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Testicular sperm extraction(TESE)outcomes in the context of malignant disease:a systematic review

Asian Journal of Andrology 2022年第6期24卷 584-590页

作者： ludmilla Ogouma Isabelle Berthaut Rachel lévy Rahaf Haj Hamid marie Prades marie Audouin Nathalie Sermondade Charlotte Dupont Fertility Center(Service de Biologie de la Reproduction CECOS) Tenon Hospital(AP-HPSorbonne-Universite)Paris F-75020France Sorbonne University Saint Antoine Research CenterInserm Us938Paris F-75012France Fertility Center Diaconesses HospitalParis F-75012France

Advances in the oncology field have led to improved survival ***,quality of life after remission is anticipated,which includes the possibility to conceive *** cancer treatments are potentially gonadotoxic,fertility preservation must be *** fertility preservation is mainly based on ejaculated sperm *** this is not possible,testicular sperm extraction(TESE)may be *** identify situations in which TESE has been beneficial,a systematic review was *** search was carried out on the PubMed,Scopus,Google Scholar,and CISMeF databases from 1 January 2000 to 19 March *** Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)recommendations were followed in selecting items of ***-four articles were included in the systematic review,including 15 articles on oncological testicular sperm extraction(oncoTESE),18 articles on postgonadotoxic treatment TESE and 1 article on both oncoTESE and postgonadotoxic treatment *** sperm freezing was possible for 42.9%to 57.7%of patients before gonadotoxic treatment and for 32.4%to 75.5%of patients after gonadotoxic treatment,depending on the type of malignant *** no formal conclusion could be drawn about the chances to obtain sperm in specific situations,our results suggest that TESE can be proposed before and after gonadotoxic *** treatment,TESE is more often proposed for men with testicular cancer presenting with azoospermia since TESE can be performed simultaneously with tumor removal or *** chemotherapy,TESE may be planned if the patient presents with persistent azoospermia.

关键词： cancer fertility preservation oncological testicular sperm extraction spermatozoa testicular sperm extraction

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Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer

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World Journal of Gastroenterology 2019年第34期25卷 5082-5096页

作者： Diane lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez marie-pierre Vullierme Alain Aubert Pascal Hammel Philippe lévy louis de Mestier Pancreatology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 75013France INSERM UMR1149Paris 92110France Departement of Gastroenterology Aix Marseille university-APHM-Hopital NordMarseille 13000France Radiology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France Oncology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France

Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and ***-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo *** appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic *** can also be used to obtain tissue ***,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to *** cost-effectiveness of screening is also *** new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising.

关键词： Endoscopic ultrasound Familial pancreatic cancer Fine-needle aspiration Intraductal papillary mucinous neoplasm Pancreatic cancer Pancreatic intraepithelial neoplasia Pancreatic cancer screening guidelines

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Expert group syndrome at high altitude

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Sports Medicine and Health Science 2022年第3期4卷 215-218页

作者： Jean-Paul Richalet marie-Anne Magnan Alice Gavet pierre lafère UniversitéSorbonne Paris Nord Laboratoire Hypoxie et PoumonUMR INSERM U1272BobignyFrance Institut National des Sports de l’Expertise et de la PerformancePôle médicalParisFrance Hôpitaux universitaires de Genève Département de médecine aiguëUnitéde médecine subaquatique et hyperbareGenevaSwitzerland Hôpitaux du Mont-Blanc Soins de suite et réadaptationChamonixFrance Universitéde Bretagne Occidentale Laboratoire ORPHYEA 44324BrestFrance HauteÉcole Bruxelles-Brabant(HE2B) EnvironmentalOccupationalAgeing(Integrative)Physiology LaboratoryBrusselsBelgium

During a training session for the university diploma of Mountain medicine delivered by University Sorbonne Paris Nord for medical doctors,one of the participants developed signs of maladaptation to high altitude at 3600 m,the severity of which was incorrectly *** was sparingly given by the patient(an anesthetist)to several of his colleagues and no one was in charge to collect clinical data,take a history,and provide appropriate *** combination of the absence of designation of a supervising doctor and the difficulty of communicating with the patient led to a lack of coordinated management and to an evolution of the symptoms towards severe acute mountain ***,the very rapid management of the patient and a rapid helicopter evacuation,as soon as the symptoms worsened towards the onset of a suspected high altitude cerebral and/or pulmonary edema,allowed rapid resolution without ***,medical,psychological,and managerial factors led to this Expert Group Syndrome.

关键词： Acute mountain sickness High altitude cerebral edema Psychology Group management

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In-flight particle characterization and coating formation under low pressure plasma spray condition

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Journal of Iron and Steel Research International 2017年第3期24卷 306-312页

作者： Nan-nan Zhang Dan-yang lin Ya-li li Yue Zhang marie-pierre Planche Han-lin liao Christian Coddet Fu-yu Dong Department of Material Science and Engineering Shenyang University of Technology IRTES-lERMPS University of Technology of Belfort-Montbeliard

Yttria-stabilized zirconia（ YSZ） coatings were deposited by low pressure plasma spray（ lPPS） in 1.0× 10^4 Pa,1.5 × 10^4 Pa,and 2.5 × 10^4 Pa. Both in-flight particle diagnostic detected by DPV-2000 system and ANSYS-FlUENT software were used to study the connection between the parameters of flying particles and the coating formation,which might help to recognize the relationship between the operation parameters and the coatings quality. The results of simulation showed that particles in a lower spray pressure could achieve a higher velocity. The particle velocity was around 380 m/s at a distance of 35 cm from the nozzle at 1.0 × 10^4 Pa while only 300 m/s at 2.5 × 10^4 Pa in actual *** results showed that the velocity of particles increased with decreasing the spray pressure,which might enhance the flattening rate of coatings and thereby decreased the porosity. The deposited YSZ coating with the lowest porosity can be gained under 1.0 × 10^4 Pa condition.

关键词： In-flight particle detection low pressure plasma spray Yttria-stabilized zirconia coating Flame simulation

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Determination of the Apparent Gas Permeability in a Macrocracked Concrete

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Engineering 2022年第10期17卷 93-98页

作者： pierre Rossi Univ Gustave Eiffel French Institute of Science and Technology for TransportDevelopment and Networks(IFSTTAR)Marne-la-Vallée F-77447France

This paper reports on analysis of an expermental study that armed to determine the apparent gas permeability in cracked *** is a lack of research on this topic in the international literature,due to the difficulty of performing reliable experimental testing for gas *** principal interest of this work is to present new and reliable experimental *** functions between the evolution of the apparent crack permeability and the apparent crack opening are also *** functions appear to be relevant in consideration of Poiseuille theory.

关键词： Concrete Macrocrack Gas transfer Permeability

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Three-dimensional modelling of shear keys in concrete gravity dams using an advanced grillage method

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Water Science and Engineering 2020年第3期13卷 223-232页

作者： Mahdi Ben Ftima Steephane lafrance pierre leeger Polytechnique Montreal Montreal University CampusMontrealH3C 3A7Canada

Contraction joint shear keys are resilient features of gravity dams that can be considered to increase the sliding safety factors or minimise seismic residual sliding displacements,allowing costly remedial actions to be *** paper presents a novel,robust,and computationally efficient three-dimensional(3D)modelling and simulation strategy of gravity dams,using a series of adjacent cantilever beam elements to represent individual *** monoliths are interconnected in the longitudinal direction by 3D no-tension link elements representing the lumped shear key stiffness contributions at a particular *** objective is to assess the shear key internal force demands,including the axial force,shear,and moment *** key demand-capacity ratios can then be assessed with related multi-axial failure *** 3D link element stiffness coefficients were derived from a series of 3D finite element(FE)solid models with a detailed representation of geometrical features of multiple shear *** results from the proposed method based on advanced grillage analysis show strong agreement with reference solutions from 3D FE solid models,demonstrating high accuracy and performance of the proposed *** application of the proposed advanced grillage method to a dam model with two monoliths clearly shows the advantage of the proposed method,in comparison to the classical approach used in practise.

关键词： Gravity dam Shear keys Seismic analysis Grillage analysis Finite element model Multi-scale approach

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Cavity optomechanics with directionally squeezed light

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 181-182页

作者： pierre Meystre Department of Physics and College of Optical Sciences University of ArizonaTucson 85721USA

It is well understood that the Heisenberg uncertainty principle imposes a fundamental limit on the precision of quantum *** way to get around this difficulty is to exploit quantum states that minimize the uncertainty on the observable of interest,increasing in the process the uncertainty on the conjugate *** states of the electromagnetic field.

关键词： field observable quantum

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Modeling and optimization of rotary kiln treating EAF dust

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Journal of University of Science and Technology Beijing 2005年第4期12卷 308-312页

作者： pierre Vix Mount Isa Mines limited MOUNT ISA

Electric arc furnace （EAF） dust from steel industries is listed by the United Sates EPA as a hazardous waste under the regulations of the Resource Conservation and Recovery Act due to the presence of lead, cadmium and chlorine. The disposal of the approximately 650000 t of EAF dust per year in the U.S. and Canada is an expensive and unresolved problem for the majority of steel companies. The Waelz process has been considered as the best process for treating the EAF dust. A process model, combined thermodynamic modeling with heat transfer calculations, has been developed to simulate the chemical reactions, mass and heat trans- fer and heat balance in the kiln. The injection of air into the slag and the temperature profile along the kiln have been modeled. The effect of （CaO＋MgO）/SiO2 on the solidus temperature of slag has also been predicted and discussed. Some optimized results have been presented.

关键词： thermodynamic model EAF dust rotary kiln solidus temperature

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Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HlA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey lena M'Ba lucil Schneider marie Titecat Benoît Foligné Michaël Genin Christel Neut Philippe Zerbib pierre Desreumaux Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France U1286-INFINITE-Institute for Translational Research in Inflammation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Development Lille 59045France Department of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France UlR 2694-METRICS:Évaluation des Technologies de Santéet des Pratiques Médicales University of LilleLille University HospitalLille 59000France Department of Hepato-Gastroenterology Lille University HospitalLille 59037France

BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the lF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the *** To evaluate the efficacy of CNCM I-3856 in preventing POR induced by lF82 in an HlA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral administration of lF82(109 colony forming units(CFUs)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFUs/d,n=7)or a combination of lF82 and CNCM I-3856(n=18).nTg rats receiving lF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and lF82(n=9)under the same conditions were used as *** was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)*** lF82 quantifications were performed weekly for each *** lF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the median with the interquartile *** nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving lF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving lF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and lF82 had no macroscopic *** to untreated TgB27 animals receiving lF82 alone,coadministration of CNCM I-3856 and lF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharomyces cerevisiae Colorectal surgery

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Harnessing the potential of additive manufacturing technologies:Challenges and opportunities for entrepreneurial strategies

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International Journal of Innovation Studies 2018年第4期2卷 123-136页

作者： marie lavoie James l.Addis York University/Glendon College-Economics Department and Glendon School of Public and International Affairs 2275 Bayview AvenueTorontoOntarioM4N3M6Canada York University/Glendon College-Economics Department 2275 Bayview AvenueTorontoOntarioM4N3M6Canada

Additive manufacturing(AM),a revolutionary production technique that will make many previously inconceivable innovations a reality,is transforming the manufacturing *** technologies behind AM have a generic character and possess immense and transformative potential that will be felt across different sectors of the *** paper studies how entrepreneurs can access,exploit,and diffuse this new disruptive knowledge,as well as the potential challenges that lie ***,we examine the magnitude of the knowledge pool created by the Top 10 countries in AM research from 2011 to 2016;specifically,we determine the leading countries,the pattern of organizational and international collaborations,leading disciplines contributing to AM,and the pattern in authors'*** find that the US is clearly the dominant country,while China witnessed a notable acceleration in AM research between 2014 and 2016;we also show that universities are the predominant actor in codified AM knowledge *** this information,we paint a vivid picture of the technological and market opportunities for entrepreneurs and identify the gaps in the current knowledge production environment;we find that the challenges currently faced by entrepreneurs could be overcome through academic entrepreneurship,collective entrepreneurship,and the actions of an entrepreneurial state.

关键词： Additive manufacturing Knowledge pool Entrepreneurship Innovation systems Innovation policy Evolutionary economics

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