检索结果-南通市图书馆

Brain Science Advances 2024年第1期10卷 6-38页

作者： Charles McGlynn Doni Dermawan Guia marie Canonizado School of earth and environment Rowan UniversityNJ 08028 New JerseyUnited States Applied Biotechnology Faculty of ChemistryWarsaw University of Technology00-661 WarsawPoland Saint Louis University School of Medicine 2600 Baguio CityPhilippines

The prevalence of neurodegenerative disorders is rising as the population ages,and many ailments,such as depression,Parkinson’s disease,Alzheimer’s disease,autism spectrum disorder,and multiple sclerosis,have intricate underlying mechanisms that are still poorly *** Neuron Foundry Mach 8 is a multi-modal neuro-supportive energy therapy device designed to treat neurodegenerative disorders through daily *** device proposes to deliver safe and controlled energy therapy through multiple therapeutic pathways,including stimulating brain mitochondrial energy,supporting homeostasis within the brain’s immune system,increasing melatonin production within neuronal mitochondria,and triggering cellular communication through the brain’s white *** combining these unique energy-based treatments,this device holds promising potential for slowing,stopping,reversing,or at least reducing the effects of neurodegenerative diseases.

关键词： energy therapy medical device multi-modal neuro-supportive energy neurodegenerative disorders Neuron Foundry Mach 8

Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(english edition) 2024年第4期45卷 633-648页

作者： e.GHAVANLOO S.eL-BORGI School of Mechanical engineering Shiraz UniversityShiraz 71963-16548Iran Mechanical engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed *** developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a *** inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed ***,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed *** discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization *** subsequent use of the second-order method of multiple scales(MMS)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed *** novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPM for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed ***,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum *** parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

关键词： nonlinear mass-spring chain discrete model continuum model LindstedtPoincare method(LPM) method of multiple scales(MMS) dispersion phase velocity

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

在线全文

学校读者我要写书评

暂无评论

Ieee/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong Zhao Jun-e Feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

Development of PROTACS degrading KRAS and SOS1

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1257-1264页

作者： GeRHARD HAMILTON marie-THeReSe eGGeRSTORFeR SANDRA STICKLeR Institute of Pharmacology Medical University of ViennaVienna1090Austria

The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung ***,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of ***,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 *** approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of ***,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal *** of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not *** CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental *** to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL e3 ubiquitin *** highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.

关键词： Proteolysis-targeting chimeras(PROTACs) Kirsten rat sarcoma virus(KRAS) Son of sevenless 1(SOS1) Von Hippel-Lindau Cereblon

Annual variation of adult survival of a south-temperate House Wren population in Argentina

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez Mariana e.Carro Paulo e.Llambías Grupo de Investigacion en ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

Study of Some Biodemographic Parameters of Caryedon serratus Olivier (Coleoptera: Chrysomelidae) Insect Pest of Tamarind (Tamarindus indica Lin.) Fruit, in Burkina Faso

在线全文

学校读者我要写书评

暂无评论

Advances in entomology 2024年第2期12卷 67-77页

作者： Kilo Francine Marina Ki Koï Wenceslas Kam emmanuel Kabore Antoine Sanon Zakaria Ilboudo Laboratoire d’entomologie Fondamentale et Appliqu&eacute e (LEFA) UFR/SVT Universit&eacute Joseph KI-ZERBO Ouagadougou Burkina Faso Institut Sup&eacute rieur du D&eacuteveloppement Durable Universit&eacute de Fada N’gourma Fada N’gourma Burkina Faso

The lack of food security leads us to turn to the riches of the forest, namely non-timber forest products (NTFP) and timber forest products (TFP). In Burkina, these products are a source of income for families, improving their living conditions. Tamarindus indica L. that is a NFTP, is widely used in both rural and urban areas. Unfortunately, tamarind is subject to attack by Caryedon serratus. Its biological activity begins on the fruit before the harvest. The aim of our study is to evaluate some biodemographic parameters of the insect pest C. serratus Olivier. First100 healthy T. indica pods were placed in contact with ten pairs of C. serratus for 24 hours. 25 pods, each carrying a maximum of two eggs, were divided into five batches of 5 pods. Then a pair of C. serratus aged less than 24 h was placed in contact with 4 healthy pods for 24 h. every day, the pair was removed and transferred to another box containing 4 new healthy pods. A total of 20 replicates were performed. The results showed that C. serratus has an average lifespan of 14 days. However, the female (16 days) lived longer and laid an average of 34 eggs during her lifetime. The egg-laying period lasted 14 days, the number of eggs increased until reaching a maximum peak on the 4th day. C. serratus has an embryonic development time of 3 days and an emergence rate of 66.63%. However, the weight of males and females differed significantly (p = 0.0108). We found an intrinsic rate of natural increase of 0.12 and a population doubling time was 5.68 days. These results have enabled us to gain a better understanding of its development cycle and its capacity for regeneration. This allows us to implement control strategies for better stock protection.

关键词： Biodemographic Parameters Stock Caryedon serratus Tamarindus indica

Physicochemical and Thermal Properties of Some Key Tropical Sawdust Woods for energy Production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sustainable Bioenergy Systems 2024年第1期14卷 1-22页

作者： Davy Fiwa Kaoke Yann Le Brech emmanuel Talla Anthony Dufour Patrick Mountapmbeme Kouotou Department of Chemical engineering School of Chemical Engineering and Mineral Industries University of Ngaoundere Ngaoundere Cameroon National Advanced School of engineering of Maroua University of Maroua Maroua Cameroon Laboratory of Reactions and Process engineering University of Lorraine-France Nancy France Higher Institute of Agriculture Wood Water and Environment University of Ebolowa Ebolowa Cameroon

In South Saharan countries, 85% of the population uses biomass as a primary energy source. Cameroon presents one of the highest biomass energy and sawmills produce important sawdust resources which are not used and are burnt in piles leading to significant air toxic emissions. Therefore, we have to valorize industrially these available sawdusts. This study focuses on the physicochemical and thermochemical analysis of Ayous, Sapelli and Tali sawdust. The proximate and ultimate analysis, particle size, structural composition, as well as heavy metal content and calorific value were determined. In addition, the thermogravimetric mass losses were also estimated. The results showed that high water contents (24% - 41%) were recorded in the raw sawdust, and the thermal treatment reduced these contents from 78% to values in the range of 4% - 9%. The values for ash and volatile matter content were respectively between 0.25% - 0.74% and 68% - 76%. The LHV is higher in Ayous (17.5 MJ/kg) and Sapelli (16.8 MJ/kg) than that of Tali (15.7 MJ/kg). The concentration of heavy metals is very low in each species. extractives are more present in Tali (16.06%) than in the other sawdusts. Pyrolysis of sawdust shows the typical decomposition of hemicellulose (270˚C - 325˚C), cellulose (325˚C - 400˚C) and lignin (200˚C - 550˚C) with a maximum loss of 75% at 370˚C and the melting point is 320˚C. The results of the sawdust parameters determined in the paper can be valorized to reduce pollutants emissions by developing the efficiency and effectiveness of biomass energy processes and promoting the use of biomass as a sustainable alternative to traditional fossil fuels.

关键词： Wood Sawmills Sawdust Combustion energy

The COVID-19 Pandemic: Present or Gone, Where Do Adolescents Stand?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2024年第2期14卷 374-386页

作者： Ifueko enadeghe Ayebo Sadoh emmanuel U. eyo-Ita Phillip O. Abiodun Department of Child Health University of Benin Teaching Hospital Benin City Nigeria Institute of Child Health University of Benin Benin City Nigeria

Introduction: The initial global response to the SARS-CoV-2 pandemic focused on adults as adolescents mainly had subclinical infections. Adolescents, however, could transmit the virus and hence be a risk to the elderly, young children and immunocompromised. Adolescents are also at risk of long-term complications. This study sought to determine the prevalence of antibodies to SARS-CoV-2 among adolescents in Southern Nigeria, and to determine the association between SARS-CoV-2 seropositivity and age, gender, socioeconomic class, school type and nutritional status. Methods: This descriptive cross-sectional study was carried out in edo state of southern Nigeria. We recruited 270 in-school adolescents aged 10 - 19 years. A WHO-adapted, pre-tested questionnaire was used to obtain data on participant history and risk factors. The questionnaire was interviewer-administered. Adolescents whose parents gave consent were recruited through a multi-stage randomized sampling method. Capillary blood for the assay was collected and analysed using a lateral-flow immunoassay device. The primary outcome was serostatus of the study. The positive predictors of serostatus were finally determined using a multiple logistics regression model. Statistical significance was set at p Results: The seroprevalence of SARS-CoV-2 was 45.9%. IgM antibodies were found in 5.6% of participants. Older adolescents had higher seropositivity rates than younger adolescents (2 = 8.101, p = 0.017). There was no association between gender and seropositivity. Adolescents in public schools were more likely to be seropositive than those in private schools (2 = 25.242, p = 0.001). A higher seroprevalence was noticed among study participants in the lower socioeconomic class (x2 = 6.928, p = 0.031), and those in overcrowded classes. (2 = 79.303, p = 0.001). Conclusion: This study showed a high seroprevalence of SARS-CoV-2 among in-school adolescents. Behavioural change communication on SARS-CoV-2, vaccination of adole

关键词： Pandemic Adolescents Seroprevalence COVID-19

Converting TRex-RGB green-channel data to 557.7 nm auroral intensity:Methodology and initial results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

earth and Planetary Physics 2024年第1期8卷 258-274页

作者： Jun Liang D.M.Gillies e.Spanswick e.F.Donovan University of Calgary CalgaryT2N 1N4Canada

The recently deployed Transition Region explorer(TRex)-RGB(red-green-blue)all-sky imager(ASI)is designed to capture“true color”images of the aurora and *** the 557.7 nm green line is usually the brightest emission line in visible auroras,the green channel of a TRex-RGB camera is usually dominated by the 557.7 nm *** this rationale,the TRex mission does not include a specific 557.7 nm imager and is designed to use the RGB green-channel data as a proxy for the 557.7 nm *** this study,we present an initial effort to establish the conversion ratio or formula linking the RGB green-channel data to the absolute intensity of 557.7 nm auroras,which is crucial for quantitative uses of the RGB *** illustrate two approaches:(1)through a comparison with the collocated measurement of green-line auroras from the TRex spectrograph,and(2)through a comparison with the modeled green-line intensity according to realistic electron precipitation flux measurements from low-earth-orbit satellites,with the aid of an auroral transport *** demonstrate the procedures and provide initial results for the TRex-RGB ASIs at the Rabbit Lake and Lucky Lake *** RGB response is found to be *** conversion ratios or formulas between RGB green-channel data and the green-line auroral intensity are given and can be applied immediately by TRex-RGB data *** methodology established in this study will also be applicable to the upcoming SMILe ASI mission,which will adopt a similar RGB camera system in its deployment.

关键词： TRex RGB green-line aurora auroral transport model

Severe asthma exacerbation:Changes in patient characteristics,management,and outcomes from 1997 to 2016 in 40 ICUs in the greater Paris area

在线全文

学校读者我要写书评

暂无评论

Journal of Intensive Medicine 2024年第2期4卷 209-215页

作者： Romy Younan Jean Loup Augy Bertrand Hermann Bertrand Guidet Philippe Aegerter emmanuel Guerot Ana Novara Caroline Hauw-Berlemont Amer Hamdan Clotilde Bailleul Francesca Santi Jean-Luc Diehl Nicolas Peron Nadia Aissaoui Intensive Care Unit AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Intensive Care Unit AP-HPSaint Antoine HospitalUniversités de SorbonneUniversitéPierre et Marie CurieParisFrance INSeRM U1136 ParisFrance Versailles Saint-Quentin-en-Yvelines University INSERM U1018Groupe Interrégional de Recherche Clinique et d'InnovationÎle-de-FranceFrance Respiratory Medicine Department AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Innovative Therapies in Hemostasis INSERM UMR-S1140Universitéde ParisParisFrance Intensive Care Unit and Biosurgical Research Lab(Carpentier Foundation) AP-HPGeorges Pompidou European HospitalParisFrance Paris-Cardiovascular-Research-Center INSERM U970ParisFrance

Background Despite advances in asthma treatments,severe asthma exacerbation(SAe)remains a life-threatening condition in adults,and there is a lack of data derived from adult patients admitted to intensive care units(ICUs)for *** current study investigated changes in adult patient characteristics,management,and outcomes of SAe over a 20-year period in 40 ICUs in the greater Paris *** In this retrospective observational study,admissions to 40 ICUs in the greater Paris area for SAe from January 1,1997,to December 31,2016 were *** primary outcome was the proportion of ICU admissions for SAe during 5-year *** outcomes were ICU and hospital mortality,and the use of mechanical ventilation and *** analysis was performed to assess factors associated with ICU *** A total of 7049 admissions for SAe were *** each 5-year period,the proportion decreased over time,with SAe accounting for 2.84%of total ICU admissions(n=2841)between 1997 and 2001,1.76%(n=1717)between 2002 and 2006,1.05%(n=965)between 2007 and 2011,and 1.05%(n=1526)between 2012 and *** median age was 46 years(interquartile range[IQR]:32–59 years),55.41%were female,the median Simplified Acute Physiology Score II was 20(IQR:13–28),and 19.76%had mechanical *** use of mechanical ventilation remained infrequent throughout the 20-year period,whereas the use of catecholamine *** and hospital mortality rates *** associated with ICU mortality were renal replacement therapy,catecholamine,cardiac arrest,pneumothorax,acute respiratory distress syndrome,sepsis,and invasive mechanical ventilation(IMV).Non-survivors were older,had more severe symptoms,and were more likely to have received *** ICU admission for SAe remains uncommon,and the proportion of cases decreased over *** a slight increase in symptom severity during a 20-year period,ICU and hospital mortality *** requirin

关键词： epidemiology Intensive care unit Mechanical ventilation Severe asthma exacerbation