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High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis

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World Journal of Gastroenterology 2005年第9期11卷 1356-1360页

作者： Kazuhiro Kotoh Makoto Nakamuta marie fukushima Chitose Matsuzaki Munechika Enjoji Hironori Sakai Hajime Nawata Department of Medicine and Bioregulatory Science Department of Gastroenterology

AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life. Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional cirrhotic patients, muscular volume is hypothesized to play an important role in albumin production. Therefore, we investigated the correlation between serum albumin levels and the fat-free mass (FFM) in cirrhotic ***: Fifty-seven patients (26 males and 31 females)with compensated liver cirrhosis were evaluated. Patients with edema or ascites were excluded from the *** volunteers (n = 104; 48 males and 56 females)were also evaluated as controls. FFM was measured using 5-500 kHz multifrequency bioelectric impedance *** minimize the difference in FFM distribution between males and females, we introduced a new marker, relative FFM (rFFM), which represents the ratio of FFM in a patient relative to that in a volunteer of the same height. Following FFM measurement, the serum albumin levels of patients were assayed ***: In patients with active cirrhosis (alanine aminotransaminase [ALT] ＞50 U/L), both albumin (the difference between maximum and minimum levels) and the standard deviation of albumin levels (SD-albumin) during the observation period showed a significant correlation with rFFM. Multiple linear regression analysis using variables such as rFFM, platelet number, and serum cholesterol levels,choline esterase, albumin, bilirubin, and ALT revealed that rFFM and ALT were significant and independent factors that influenced albumin or SD-albumin in cirrhotic ***: Our results indicate that cirrhotic patients with high rFFM showed less of a decrease in albumin levels, and that the muscle volume is one of the most important factors for maintaining serum albumins level in active cirrhosis. Exercise and protein-rich nutrition at the early stage of liver cirrhosis may be advisable for maintaining or increas

关键词： Muscular volume Fat-free mass (FFM) Multifrequency bioelectric impedance analysis Albumin Liver cirrhosis

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Clinical significance of serum levels of vascular endothelial growth factor and its receptor in biliary disease and carcinoma

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World Journal of Gastroenterology 2005年第8期11卷 1167-1171页

作者： Munechika Enjoji Makoto Nakamuta Koji Yamaguchi Satoshi Ohta Kazuhiro Kotoh marie fukushima Masami Kuniyoshi Tomomi Yamada Masao Tanaka Hajime Nawata Department of Medicine and Bioregulatory Science Department of Surgery and Oncology Medical Information Science

AIM: To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (VEGFRl/Flt-1) (sVEGFR1) levels in biliary diseases. METHODS: We analyzed the serum levels of these proteins in patients with acute cholangitis (group 1), biliary malignancies (group 2), and primary biliary cirrhosis or primary sclerosing cholangitis (group 3), and in healthy donors (group 4). The influence of inflammation was also analyzed. Serum VEGF levels were expressed as VEGF per platelet (VEGF/PLT, pg/106) in order to exclude the influence of platelet counts. RESULTS: sVEGFRl levels were significantly higher in groups 1 and 2 than in the control group, but did not correlate with inflammatory markers. VEGF/PLT levels were generally higher in patients with active inflammation than in those with carcinoma. C-reactive protein strongly correlated with the levels of serum VEGF independently of platelet and leukocyte counts, even in cancer patients. In cancer patients, VEGF/PLT and sVEGFRl levels might be indicators for evaluating the effect of medical treatment or the disease progression. CONCLUSION: Serum VEGF and VEGFR1 might be useful markers for gauging the clinical effect of various treatments on patients.

关键词： VEGF VEGFRl Cholangiocarcinoma Cholangitis

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Vectra 3D Imaging for Quantitative Volumetric Analysis of the Efficacy of Propranolol in Infantile Hemangioma

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Modern Plastic Surgery 2019年第3期9卷 45-51页

作者： Reina Kitabata Noriko Aramaki-Hattori Hiroyuki fukushima Jun Maeda Tomoki Kiuchi marie Aoki Kazuo Kishi Department of Plastic and Reconstructive Surgery Keio University School of Medicine Tokyo Japan Department of Pediatrics Keio University School of Medicine Tokyo Japan Department of Plastic and Reconstructive Surgery International University of Health and Welfare Hospital Nasushiobara Tokyo Japan Department of Plastic and Reconstructive Surgery Tokyo Metropolitan Children’s Medical Center Tokyo Japan

Infantile hemangioma (IH) is a common tumor in infants. After the proliferative phase, hemangiomas regress, but sometimes leave scars. Propranolol is now the recommended first-line oral therapy for IH. To evaluate the effectiveness of oral propranolol administration, we measured quantitative changes in an IH by digital camera and Computed Tomography (CT) or Magnetic Resonance Imaging (MRI). Although digital cameras are very simple, changes in color tones occur with time, lesions are evaluated in two dimensions, and changes in the thickness of the hemangioma are difficult to evaluate. Therefore, we investigated the feasibility of 3D photography to quantify volumes in IH during oral propranolol treatment.

关键词： Infantile Hemangioma Propranolol 3D Photography

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