检索结果-南通市图书馆

Interplay of S and As in Mekong Delta sediments during redox oscillations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第5期10卷 1715-1729页

作者： Van T.H. Phan Fabrizio Bardelli pierre Le Pape Raoul-marie Couture Alejandro Fernandez-Martinez Delphine Tisserand Rizlan Bernier-Latmani Laurent Charlet University Grenoble Alpes CNRSIRDIFSTTARISTerre38000GrenobleFrance Ho Chi Minh City University of Technology (HCMUT) Vietnam National UniversityHo Chi Minh City (VNU-HCM)268 Ly Thuong KietDistrict 10Ho Chi Minh CityViet Nam Institute of Nanotechnology (CNR-Nanotec) 00186RomeItaly Institut de Mineralogie de Physique des Materiaux et de Cosmochimie (IMPMC)UMR 7590 CNRS-UPMC-IRD-MNHN4 Place Jussieu75252Paris cedex 05France Département de chimie Université Laval1045 Avenue de la MédecineQuébecQCG1V 0A6Canada Ecole Polytechnique Fédérale de Lausanne (EPFL) e Environmental Microbiology Laboratory (EML) EPFL-ENAC-IIE-EMLStation 6CH-1015LausanneSwitzerland

The cumulative effects of periodic redox cycling on the mobility of As,Fe,and S from alluvial sediment to groundwater were investigated in bioreactor *** particular sediments from the alluvial floodplain of the Mekong Delta River were investigated: Matrix A (14 m deep) had a higher pyrite concentration than matrix B (7 m deep) *** present in matrix B but absent in matrix *** the reactors,the sediment suspensions were supplemented with As(III) and SO4^2-,and were subjected to three full-redox cycles entailing phases of nitrogen/CO2,compressed air sparging,and cellobiose *** differences in As concentration and speciation were observed upon redox *** support the fact that initial sediment composition is the main factor controlling arsenic release and its speciation during the redox ***,a high pyrite content associated with a low SO4^2- content resulted in an increase in dissolved As concentrations,mainly in the form of As(III),after anoxic half-cycles;whereas a decrease in As concentrations mainly in the form of As(V),was instead observed after oxic *** addition,oxic conditions were found to be responsible for pyrite and arsenian pyrite oxidation,increasing the As pool available for *** same processes seem to occur in sediment with the presence of gypsum,but,in this case,dissolved As were sequestered by biotic or abiotic redox reactions occurring in the FeeS system,and by specific physico-chemical condition (***).The contrasting results obtained for two sediments sampled from the same core show that many complexes and entangled factors are at work,and further refinement is needed to explain the spatial and temporal variability of As release to groundwater of the Mekong River Delta (Vietnam).

关键词： Redox oscillation Pyrite oxidation Gypsum dissolution Isotope sulfur Isotope oxygen

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2016年第2期8卷 129-143页

作者： pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin *** mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are *** this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse *** of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and *** glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional *** disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

Interval Estimation for the Stress-Strength Reliability with Bivariate Normal Variables

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Statistics 2014年第8期4卷 630-640页

作者： pierre Nguimkeu marie Rekkas Augustine Wong Department of Economics Georgia State University Atlanta GA USA Department of Economics Simon Fraser University Burnaby Canada Department of Mathematics and Statistics York University Toronto Canada

We propose a procedure to obtain accurate confidence intervals for the stress-strength reliability R = P (X > Y) when (X, Y) is a bivariate normal distribution with unknown means and covariance matrix. Our method is more accurate than standard methods as it possesses a third-order distributional accuracy. Simulations studies are provided to show the performance of the proposed method relative to existing ones in terms of coverage probability and average length. An empirical example is given to illustrate its usefulness in practice.

关键词： Bivariate Normal Distribution Interval Estimation Likelihood Analysis Reliability

Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir.(Fabaceae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 46-51页

作者： Ouedraogo Noufou Sawadogo Richard Wamtinga Tibiri Andre Bayet Christine Lompo Marius Hay A Emmanuelle Koudou Jean Dijoux marie-Genevieve Guissou Innocent pierre Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologie UFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso Universite de Lyon F-69622LyonFrance Universite Lyon I Villeurbanne CNRS UMR 5557Ecologie MicrobienneISPB69373 LyonFrance Laboratoire de chimie des substances naturelles Faculte des SciencesUniversite de Bangui.BP908Bangui.Republique Centrafricaine Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologieUFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso

Objective:To sereen methanol and dichloromethane extracts of stem bark of Pterocarpus erinaceus for anti-inflammatory,*** vitro antioxidant activities and phytochemical ***:Anti-inflammatory activity was detcrmined by using carrageenan inducededema of mice paw and croton oil-induced edema of mice ear:analgesic effect was evaluated using acetic acid-induced *** screening of extracts was performed by thin layer *** chromatographic fractionation led to the isolation of main active components as *** and *** structures were established hy TLC and nuclear magnetic resonance ***:Both methanol and dichloromethane extracts, *** and epicatechin showed a significant anti—inflammatory effect using croton oil induced—ear ***,the action of dichloroinethane extract was more important. At the doses of 100 and 200 mg/*** methanol extract was able to reduce the carrageeuan induced-hind paw edema,while al the doses of 100.200 and 400 mg/*** showed an important analgesic effect against writhing induced by acetic acid injection of 38.8%.68.0%and 74.3%, *** properties of methanol extract and its dichloromethane and ethyl acetate fractions were assessed by using the 1,1—diphenyl—2—picrylhydrazyl *** methanol extract showed the stronger radical scavenging activity than dichloromethane and ethyl acetate fractions,with an antiradical power of 5.3.5 and 2 *** main components isolated from these extracts as friedelin,lupeol and epicathechin were responsible of these ***:The results suggest that the stem hark extracts of Pterocarpus erinaceus possessed important *** activities and strong antioxidant properties, therefore,they could he used as natural potential ingredients for pharma ceutical industry.

关键词： Pterocarpus erinaceus Phytochemical Anti-inflammatory Analgesic Antioxidant

Actigraphy: A new diagnostic tool for hepatic encephaiopathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第14期12卷 2243-2244页

作者： Isabelle Hourmand-Ollivier marie-Astrid Piquet Jean pierre Toudic pierre Denise Thng Dao Department of Nutrition and Hepatogastroenterology CHU Cte de Nacre-14033 cedex Caen France Physiology Laboratory CHU Cte de Nacre-14033 cedex Caen France

AIM： To assess the actigraphy, an ambulatory and continuous monitoring of wrist motor activity fitted to study sleep/wake patterns in hepatic encephalopathy （HE）. METHODS： Twenty-five cirrhotic patients （17 M, 8 F, mean age 56± 11 years, 24/25 alcoholic, Child-Pugh A, B, C： 2, 6, 17） were included. The patients were classified into 3 groups： stage 0 group （n = 12）, stage 1-2 group （n = 6）, and stage 3-4 group （n = 7） of encephalopathy. Over three consecutive days, patients had clinical evaluation 3 times a day with psychometric test, venous ammoniemia, flash visually evoked potentials （VEP）, electroencephalogram and continuous actigraphic monitoring for 3 d, providing 5 parameters： mesor, amplitude, acrophase, mean duration of activity （MDAI） and inactivity （MDII） intervals. RESULTS： Serum ammonia and VEP did not differ among the 3 groups. Electroencephalography mean dominant frequency （MDF） correlated significantly with clinical stages of HE （r=0.65, P=0.003）. The best correlation with HE stage was provided by actigraphy especially with MDAI （r= 0.7, P〈10^-4） and mesor （r= 0.65, P〈 10^-4）. MDAI correlated significantly with MDF （r= 0.62, 0.004） and was significantly shorter in case of HE compared to patients without HE （stage 0： 5.33± 1.6 min; stage 1-2：3.28±1.4 min; stage 3-4：2.52±1.1 min; P〈0.05）. Using a threshold of MDAI of less than 4.9 min, sensitivity, specificity, positive predictive value, negative predictive value for HE diagnosis were 85%, 67%, 73% and 80%, respectively. CONCLUSION： Actigraphy may be an objective method to identify HE, especially for early HE detection. Motor activity at the wrist correlates well with clinical stages of HE. MDAI and mesor are the most relevant parameters.

关键词： Hepatic encephalopathy Cirrhosis Actigraphy

Ultra High Field Magnetic Resonance Imaging 2006

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolation and structural elucidation of cytotoxic compounds from the root bark of Diospyros quercina (Baill.) endemic to Madagascar

丛书名： Biological Magnetic Resonance

2006年

作者： pierre-marie Robitaille Lawrence Berliner

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 169-175页

作者： Fatiany pierre Ruphin Robijaona Baholy Randrianarivo Emmanuel Raharisololalao Amelie marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187University of Toliara601 ToliaraMadagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.OBOX 3833.102 AntananarivoMadagascar Antananarivo Poly-technique High School University of Antananarivo101 AntananarivoMadagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centrefor Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.OBOX 190 Kinshasa XI.Democratic Republic of the Congo

Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)***&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to August ***-guided fractionation assay was carried out on the root bark of Diospyros quercina,using cytotoxicity bioassay on murine P388 leukemia cell lines as *** structures of the cytotoxic compounds were elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological experiments resulted in the isolation of three bioactive pure compounds(named TR-21,TR-22,and TR-23)which exhibited very good in vitro cytotoxic activities with the IC_(50)values of(0.017 5±0.0060)μg/mL,(0.089±0.005)μg/mL and(1.027±0.070)μg/mL ***,they support the claims of traditional healers and suggest the possible correlation between the chemical composition of this plant and its wide use in Malagasy folk medicine to treat ***:The ability of isolated compounds in this study to inhibit cell growth may represent a rational explanation for the use of Diospyros quercina root bark in treating cancer by Malagasy traditional *** studies are,therefore,necessary to evaluate the in vivo antineoplastic activity of these cytotoxic compounds as effective anticancer drugs.

关键词： Diospyros quercinia Cytotoxic activities Isodiospyrin 6’-Ethoxy-1’ 3’-dihydroxy-4 6-dimethyl-1,2’-binaphthyl-2,5’3,8’tetraones (E)-5,6-Dimethyl-2-(2-methyl-3-(prop-1-enyl) phenyl)-2H-Chromene Madagascar

Anti-Aging Efficacy of a New Alendronate-Pravastatin Cosmetic Combination: A Randomized Double Blind Comparative Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 163-171页

作者： Bénédicte Cantecor marie-pierre Savelli marie-pierre Savelli Philippe Piccerelle Nicolas Lévy Vincent Bonniol pierre Cau Inserm UMR_S 910 Aix-Marseille University Marseille France Pharmaco-Technology Laboratory Aix-Marseille University Marseille France

Progeria is a rare genetic disease that causes accelerated aging and death in children at a mean age of 13.5 years. An?aminobisphosphonate-statin combination has been shown to reduce the toxicity of the mutated protein, progerin, in progeria patient cell cultures and in a mouse model of the disease. This combination is currently being tested in a European Therapeutic Trial for progeria in Marseille (*** identifier NCT00731016). Progerin has been shown to be produced by skin cells during physiological aging. The objective of this study was to assess the efficiency of a new and original cosmetic formulation containing alendronate and pravastatin sodium salts, reduce crow’s feet wrinkles, and cheek hollow in a double blind, randomized and placebo controlled comparative study. Three cosmetic preparations were evaluated using Fast Optical in vivo Topometry of human Skin (FOITS): one containing sodium alendronate and sodium pravastatin, a placebo, and a commercial anti-aging product. Fifty-seven female and twenty-five male volunteers between 51 and 71-year-old were selected. Each subject tested two of the three products once a day, in the evening, by spreading each selected product on one side of the face. Skin micro-relief was analyzed at 0, 28, 56 and 84 days. Statistical analysis of 7 clinical qualitative (left or right side of face, gender, and 3 skin types) and 6 quantitative parameters (age, weight at each test time, wrinkle clinical grade at inclusion time) showed no statistical differences between the three tested products. In contrast, most of the 8 quantitative FOITS parameters describing skin micro-relief were statistically improved by the alendronate-pravastatin combination compared to the placebo or to the commercial anti-aging product. A cosmetic preparation containing alendronate and pravastatin sodium salts exhibited anti-aging effects by reducing crow’s feet wrinkles and restoring cheek volume.

关键词： Skin Aging Progerin Statin Aminobisphosphonate Double Blind Comparative Clinical Study Placebo FOITS

Relationships between mucinous gastric carcinoma, MUC2 expression and survival

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第21期12卷 3324-3331页

作者： Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy marie-Christine Copin Christophe mariette Jean-pierre Aubert Nicole Porchet marie-pierre Buisine INSERM U560 59045Lille cedexFrance Service d'Anatomie et Cytologie Pabologiques Pôle Biologie-Pathogie Pac Eurasanté.CHR-U de Lille59037 Lille cedexFrance Service de Biochimie et Biologie Moléculaire CHR-U de Lille59037 Lille cedexFrance Facultéde Médecine H.Warembourg 59045 Lille cedexFrance Service.de Chirurgie Digetive et Générale CAEB CHR-U de Lille59045 Lille cedexFrance

AIM:To investigate the expression of the four secreted gel-forming mucins(MUC2,MUCSAC,MUCSB and MUC6)in a series of gastric carcinomas,classified according Laurén's,Mulligan's,WHO and Goseki's classifications,with special attention to all the different components(major and minor)present in tumors and to follow up clinical ***:Expression of MUC2,MUC5AC,MUC5B and MUC6 was investigated using immunohistochemistry and in situ ***:Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex,each mucin being not restricted to any histopathological type even considering all components(major and minor)present in a given *** was a worst survival in patients with a higher content of mucus(GosekiⅡorⅣ)and high positive MUC2 ***:Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification *** expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with groupⅡof Goseki's classification identified by the major component of a particular *** quantity and quality of mucus were related to survival.

关键词： Gastric cancer Secreted gel-forming mucin MUC Immunohistochemistry in situ hybridization Survival