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瓦格纳首部歌剧《仙女》登上法国舞台

歌剧 2009年第6期 26-27页

作者：李绚 marie-Noёlle robert

瓦格纳最早的三部歌剧《仙女》、《爱情禁令》以及《黎恩济》近年来成为各大演出季的热门剧目，这几部以往鲜能在舞台上觅得踪迹的歌剧有些曾因作曲家青年时的鲁莽生涩而中止创作，也曾在拜罗伊特遭到永久禁演。纽约库珀镇的格林美格拉... 详细信息

瓦格纳最早的三部歌剧《仙女》、《爱情禁令》以及《黎恩济》近年来成为各大演出季的热门剧目，这几部以往鲜能在舞台上觅得踪迹的歌剧有些曾因作曲家青年时的鲁莽生涩而中止创作，也曾在拜罗伊特遭到永久禁演。纽约库珀镇的格林美格拉斯歌剧院2008年夏季将《爱情禁令》搬上舞台，

关键词：《仙女》歌剧院瓦格纳舞台法国首部演出季作曲家

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美好的老时光:音乐剧《窈窕淑女》巴黎上演

歌剧 2011年第2期 24-25页

作者：胡越菲 marie-Noёlle robert Thétre du Chtelet

1956年,音乐剧《窈窕淑女》在百老汇首演并获得巨大成功。此后,该剧被誉为史上＂最完美的音乐剧＂,创下了当时上演时间最长的纪录。半个多世纪以后,《窈窕淑女》在巴黎的夏特莱剧院（Théatre du Chatelet）成功演出,这个制作同样非常精... 详细信息

1956年,音乐剧《窈窕淑女》在百老汇首演并获得巨大成功。此后,该剧被誉为史上＂最完美的音乐剧＂,创下了当时上演时间最长的纪录。半个多世纪以后,《窈窕淑女》在巴黎的夏特莱剧院（Théatre du Chatelet）成功演出,这个制作同样非常精彩,值得称道。

关键词：《窈窕淑女》音乐剧巴黎美好百老汇成功演出

Microscopic enteritis:Bucharest consensus

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World Journal of Gastroenterology 2015年第9期21卷 2593-2604页

作者： Kamran Rostami David Aldulaimi Geoffrey Holmes Matt W Johnson marie robert Amitabh Srivastava Jean-Francois Fléjou David S Sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan Sauid Ishaq Mohammad Rostami-Nejad A Salvador Pe?a Gabrio Bassotti Michael N Marsh Vincenzo Villanacci Department of Gastroenterology Alexandra HospitalWorcestershire B98 7UBUnited Kingdom Department of Gastroenterology Royal Derby HospitalDerby DE22 3NEUnited Kingdom Gastroenterology Unit Luton Dunstable University FT Hospital LU4 0DZUnited Kingdom Department of Pathology and Medicine Yale University School of MedicineNew HavenCT 06520United States Department of Pathology Staff PathologistBrigham and Women’s HospitalHarvard Medical School BostonBostonMA 02115United Sates Department of Pathology Serviced’Anatomie PathologiqueHopital Saint-AntoineAP-HPUniversité Pierre et Marie Curie75005 ParisFrance Department of Gastroenterology University of SheffieldSouth Yorkshire S10 2TNUnited Kingdom Department of Gastroenterology Department of Medical and Surgical SciencesUniversity of Bologna40126 BolognaItaly Section of Gastroenterology Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgow G12 8QQUnited Kingdom Department of Pathology Southern General HospitalLanarkshire G51 4TFUnited Kindom Department of Pathology Carol Davila Univerity of Medicine and PharmacyBucharest 050474Romania Università Politecnica delle Marche AnconaItalyPresidente Società Italiana di GastroenterologiaEpatologia e Nutrizione PediatricaCo-DirectorCenter For Celiac Research University of Maryland School of Medicine BaltimoreMD 21201United States Grigore T Popa" University of Medicine and Pharmacy Iasi 747800Romania Laboratory Department Mashad Razavi HospitalKhorasan Razavi ***Iran Dudley group of Hospitals Birmingham City UniversityBirmingham B42 2SUUnited Kindom Gastroenterology and Liver Diseases Research Institute Shahid Beheshti University of Medical SciencesTehran ***Iran Laboratory of Immunogenetics Department of Medical Microbiology and Infection ControlVrije Universiteit medical centre (VUmc)1081 HZ AmsterdamThe Netherlands Gastroenterology Section Department of MedicineUniversity of Perugia Medical School06100 PerugiaItaly Wolfson College University of OxfordOxford

Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient *** is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern *** work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical *** consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and *** the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,*** was strong agreement on all statements about ME histology(95%-100%).Statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of *** was strong agreement on the histological definition of *** agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for *** ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy.

关键词： Microscopic enteritis Enteropathy Gluten Malabsorption Non-celiac gluten Bucharest consensus

*** involvement in epidermolysis bullosa

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Annals of Eye Science 2018年第1期 484-484页

作者： Soumaya Bouhout marie-Claude robert Faculty of medicine McGill UniversityMontrealQCCanada CHUM Notre-Dame HospitalMontreal UniversityMontrealQCCanada

Background:Epidermolysis bullosa(EB)is a heterogynous group of skin disorders characterized by formation of blisters and erosions of the skin in response to minor *** include EB simplex(EBS),junctional EB(JEB),dystrophic form of EB(DEB)and finally Kindler syndrome(KS).In addition to dermal manifestation,patients can present with various ophthalmic ***:We reviewed the pathobiology,epidemiology and management of ocular manifestations as well as current and future innovative therapies for ***:The severity and incidence of ocular involvement were the highest in the recessive DEB-generalized severe and JEB-generalized severe *** corneal erosions and blisters were the most common finding and seem to correlate with skin *** manifestations include corneal scaring,blepharitis,ectropion,symblepharon,infantile cataracts,lacrimal duct obstruction as well as meibomian gland ***:Ophthalmology consult as well as regular follow-up are essential in the multi-disciplinary approach of this ***,parents’and patients’education as well as early diagnosis and treatment are crucial to prevent permanent and long-term visual disabilities.

关键词： Review epidermolysis bullosa(EB) eye cornea

*** for the anatomopathological,functional and surgical characterization of the cornea

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Annals of Eye Science 2018年第1期 498-498页

作者： Jean Meunier Mona Dagher Julia Talajic marie-Claude robert Isabelle Brunette Département d'informatique et de recherche opérationnelle Universitéde MontréalMontréalQCCanada Département Neurosciences CHUM Research CenterMontréalQCCanada Département ophtalmologie Universitéde MontréalMontréalQCCanada Centre Michel-Mathieu Institut d’excellence en ophtalmologiePavillon MaisonneuveHôpital Maisonneuve-RosemontMontréalQCCanada Centre Universitaire d'Ophtalmologie de l'Universitéde Montréal et Centre de Recherche de l'Hôpital Maisonneuve-Rosemont CIUSSS-EMontréalCanada Hôpital Maisonneuve-Rosemont Research Center CIUSSS-EMontréalCanada

Background:The purpose of this infrastructure is to provide to the Network researchers a database and diverse related tools for the anatomical and functional analysis of the normal,pathological and surgical ***:This database is composed of normal and pathological individuals,totaling more than 36,000 *** includes anatomical and functional imaging data,physiological optics data,psychometric and clinical data(medical history,surgical parameters,acuteness,etc.).Various corneal topography tools were added,giving the database a unique character:tools for analyzing individual maps,average map tools for the study and comparison of populations,3D modeling and visualization tools,statistical tools,*** are also screening tools for detecting various corneal conditions(LASIK,PRK,RK,keratoconus)and for secure data exchange between ***:Several studies were made in recent years thanks to this common *** example,this database has provided important information regarding the evolution of the 3D shape of the normal cornea with age and ametropia and has confirmed the mirror symmetry of corneas for the right and the left eyes(enantiomorphism).The different stages of Fuchs’dystrophy were also characterized to provide essential knowledge for surgery of the posterior layer of the *** database also allowed studying the anatomy of the wounds and the shape of the cornea before and after a transfixing transplant or an endothelial transplant(DSAEK and DSEK).The data on the characterization of experimentally transplanted corneas with corneal equivalents generated by tissue engineering and the recent addition of clinical data on the replacement of a diseased cornea with a synthetic corneal equivalent(keratoprosthesis)also resulted in several *** recently,the database has allowed to develop innovative algorithms to determine the optimal shape of an implant according to the clinical parameters of the *** the other

关键词： Cornea corneal topography atlas keratoprosthesis transplant biometrics

Pharmacogenetics in inflammatory bowel disease

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World Journal of Gastroenterology 2006年第23期12卷 3657-3667页

作者： marie Pierik Paul Rutgeerts robert Vlietinck Severine Vermeire Department of Gastroenterology University Hospital GasthuisbergLeuvenBelgium Department of Epidemiology and Human Genetics Katholieke Universiteit LeuvenLeuvenBelgium

Pharmacogenetics is the study of the association between variability in drug response and （or） drug toxicity and polymorphisms in genes. The goal of this field of science is to adapt drugs to a patient＇s specific genetic background and therefore make them more efficacious and safe. In this article we describe the variants in genes that influence either the efficacy or toxicity of common drugs used in the treatment of inflammatory bowel diseases （IBD）, ulcerative colitis （UC）, and Crohn＇s disease （CD） including sulfasalazine and mesalazine, azathioprine （AZA） and 6-mercaptopurine （6-MP）, methotrexate （MTX）, glucocorticosteroids （CSs） and infliximab. Furthermore, difficulties with pharmacogenetic studies in general and more specifically in IBD are described. Although pharmacogenetics is a promising field that already contributed to a better understanding of some of the underlying mechanisms of action of drugs used in IBD, the only discovery translated until now into daily practice is the relation between thiopurine S-methyltransferase （TPMT） gene polymorphisms and hematological toxicity of thiopurine treatment. In the future it is necessary to organize studies in well characterized patient cohorts who have been uniformly treated and systematically evaluated in order to quantitate drug response more objectively. An effort should be made to collect genomic DNA from all patients enrolled in clinical drug trials after appropriate informed consent for pharmacogenetic studies.

关键词： Inflammatory bowel disease Pharmaco-genetics Crohn's disease Ulcerative colitis

ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation

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Cellular & Molecular Immunology 2021年第8期18卷 1904-1919页

作者： Yawei Liu robert Bockermann Mahdieh Hadi Iman Safari Belinda Carrion marie Kveiborg Shohreh Issazadeh-Navikas Neuroinflammation Unit Biotech Research&Innovation Centre(BRIC)Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark BRIC Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark

A disintegrin and metalloproteinase(ADAM)12 was previously found to be expressed in T cells in the inflamed ***,the function of ADAM12 in T-cell responses in general and in tissue inflammation has not been ***,we studied the role of ADAM12 in T-cell responses,fate determination on activation,and its functions in T cells to mediate tissue *** identified ADAM12 as a costimulatory molecule that is expressed on naive T cells and downregulated on ***12 mimics CD28 costimulatory signaling to activate and induce the proliferation of T-helper 1(Th1)*** ADAM12 Fab antibodies trigger T-cell activation by amplifying TCR signaling to stimulate T-bet-mediated IFNγ*** of genomic ADAM12 and its knockdown in T cells diminished T-bet and IFNγproduction in Th1 cells,whereas other T cells,including Th17 cells,were ***12 had similar functions in vivo on myelin antigen(MOG_(35-55))-induced T-cell *** found that genetic loss of ADAM12 profoundly alleviated Th1-mediated neuroinflammation and thus disease severity in experimental autoimmune encephalomyelitis,a model of multiple *** profiling of MOG_(35-55)-specific ADAM12^(−/−)T cells revealed differentially expressed genes that are important for T-cell activation,proliferation,and costimulatory signaling and Th1 pathogenicity,consistent with their inability to cause T-cell-mediated skin inflammation in a model of adoptive delayed-type *** conclude that ADAM12 is a T-cell costimulatory molecule that contributes to the pathogenesis of tissue inflammation and a potential target for the treatment of Th1-mediated diseases.

关键词： T cells T-bet Th17 EAE DTH GM-CSF

Utility of current thrombophilia screening in young patients with stroke and TIA

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Stroke & Vascular Neurology 2018年第4期3卷 231-236页

作者： Vafa Alakbarzade Alice Taylor marie Scully robert Simister Arvind Chandratheva Hyper-acute Stroke Unit University College London Hospitals NHS Foundation TrustLondonUK Department of Haematology University College London Hospitals NHS Foundation TrustLondonUK

Introduction Approximately 40%of strokes in young adults are *** diagnostic yield of thrombophilia screening remains *** aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack(TIA).Methods We present a retrospective review of all patients with stroke and TIA≤60 years presenting to University College London Hospital stroke unit and daily TIA clinic from 1 January 2015 to 1 August *** clinical records and thrombophilia tests,including factor V Leiden(FVL),prothrombin G20210A mutation(PGM),antiphospholipid antibody(APA),and protein S,C and antithrombin(AT)levels,were *** The mean age of 628 patients with stroke and TIA was 49.1 years(SD 9.2).Thrombophilia testing was performed in 360(57%)patients,including 171 with stroke and 189 with *** tests were found in 50(14%)patients,of whom 24 patients were<50 *** results were found in 36(10%)with acute ischaemic stroke,4(1%)with haemorrhagic stroke and 10(3%)with *** patients(4%)had homozygous/heterozygous FVL or PGM,and 27(7.5%)had positive APA(anticardiolipin antibody,anti-β2 glycoprotein antibody or lupus anticoagulant).Of 27(7.5%)patients with protein C,S or AT deficiency,10(2.8%)had primary deficiency,presumed hereditary with other secondary causes excluded.9%of patients with protein C,S or AT and 27%with APA were followed by confirmatory *** Thrombophilia testing was positive in only 14%of cases *** mutations and protein C,S or AT abnormalities were found rarely and were very uncommon in patients with ***-up of abnormal results was generally poor for all groups,which further limited the impact of the thrombophilia testing policy.

关键词： patients testing TIA

Vertical accuracy evaluation of freely available latest high-resolution(30 m)global digital elevation models over Cameroon(Central Africa)with GPS/leveling ground control points.

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International Journal of Digital Earth 2019年第5期12卷 500-524页

作者： Loudi Yap Ludovic Houetchak Kande robert Nouayou Joseph Kamguia Nasser Abdou Ngouh marie Brigitte Makuate Research Laboratory in Geodesy National Institute of CartographyYaound3Cameroon Department of Physics Faculty of SciencesUniversity of Yaoundé1YaoundéCameroon

Digital Elevation Models(DEMs)contain topographic relief data that are vital for many geoscience *** study relies on the vertical accuracy of publicly available latest high-resolution(30 m)global DEMs over *** models are(1)the ALOS World 3D-30 m(AW3D30),(2)the Shuttle Radar Topography Mission 1 Arc-Second CBand Global DEM(SRTM 1)and(3)the Advanced Spaceborne Thermal Emission and Reflection Global DEM Version 2(ASTER GDEM 2).After matching their coordinate systems and datums,the horizontal positional accuracy evaluation was carried out and it shows that geolocation errors significantly influence the vertical accuracy of global *** this,the three models are compared among them,in order to access random and systematic effects in the elevation data each of them ***,heights from 555 GPS/leveling points distributed all over Cameroon are compared to each DEM,for their vertical accuracy *** and robust statistical measures,normality test,outlier detection and removal were used to describe the vertical quality of the *** test of the normality rejected the hypothesis of normal distribution for all tested global *** vertical accuracies obtained for the three models after georeferencing and gross error removal in terms of Root Mean Square(RMS)and Normalized Median Absolute Deviation(NMAD)are:AW3D30(13.06 m and 7.75 m),SRTM 1(13.25 m and 7.41 m)and ASTER GDEM 2(18.87 m and 13.30 m).Other accuracy measures(MED,68.3% quantile,95% quantile)supply some evidence of the good quality of AW3D30 over ***,the effect of land cover and slope on DEM vertical accuracy was also *** models have proved to be worse in the areas dominated by forests and shrubs *** 1 and AW3D30 are more resilient to the effects of the scattering objects respectively in forests and cultivated *** dependency of DEMs accuracy on the terrain roughness is *** all slope intervals,AW3D30 is performing

关键词： DEM AW3D30 SRTM 1 ASTER GDEM 2 Cameroon GPS/leveling orthometric heights vertical accuracy