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Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel fleury Imane Boukhatem marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance Service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(eCD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR eCD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) eCD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) eCD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia

Preparation of Al-Cu-Fe-(Sn,Si) quasicrystalline bulks by laser multilayer cladding

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International Journal of Minerals,Metallurgy and Materials 2012年第5期19卷 434-440页

作者： Li-ping Feng eric fleury Guo-sheng Zhang Tianjin Research Institute of Construction Machinery Tianjin 300409 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China Center for High Temperature energy Materials Korea Institute of Science ＆ Technology （K/ST） Seou1130 650 Korea

（A165Cu20Fe15）100-xSnx （x=0, 12, 20, 30） and A157SitoCulsFe15 powders were cladded on a medium carbon steel （45# steel） substrate by laser multilayer cladding, respectively. The phases and properties of the produced quasicrystalline bulks were investigated. It was found that the main phases in the A165Cu2oFe15 sample were crystalline L-Al13Fe4 and icosahedral quasicrystal together with a small volume fraction of 0-A12Cu phase. The volume fraction of icosahedral phase decreased as the Sn content in the （A165Cu20Fe18）100-xSnx samples increased owing to the formation of β-CuSn phase. The increase of Sn content improved the brittleness of the quasicrystal samples. The morphology of the solidification microstructure in the Al57Si10Cu18Fe15 sample changed from elongated shape to spherical shape due to the addition of Si. The nanohardness of the laser multilayer cladded quasicrystal samples was equal to that of the as-cast sample prepared by vacuum quenching. In terms of hardness, the laser cladded A157Si10Cu18Fe15 quasicrystalline alloy has the highest value among all the investigated samples.

关键词： quasicrystals laser cladding phase composition morphology mechanical properties nanohardness

Protective behaviors regarding coastal flooding risk in a context of climate change

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Advances in Climate Change Research 2020年第4期11卷 310-316页

作者： Colin LeMee Oscar NAVARRO Diego ReSTRePO-OCHOA Denis MeRCIeR Ghozlane fleury-BAHI University of Brest Brest29200France Laboratoire de Psychologie des Pays de La Loire University of NantesNantes44312France CeS University Medellin050022Colombia Laboratoire de Geographie Physique(UMR 8591-CNRS) Sorbonne UniversiteParis75000France

The physical vulnerability of coastal areas due to rising sea level and the flooding risk consequent,does not guarantee the implementation of protective behaviors by these risk zones’*** study aims to establish the link between the willingness to carry out protective behaviors and physical and perceived indicators of vulnerability.A typology of coastal flooding vulnerability,uses various physical indicators and their perceived counterparts which have been collected from 490 inhabitants of Cartagena(Colombia,declared world heritage of humanity by UNeSCO in 1984),resident in areas of coastal flooding *** item-response theory(IRT)approach has been *** results reveal that the implementation of protective behaviors is more related to perceived indicators,such as distance to the sea,than to actual physical *** observe that physical vulnerability is linked to the intention to carry out protective *** presence of a defensive structure against coastal flooding could be considered as a visual cue and be a good predictor of the willingness to carry out protective *** the contrary,people in the most vulnerable situation(single-storey house)do not demonstrate a higher level of willingness to carry out protective behavior,as well of participants who lived in residential buildings which have demonstrated lower level of willingness to carry out such ***,vulnerability of the house is not seen as a criterion that encourages participants to better protect themselves.

关键词： Coastal flooding risk Protective behaviors Climate change Vulnerability Item response theory

Laser cladded AlCuFe+Sn quasicrystalline composite coatings

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中国有色金属学会会刊：英文版 2005年第2期15卷 432-436页

作者：冯莉萍邵天敏金永吉 e.fleury D.H.Kim 陈大融魏悦广 State Key Laboratory of Tribology Tsinghua University Beijing 100084 China State Key Laboratory of Non-Linearity Mechanics Insititute of Mechanics Chinese Academy of Sciences Beijing 100080 China Korea Institute of Science and Technology Seoul 130-650 Korea Center for Noncrystalline Materials Yonsei University Seoul 120-749 Korea

Al-Cu-Fe+Sn quasicrystalline(QC) composite coatings with different volume fractions of Sn, i.e.(12%,) (20%) (and 30%,) were prepared by laser cladding technique. The effects of soft phase Sn and processing parameters on the microstructure, microhardness and frictional behavior of the coatings were investigated. The results show that after laser cladding, i-phase existing in the powder is decomposed and element Sn reacts with Cu, forming β-CuSn. The volume fraction of Sn addition has less obvious effect on the microstructure, microhardness and friction performance than that of plasma sprayed coatings. The best performance in terms of microhardness and friction are (obtained) for the coating containing 20% Sn additions prepared with the laser power of 950 W and scanning velocity of 3 mm/s.

关键词：激光覆层电镀工艺铝铜铁锡复合材料摩擦性质

elaboration of AlSi10Mg casting alloys using directional solidification processing

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 509-515页

作者： Khadoudja Ghedjati eric fleury Mohamed Seghir Hamani Mostefa Benchiheub Khaider Bouacha Bernard Bolle Systems and Advanced Materials Laboratory (LASMA) Department of Physics Faculty of Science Badji Mokhtar University of Annaba Microstructure Investigation and Material Mechanic Laboratory (LeM3) CNRS Lorraine-Metz University Faculty of Science Souk Ahras University Foundry Research Laboratory (LRF) Department of Physics Faculty of Science Badji Mokhtar University of Annaba

The effects of pulling velocity on the solidification behavior and microstructural parameters of A1Sil0Mg alloys prepared in a Bridgman-type directional solidification furnace were investigated. The microstructure, particularly the secondary dendritic arm spacing （SDAS）, and the Brinell hardness （BH） of the solidified A1Sil0Mg alloys were characterized for samples with cylindrical shapes and differ- ent conicities （θ = 0°, 5°, and 10°）. Microstructural studies revealed an increased density of ct-A1 phase dendrites and a decreased interden- dritic distance with increasing pulling velocity. The dendrites were found to be preferentially oriented along the pulling direction for low pulling velocities. For larger pulling velocities, the dendrites grew first in the cooling direction but then broke as others nucleated and coars- ened. The HB values of the solidified samples increased as the pulling velocity increased. In regard to sample conicity, smaller dendrites were observed for an apex angle of θ = 5°, resulting in the largest HB value. This result was interpreted in terms of the favorable orientation of the dendrite along the pulling direction.

关键词： aluminum-silicon-magnesium alloys directional solidification Bridgman technique mierostructure hardness heat flow growth

Carboxymethyl glycoside lactone(CMGL) synthons:Scope of the method and preliminary results on step growth polymerization of α-azide-ω-alkyne glycomonomers

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Science China Chemistry 2010年第9期53卷 1880-1887页

作者： CHAMBeRT Stéphane BeRNARD Julien fleury etienne QUeNeAU Yves INSA-Lyon Laboratoire de Chimie Organique et Bioorganique Bat.J.Verne 20 Avenue A.Einstein69621 Villeurbanne CedexFrance ICBMS Institut de Chimie et de Biochimie Moléculaires et SupramoléculairesUMR5246 CNRS université de Lyon université Lyon 1 INSA-Lyon CPe-Lyon Bat.Curien 43 Bd du 11 Novembre 1918F 69622 VilleurbanneFrance INSA-LYON IMP1ngénierie des Matériaux Polymères UMR5223 université de Lyon université Claude Bernard Lyon 1F-69621 Villeurbanne CedexFrance

Carboxymethyl glycoside lactones(CMGLs) are bicyclic synthons which open readily for accessing new types of pseudo-glycoconjugates,such as sugar-amino acid hybrids,neoglycolipids,pseudodisaccharides,and membrane imaging *** lactone opening,free OH-2 is available for further functionalization,leading to 1,2-bisfunctionalized *** strategy is illustrated herein with new polymerizable systems of the AB type bearing both azide and alkyne functions prepared from α or β gluco-CMGL *** the reaction of lactones with propargylamine,an azido group was introduced by two different sequences leading to either the 2-manno-azido or the 6-gluco-azido *** capability of these AB monomers to undergo step growth polymerization through copper(I) catalyzed alkyne-azide cycloaddition(CuAAC) and generate glycopolytriazoles was evidenced.

关键词： carbohydrates glycopolymers lactones click chemistry step growth polymerization glycoconjugates azides alkynes Huisgen cycloaddition

Digital Social and emotional Literacy Intervention for Vulnerable Children in Brazil:Participants’experiences

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International Journal of Mental Health Promotion 2022年第1期24卷 51-67页

作者： Louise Freeland Michelle O’Reilly Juliana fleury Sarah Adams Panos Vostanis Department Neuroscience Psychology and BehaviourUniversity of LeicesterLeicesterLE17RHUK Department of Sociology University of LeicesterLeicesterLE17RHUK Associação pela Saúde emocional de Crianças(ASeC) São Paulo01000Brazil Department of education University of LeicesterLeicesterLE17RHUK

Social emotional literacy(SeL)interventions are widely implemented through schools,with growing evidence for a range of positive child ***,such interventions are delivered on online *** date,there is limited evidence about digital SeL interventions in low-and middle-income countries(LMIC).The aim of this study was to explore the perceptions and experiences of children,parents and facilitator of the potential value of addressing SeL via tailored digital *** intervention was designed to help children,in Brazil,to cope during the first COVID-19 pandemic *** intervention was delivered via a digital platform to groups of three children for 45 min per week for *** children,nine parents and nine facilitators were interviewed following the completion of the *** data was analysed through a codebook thematic approach,which led to three themes:empowerment,participatory aspects of the intervention and digital ***,children’s SeL development was reported to be supported during the COVID-19 pandemic,by the application of new skills outside the *** reported a number of empowering factors such as being heard and belonging.A range of useful participatory tools were identified including storytelling,games,drawings and *** SeL interventions involving both face-to-face and web-based facilitation could be developed within a tiered model of universal mental health promotion and targeted *** to online platforms would increase reach to large numbers of children in LMIC,especially in contexts of disadvantage.

关键词： Child social emotional literacy intervention digital low-and middle-income countries

error Resilient IPTV for an Ieee 802.16e Channel

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Wireless engineering and Technology 2011年第2期2卷 70-79页

作者： Laith Al-Jobouri Martin fleury Mohammed Ghanbari 不详

Data-partitioning of IPTV video streams is a way of providing graceful quality degradation in a form that will work in good and difficult wireless channel conditions, as experienced by mobile devices. This paper’s proposal is to combine redundant slice protection along with an adaptive channel coding scheme that is also proposed in the paper. Adaptive channel coding is achieved by retransmission when necessary of additional redundant data to reconstruct corrupted packets. In the proposal, outright packet loss is provided for by a form of redundant slice protection. The paper finds that it is preferable: not to simply protect only the highest priority packets;that a moderate quantization level should be employed;and that video quality is differentiated by content type. It is important also to configure the partitioning correctly to remove inter-partition dependencies when possible.

关键词： Ieee 802.16 IPTV Mobile TV Rateless Channel Coding Redundant Slices WiMAX

Purpose, Composition and Function of the Research ethical Committee in the Sarah Rehabilitation’s Hospital

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International Journal of Clinical Medicine 2016年第2期7卷 127-132页

作者： Kátia Torres Batista eliane Maria fleury Seidl Sarah Hospital and University of Brasilia Brasilia Brazil University of Brasilia Brasilia Brazil

Introduction: The Research ethical Committee (ReC) is responsible for the ethical evaluation of the projects presented by the scientific community to inform and train the members and researchers. Objective: To describe the purpose, composition and function of the ReC of the Association of Social Pioneers (APS) located in the Sarah Rehabilitation’s Hospital (Brasilia, Brazil). Methodology: Descriptive analysis of the ReC/APS based on 2013’s collected data was done. Results: The ReC/APS is an independent collegiate body, which was established in 1998 in accordance with Brazilian regulation. The main objective is promoting the application of ethical principles and human rights in research involving humans. The ReC was composed by chairperson and a substitute;secretary, fourteen regular members and five substitutes. We analyzed 164 projects submitted. The minimum time to a committee member who came up with the first opinion has been estimated as 14 days and the insurance of the consolidation occurred in 30 days. We approved 64 projects, of which 25 had pendencies in the first analysis, one project failed and 99 were excluded. The main problems were related to the writing of informed consent and the multicenter projects that did not include aspects such as costs, schedule and methodological limitations. We observed that the researcher could provide assistance. We considered the important role of the ReC/APS to ensure trust between researchers and participants in the research. Conclusion: Despite the purpose, composition and function of the APS research ethical committee, there were encountered many obstacles in its formation, considering monitoring the progress of the research, national normative, international researches and others. The ethical committee does a vital public service with the variety of the specialized views on the meeting. We need to strike a balance and we must weigh up risks and benefits related to knowledge, in its essence, to research’s participant a

关键词： ethics Review Research ethical Committee Bioethics and Research