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Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana

Chinese journal of Integrative Medicine 2010年第4期16卷 337-343页

作者： Victor Kuete Marlise D.j.Dongfack Armelle T.Mbaveng marie-Christine Lallemand Hanh T.Van-Dufat jean-Duplex Wansi Elisabeth Seguin Francois Tillequin jean Wandji Department of Biochemistry Faculty of ScienceUniversity of Dschang.P.O.Box 67 DschangCameroon Department of Organic Chemistry Faculty of ScienceUniversity of Yaounde I.P.O.Box 812 YaoundeCameroon Laboratoire de Pharmacognosie de I'Universite Paris Descartes UMR/CNRS N° 8638Faculte des Sciences Biologiques et Pharmaceutiques4-Avenue de I'Observatoire75006 ParisFrance Department of Biochemistry Faculty of ScienceUniversity of Yaounde IP.O.Box 812 YaoundeCameroon Department of Chemistry University of DoualaFaculty of ScienceP.O.Box 24157 DoualaCameroon Laboratoire de Pharmacognosie UFR de Medecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France

Objective： To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana, fractions （DTB1-5） as well as compounds [friedelin （2）, 3,7-dioxofriedelane （3）, 3,15-dioxofriedelane （4）, 313 -O-（E）-3,5-dihydroxycinnamoyl-11 -oxo-olean-12-ene （6）, and 313,6 α -dihydroxylup- 20（29）-ene （7）. Methods： Agar disc diffusion was used to determine the sensitivity of the above samples, whilst the microdilution method was used for the determination of the minimal inhibitory concentration （MIC） and the minimal microbicidal concentrations （MMC）. Results： The diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. The inhibitory effect of the fraction DTB2 was noted on 63.7%, that of DTB1 and DBT3 on 54.6%, whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4, 36.7% for compound 6, and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples, MICs were detected on 0-63.7%. The lowest MIC value （78.12 μg/mL） for the crude extract and fractions （DTB2） was observed on M. audouinii. The corresponding value for isolated compounds （156.25 μg/ mL） was noted with compounds 3 on S. faecalis and 4 on M. audouinii. The results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. Conclusion： The methanol extract from the stem bark of Drypetes. tessmanniana （Euphorbiaceae） as well as some of the isolated compounds might be potential sources of new antimicrobial drues.

关键词： Drypetes tessmanniana Euphorbiaceae compounds antimicrobial activity

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Control of light emission of quantum emitters coupled to silicon nanoantenna using cylindrical vector beams

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Light(Science & Applications) 2023年第10期12卷 2248-2255页

作者： Martin Montagnac Yoann Brûlé Aurélien Cuche jean-marie Poumirol Sébastien j.Weber jonas Müller Guilhem Larrieu Vincent Larrey Franck Fournel Olivier Boisron Bruno Masenelli Gérard Colas des Francs Gonzague Agez Vincent Paillard CEMES-CNRS Universitéde ToulouseToulouseFrance ICB Universitéde BourgogneCNRSDijonFrance LAAS-CNRS Universitéde ToulouseToulouseFrance CEA-LETI UniversitéGrenoble-AlpesGrenobleFrance Universitéde Lyon UniversitéLyon 1CNRS UMR 5510ILMVilleurbanneFrance Universitéde Lyon INSA LyonCNRSEcole Centrale de LyonUniversitéLyon 1CPEUMR 5270INLVilleurbanneFrance Bruno Masenelli

Light emission of europium(Eu^(3+))ions placed in the vicinity of optically resonant nanoantennas is usually controlled by tailoring the local density of photon states(LDOS).We show that the polarization and shape of the excitation beam can also be used to manipulate light emission,as azimuthally or radially polarized cylindrical vector beam offers to spatially shape the electric and magnetic fields,in addition to the effect of silicon nanorings(Si-NRs)used as *** photoluminescence(PL)mappings of the Eu^(3+)transitions and the Si phonon mappings are strongly dependent of both the excitation beam and the Si-NR *** experimental results of Raman scattering and photoluminescence are confirmed by numerical simulations of the near-field intensity in the Si nanoantenna and in the Eu^(3+)-doped film,*** branching ratios obtained from the experimental PL maps also reveal a redistribution of the electric and magnetic emission *** results show that it could be possible to spatially control both electric and magnetic dipolar emission of Eu^(3+)ions by switching the laser beam polarization,hence the near field at the excitation wavelength,and the electric and magnetic LDOS at the emission *** paves the way for optimized geometries taking advantage of both excitation and emission processes.

关键词： excitation cylindrical spatially

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The moon

The moon

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作者： edited by Lerke Rydal jorgensen and marie Laurberg

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Eosinophil associated genes in the inflammatory bowel disease 4 region:Correlation to inflammatory bowel disease revealed

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World journal of Gastroenterology 2012年第44期18卷 6409-6419页

作者： Kristin Blom jenny Rubin jonas Halfvarson Leif Trkvist Anders Rnnblom Per Sangfelt Mikael Lrdal Ulla-Britt jnsson Urban Sjqvist Lena Douhan Hkansson Per Venge marie Carlson Department of Medical Sciences Clinical ChemistryUppsala University HospitalSE-75185 UppsalaSweden Division of Gastroenterology Department of Intestinal Medicinerebro University HospitalSE-70185 rebroSweden School of Health and Medical Sciences rebro UniversitySE-70185 rebroSweden IBD Clinical research group Karolinska University HospitalSE-17177 StockholmSweden Department for Clinical Science Intervention and TechnologyKarolinska University HospitalSE-17177 StockholmSweden Department of Medical Sciences Gastroenterology Research GroupUppsala UniversitySE-75185 UppsalaSweden Department of Medicine Karolinska InstitutetSE-17177 StockholmSweden

AIM:To study the association between inflammatory bowel disease(IBD) and genetic variations in eosinophil protein X(EPX) and eosinophil cationic protein(ECP).METHODS:DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn's disease(CD),592 with ulcerative colitis(UC) and 300 healthy *** EPX405(G > C,rs2013109),ECP434(G > C,rs2073342) and ECP562(G > C,rs2233860) gene polymorphisms were analysed,by the 5'-nuclease allelic discrimination *** determination of intracellular content of EPX and ECP in granulocytes,39 blood samples was collected and extracted with a buffer containing cetyltrimethylammonium *** intracellular content of EPX was analysed using an enzyme-linked immunosorbent *** intracellular content of ECP was analysed with the UniCAP system as described by the *** tests for calculations of results were χ 2 test,Fisher's exact test,ANOVA,Student-Newman-Keuls test,and Kaplan-Meier survival curve with Log-rank test for trend,the probability values of P ject's genotype frequencies of ECP434(GG = 57%,GC = 38%,CC = 5%;P = 0.010) and ECP562(GG = 68%,GC = 29%,CC = 3%;P = 0.009).The genotype frequencies for females,with an age of disease onset of ≥ 45 years with CD(n = 62),was for the ECP434 and ECP562 genotypes GG = 37%,GC =52%,CC = 11% and GG = 48%,GC = 47% and CC = 5% *** was also statistically different from healthy controls for both ECP434(P = 0.010) and ECP562(P = 0.013).The intracellular protein concentration of EPX and ECP was calculated in μg/10 6 eosinophils and then correlated to the EPX 405 *** protein content of EPX was highest in the patients with the C

关键词：嗜酸性粒细胞肠道疾病曲线显示炎症相关基因 Fisher精确检验基因型频率蛋白质含量

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The Introduction of Bedaquiline Regimen for Drug-Resistant Tuberculosis in the Philippines: An Operational Study

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journal of Tuberculosis Research 2022年第4期10卷 205-219页

作者： Vincent M. Balanag jr. Vivian S. Lofranco Mariquita j. Mantala Mary Rosary T. Santiago Patrice jamie E. Cabasis Arnyl G. Araneta Anna marie Celina G. Garfin Lung Center of the Philippines National Center for Pulmonary Research Quezon Philippines Department of Health National Tuberculosis Control Program Management Office Manila Philippines Philippine Business for Social Progress The Global Fund Project Manila Philippines Department of Health Disease Prevention and Control Bureau Manila Philippines

Objectives: Bedaquiline (BDQ) is the first new anti-tuberculosis (TB) drug introduced to the market after 45 years. Recent studies have shown the potential benefits of adding bedaquiline to regimens for drug-resistant TB (DR-TB). In search of more effective regimens for DR-TB, bedaquiline was introduced in the TB program in the Philippines under operational research to assess its effectiveness, safety, and tolerability when given with background regimens among patients with multi-or extensively DR-TB (MDR/XDR-TB). Design: A prospective cohort study of patients with MDR/XDR-TB was given with a bedaquiline-containing regimen from june 2016 to May 2017. Demographic data, presence of comorbidities, and microbiologic profile on entry were recorded. Bedaquiline was administered at the recommended dose of 400 mg once daily for 14 days, then 200 mg three times a week for 22 weeks together with World Health Organization (WHO)-compliant background regimen. The time to culture conversion, interim outcomes at the 6th month of treatment, end-of-treatment outcomes, and post-treatment follow-up outcomes after one year was determined. The frequency and severity of adverse events (SAE) were recorded as part of pharmacovigilance. Results: Seventy-five patients were given with bedaquiline-containing regimen during the study period. Forty-two (56.0%) had second-line injectable resistance, 23 (30.7%) had fluoroquinolone-resistance, 6 (8.0%) had MDR-TB, and 4 (5.3%) had XDR-TB. In the 6th month of post-enrolment, 79% were culture-negative. The treatment success rate was 65.3% (37 were cured and 12 completed treatment), 7 (9.3%) died, 17 (22.7%) lost to follow-up, and 2 (2.7%) were withdrawn from treatment. Adverse events included vomiting (80%), dizziness (69%), nausea (52%), cough (44%), and headache (36%). The post-treatment follow-up of 49 patients in the 12th month showed 92% were culture-negative while 8% of TBC were not done. Conclusion: Bedaquiline-containing regimens for patients

关键词： Bedaquiline Drug-Resistant TB XDR-TB

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Loss of Surround Inhibition and After Sensation as Diagnostic Parameters of Complex Regional Pain Syndrome

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Neuroscience & Medicine 2012年第4期3卷 344-353页

作者： marie Wojcik Wolanin Robert j. Schwartzman Guillermo Alexander john Grothusen Department of Neurology Drexel University College of Medicine Philadelphia USA

Complex Regional Pain Syndrome (CRPS) is a severe chronic pain condition. Patients with CRPS experience allodynia, hyperalgesia, autonomic dysfunction, movement difficulties and dystrophic changes. However other characteristics that may be unique to the pain in CRPS require further study. This study evaluated pain parameters in ninety five subjects composed of three groups: healthy pain free controls, patients with radiculopathy and CRPS patients. Healthy subjects were tested in all four extremities, whereas radiculopathy and CRPS patients were tested only on the most affected extremity. All subjects were tested for the following pain parameters: thermal allodynia, mechanical static and dynamic allodynia, windup, and a hyperalgesic mechanical stimulus. All subjects were also evaluated for autonomic dysfunction, movement disorder and dystrophic skin changes. Statistically significant differences were found between both pain groups and the healthy control subjects as well as between the two pain groups. The finding that statistically differentiated CRPS from radiculopathy and normal controls was pain spread following an algesic mechanical and cold stimulus as well as after sensations to these stimuli. The study demonstrated a simple bedside test that discriminated between CRPS, radiculopathy and healthy control subjects.

关键词： CRPS Complex Regional Pain Syndrome Radiculopathy Pain After Sensation Spread Chronic Pain

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Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

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World journal of Gastroenterology 2012年第14期18卷 1579-1589页

作者： Sébastien AB Roy marie-josée Langlois julie C Carrier Franois Boudreau Nathalie Rivard Nathalie Perreault Canadian Institutes of Health Research Team on Digestive Epithelium Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada Canadian Institutes of Health Research Team on Digestive Epithelium Service of GastroenterologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada

AIM:To investigate the impact of phosphatase and tensin homolog(Pten) in the specification of intestinal enteroendocrine ***:Using the Cre/loxP system,a mouse with conditional intestinal epithelial Pten deficiency was *** mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain *** was collected on 16 h fasted mice by cardiac ***-linked immunosorbent assay was used to measure blood circulating ghrelin,somatostatin(SST) and glucose-dependent insulinotropic peptide(GIP) ***:Results show an unexpected dual regulatory role for epithelial Pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small *** data indicate that Pten positively regulates chromogranin A(CgA) expressing subpopulations,including cells expressing secretin,ghrelin,gastrin and cholecystokinin(CCK).In contrast,Pten negatively regulates the enteroendocrine subtype specification of non-expressing CgA cells such as GIP and SST expressing ***:The present results demonstrate that Pten signalling favours the enteroendocrine progenitor to specify into cells expressing CgA including those producing CCK,gastrin and ghrelin.

关键词：内分泌细胞调节作用磷酸酶同源物肠道亚型蛋白张力

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Polypeptide analysis for nanopore-based protein identification

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Nano Research 2022年第11期15卷 9831-9842页

作者： Mazdak Afshar Bakshloo Safia Yahiaoui Fabien Piguet Manuela Pastoriza-Gallego Régis Daniel jérôme Mathé john j.Kasianowicz Abdelghani Oukhaled CY Cergy Paris Université CNRSLAMBE95000CergyFrance UniversitéParis-Saclay Univ EvryCNRSLAMBE91025Evry-CourcouronnesFrance University of South Florida Dept.of PhysicsTampaFL 33620USA Freiburg Institute for Advanced Studies Universität FreiburgFreiburg 79104Germany

Presently,proteins are identified by cleaving them with proteases,measuring the mass to charge ratio of the fragments with a mass spectrometer,and matching the fragments to segments within known proteins in *** earlier demonstrated that a nanometer-scale pore formed by aerolysin(AeL)can discriminate between,and therefore identify,three similar size proteins from their trypsin-cleaved polypeptide *** this nanopore-protease method,the protein’s identity is instead determined from characteristic ionic current blockade patterns caused by the polypeptide fragments that enter the *** results also suggested that not all of the theoretically expected cleavage products partition into the *** better understand the mechanism by which polypeptide fragments are captured,and how different polypeptides reduce the pore’s ionic current,we studied the effects of 11 identical length polypeptides with different net charges and charge *** show that under certain experimental conditions,negative,positive,and neutral polypeptides are driven into the AeL pore by the same applied voltage *** capture rate and dwell time of polypeptides in the pore depend strongly on the ionic strength,the magnitude of the applied voltage,and the net charge and charge distribution of the *** dwell time distribution depends nonmonotonically on the applied voltage(regardless of the polymer’s net charge),and its maximum value depends on the polypeptide net charge and charge *** maximum dwell time for different polypeptides does not occur at the same applied voltage amplitude,which conceivably might complicate the detection and discrimination of some polypeptide *** additional experiments,computer simulations,and artificial intelligence research are needed to better understand how to optimize the partitioning of enzymatically cleaved fragments into the AeL nanopore,the method is still capable of accurately identifying

关键词： protein identification nanopores trypsin enzymatic degradation

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In vitro anthelminthic efficacy of Dichrocephala integrifolia(Asteraceae)extracts on the gastro-intestinal nematode parasite of mice:Heligmosomoides bakeri(Nematoda,Heligmosomatidae)

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Asian Pacific journal of Tropical Biomedicine 2013年第2期3卷 100-104页

作者： Wabo Poné j Payne V K Mbogning Tayo Gertrude Komtangi marie Claire Yondo jeannette Ngangout Alidou M Mpoame Mbida Bilong Bilong CF Laboratory of Applied Biology and Ecology(LABEA) Department of Animal BiologyFaculty of ScienceUniversity of Dschang Laboratory of General Biology Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé1

Objective:To evaluate the ovicidal and larvicidal activities of aqueous and ethanolic extracts of leaves of Dichrocephala integrifolia(***)against the eggs(fresh and embryonnated),the first and second larval stages of Heligmosomoides *** order to verify if this medicinal plant possesses active compounds capable of inhibiting the embryonation and hatching of eggs or to induce the mortality of larvae(L1 and L2).Methods:Dried extracts were diluted in distilled water to obtain five different concentrations:625,1 250,2500,3750 and 5000μg/*** eggs obtained from artificially infected mice feces were exposed to these different concentrations for 48 *** of contact for embryonated eggs was 6 h while L1 and L2 larvae were exposed for 24 *** water(placebo)and 1.5%DMSO were used as negative ***:Distilled water,and1.5%DMSO had no effect on embryonation,hatching and larval *** extracts of *** showed a weak activity against all stages of the parasite at all concentrations *** the contrary,the ethanolic extract of *** inhibited the embryonation of 87.5%of fresh eggs,the hatching of 81.1%of embryonated eggs and induced the mortality of 98.1%and 98%of L1 and L2 larvae respectively at 5000μg/***:The results of the present study indicate that the ethanolic extracts of *** contained compounds with ovicidal and larvicidal *** spite of these results,in vivo tests,studies on toxicity and mechanism of action of active compounds are also needed to validate the utilisation of this medicinal plant by population of Dschang-Cameroon to treat gastro-intestinal parasites.

关键词： Dichrocephala integrifolia Heligmosomoides bakeri In vitro Eggs Larvac

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Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis

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journal of Geriatric Cardiology 2018年第4期15卷 261-267页

作者： Marjo jAG De Ronde-Tillmans Tom Aj de jager jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWj. Utens Francesco US Mattace-Raso marie j Lenzen Peter PT de jaegere Erasmus Medical Center Department of Cardiology Thorax Center Rotterdam the Netherlands Erasmus Medical Center Section of Geriatrics Department of Internal Medicine Rotterdam the Netherlands Erasmus Medical Center Department of Child and Adolescent Psychiatry/Psychology Sophia Children 's Hospital Rotterdam the Netherlands The Netherlands Research Institute of Child Development and Education University of Amsterdam the Netherlands

BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相... 详细信息

BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 *** 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估，用短 Form-36 ( SF-36 )，吗 EuroQoL-5D ( EQ-5D )和 *** 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚?

关键词：大动脉阀门培植狭窄征兆质量生活风险

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