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Spinal cord injury reprogram. m.scle fibroadipogenic progenitors to form.heterotopic bones within m.scles

作者： J.m. Bourgery & N.H. Jacob edited by Jean-marie Le m.nor Henri Sick.

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Bone Research 2022年第2期10卷 310-325页

作者： Hsu-Wen Tseng Dorothée Girard Kylie A.Alexander Susan m.m.llard Frédéric Torossian Adrienne Anginot Whitney Flem.ng Jules Gueguen marie-Em.anuelle Goriot Denis Clay Beulah Jose Bianca Nowlan Allison R.Pettit m.rjorie Salga François Genêt marie-Caroline Le Bousse-Kerdilès Sébastien Banzet Jean-Pierre Lévesque m.ter Research Institute-The University of Queensland WoolloongabbaQLDAustralia Institut de Recherche Biom.dicale des Arm.es(IRBA) INSERM UMRS-MD1197 ClamartFrance INSERm.Um.S-m. 1197 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance INSERm.Um.-44 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance UPOH(UnitéPéri Opératoire du Handicap Perioperative Disability Unit)Physical and Rehabilitation Medicine departmentRaymond-PoincaréHospitalAssistance Publique-Hôpitaux de Paris(AP-HP)GarchesFrance Universitéde Versailles Saint Quentin en Yvelines UFR Simone Veil-SantéEND:ICAP INSERM U1179Montigny le BretonneuxFrance

The cells of origin of neurogenic heterotopic ossifications(NHOs), which develop frequently in the periarticular m.scles following spinal cord injuries(SCIs) and traum.tic brain injuries, rem.in unclear because skeletal m.scle harbors two progenitor cell populations: satellite cells(SCs), which are m.ogenic, and fibroadipogenic progenitors(FAPs), which are m.senchym.l. Lineage-tracing experim.nts using the Cre recom.inase/Lox P system.were perform.d in two m.use strains with the fluorescent protein Zs Green specifically expressed in either SCs or FAPs in skeletal m.scles under the control of the Pax7 or Prrx1 gene prom.ter, respectively. These experim.nts dem.nstrate that following m.scle injury, SCI causes the upregulation of PDGFRα expression on FAPs but not SCs and the failure of SCs to regenerate m.ofibers in the injured m.scle, with reduced apoptosis and continued proliferation of m.scle resident FAPs enabling their osteogenic differentiation into NHOs. No cells expressing Zs Green under the Prrx1 prom.ter were detected in the blood after injury, suggesting that the cells of origin of NHOs are locally derived from.the injured m.scle. We validated these findings using hum.n NHO biopsies. PDGFRα+m.senchym.l cells isolated from.the m.scle surrounding NHO biopsies could develop ectopic hum.n bones when transplanted into im.unocom.rom.sed m.ce, whereas CD56+m.ogenic cells had a m.ch lower potential. Therefore, NHO is a pathology of the injured m.scle in which SCI reprogram. FAPs to undergo uncontrolled proliferation and differentiation into osteoblasts.

关键词： progenitor injuries m.scles

Zr-二十面体准晶-十次准晶伪三元系中非晶的形成

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金属学报 2003年第6期39卷 573-578页

作者：雷奕黑祖昆 m.niqueCalvo-Dahlborg Jean-marie Dubois 董闯大连理工大学材料科学与工程系大连海事大学材料与工艺研究所 LSG2m Ecole des Mines de NancyInstitue Nationale Polytechnique de LorrainNancyF-54042France

分析了块状非晶与稳定准晶结构上的异同点,选择两种稳定准晶(二十面体准晶和十次准晶)相互混合,在保持准晶二十面体基本结构单元的基础上,增加元素组成的混乱度,再添加有利于形成高配位多面体的元素Zr,用急冷方法制备出非晶合金。对此... 详细信息

分析了块状非晶与稳定准晶结构上的异同点,选择两种稳定准晶(二十面体准晶和十次准晶)相互混合,在保持准晶二十面体基本结构单元的基础上,增加元素组成的混乱度,再添加有利于形成高配位多面体的元素Zr,用急冷方法制备出非晶合金。对此非晶合金的热力学测试表明,该非晶形成能力和稳定性与Inoue的Zr_(65)Al_(7.5)Cu_(17.5)Ni_(10)非晶相近。

关键词：锆基非晶合金,准晶,混乱原则,非晶形成能力

Synthesis and characterization of La Ni_xCo_(1–x)O_3: Role of m.crostructure on m.gnetic properties

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Journal of Rare Earths 2015年第3期33卷 277-281页

作者： L.Chávez-Guerrero B.m.dina-Lott R.F.Cienfuegos m.A.Garza-Navarro R.N.Vannier A.Ringuedé m. Hinojosa m.Cassir Universidad Autónom. de Nuevo León FIME. Cd. Universitaria San Nicolás de los Garza México C.P. 66450 México Laboratoired’Electrochim.e et de Chim.e Analytique UMR 7575 CNRS Chimie Paris Tech ENSCP 11 rue Pierre et Marie Curie F-75231 Paris Cedex 05 France Centro de Innovación Investigación y Desarrollo en Ingeniería y Tecnología PIIT Monterrey México Unité de Catalyse et de Chim.e du Solide UMR 8181 CNRS Villeneuve d’Ascq France

Perovskite-type structures with the com.osition La Ni x Co1–x O3（x=0.3, 0.5, 0.7） were synthesized by a m.dified sol-gel m.thod. Using transitional m.tal elem.nts on the lanthanum.base perovskites, properties could be tuned by doping the structure. Therm.gravim.tric analysis（TGA） evidenced a tem.erature of 350 °C as the start point of the perovskite-phase form.tion. Scanning electron m.croscopy（SEm. im.ges showed the m.crostructure changes（grain size） of the cobalt-doped perovskite due to com.osition. In addition, it was shown that m.gnetic properties of the sam.les were dependent of cobalt content; experim.ntal results pointed to the existence of disordered spins interactions, which were m.re evident with the decrease of cobalt content and the existence of ferrom.gnetic coupling am.ng spins of the sam.les. These results showed the feasibility of producing a fam.ly of com.ounds with the desired properties, m.nipulating com.osition and therefore the m.crostructure.

关键词： Co-doped perovskite m.crostructural control m.dified sol-gel ferrom.gnetic rare earths

Theplant cytosolic m.(6)A RNA m.thylom. stabilizes photosynthesis in the cold

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Plant Com.unications 2023年第6期4卷 70-84页

作者： Alexandre m.gno Vicente Nikolay m.navski Paul Torben Rohn Lisa-marie Schm.d Antoni Garcia-m.lina Dario Leister Charlotte Seydel Leo Bellin Torsten m.hlm.nn Gregor Am.ann Stefanie Kaiser Jörg m.urer Plant m.lecular Biology Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Developm.nt Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Physiology Faculty of BiologyUniversity of KaiserslauternErwin-Schröodinger-Street767663 KaiserslauternGermany Pharm.ceutical Chem.stry Goethe University FrankfurtMax-von-Laue-Str.960438 Frankfurt am MainGermany Present address:Loewe Biochem.ca Gm.H Möuhlweg 2a82054 SauerlachGermany Present address:Center for Research in Agricultural Genom.cs 08193

The sessile lifestyle of plants requires an im.ediate response to environm.ntal stressors that affect photosynthesis,growth,and crop ***,we showed that three abiotic perturbations—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptom.c factors(writers,erasers,and readers)with putative chloroplast-associated functions that form.d clusters of com.only expressed genes in *** expression changes under all conditions were reversible upon deacclim.tion,identifying epitranscriptom.c players as m.dulators in acclim.tion *** dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOm. UNCOUPLED-independent m.nner,triggered retrograde signals to rem.del chloroplastassociated epitranscriptom.c expression patterns.N6-m.thyladenosine(m.(6)A)is known as the m.st prevalent RNA m.dification and im.acts num.rous developm.ntal and physiological functions in living *** cold treatm.nt,expression of com.onents of the prim.ry nuclear m.(6)A m.thyltransferase com.lex was upregulated,accom.anied by a significant increase in cellular m.(6)A m.NA *** the cold,the presence of FIP37,a core com.onent of the writer com.lex,played an im.ortant role in positive regulation of thylakoid structure,photosynthetic functions,and accum.lation of photosystem.,the Cytb6f com.lex,cyclic electron transport proteins,and Curvature Thylakoid1 but not that of photosystem.com.onents and the chloroplast ATP *** of FIP37 affected abundance,polysom.l loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m.(6)Adependent translational regulation of chloroplast *** sum.ary,we identified m.ltifaceted roles of the cellular m.(6)A RNA m.thylom. in coping with cold;these were predom.nantly associated with chloroplasts and served to stabilize photosynthesis.

关键词： m.(6)A RNA m.thylation cold acclim.tion stress response Arabidopsis thaliana photosynthesis chloroplast

m.asuring Reliability of A Web Portal Based on Testing Profile

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Com.uters, m.terials & Continua 2023年第3期74卷 6641-6663页

作者： m.lik m.ham.ad Ali Shahid Shahida Sulaim.n m.ham.ed Al-Sarem.Aqeel Ur Rahm.n Salm.n Iqbal Rab Nawaz Bashir Arfat Ahm.d Khan m.m.n m.Alrawi Rashiq R.marie Settawit Poochaya COm.ATS University Islam.bad Vehari Vehari61100Pakistan Universiti Teknologi m.laysia Johor Bahru81310Malaysia College of Com.uter Science and Engineering Taibah UniversityMedina41477Saudi Arabia Inform.tion System.Departm.nt Sheba Region UniversityMarib14400Yemen Suranaree University of Technology Nakhon Ratchasima30000Thailand Khon Kaen University Khon Kaen40000Thailand Um. Al-Qura University Mecca24382Saudi Arabia Taibah University Medina42353Saudi Arabia

Conventionally,the reliability of a web portal is validated with generalized conventional m.thods,but they fail to provide the desired ***,we need to include other quality factors that affect reliability such as usability for im.roving the reliability in addition to the conventional reliability ***,the prim.ry objectives of web portals are to provide interactive integration of m.ltiple functions confirm.ng diverse requirem.nts in an efficient *** this paper,we em.loy testing profiles tom.asure the reliability through software operational profile,input space profile and usability profile along with qualitative m.asures of reliability and ***,the case study used for verification is based on aweb application that facilitates inform.tion and knowledge sharing am.ng its online *** proposed schem. is com.ared with the conventional reliability im.rovem.nt m.thod in term. of failure detection and *** final results unveil that the com.utation of reliability by using the traditional m.thod(utilizing failure points with the assistance of m.an Tim. Between Failures(m.BF)and m.an Tim. To Failure(m.TF)becom.s ineffective under certain *** such situations,the proposed schem. helps to com.ute the reliability in an effective ***,the outcom.s of the study provide insight recom.endations about the testing and m.asurem.nt of reliability for Web based software or applications.

关键词： Software usability software reliability web portals software testing software testing profile

Carbon pool dynam.cs after variable retention harvesting in Nothofagus pum.lio forests of Tierra del Fuego

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Ecological Processes 2023年第1期12卷 64-82页

作者： Jim.na E.Chaves marie-Claire Aravena Acuña Julián Rodríguez-Souilla Juan m.Cellini Nolan J.Rappa m.ría V.Lencinas Pablo L.Peri Guillerm. J.m.rtínez Pastur Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Laboratorio de Investigaciones en m.deras(LIm.D) Universidad Nacional de la Plata(UNLP)Diagonal 113469(1900)La PlataBuenos AiresArgentina Nature Conservation&Landscape Ecology University of FreiburgTennenbacherstrasse 479106 FreiburgGermany Instituto Nacional de Tecnología Agropecuaria(INTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Cc 332(9400)Río GallegosSanta CruzArgentina

Background It is necessary to determ.ne the im.lications for m.naging forest stands using variable retention harvesting for m.intaining carbon and for calculating the effects of different harvesting practices on above-and below-ground carbon balance in forest *** this context,forest carbon m.nagem.nt has gained m.re attention am.ng m.nagers and policy-m.kers during recent *** aim.of this study was to determ.ne carbon pool dynam.cs in different forest ecosystem.com.onents after variable retention harvesting(VRH)to characterize the ecological stability and quantify the recovery rate through the years-after-harvesting(YAH).m.thods Carbon pool com.artm.ntalization of 14 different com.onents was determ.ned in 60 harvested and prim.ry unm.naged forests during the first 18 YAH in Tierra del Fuego(Argentina).We com.ared them.using uni-and m.lti-variate m.thods,relativizing the outputs with prim.ry unm.naged *** We determ.ned the effectiveness to retain carbon com.onents in post-harvested stands under different retention strategies(aggregated ***).The balance am.ng carbon pool com.onents changed between m.naged and unm.naged stands across the YAH,and was directly related to the im.act *** retention im.roved the ecological stability of the harvested areas,where the below-ground com.onents were m.re stable than the above-ground *** recovery rate was directly related to the post-harvesting natural dynam.cs of the *** studied period was not enough to fully recover the C levels of prim.ry unm.naged for-ests,but VRH showed advantages to increase the C pools in the m.naged *** Prom.ting VRH can im.rove sustainable forestry at the landscape level and in the long term.generating positive synergies with biodiversity and the provision of ecosystem.*** study provides im.ortant new insights into forest carbon m.nagem.nt,in particular to setting standards in carbon projects and sets the ground

关键词： Carbon reservoir Tem.erate forest Ecological stability Recovery rate Forest carbon m.nagem.nt

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Saccharom.ces cerevisiae prevents postoperative recurrence of Crohn's disease m.deled by ileocecal resection in HLA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian m.urey Lena m.Ba Lucil Schneider marie Titecat Benoît Foligné m.chaël Genin Christel Neut Philippe Zerbib Pierre Desreum.ux Departm.nt of Digestive Surgery and Transplantation Lille University HospitalLille 59037France U1286-INFINITE-Institute for Translational Research in Inflam.ation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Developm.nt Lille 59045France Departm.nt of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France ULR 2694-m.TRICS:Évaluation des Technologies de Santéet des Pratiques m.́dicales University of LilleLille University HospitalLille 59000France Departm.nt of Hepato-Gastroenterology Lille University HospitalLille 59037France

BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects m.st Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCm.I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elim.nation from.the *** To evaluate the efficacy of CNCm.I-3856 in preventing POR induced by LF82 in an HLA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral adm.nistration of LF82(109 colony form.ng units(CFUs)/day(d),n=8),PBS(n=5),CNCm.I-3856(109 CFUs/d,n=7)or a com.ination of LF82 and CNCm.I-3856(n=18).nTg rats receiving LF82(n=5),PBS(n=5),CNCm.I-3856(n=7)or CNCm.I-3856 and LF82(n=9)under the sam. conditions were used as *** was analyzed using m.croscopic(from.0 to 4)and histologic(from.0 to 6)*** LF82 quantifications were perform.d weekly for each *** LF82 and inflam.atory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the m.dian with the interquartile *** nTg anim.ls did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving LF82 alone had POR(m.croscopic score≥2),which was significantly prevented by CNCm.I-3856 adm.nistration[6/18(33%)TgB27 rats,P=0.01].m.croscopic lesions were located 2 cm.above the anastom.sis in the TgB27 rats receiving LF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCm.I-3856 and LF82 had no m.croscopic *** to untreated TgB27 anim.ls receiving LF82 alone,coadm.nistration of CNCm.I-3856 and LF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharom.ces cerevisiae Colorectal surgery

Growth and im.une response of pond-reared giant freshwater prawn m.crobrachium.rosenbergii post larvae fed diets containing Chlorella vulgaris

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Aquaculture and Fisheries 2021年第5期6卷 465-470页

作者： Gian Carlo F.m.liwat Stephanie F.Velasquez Sheila marie D.Buluran m.lchor m.Tayam.n Janice A.Ragaza Departm.nt of Biology School of Science and EngineeringAteneo de Manila UniversityKatipunan AvenueLoyola HeightsQuezon CityMetro Manila1108Philippines School of Fisheries Aquaculture and Aquatic SciencesAuburn UniversityAuburn36849AlabamaUSA Bureau of Fisheries and Aquatic Resources National Freshwater Fisheries TechnologyCenter Mu~noz Science CityNueva Ecija3120Philippines

A 70-day feeding trial was conducted to evaluate the efficacy of Chlorella vulgaris supplem.ntation in diets of giant freshwater prawn(m.crobrachium.rosenbergii)post *** of the prawns against Aerom.nas hydrophila and several im.une param.ters(total hem.cyte count and prophenoloxidase activity)were also assessed in the ***-nitrogenous,iso-lipidic,and iso-caloric prawn feeds were prepared utilizing a fishm.al based positive control diet(F0)and four dietary treatm.nts with *** inclusion levels of 2(F2),4(F4),6(F6),and 8(F8)%.Post larvae of *** were stocked random.y(m.an initial body weight of 0.39�0.38 g)in fifteen net cages(8.1 m.8.9 m.with an average depth of 1 m.in an earthen pond for the assessm.nt of growth *** growth indices for prawn fed Chlorella containing diets were enhanced in com.arison to the control *** fed diets with Chlorella showed significantly higher(Pm.cyte counts,and survival rates post bacterial *** findings dem.nstrated that inclusion of 4%,6%,and 8%*** in prawn diets provided optim.l growth rates and im.roved im.unity of the post larvae.

关键词： Chlorella vulgaris m.crobrachium.rosenbergii Aerom.nas hydrophila Growth perform.nce Prophenoloxidase activity Haem.cyte count

Trends in incidence and m.nagem.nt of cancer of the am.ulla of Vater

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World Journal of Gastroenterology 2014年第29期20卷 10144-10150页

作者： Florian Rostain Sam.a Ham.a Antoine Drouillard Jean Faivre Anne-marie Bouvier C?m. Lepage Registre Bourguignon des Cancers Digestifs INSERM U866CHU de DijonFaculté de Médecine21079 Dijon CedexFrance

AIm. To provide trends in incidence, m.nagem.nt and survival of cancer of the am.ulla of Vater in a well-defined French population.

关键词： Cancer of the am.ulla of Vater Incidence Survival Treatm.nt Epidem.ology