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Optical coherence tomography angiography at the acute phase of optic disc edema

Eye and Vision 2018年第1期5卷 144-150页

作者： marie-bénédicte rougier Mélanie Le Goff Jean-François Korobelnik Service d’Ophtalmologie CHU de BordeauxBordeauxFrance bordeaux Population Health Research Center Team LEHAUniversity BordeauxINSERMUMR 1219F-33000 BordeauxFrance

background:The differential diagnosis of optic disc edema at the acute phase can be *** angiography(OCTA)is a new technology allowing the visualization of the peripapillary vascular network and optic disc *** peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy(nAIOn)were ***,no OCTA studies on acute optic disc edema from various *** aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute ***:In this retrospective study,patients with non-arteritic anterior ischemic optic neuropathy(nAIOn),papillitis or papilledema were *** patient was imaged using the AngioPlex^(TM)CIRRUS^(TM)HD-OCT device(model 5000,Carl Zeiss Meditec,Inc.,Dublin,USA)with a scanning area of 6×6 mm^(2) centered on the optic disc.A morphological analysis of the peripapillary network was *** some patients with unilateral optic disc edema,a quantitative analysis was performed using a swept-source OCT-A system(PLEX®Elite 9000,Carl Zeiss Meditec,Inc.,Dublin,USA).Vessel perfusion density and flux index of the peripapillary area were ***:Eight eyes with nAIOn(4 patients),12 eyes with papillitis(6 patients)and 25 eyes with papilledema(13 patients)were *** apparent disappearance or moderate pattern alteration of the peripapillary capillary vessels were observed in patients with nAIOn or papillitis,*** papilledema,the capillaries at the surface of the optic disc were dilated and tortuous,but no peripapillary network pattern changes were *** quantitative analysis did not show any difference of peripapillary network between nAIOn and healthy *** papillitis,the flux index was higher in inflammatory eyes compared to the healthy eyes in average(p=0.03).Conclusion:At the acute phase,the morphological analysis of OCT-A appeared to be more useful than the q

关键词： Optical coherence tomography angiography Optic nerve head Edema nAIOn Microvascular network And morphology

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Testing for hepatitis b virus alone does not increase vaccine coverage in non-immunized persons

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World Journal of Gastroenterology 2017年第38期23卷 7037-7046页

作者： Anders boyd Julie bottero Fabrice Carrat Joel Gozlan Hayette rougier Pierre-marie Girard Karine Lacombe Institute Pierre Louis d’épidémiologie et de SantéPublique(IPLESP UMRS 1136) INSERMSorbonne Universités Service de maladies infectieuses Hopital Saint-AntoineAP-HP Département de santépublique Hopital Saint-AntoineAP-HP Laboratoire de Virologie Hopital Saint-AntoineAP-HP InSERM UMR_S1135 CIMI

AIM To determine whether hepatitis b virus(HbV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent *** non-immunized subjects participating in a multi-center, HbV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol(for all respondents) and intent-to-treat analysis(assuming all non-responders did not vaccinate).RESULTS In total, 1215/4924(24.7%) enrolled subjects with complete HbV serology were identified as nonimmunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HbV vaccination after screening: per-protocol, 11.0%(95%CI: 9.0-13.2); intent-to-treat, 8.2%(95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HbV-endemic countries(P nts with limited healthcare coverage(P = 0.01) and men who have sex with men(P = 0.02). When asked about the reasons for not initiating HbV vaccination, the most frequent response was "will be vaccinated later"(33.4%), followed by "did not want to vaccinate"(29.8%), and "vaccination was not proposed by the physician"(21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%.COnCLUSIOn HbV-vaccination after HbV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level.

关键词： Health service organization Hepatitis b virus vaccination Public health Testing intervention Vaccine coverage

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A new Symmetrodont Mammal with Fur Impressions from the Mesozoic of China

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 7-14页

作者： GuillermoW.rougier MichaelJ.nOVACEK Department of Anatomical Sciences and neurobiology University of Louisville Louisville KY 40292USADivision of Paleontology American Muscum of Natural History Central Park West at 79th StreetNew York NY 10024-5192 USA

Western Liaoning of northeastern China is world-renowned for the MesozoicJehol biota, especially for yielding many feathered dinosaurs, primitive birds, mammals and fossilangiosperm. This paper describes a complete specimen of a symmetrodont mammal with well-preservedhairs and soft tissue from the basal part of the Yixian Formation in the Sihetun area, beipiao,western Liaoning. It is significant for understanding the morphology, osteology, phylogeny and lifehabits of Mesozoic symmetrodont mammals.

关键词： symmetrodont mammals Yixian Formation western Liaoning China

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Electrochemical ageing study of mixed lanthanum/praseodymium nickelates La2-xPrxniO4+δ as oxygen electrodes for solid oxide fuel or electrolysis cells

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Journal of Energy Chemistry 2020年第7期29卷 62-70,I0003页

作者： Vaibhav Vibhu Aurélien Flura Aline rougier Clément nicollet Sébastien Fourcade Teresa Hungria Jean-Claude Grenier Jean-Marc bassat CnRS Univ.BordeauxBordeaux INPICMCBUMR 5026F-33600 PessacFrance Centre de Microcaractérisation Raimond CASTAInG Universitéde ToulouseCNRSUT3–Paul SabatierINPINSAEspace Clément Ader3 rue Caroline AigleToulouse 31400France

The chemical and electrochemical stability of lanthanide nickelates La2 niO4+δ(LnO),Pr2 niO4+δ(PnO)and their mixed compounds La(2-x)PrxniO4+δ(LPnOs)with x=0.5,1 or 1.5 is *** aim is to promote these materials as efficient electrodes for solid oxide fuel cell(SOFC)and/or solid oxide electrolysis cell(SOEC).La2 niO4+δand La1.5Pr0.5niO4+δcompounds are chemically very stable as powders over one month in the temperature range 600-800℃,while the other materials rich in praseodymium progressively decompose into various perovskite-deriving components with additional Pr6 *** their uneven properties,all these materials are quite efficient and sustainable as electrodes on top of gadolinium doped ceria(GDCbL)//yttrium doped zirconia(8 YSZ)electrolyte,for one month at 700℃without *** polarization(300 mA·cm-2),the electrochemical performances of LnO,PnO and La1.5Pr0.5niO4+δ(LP5 nO)quickly degrade in SOFC mode,*** the oxygen reduction reaction,while they show durability in SOEC mode,*** the oxide oxidation reaction.

关键词： Lanthanide nickelates SOFC cathode SOEC anode Stability Inductive loop Degradation

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neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第17期17卷 2255-2258页

作者： nicolas Williet Olivier Dubreuil Tarek boussaha Isabelle Trouilloud bruno Landi Martin Housset Muriel botti Philippe rougier Jacques belghiti Julien Taieb Department of Gastroenterology Europeen Georges Pompidou HospitalMedical University75908 ParisFrance Department of Radiotherapy Europeen Georges Pompidou HospitalMedical University75908 ParisFrance beaujon Hspital Medical University100boulevard du Général Leclerc92110 ClichyFrance

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative *** potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial.

关键词： Hepatocellular carcinoma Gemcitabine Oxaliplatin Sorafenib neoadjuvant therapy

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Autoimmune pancreatitis with atypical imaging findings that mimicked an endocrine tumor

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World Journal of Gastroenterology 2010年第23期16卷 2954-2958页

作者： Cindy neuzillet Céline Lepère Mostafa El Hajjam Laurent Palazzo Monique Fabre Hajer Turki Pascal Hammel Philippe rougier Emmanuel Mitry Department of Digestive Surgery and Gastroenterology and Digestive Oncology Ambroise Paré Hospital9avenue Charles de Gaulle Radiology Unit Ambroise Paré Hospital9avenue Charles de Gaulle Medical off ice of Gastroenterology 30rue d'Astorg Pathology Unit Bicêtre Hospital78rue du Général Leclerc Department of Digestive Surgery and Gastroenterology PMADBeaujon Hospital100 boulevard du Général Leclerc EA 4340 Faculty of Medicine of West Paris University of Versailles Saint-Quentin9 boulevard d'Alembert

Autoimmune pancreatitis(AIP) is a rare cause of recurrent acute pancreatitis or chronic pancreatitis in middleaged patients,and is characterised by a marked infiltration of lymphocytes and plasma cells in pancreatic *** of focal forms can be diff icult as AIP may mimic pancreatic *** cases of AIP are *** report the case of a 15-yearold girl who had a focal AIP and associated cholangitis,with a very unusual vascularized mass that mimicked a pancreatic endocrine *** diagnosis was obtained by a pancreatic biopsy,thus avoiding surgical resection,and all the clinical,biological and radiological abnormalities resolved after steroid therapy with 6 mo of follow-up.

关键词： Pancreas Autoimmune pancreatitis Adolescent Endocrine tumor biopsy

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修饰性化妆在皮肤病患者管理中的作用

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中华皮肤科杂志 2017年第12期50卷 939-940页

作者： S Seité P Deshayes b Dréno L Misery P Reygagne P Saiag F Stengel Am Roguedas-Contios A rougier La Roche-Posay Pharmaceutical Laboratories Asnières France.

皮肤病，尤其是损容性皮肤病（disfiguringdermatoses），如白癜风和其他色素性疾病、血管畸形、痤疮和手术或创伤后的瘢痕，能够引起患者心理障碍。它们对患者的生活质量（QOL），即与他人的关系、自身形象和自尊可产生显著影响，并能... 详细信息

皮肤病，尤其是损容性皮肤病（disfiguringdermatoses），如白癜风和其他色素性疾病、血管畸形、痤疮和手术或创伤后的瘢痕，能够引起患者心理障碍。它们对患者的生活质量（QOL），即与他人的关系、自身形象和自尊可产生显著影响，并能够导致抑郁和（或）情绪低落。这些心理因素对皮肤科医生在优化管理患者方面具有重要影响：患者满意度差可导致对治疗依从性差，最终出现不良的健康状况。

关键词：损容性皮肤病患者管理修饰性化妆色素性疾病患者满意度皮肤科医生血管畸形

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中温固体氧化物燃料电池阴极材料LabiMn_2O_6的制备与性能

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无机化学学报 2015年第6期31卷 1139-1144页

作者：肖辉孙丽萍赵辉霍丽华 Jean-Marc bassat Aline rougier Sébastien Fourcade Jean-Claude Grenier 黑龙江大学化学化工与材料学院功能无机材料化学教育部重点实验室 CnRS Université de BordeauxICMCB87 avenue du Dr. A. Schweitzer F-33608 Pessac-CedexFrance

采用固相法合成了中温固体氧化物燃料电池（IT-SOFCs）阴极材料La bi Mn2O6,并利用X射线衍射（XRD）和电化学阻抗谱（EIS）进行表征。结果表明该材料与电解质Ce0.7bi0.3O1.85（CbO）在1 000℃烧结12 h不发生反应。交流阻抗和直流极化测... 详细信息

采用固相法合成了中温固体氧化物燃料电池（IT-SOFCs）阴极材料La bi Mn2O6,并利用X射线衍射（XRD）和电化学阻抗谱（EIS）进行表征。结果表明该材料与电解质Ce0.7bi0.3O1.85（CbO）在1 000℃烧结12 h不发生反应。交流阻抗和直流极化测试结果发现,阴极极化电阻随测试温度的增加而逐渐减小,700℃空气中的极化电阻为0.71Ω·cm2;氧分压测试结果显示,在600～700℃范围内,电极反应的速率控制步骤为电极上发生的电荷转移反应。电极过电位为85 m V时,700℃的阴极电流密度达到216 m A·cm-2,表明La bi Mn2O6是一种潜在的中温固体氧化物燃料电池（IT-SOFCs）阴极材料。

关键词：中温固体氧化物燃料电池(IT-SOFCs) 阴极材料 LabiMn2O6 电极反应

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病理学家对癌前损害的观点

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国际口腔医学杂志 1981年第3期 162-163页

作者： b.Kuffer M.rougier 吴少鹏

对宫颈上皮的研究比侵润性癌为早。回顾至1908年,已有很多种名词或分类。这些在妇科已明确的概念也适用于上呼吸——消化道粘膜与皮肤。作者希望把这些不同的名词予以统一,并提出将癌前病分为三种:

关键词：上皮内癌增生性粘膜生物膜先天性皮肤病角化病乳头状瘤间变性核深染病理检查核分裂

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钴掺杂Sr1.5La0.5MnO4的合成及高温电化学性能研究

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无机化学学报 2016年第10期32卷 1730-1738页

作者：范宇航孙丽萍霍丽华赵辉 Jean-Marc bassat Aline rougier Sebastien Fourcade Jean-Claude Grenier 黑龙江大学化学化工与材料学院功能无机材料化学教育部重点实验室哈尔滨150080 CnRS Universite de Bordeaux ICMCB 87 avenue du Dr. A. Schweitzer F-33608 Pessac-Cedex France

采用EDTA-柠檬酸法合成了中温固体氧化物燃料电池阴极材料Sr_(1.5)La_(0.5)Mn_(1-x)Co_xO_4(SLMCOx),并利用粉末X射线衍射(XRD)、X射线光电子能谱(XPS)以及电化学交流阻抗谱(EIS)进行表征。结果表明,该材料与Ce0.9Gd0.1O1.95(CGO)在1 200℃烧结12 h不发生化学反应。随着Co掺入量的增加,氧化物中Mn^(3+)和Co^(2+)含量增多,晶格氧含量降低,晶格畸变率增大。交流阻抗谱(EIS)测试结果显示,钴的掺杂明显降低电极的极化电阻,其中Sr_(1.5)La_(0.5)Mn_(0.7)Co_(0.3)O_4阴极在700℃空气中的极化电阻为0.62Ω·cm^2,明显小于Sr_(1.5)La_(0.5)MnO_4阴极在750℃的极化电阻(1.5Ω·cm^2),表明钴掺杂的Sr_(1.5)La_(0.5)Mn_(1-x)CoxO_4是一种潜在的IT-SOFC阴极材料。

关键词：中温固体氧化物燃料电池阴极材料

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