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Prognosis Factors of Urinary Quality of Life in Parkinson Disease

Open Journal of Therapy and Rehabilitation 2024年第1期12卷 10-17页

作者： Ngor Side Diagne Sakhi Othman Ababacar Mamadou Gueye marie jeanne sakho Fatou Dialo Mboup Amélie Ndeye Makarame Sy Papa Ndiouga Lo Ba Seydina Ousmane Anna Modji Basse Maouly Fall Adjaratou Dieynaba Sow Moustapha Ndiaye Amadou Gallo Diop Physical Médicine and Rehabilitation Department Fann Teaching Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal Physical Médicine and Rehabilitation Department Ibn Rochd Teaching Hospital Casablanca Morocco Physical Médicine and Rehabilitation Department Military Hospital Dakar Senegal Neurology Department Fann Teaching Hospital Dakar Senegal

Introduction: Quality of life in Parkinson disease is not necessary linked to motor symptoms. It’s correlated of overactive bladders and prostatic symptoms. Prognosis factors of urinary quality of life are unknown. Objectives: Our study aims to find prognosis factors of quality of life associated specifically of urinary disorders in PD. Patients and methods: We conducted a transversal, analytic and descriptive study in Physical Medicine, and Neurology departments, Fann Teaching Hospital, Dakar and included patients followed for treatment of PD. Urinary disorders, quality of life and functional autonomy were assessed respectively by Urinary Symptoms Profile (USP), Qualiven Short Form, Schwab and England Scale. Results: 38 patients presented PD, with a mean age of 60.89 ± 13.6 years and sex-ratio of 2.45. Mean duration of PD was 3.1 ± 2.9 years. Urinary disorders were found in 47.36% and dominated by incontinence (88.88%) and overactive bladders (88.88%) which were minor in more than 55%. Quality of life was impaired in 88.88% of cases. Minor forms (43.75%) were predominant and constraint dimension (50%) was the most severely altered. Prognosis factors for quality of life of urinary disorders were PD stages (0.046) and functional autonomy (0.042). Discussion and conclusion: Urinary disorders in PD are common, impaired quality of life, especially the constraint dimension, depends on stage of evolution of PD and functional autonomy of patients.

关键词： Urinary Quality of Life Parkinson Disease Dakar

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Uniformity in premating reproductive isolation along an intraspecific cline

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Current Zoology 2018年第5期64卷 641-652页

作者： jeanne marie ROBERTSON Roman NAVA Andrds VEGA Kristine KAISER Department of Biology California State University Northridge 18111 Nordhoff Street Northridge CA 91330-8303 USA Naturel History Museum of Los Angeles County 900 Exposition Boulevard Los Angeles CA 90007 USA Department of Biology San Diego State University 5500 Campanile Drive San Diego CA 92116 USA AMBICOR 400 E. 75 S. 75 E. de la Municipalidad de Tibas Tibas Costa Rica

Premating reproductive isolation (RI) may reduce gene flow across populations that have differentiated in traits important for mate choice. Examining RI across genetic and phenotypic clines can inform the fundamental evolutionary processes that underlie population and lineage differentiation. We conducted female mate-choice studies across an intraspecific red-eyed treefrog cline in Costa Rica and Panama with 2 specific aims: (1) to characterize RI across the cline and examine the relationship between premating RI and genetic and phenotypic distance and (2) to evaluate our results within a broader evolutionary and taxonomic perspective through examination of other RI studies. We found that female red-eyed treefrogs prefer local males relative to non-local males, indicating that some premating RI has evolved in this system, but that preference strength is not associated with phenotypic or geographic distance. Our analysis of 65 other studies revealed no clear pattern between the strength of RI and geographic distribution (allopatry, parapatry, cline) or phenotypic distance, but revealed extreme variation and overlap in levels of intra- and interspecific levels of RI. This work contributes to a growing body of literature that examines intraspecific RI across a cline to understand the selective processes that shape evolutionary patterns at the earliest stages of divergence.

关键词：繁殖一致性地理距离基因流动配偶选择进化过程哥斯达黎加进化模式

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Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation

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World Journal of Gastroenterology 2022年第22期28卷 2509-2522页

作者： Florian Mourey Amélie Decherf Jean-François jeanne Mathieu Clément-Ziza marie-Lise Grisoni François Machuron Sophie Legrain-Raspaud Arnaud Bourreille Pierre Desreumaux Research and Applications Department Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France Data Science and Bioinformatics Laboratory Research and Development DepartmentLesaffre InternationalLesaffre GroupMarcq-en-Baroeul 59700France Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de NantesNantes 44093France Institute for Translational Research in Inflammation Centre Hospitalier Universitaire de LilleLille 59000France

BACKGROUND Probiotics are a promising solution for managing irritable bowel syndrome(IBS).Saccharomyces cerevisiae(***)I-3856 has already demonstrated beneficial effects in IBS subjects,particularly in IBS with predominant constipation(IBS-C).AIM To confirm the efficacy of *** I-3856 in the management of gastrointestinal symptoms in *** A randomized,double-blind,placebo-controlled clinical study was performed in a total of 456 *** a run-in period,subjects were randomly assigned to the group receiving *** I-3856(8×109 CFU daily)or the placebo for 8 wk,and they performed daily self-evaluations of gastrointestinal *** primary objective was to assess the effect of the probiotic on abdominal *** secondary objectives were the evaluation of other gastrointestinal symptoms,bowel movement frequency and consistency,and quality of life(QOL).RESULTS A significantly higher proportion of abdominal pain responders was reported in the Probiotic group(45.1%vs 33.9%,P=0.017).A nonsignificant difference in the area under the curve for abdominal pain over the second month of supplementation was observed in subjects receiving probiotic vs placebo[P=0.073,95%CI:-0.59(-1.23;0.05)].No statistically significant differences were reported in the evolution of bowel movement frequency and stool consistency between the *** 8 wk of supplementation,the overall QOL score was significantly higher in the Probiotic group than in the Placebo group[P=0.047,95%CI:3.86(0.52;7.20)].Furthermore,exploratory analyses showed statistically significant and clinically relevant improvements in QOL scores in abdominal pain responders vs *** The results of this clinical study confirmed the abdominal pain alleviation properties of *** I-3856 in *** pain relief was associated with improved *** identifier:NCT03150212.

关键词： Probiotic Yeast Saccharomyces cerevisiae Irritable bowel syndrome Abdominal pain Quality of life

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RIP140 regulates POLK gene expression and the response to alkylating drugs in colon cancer cells

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Cancer Drug Resistance 2022年第2期5卷 401-414页

作者： Pascale Palassin Marion Lapierre Sandrine Bonnet marie-jeanne Pillaire Balázs Győrffy Catherine Teyssier Stéphan Jalaguier Jean-Sébastien Hoffmann Vincent Cavaillès Audrey Castet-Nicolas IRCM Institut de Recherche en Cancérologie de MontpellierINSERMU1194Institut Régional du Cancer de MontpellierUniversitéde MontpellierMontpellier 34298France Institut de Pharmacologie et de Biologie Structurale IPBSUniversitéde ToulouseCNRSUPSToulouse 31077France. Department of Bioinformatics Semmelweis University and TTK Lendület Cancer Biomarker Research GroupBudapest H-1117Hungary Laboratoire de pathologie Laboratoire d’excellence Toulouse CancerInstitut Universitaire du Cancer-ToulouseOncopoleToulouse 31059France Département de Pharmacie Clinique Centre Hospitalo-Universitaire MontpellierMontpellier 34295France. Unitéde Formation et de Recherche des Sciences Pharmaceutiques et Biologiques Montpellier 34090France.

Aim:The transcription factor RIP140(receptor interacting protein of 140 kDa)is involved in intestinal *** plays a role in the control of microsatellite instability(MSI),through the regulation of MSH2 and MSH6 gene *** aim of this study was to explore its effect on the expression of POLK,the gene encoding the specialized translesion synthesis(TLS)DNA polymeraseκknown to perform accurate DNA synthesis at ***:Different mouse models and engineered human colorectal cancer(CRC)cell lines were used to analyze by RT-qPCR,while Western blotting and luciferase assays were used to elucidate the role of RIP140 on POLK gene *** DNA microarray datasets were *** in vitro sensitivity of CRC cells to methyl methane sulfonate and cisplatin was ***:RIP140 positively regulates,at the transcriptional level,the expression of the POLK gene,and this effect involves,at least partly,the p53 tumor *** different cohorts of CRC biopsies(with or without MSI),a strong positive correlation was observed between RIP140 and POLK gene *** connection with its effect on POLK levels and the TLS function of this polymerase,the cellular response to methyl methane sulfonate was increased in cells lacking the Rip140 ***,the association of RIP140 expression with better overall survival of CRC patients was observed only when the corresponding tumors exhibited low levels of POLK,thus strengthening the functional link between the two genes in human ***:The regulation of POLK gene expression by RIP140 could thus contribute to the maintenance of microsatellite stability,and more generally to the control of genome integrity.

关键词： Colorectal cancer genome stability translesion DNA synthesis polymerase Pol Kappa RIP140

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Inorganic Elements in Eggs of Two Cavity-Nesting Passerine Species at and around Los Alamos National Laboratory, Los Alamos, New Mexico

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Journal of Environmental Protection 2018年第9期9卷 932-947页

作者： Shannon marie Gaukler Charles Dean Hathcock jeanne marie Fair Environmental Stewardship Group Los Alamos National Laboratory Los Alamos NM USA Biosecurity and Public Health Los Alamos National Laboratory Los Alamos NM USA

Los Alamos National Laboratory (LANL) was established in 1943 as part of the Manhattan Project to build nuclear weapons, and currently operates as a national research laboratory. As part of an ongoing assessment of site-related ecological risk at LANL, western bluebird (Sialia mexicana) and ash-throated flycatcher (Myiarchus cinerascens) eggs were collected from 1997 to 2012 and analyzed for 18 inorganic elements. Concentrations of many inorganic elements in eggs were below reporting limits. Between species comparisons revealed that western bluebird eggs had higher levels of barium while ash-throated flycatcher eggs had higher levels of mercury. No statistically significant differences were observed in concentrations of inorganic elements in western bluebird eggs collected from the study area (which consists of areas within the current and historic LANL boundary) and from a non-industrial reference site;nor were any statistically significant differences observed between two canyons of interest, known to have received effluents and storm water runoff from LANL facilities, and the non-industrial reference site. Inorganic element levels detected in western bluebirds were typically within the range measured in eggs of other passerine in the published literature. These data suggest that concentrations of inorganic elements in passerine eggs collected from the study area appear to be at levels causing negligible risks to local bird populations.

关键词： Ash-Throated Flycatcher Biomonitoring Metals Western Bluebird

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Rude Awakening

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语言教育 1997年第11期 37-38页

作者： jeanne marie Laskas 张江云

I was driving late one night, alone. This was not easy, as twofeet of snow lay on the road. The heck with what lane I was in:I was just trying to keep my car pointed forward. A guy behind me in a *four-wheel-drive vehicle began flash-ing his headlights. I figured there must be some danger ahead orthat something was wrong with my ca. So I slowed down.

关键词： something night behind ahead danger alone Rude Awakening slowed wrong trying

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CERN的ISOLDE装置上的ECR离子剥离器Phoenix的最新进展(英文)

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Chinese Physics C 2007年第S1期31卷 216-218页

作者： M.marie-jeanne P.Delahaye CERN GenevaCH-1211Switzerland LPSCGrenobleF-38000France Université Joseph FourierGrenobleF-38000France CERN GenevaCH-1211Switzerland

At ISOLDE (CERN),an on-line test bench is dedicated to charge breeding experiments with a 14GHz Phoenix ion source,for the investigation of the 1+→n+ scenario at next generation ISOL-type *** year,various technical developments have been undertaken for intensifying the tests of the on- line performances of the booster with a high diversity of stable and radioactive ion *** contribution will present an overview of the latest developments,the current challenges,and some perspectives for the future use of the Phoenix booster for physics experiments at ISOLDE.

关键词： ion sources charge breeding mass and energy spectrometer

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Diagnostic and Therapeutic Options of Breast Cancer Patients in Yaounde, Cameroon

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Advances in Breast Cancer Research 2022年第1期11卷 50-62页

作者： Jean Dupont Kemfang Ngowa Hortense jeanne Fouedjio Annaïk Morelle Tchami Julienne Louise Ngo Likeng Christelle Domngang Noche Brigitte Wandji Djouonang Florent Fouelifack Ymele Pascal Foumane Emile Telesphore Mboudou Pierre marie Tebeu Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon University of Montagnes Bangangté Cameroon Catholic University of Central Africa Yaounde Cameroon Higher Institute of Medical Technology Nkolondom Cameroon

Introduction: Breast cancer remains a public health problem due to its severity and because it is the leading cause of death from cancers in women worldwide as well as in Cameroon. Our objective was to study the diagnostic and therapeutic options that patients followed for breast cancer choose in Yaounde. Method: This was an analytical cross-sectional study with prospective data collection among patients followed for breast cancer at two referral hospitals in Yaounde from February 1, 2019 to August 31, 2019. Data collected were recorded and analyzed using R application version 3.5.0., p va

关键词： Breast Cancer Traditional Medicine Therapeutic Abstention Naturopathy Contemporary Medicine

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Caring for Individuals with Early-Onset Dementia and Their Family Caregivers: The Perspective of Health Care Professionals

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Advances in Alzheimer's Disease 2014年第1期3卷 33-43页

作者： Francine Ducharme marie-jeanne Kergoat Pascal Antoine Florence Pasquier Renée Coulombe Centre de Recherche Institut Universitaire de Gériatrie de Montréal Montréal Canada Centre National de Référence pour les Patients Jeunes Atteints de la Maladie d’Alzheimer et Maladies Apparentées Lille France Faculty of Nursing Université de Montréal Montréal Canada Unité de Recherche en Sciences Cognitives et Affectives (URECA) Maison Européenne des Sciences de l’Homme et de la Société (MESHS) Université Lille 3 Charles de Gaulle Lille France

The phenomenon of early-onset dementia remains an under-researched subject from the perspective of health care professionals. The aim of this qualitative study was to document the experiences and service needs of patients and their family caregivers for optimal clinical management of early-onset dementia from the perspective of health care professionals. A sample of 13 health care professionals from various disciplines, who worked with individuals who suffered from Alzheimer’s disease or related disorders and their family caregivers, took part in focus groups or semi-structured individual interviews, based on a life course perspective. Three recurrent themes emerged from the data collected from health care professionals and are related to: 1) identification with the difficult experiences of caregivers and powerlessness in view of the lack of services;2) gaps in the care and services offered, including the lack of clinical tools to ensure that patients under age 65 were diagnosed and received follow-up care, and 3) solutions for care and services that were tailored to the needs of the caregiver-patient dyads and health care professionals, the most important being that the residual abilities of younger patients be taken into account, that flexible forms of respite be offered to family caregivers and that training be provided to health care professionals. The results of this study provided some innovative guidelines for optimal clinical management of early-onset dementia in terms of the caregiver-patient dyad.

关键词： Early-Onset Dementia Family Caregivers Perspective of Health Care Professionals Service Needs

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Impacts of Environmental Management on the Quality of Traditional Well Water in the Soubre Region(South-West of Cote d’Ivoire)

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Journal of Water Resource and Protection 2017年第13期9卷 1634-1644页

作者： Ohou-Yao marie jeanne Adelaide Ouattara Leygnima Yaya Yapo Ossey Bernard Mambo Veronique UFR Environment University Jean Lorougnon GuédéDaloaIvory Coast UFR Science and Environmental Management University Nangui AbrogouaAbidjanIvory Coast Central Environmental Laboratory Ivorian Central for Pollution ControlAbidjanIvory Coast

Water supply is a global problem. A study was conducted on twelve (12) traditional wells water in Daba Dagnogo and Gnipi 2 to determine their physico-chemical quality. Two sampling campaigns (dry season and rainy season), were performed on 16 physical and chemical parameters. The results show that the water is acidic with an average pH of 6.41 ± 0.4;moderately mineralized with an average conductivity of 731.14 ± 611.98 μS·cm-1;moderately saline with an average rate of 1.56 ± 1.22. The average temperature of 28.07 ± 0.86°C is above the norm for all wells. All major ions are consistent with WHO standards except calcium and potassium. 41.67% of wells exceed the standard ammonium ion whose average was 1.43 ± 2.79 mg·L-1 nitrate and 100% with an average of 492.42 ± 434.02 mg·L-1. The ion concentrations are highest in the urban area and are higher in the dry season. The quality of the water sampled wells deteriorated. Several factors affect the degradation, namely the shallow wells, their proximity to toilet, the lack of sanitation and poor management of household waste. It will carry out a campaign to educate people to protect the immediate environment of the water points, avoiding the deposit of garbage and to provide the appropriate wells lids.

关键词： Soubré Traditional Wells Physico-Chemical Quality Environmental Management

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