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Prediction of delayed graft function using different scoring algorithms: A single-center experience

World Journal of Transplantation 2017年第5期7卷 260-268页

作者： Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen marie-paule emonds Daniel Abramowicz Jean-Louis Bosmans Department of Nephrology-Hypertension Antwerp University Hospital Department of Medical Statistics Antwerp University Hospital StatUa Center for Statistics University of Antwerp Department of Hepatobiliary Endocrine and Transplantation SurgeryAntwerp University Hospital Histocompatibility and Immunogenetic Laboratory

AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each *** This single-center,retrospective study included 247 consecutive kidney transplants from a deceased *** kidney transplantations were performed at our institution between January 2003 and December *** compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under *** c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without *** sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations.

关键词： Delayed graft function Kidney transplantation Nomogram Receiver operating characteristic curve Risk calculation

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Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells

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World Journal of Gastroenterology 2010年第16期16卷 1970-1978页

作者： Elisabeth emonds Brit Fitzner Robert Jaster Department of Medicine II Division of GastroenterologyMedical FacultyUniversity of Rostock

AIM:To gain molecular insights into the action of the histone deacetylase inhibitor(HDACI) trichostatin-A(TSA) in pancreatic cancer(PC) ***:Three PC cell lines,BxPC-3,AsPC-1 and CAPAN-1,were treated with various concentrations of TSA for def ined periods of *** synthesis was assessed by measuring the incorporation of 5-bromo-2'*** expression at the level of mRNA was quantif ied by real-time polymerase chain *** and phosphorylation of proteins was monitored by immunoblotting,applying an infrared imaging *** study the role of p38 MAP kinase,the specif ic enzyme inhibitor SB202190 and an inactive control substance,SB202474,were ***:TSA most eff iciently inhibited BrdU incorporation in BxPC-3 cells,while CAPAN-1 cells displayed the lowest and AsPC-1 cells an intermediate *** biological response of the cell lines correlated with the increase of histone H3 acetylation after TSA *** BxPC-3 cells(which are wild-type for KRAS),TSA strongly inhibited phosphorylation of ERK 1/2 and *** contrast,activities of ERK and AKT in AsPC-1 and CAPAN-1 cells(both expressing oncogenic KRAS) were not or were only modestly affected by TSA *** all three cell lines,but most pronounced in BxPC-3 cells,TSA exposure induced an activation of the MAP kinase *** of p38 by SB202190 slightly but signif icantly diminished the antiproliferative effect of TSA in BxPC-3 ***,only BxPC-3 cells responded to TSA treatment by a signif icant increase of the mRNA levels of bax,a pro-apoptotic member of the BCL gene ***,in BxPC-3 and AsPC-1 cells,but not in the cell line CAPAN-1,signif icantly higher levels of the cell cycle inhibitor protein p21Waf1 were observed after TSA ***:The biological effect of TSA in PC cells correlates with the increase of acetyl-H3,p21Waf1,phospho-p38 and bax levels,and the decrease of phosphoERK 1/2 and phospho-AKT.

关键词： Pancreatic cancer Histone deacetylase inhibitor Trichostatin-A KRAS MAP kinases p21Waf1 AKT

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