material applications;however,changing their magnetic properties post synthesis is *** this study,we introduce easily programmable polymer magnetic composites comprising 2D lattices of droplets of solid-liquid phase change material,with each droplet containing a single magnetic dipole *** composites are ferromagnetic with a Curie temperature defined by the rotational freedom of the particles above the droplet melting *** demonstrate magnetopolymers combining high remanence characteristics with Curie temperatures below the composite degradation *** easily reprogram the material between four states:(1)a superparamagnetic state above the melting point which,in the absence of an external magnetic field,spontaneously collapses to;(2)an artificial spin ice state,which after cooling forms either;(3)a spin glass state with low bulk remanence,or;(4)a ferromagnetic state with high bulk remanence when cooled in the presence of an external magnetic *** observe the spontaneous emergence of 2D magnetic vortices in the spin ice and elucidate the correlation of these vortex structures with the external bulk *** also demonstrate the easy programming of magnetically latching structures.

关键词： composites composite ferromagnetic

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