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Nitric oxide activation of a potassium channel (BK_(Ca)) in feline lower esophageal sphincter

World Journal of Gastroenterology 2010年第46期16卷 5852-5860页

作者： marie-Claude l'Heureux Ahmad Muinuddin Herbert Y Gaisano Nicholas E Diamant Department of Physiology University of Toronto Ahmad Muinuddin Nicholas E DiamantToronto Western Research InstituteUniversity Health Network Department of Medicine University of Toronto

AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (lES) to determine its regulation of resting tone and ***:Freshly enzymatically-digested and isolated circular smooth muscle cells were prepared from each lES *** study outward K + currents,the perforated patch clamp technique was *** assess lES resting tone and relaxation,muscle strips were mounted in perfused organ ***:(1) Electrophysiological recordings from isolated cells:(a) CM was more depolarized than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P l outward current was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The NO donor sodium nitroprusside (SNP) increased outward currents only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P 0.05);(c) SNP added in the presence of the BK Ca antagonist iberiotoxin (IbTX) produced no increase in the outward current in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) l-NNA caused a small insignificant inhibition of outward K + currents in both muscles;and (2) Muscle strip studies:(a) Blockade of the nerves with tetrodotoxin (TTX),or BK Ca with IbTX had no significant effect on resting tone of either muscle;and (b) SNP reduced tone in both muscles,and was unaffected by the presence of TTX or ***:Exogenous NO activates BK Ca only in CM of the ***,as opposed to other species,exogenous NO-induced relaxation is predominantly by a non-BK Ca mechanism,and endogenous NO has minimal effect on resting tone.

关键词： Circular smooth muscle Feline K+ channel lower esophageal sphincter Nitric oxide Sling Tone

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源自蝎毒的Shal型(Kv4)钾通道孔区阻断剂(英文)

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生理学报 2015年第3期67卷 248-254页

作者： pierre Edouard Bougis marie-France Martin-Eauclaire 艾克斯-马赛大学法国国家科学研究中心马赛神经生物学和神经生理学研究中心UMR7286

KCND/Kv4(Shal)家族成员负责编码电压门控钾通道(Kv4.1,Kv4.2和Kv4.3),这类通道在心脏和神经元中调节自然和快速失活的A型钾电流。该A型钾电流可被隶属于α钾通道毒素第15家族的短链蝎神经毒素特异性地抑制。这类毒素也被称为孔区阻断剂... 详细信息

KCND/Kv4(Shal)家族成员负责编码电压门控钾通道(Kv4.1,Kv4.2和Kv4.3),这类通道在心脏和神经元中调节自然和快速失活的A型钾电流。该A型钾电流可被隶属于α钾通道毒素第15家族的短链蝎神经毒素特异性地抑制。这类毒素也被称为孔区阻断剂,与调节通道门控特征的蜘蛛毒素的作用模式是不同的。本文综述了α钾通道毒素第15家族的化学及药理学信息。

关键词：钾通道电压门控钾通道第4家族孔区阻断剂蝎毒

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Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist

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World Journal of Gastroenterology 2017年第5期23卷 899-905页

作者： marie Sinclair Eduard Poltavskiy Jennifer l Dodge Jennifer C lai Gastroenterology and Hepatology University of CaliforniaSan FranciscoCa 94143United States

AIMTo investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant *** listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MElD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios (IRR).RESUlTSOf 587 cirrhotics, 64% were male, median age (interquartile range) was 60 (53-64) years and MElD score was 15 (12-18). Median Fried Frailty Index was 2 (1-3); 31.6% were classified as frail (fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1 hospitalisation; 38% of which involved major infection. 107/184 (58%) frail and 142/399 (36%) non-frail patients were hospitalised at least once (P le analysis, Fried Frailty Index was associated with total hospitalisation days per year (IRR = 1.51, 95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MElD, albumin, and gender (IRR for frailty of 1.21, 95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by *** cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity.

关键词： Hospitalisation Infection Cirrhosis Frailty Transplantation

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Conservation and sustainable development in a VUCA world: the need for a systemic and ecosystem- based approach

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Ecosystem Health and Sustainability 2017年第4期3卷 2-13页

作者： Axel Schick Peter R.Hobson pierre l.Ibisch Faculty of Forest and Environment Centre for Econics and Ecosystem ManagementEberswalde University for Sustainable DevelopmentAlfred-Moeller-Straße 1Eberswalde16225 Germany Centre for Econics and Ecosystem Management Writtle School of Sustainable EnvironmentsChelmsfordEssexCM13RR UK

Targeting the maintenance of functional ecosystems that provide the significant basis for human well-being is an integral part of an ecosystem-based sustainable *** causes of ecosystem degradation such as global climate change and ever-growing human demands that rapidly shift socioeconomic and political baselines are often unmanageable at a local scale and require a new approach to planning and action in ecosystem *** framework conditions that challenge sustainable development are shaped by increasing Volatility,Uncertainty,Complexity,and Ambiguity(VUCA concept).Using the MARISCO method(adaptive management of vulnerability and risks at conservation sites),we analyzed 22 conservation sites,covering 26 protected areas and six administrative areas on four different continents and involving 524 *** conditions were present across cultures and biomes,yet the responses in planning and management varied among conservation *** findings of both the qualitative and quantitative analyses confirm that participants understand how far human well-being heavily depends on the functionality of ecosystems that were seen to suffer from a wide range of stresses and threats of varying ***,local stakeholders and experts rated impacts of global climate change as most *** attempts to achieve ecosystem-based sustainable development,most management teams strive for more risk-robust and adaptive strategies by advocating for active risk management.A common factor identified among all case studies was the need for cooperative management between smaller conservation sites in order to address large-scale challenges.

关键词： conservation development ecosystem-based approach MARISCO VUCA.

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The value does not exist!A motivation for extremal analysis

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Probability, Uncertainty and Quantitative Risk 2022年第3期7卷 195-214页

作者： Jean-pierre Aubin Hélène Frankowska Retired 14Rue Domat75005 ParisFrance CNRS IMJ-PRGSorbonne Université4Place Jussieu75252 ParisFrance

Standard mathematical economics studies the production,exchange,and consumption of goods“provided with units of measurement,”as in physics,in order to be enumerated,quantified,added,***,“baskets of goods,”which should describe subsets of goods,are mathematically represented as commodity vectors of a vector space,linear combination of units of goods,evaluated by prices,which are linear numerical ***,in this sense,mathematical economics is a branch of ***,economics,and many other domains of life sciences,investigate also what will be called entities,defining elements deprived of units of measure,which thus cannot be enumerated.(1)Denoting by X the set of entities x∈X deprived of units of measurement,a“basket of goods”is actually a subset K■X of the set entities,i.e.,an element of the“hyperset”P(X),the family of subsets of X,and no longer a commodity vector of the vector space of commodities;(2)Entities can be“gathered”instead of being“added”;(3)Entities can still be evaluated by a family of functions A:x 2 X 7!A(x)2 Rregarded as a“valuators,”in lieu and place of linear“prices”evaluating the units of economic goods.(4)Subsets of entities can be evaluated by an“interval of values”between two extremal ones,the minimum and the maximum,instead of the sum of values of units of goods weighted by their *** sciences dealing with intertwined relations among many combinations of entities,hypersets offer metaphors of“lamarckian complexity”that keeps us away from binary relations,graphs of functions,and set-valued maps,to focus our attention on“multinary relations”between families of *** deprived of units of measurement,these“proletarian”entities still enjoy enough properties for this pauperization to be mathematically *** is the object of this extremal manifesto:in economics and other domains of life sciences,vector spaces should yield their imperial status of“state space”to hypersets and linear prices to hy

关键词： Valuators Extremal topologies Transfer of topologies Confined sets Extremal evolution Inert relation Viability kernel Regulator

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local and systemic effects of Il-17 in joint inflammation:a historical perspective from discovery to targeting

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Cellular & Molecular Immunology 2021年第4期18卷 860-865页

作者： pierre Miossec Department of Clinical Immunology and Rheum atology and the Immunogenomics and Inflammation Research Unit University of lyon Hdpital Edouard Herriot LyonFrance

The role of Il-17 in many inflammatory and autoimmune diseases is now well established,with three currently registered anti-Il-17-targeted *** story has taken place over a period of 20 years and led to the demonstration that a T cell product could regulate,and often amplify,the inflammatory *** first results described the contribution of Il-17 to local features in ***,understanding was extended to its systemic effects,with a focus on cardiovascular *** review provides a historical perspective of these discoveries focused on arthritis,which started in 1995,followed 10 years later by the description of Th17 ***,Il-17 inhibitors for three chronic inflammatory diseases have been *** options are now being tested in ongoing and future clinical *** of Il-17 family members and Th17 cells ranging from antibodies to small molecules are under active *** identification of patients with Il-17-driven disease is a key target for the improved selection of patients expected to have a strongly positive response.

关键词： Interleukin-17 Th17 cells Inflammation Arthritis,targeting

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C*-Algebraic Intertwiners for Degenerate Principal Series of Special linear Groups

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Chinese Annals of Mathematics,Series B 2014年第5期35卷 691-702页

作者： pierre ClARE Department of Mathematics Pennsylvania State University McAllister Building University Park

The author constructs unitary intertwiners for degenerate C*-algebraic universal principal series of Sl(n + 1) over a local field by explicitely normalizing standard intertwining integrals at the level of Hilbert modu... 详细信息

关键词： Group C*-algebras Hilbert modules Semisimple lie groups Principalseries representations Intertwining operators

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Sendai Five Years on: Reflections on the Role of International law in the Creation and Reduction of Disaster Risk

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International Journal of Disaster Risk Science 2020年第2期11卷 230-238页

作者： marie Aronsson-Storrier School of law University of ReadingReading RG66EP.UK

This article offers a critical examination of the position of the Sendai Framework for Disaster Risk Reduction 2015–2030 within international law. It is argued that any interrogation into the relationship between international law and disaster risk reduction(DRR) must begin not with existing DRR laws and policies, but rather with an enquiry into the nature of disaster risk and the role of international law in its creation and reduction. It is demonstrated how, while areas such as international human rights law can be utilized to enforce obligations in support of DRR, other areas—in particular international investment law—actively work to undermine DRR efforts. In order for international law to be a productive tool in the reduction of disaster risk, international lawyers must engage with critical work in disaster studies and explore the role that international law has played, and can play, in creating and addressing hazards, vulnerabilities, and capacities.

关键词： Disaster risk creation Disaster risk reduction International law Sendai Framework

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Determination of Electron Collision Cross Sections Set for Tetramethysilane

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Plasma Science and Technology 2007年第6期9卷 756-759页

作者： marie-Claude BORDAGE Toulouse University lAPlACE UMR 5213 CNRS-UPSPaul Sabatier University118Route de Narbonne31062 Toulouse CedexFrance

A swarm analysis technique based on the solution of the Boltzmann equation is used to derive low energy electron collision cross sections for tetramethylsilane （TMS）. The calculated swarm parameters with this first available cross sections set is consistent with measured values of the swarm parameters. Calculations of transport parameters in mixtures of TMS with argon are also presented.

关键词： tetramethysilane electron cross section swarm parameters

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Displacement Talbot lithography for nanoengineering of III-nitride materials

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Microsystems & Nanoengineering 2019年第1期5卷 38-49页

作者： pierre-marie Coulon Benjamin Damilano Blandine Alloing pierre Chausse Sebastian Walde Johannes Enslin Robert Armstrong Stephane Vezian Sylvia Hagedorn Tim Wernicke Jean Massies Jesus Zuniga‐Perez Markus Weyers Michael Kneissl Philip A.Shields Department of Electrical&Electronic Engineering University of BathBath BA27AYUK Universite Cote d’Azur CNRSCRHEArue B.Gregory06560 ValbonneFrance Ferdinand-Braun-Institut Leibniz-Institut fur HochstfrequenztechnikGustav-Kirchhoff-Str.412489 BerlinGermany Technische Universität Berlin Institute of Solid State Physics10623 BerlinGermany

Nano-engineering III-nitride semiconductors offers a route to further control the optoelectronic properties,enabling novel functionalities and *** a variety of lithography techniques are currently employed to nanoengineer these materials,the scalability and cost of the fabrication process can be an obstacle for large-scale *** this paper,we report on the use of a fast,robust and flexible emerging patterning technique called Displacement Talbot lithography(DTl),to successfully nano-engineer III-nitride ***,along with its novel and unique combination with a lateral planar displacement(D^(2)Tl),allow the fabrication of a variety of periodic nanopatterns with a broad range of filling factors such as nanoholes,nanodots,nanorings and nanolines;all these features being achievable from one single *** illustrate the enormous possibilities opened by DTl/D2Tl,dielectric and metal masks with a number of nanopatterns have been generated,allowing for the selective area growth of InGaN/GaN core-shell nanorods,the top-down plasma etching of III-nitride nanostructures,the top-down sublimation of GaN nanostructures,the hybrid top-down/bottom-up growth of AlN nanorods and GaN nanotubes,and the fabrication of nanopatterned sapphire substrates for AlN *** with their planar counterparts,these 3D nanostructures enable the reduction or filtering of structural defects and/or the enhancement of the light extraction,therefore improving the efficiency of the final *** results,achieved on a wafer scale via DTl and upscalable to larger surfaces,have the potential to unlock the manufacturing of nano-engineered III-nitride materials.

关键词： Talbot planar nitride

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