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Prevalence of migraine among university students at Parakou,Benin:A cross-sectional study

World Journal of Neuroscience 2014年第1期4卷 18-24页

作者： Thierry Adoukonou Francis Tognon-Tchegnonsi Kouna Philomene Abdias Alabi Dismand Houinato pierre-marie Preux Unite d’Enseignement et de Recherche de Neurologie Faculte de MedecineUniversite de ParakouParakouBenin Unite de Neurologie du Service de Medecine Hopital de Parakou ParakouBenin Faculte de Medecine Universite des Sciences de la Sante de LibrevilleLibrevilleGabon Unite d’Enseignement et de Recherche de Neurologie Faculte des Sciences de la Sante de Universite d’Abomey-CalaviCotonouBenin Institut d’Epidemiologie Neurologique et de Neurologie Tropicale LimogesFrance

Objective: To determine the prevalence of migraine and its associated factors in students at the University of Parakou. Methods: It was a cross-sectional study carried out from February 1st to April 30th 2011. It included all students registered during the academic year 2010-2011 and selected by systematic random sampling. Migraine was defined according to IHS 2004 criteria. To assess the link between migraine and body mass index we collected height and weight of each student. Multivariate analysis was used to study the factors associated with migraine, odds-ratio and their confidence interval were estimated. SPSS Soft-ware was used to perform statistical analysis. Results: During the study period 1200, students returned their questionnaires. They were 842 males and 358 females. 171 fulfilled migraine criteria, and the overall prevalence of migraine was 14.2% (CI 95%: 11.6% - 17.4%). The main associated factors were the sex with an OR: 2.3 (CI 95%: 1.6 - 3.2) and family history of headache with an OR: 1.6 (CI 95%: 1.1 - 2.4). Migraine with aura was the frequent form (59.1%) and visual aura the frequent form of aura. No association was found between migraine and body mass index but students with obesity had high risk of migraine with aura OR: 3.8 (CI 95%: 1.5 - 9.7) compared with those with normal weight. The main triggering factors were sleeplessness (90.1%) and mental fatigue (85.4%). Conclusion: The results suggest a high prevalence of migraine among students at Parakou University and no association between obesity and migraine.

关键词： Migraine Prevalence Epidemiology students Obesity

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Electrostatic interactions in twisted bilayer graphene

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Nano Materials Science 2022年第1期4卷 27-35页

作者： Tommaso Cea pierre A.Pantaleón Niels R.Walet Francisco Guinea Imdea Nanoscience Faraday 928015MadridSpain Department of Physics and Astronomy University of ManchesterManchesterM13 9PYUK Donostia International Physics Center Paseo Manuel de Lardizabal 420018San SebastianSpain

The effects of the long range electrostatic interaction in twisted bilayer graphene are described using the HartreeFock approximation. The results show a significant dependence of the band widths and shapes on electron filling,and the existence of broken symmetry phases at many densities, either valley/spin polarized, with broken sublattice symmetry, or both.

关键词： Graphene Twisted Interactions

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A MEDIAN FOLLOW-UP OF TWENTY-TWO MONTHS FOR CARDIOVERTER DEFIBRILLATOR IMPLANTATION IN SYMPTOMATIC OR ASYMPTOMATIC PATIENTS WITH BRUGADA SYNDROME

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Medical Bulletin of Shanghai Jiaotong University 2010年第1期22卷 47-53页

作者：蔡煦苏静英黄剑锋沈卫峰 stéphane Garrigue pierre Bordachar Jacques Cl menty Department of Cardiology Ruijin HospitalSchool of MedicineShanghai Jiaotong University Department of Cardiac Pacing and Clinical Electrophysiology Hpital Cardiologique du Haut-LévêqueUniversity Bordeaux Ⅱ19 Avenue de Magellan

Objective To explore the outcome of patients with Brugada syndrome by remedial or prophylactic implantable cardioverter defibrillator （ ICD ） for ventricular tachyarrhythmia. Methods Sixteen single chamber ICDs and 5 double chamber ICDs in 21 consecutive patients [ 17 males, 4 females; mean age, （ 36 ± 11） years ] with Brugada syndrome were involved. Fifteen patients with spontaneous or induced ventricular tachycardia/ventricular fibrillation （VT/VF） received the remedial and prophylactic ICD implantation. Six patients only with positive family history or syncope accepted the ICD implantation for prophylaxis. Results After a median follow-up of （22.3 ± 13. 4） months, all patients were alive. One patient was suspected with febrile syndrome due to endocarditis on the auricular face of the lead of defibrillator 18 months after 1CD implantation and disappearance of vegetation was found after receiving one-month antibiotic treatment. Nine appropriate ICD interventions took place in 3 individuals with documented spontaneous ventricular arrhythmias. Multivariable analysis suggested that occurrence of appropriate interventions was related to the spontaneous ventricular arrhythmias （ P 〈 0. 0001 ）. Eleven inappropriate ICD interventions occurred in 3 patients for atrial fibrillation or atrial flutter with rapid ventricular rate. Multivariable analysis suggested that occurrence of inappropriate interventions was related to documented spontaneous supraventricular arrhythmias （P 〈 O. 0062 ）. All appropriate interventions and inappropriate interventions occurred within six months after ICD implantation. Conclusion Appropriate interventions may associate to spontaneous ventricular arrhythmias before 1CD implantation in patients with Brugada syndrome. Patients may suffer from inappropriate ICD intervention for supraventricular arrhythmias with rapid ventricular rate when they had a history of supraventricular arrhythmias.

关键词： Brugada syndorme implantable cardioverter defibrillator

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Radiated Ultrashort High-Power Electromagnetic Pulses Induce ATP Release in B16F10 Murine Melanoma Cells

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Journal of Electromagnetic Analysis and Applications 2015年第3期7卷 66-74页

作者： Sabrina Macaire Alexandre Catrain stéphane Tortel Jean-Christophe Joly Sébastien Girard pierre Bonnet Alain Vian CEA DAM Gramat France Institut Pascal Université Blaise Pascal Clermont-Ferrand France CNRS UMR 6602 Aubière France ARCH-E. Université d’Angers UMR 1345 IRHS Angers France

Ultrawideband electromagnetic pulses with high amplitude and short duration are reported to affect several aspects of cell physiology. They are usually delivered to the living material through electrodes in small dedicated chambers. Here we showed, using a totally different experimental setup, that radiated EM pulses illuminating the living material through a specialized antenna (without any direct contact) are able to trigger a rapid release of ATP in cultured murine cells that was concomitant with a drop of intracellular AEC. Despite this rapid and strong response, we found that cell viability and clonogenicity were only slightly affected by the EMF exposure.

关键词： Radiated Electromagnetic Pulses Koshelev Antenna eATP Cell Viability

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Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1357-1364页

作者： Romain Altwegg Marc Ychou Vanessa Guillaumon Simon Thezenas pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo stéphanie Faure Emmanuelle Samalin Eric Assenat the Oncology and Digestive Endoscopy Department of the CRLC Val d'Aurelle 34000 MontpellierFrance

AIM： To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [（frequency, response, outcome, course of carbohydrate antigen 19-9 （CA 19-9）].METHODS： This retrospective study included all patients with advanced or metastatic pancreatic cancer （adenocarcinoma or carcinoma） treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 （range： 1-12） and the median duration of treatment was 2.6 mo （range： 0.3-7.4）. The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 （95% CI： 4.1-6.6） and 3.4 mo （95% CI： 2.4-4.2）, respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo （95% CI： 4.5-11.6） vs 5.2 mo （95% CI： 4.0-6.4） for others （P = 0.008）.CONCLUSION： A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy.

关键词： Second-line Chemotherapy Pancreatic can-cer Gemcitabine Carbohydrate antigen 19-9

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strong dependency of the tribological behavior of CuZr-based bulk metallic glasses on relative humidity in ambient air

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Friction 2023年第5期11卷 785-800页

作者： Solène BARLEMONT Paul LAFFONT Rémi DAUDIN Alexis LENAIN Guillaume COLAS pierre-Henri CORNUAULT Femto-st Institute Department of Applied MechanicsUniversity of Bourgogne Franche-ComtéCNRS/UFC/ENSMM/UTBMBesançon 25030France University of Grenoble Alpes CNRSSIMaPGrenoble 38000France Vulkam Inc.Amorphous metal micro casting Gières 38610France

Thanks to their outstanding mechanical properties,Bulk Metallic Glasses(BMGs)are new alternatives to traditional crystalline metals for mechanical and micromechanical applications including power ***,the tribological properties of BMGs are still poorly understood,mostly because their amorphous nature induces counter intuitive responses to friction and *** the present study,four different BMGs(Cu_(47)Zr_(46)Al_(7),Zr_(46)Cu_(45)Al_(7)Nb_(2),Zr_(60)Cu_(28)Al_(12),and Zr_(61)Cu_(25)Al_(12)Ti_(2))underwent ball-on-disc friction tests against 100Cr6 steel balls(American Iron and steel Institute(AISI)52100)at different relative humidities(RHs)ranging from 20%to 80%.Controlling humidity enabled to observe a high repeatability of the friction and wear responses of the ***,the friction coefficient decreased by a factor of 2 when the humidity was increased,and the wear rate of BMGs was particularly low thanks to a 3rd-body tribolayer that forms on the BMG surface,composed of oxidized wear particles originating from the *** morphology of this tribolayer is highly correlated to *** study also identifies how the tribolayer is built up from the initial contact until the steady state is achieved.

关键词： Bulk Metallic Glasses(BMGs) tribology oxide transfer layer relative humidity(RH)

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粗饲料种类、可代谢蛋白质浓度、碳水化合物来源对奶牛养分消化率及生产性能的影响

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中国畜牧杂志 2018年第11期54卷 149-156页

作者：郑宇慧李胜利 Weiss WP st-pierre N R Willett L B 中国农业大学动物科学技术学院北京100193

本试验采用中心组合试验设计对粗饲料来源、可代谢蛋白质(MP)浓度、碳水化合物种类及其互作效应对奶牛养分消化率和生产性能的影响进行了评价。所有日粮(干物质基础)均有50%由苜蓿青贮、玉米青贮构成的粗饲料、10.7%的瘤胃降解蛋白质(R... 详细信息

本试验采用中心组合试验设计对粗饲料来源、可代谢蛋白质(MP)浓度、碳水化合物种类及其互作效应对奶牛养分消化率和生产性能的影响进行了评价。所有日粮(干物质基础)均有50%由苜蓿青贮、玉米青贮构成的粗饲料、10.7%的瘤胃降解蛋白质(RDP)、4.1%~7.1%的瘤胃未降解蛋白质(RUP)、8.8%~12%的MP和22%~30%的淀粉组成。本试验共有15种日粮,试验牛分为6个区组,每个区组6头荷斯坦奶牛,分别进行3个为期21 d的试验。每期按特定顺序饲喂3种日粮后测定试验牛的产奶量、乳成分、采食量及主要营养物质消化率,还考虑了几个主要影响因素间的互作效应。结果表明:日粮淀粉浓度对奶牛养分消化率和生产性能影响较小;用苜蓿青贮代替玉米青贮可降低奶牛的氮消化率、提高中性洗涤纤维(NDF)消化率,还能增加奶牛对日粮干物质(DM)和日粮消化能(DE)摄入量,从而提高能量校正乳(ECM)、乳脂及乳蛋白产量;增加日粮MP浓度可提高奶牛对氮的消化率、ECM和乳蛋白产量,但乳蛋白含量的变化远小于NRC所推荐模型的预测值;DE浓度随淀粉浓度升高呈线性升高,但同时受粗饲料种类和MP浓度互作的影响,即日粮MP浓度较低时,DE浓度会随苜蓿青贮比例升高而降低,而日粮MP浓度较高时,DE浓度会随苜蓿青贮比例升高而升高。

关键词：消化率淀粉苜蓿蛋白质

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Use of Cucurbita pepo Oil to Fight against the UV Action on the Skin

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Green and Sustainable Chemistry 2021年第2期11卷 49-58页

作者： Aristide H. W. Nakavoua Guy Crépin Enoua stéphanie Manhan-Iniangas pierre Chalard Gilles Figuérédo Laboratory of Natural Substances Chemistry (IRSEN) Brazzaville Republic of Congo Analytical Chemistry and Bioactive Substances Team Faculty of Science and Technology Marien Ngouabi University Brazzaville Republic of Congo Laboratory for the Valorisation of Agri-Resources National Polytechnic High School (ENSP) Marien Ngouabi University Brazzaville Republic of Congo Institute of Chemistry of Clermont-Ferrand (ICCF) Clermont-Ferrand France LEXVA Analytical Clermont Ferrand France

Skin aging is a process most often attributed to UV [1] and also to the use of creams and other cosmetic products low in antioxidant compounds [2]. Photochemically stable pepo Cucurbita oil can be used as an exogenous cosmetic supplement due to its high antioxidant content. Incorporated in an agar, media containing a synthetic melanin solution with added pumpkin oil are subjected to UV light, the aging thus modeled is followed by the measurement of photoresistance values correlated with chemical and spectrophotometric analyses. This study confirms that pumpkin oil is highly effective in protecting the skin, especially the most sensitive skins such as babies’ skin

关键词： Aging Vegetable Oil Cucurbita pepo Photoresistance Melanin UV

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高温渗碳缩短热处理周期高温真空渗碳缩短热处理周期降低成本

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铸锻热（热处理实践） 1992年第1期 42-44页

作者： Jeremy st.pierre 施国威

真空渗碳是在近似真空但存在部分碳氢气分压中一种不平衡的强渗/扩散型渗碳过程。本文的第二部分是***公司在它的工业热处理设备上对渗碳气体循环和高温热处理过程(在950℃以上)进行了四年多研究结果的评论。对渗碳气体的组成和热处理... 详细信息

真空渗碳是在近似真空但存在部分碳氢气分压中一种不平衡的强渗/扩散型渗碳过程。本文的第二部分是***公司在它的工业热处理设备上对渗碳气体循环和高温热处理过程(在950℃以上)进行了四年多研究结果的评论。对渗碳气体的组成和热处理模拟试验的研究结果也作了评论。

关键词：高温真空渗碳热处理周期

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High-throughput extraction on a dynamic solid phase for low-abundance biomarker isolation from biological samples

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Microsystems & Nanoengineering 2023年第5期9卷 101-112页

作者： Lucile Alexandre Monica Araya-Farias Manh-Louis Nguyen Nikoletta Naoumi Giacomo Gropplero Electra Gizeli Laurent Malaquin stéphanie Descroix Laboratoire Physico-Chimie Curie CNRS UMR 168Institut CuriePSL Research UniversityParisFrance Institut pierre-Gilles de Gennes(IPGG) Sorbonne UniversityParisFrance Department of Biology University of CreteHeraklionGreece Institute of Molecular Biology and Biotechnology(IMBB)-FORTH HeraklionGreece Laboratoire d’analyse et d’architecture des systèmes(LAAS)CNRS Elia GroupToulouseFrance Present address:Frédéric Joliot Institute for Life Sciences Pharmacology and Immunoanalysis UnitImmunoanalysis Studies and Research LaboratoryAlternative Energies and Atomic Energy Commission(CEA)Gif-sur-YvetteFrance

Liquid biopsy,in particular circulating tumor DNA(ctDNA)analysis,has paved the way for a new noninvasive approach to cancer diagnosis,treatment selection and *** a crucial step in the analysis,the extraction of the genetic material from a complex matrix needs to meet specific requirements such as high specificity and low loss of ***,we developed a new generation of microfluidic fluidized beds(FBs)that enable the efficient extraction and preconcentration of specific ctDNA sequences from human serum with flow rates up to 15µL/*** first demonstrated that implementation of a vibration system inducing flow rate fluctuations combined with a mixture of different bead sizes significantly enhanced bead homogeneity,thereby increasing capture *** advantage of this new generation of high-throughput magnetic FBs,we then developed a new method to selectively capture a double-stranded(dsDNA)BRAF mutated DNA sequence in complex matrices such as patient ***,as proof of concept,ligation chain reaction(LCR)assays were performed to specifically amplify a mutated BRAF sequence,allowing the detection of concentrations as low as 6×104 copies/µL of the mutated DNA sequence in serum.

关键词： diagnosis specificity thereby

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