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Viro-immune therapy:A new strategy for treatment ofpancreatic cancer

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World Journal of Gastroenterology 2016年第2期22卷 748-763页

作者： Andrea marie Ibrahim Yao-he Wang Centre for Molecular Oncology Barts Cancer InstituteQueen Mary University of LondonEC1M6BQ LondonUnited Kingdom National Centre for International Research in Cell and Gene Therapy Sino-British Research Centre for Molecular OncologyZhengzhou UniversityZhengzhou 450000Henan provinceChina

Pancreatic ductal adenocarcinoma(PDAC) is an almost uniformly lethal disease with less than 5% survival at five years. This is largely due to metastatic disease, which is already present in the majority of patients when diagnosed. Even when the primary cancer can be removed by radical surgery, local recurrence occurs within one year in 50%-80% of cases. Therefore, it is imperative to develop new approaches for the treatment of advanced cancer and the prevention of recurrence after surgery. Tumour-targeted oncolytic viruses(TOVs) have become an attractive therapeutic agent as TOVs can kill cancer cells through multiple mechanisms of action, especially via virus-induced engagement of the immune response specifically against tumour cells. To attack tumour cells effectively, tumour-specific T cells need to overcome negative regulatory signals that suppress their activation or that induce tolerance programmes such as anergy or exhaustion in the tumour microenvironment. In this regard, the recent breakthrough in immunotherapy achieved with immune checkpoint blockade agents, such as anti-cytotoxic T-lymphocyte-associate protein 4, programmed death 1(PD-1) or PD-L1 antibodies, has demonstrated the possibility of relieving immune suppression in PDAC. Therefore, the combination of oncolytic virotherapy and immune checkpoint blockade agents may synergistically function to enhance the antitumour response, lending the opportunity to be the future for treatment of pancreatic cancer.

关键词： anti-cytotoxic T-lymphocyte-associateprotein 4 Anti-programmed death receptor ligand 1 Anti-programmed death receptor 1 Immunotherapy Oncolytic viruses Pancreatic ductal adenocarcinoma Pancreatic cancer Immune checkpoint blockadeinhibitors cancer vaccine

Psychiatric morbidity after surgery for inflammatory bowel disease:A systematic review

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World Journal of Gastroenterology 2017年第48期23卷 8651-8659页

作者： marie Strom Zangenberg Alaa El-Hussuna Center for Surgical Science Department of SurgeryZealand University Hospital Department of Surgery Aalborg University Hospital

AIM To examine the evidence about psychiatric morbidity after inflammatory bowel disease(IBD)-related surgery. METHODS PRISMA guidelines were followed and a protocol was published at PROSPERO(CRD42016037600). Inclusion criteria were studies describing patients with inflammatory bowel disease undergoing surgery and their risk of developing psychiatric disorder. RESULTS Twelve studies(including 4340 patients) were eligible. All studies were non-randomized and most had high risk of bias. Patients operated for inflammatory bowel disease had an increased risk of developing depression,compared with surgical patients with diverticulitis or inguinal hernia,but not cancer. In addition,patients with Crohn's disease had higher risk of depression after surgery compared with non-surgical patients. Patients with ulcerative colitis had higher risk of anxiety after surgery compared with surgical colorectal cancer patients. Charlson comorbidity score more than three and female gender were independent predictors for depression and anxiety following surgery. CONCLUSION The review cannot give any clear answer to the risks of psychiatric morbidity after surgery for IBD studies with the lowest risk of bias indicated an increased risk of depression among surgical patients with Crohn's disease and increased risk of anxiety among patients with ulcerative colitis.

关键词： Inflammatory bowel disease General surgery Psychiatry Depression Anxiety Postoperative complications

Extra-intestinal and long term consequences of Giardia duodenalis infections

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World Journal of Gastroenterology 2013年第47期19卷 8974-8985页

作者： marie CM Halliez André G Buret Department of Biological Sciences Inflammation Research NetworkUniversity of CalgaryCalgaryAlbertaAB T2N 1N4Canada Parasitology Department Rouen University Hospital & EA 3800 Institute for Biomedical & Research University of RouenRouen76183France

Giardiasis is the most common waterborne parasitic infection of the human intestine *** etiological agent,Giardia duodenalis(***,***),is a flagellated,binucleated protozoan parasite which infects a wide array of mammalian *** giardiasis is a true cosmopolitan pathogen,with highest prevalence in developing *** can present with a broad range of clinical manifestations from asymptomatic,to acute or chronic diarrheal disease associated with abdominal pain and *** infections are self-limiting,although re-infection and chronic infection can *** evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense *** causes of the post-infectious clinical manifestations due to Giardia,even after complete elimination of the parasite,remain *** review offers a state-of-the-art discussion on the long-term consequences of Giardia infections,from extra-intestinal manifestations,growth and cognitive deficiencies,to post-infectious irritable bowel *** discussion also sheds light on some of the novel mechanisms recently implicated in the production of these postinfectious manifestations.

关键词： Giardiasis Inflammatory disorders Extraintestinal manifestations of enteritis Failure to thrive Post-infectious irritable bowel syndrome

Biology and control of the fruit borer, Conopomorpha sinensis Bradley on litchi （Litchi chinensis Sonn.） in northern Thailand

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Insect Science 2007年第6期14卷 525-529页

作者： marie JOY SCHULTE KONRAD MARTIN JOACHIM SAUERBORN Institute of Plant Production and Agroecology in the Tropics and Subtropics University of Hohenheim Stuttgart Germany

Fruit and leaf shoot of litchi （Litchi chinensis） infestation by naturally occurring populations of the fruit bprer, Conopomorpha sinensis larvae and C. sinensis parasitization rates were determined in litchi orchards in northern Thailand at high （ca. 1 400 m ASL） and low （ca. 800 m ASL） elevations with different, non-overlapping fruiting seasons. In addition, spray applications of Bacillus thuringiensis var. aizawai, the natural compound spinosad and the chemical pesticide imidacloprid were conducted in the field to test the effects of these agents on C. sinensis fruit infestation rate. Fruit infestation rate and fruit growth, studied in a low elevation orchard, were sigmoidal and showed a highly significant positive correlation （P ≤ 0.01）. Leaf shoot infestation rate in the low elevation orchard decreased in the course of the fruiting season （March until May）, but increased in the high elevation orchard, where no fruits were present within the same period of time. Together, these results indicate that females of C. sinensis clearly prefer fruits over shoots for oviposition. If no fruits are available, which was the case in the high elevation orchard during that time, they are constrained to lay their eggs on shoots. The parasitization rate of C. sinensis larvae in untreated fruits was 54.3%. The parasitoid species were Chelonus chailini （90.8%） and Phanerotoma sp. （9.2%）. In the leaf shoots, C. sinensis was found to be parasitized by Phanerotoma sp. and Apanteles briareus. The applications of the different active agents had no significant effect on C. sinensis fruit infestation compared to the untreated control. Besides the cryptic life of the larvae, this is most probably explained by the fact that C. sinensis has several generations during the fruiting season. Because of the high parasitization rates recorded, an alternative and more effective control measure than the application of pesticides might be the augmentative release of parasitoids.

关键词： Conopomorpha sinensis fruit infestation Litchi chinensis northern Thailand,parasitoids pest control

Incorporating Optimal Operation Strategies into Investment Planning for Wind/Electrolyser System

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 347-359页

作者： Yi Zheng Shi You Henrik W.Bindner marie Munster the Department of Electrical Engineering Technical University of Denmark2800 Kgs.LyngbyDenmark the Department of Technology Management and EconomicsTechnical University of Denmark2800 Kgs.LyngbyDenmark

As a conducive and prevalent technique for producing green hydrogen,hybrid wind-based electrolyzer system requires both effective planning and operation to realize its techno-economic *** of the existing studies are focused on either of these two,but none of them sufficiently emphasize on their *** this paper,we propose a two-stage multi-objective optimization framework to reveal optimal investment plans considering various operational strategies,such as economic revenue maximization and green hydrogen production *** results reveal that:1)A trade-off exists between system investment and the capacity to accomplish optimal operational *** example,the system demands flexibility to boost operational profits,but this results in high investment costs.2)Differentiated operation objectives generate different component capacities during the planning phase.3)Regarding a wind-hydrogen system with gas storage,the Pareto optimal design manifesting the trade-off between system investment and prime operational performance can be actualized along the margins of a feasible solution.

关键词： Hybrid wind-hydrogen system multi-objective optimization optimal operation planning sizing

A corpus-based approach to understanding market access in fisheries and aquaculture international business research:A systematic literature review

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Aquaculture and Fisheries 2019年第6期4卷 219-230页

作者： Cheryl marie Cordeiro Nofima The Norwegian Institute of FoodFisheries and Aquaculture ResearchMuninbakken 9BreivikaTromsø9291Norway

Although fisheries and aquaculture studies might seem marginal to international business(IB)studies in general,fisheries and aquaculture IB(FAIB)management is currently facing increasing pressure to meet global demand and consumption for fish in the next coming *** part address to this challenge,the purpose of this systematic review of literature(SLR)study is to investigate the use of the term‘market access’in its context of use in the generic literature and business sector discourse,in comparison to the more specific literature and discourse in fisheries,aquaculture and *** SLR aims to uncover the knowledge/interest gaps between the academic subject discourses and business sector *** driven in methodology and using a triangulation method of three different text analysis softwares including AntConc,VOSviewer and Web of Science(WoS)analytics,the SLR results indicate a gap in conceptual knowledge and business practices in how market access is conceived,studied and managed in the pharmaceutical and healthcare marketing industry in comparison to fisheries and ***'s complexity is directly acknowledged in the 2030 Agenda for Sustainable Development and Zero *** while the product orientation of different business sectors might differ,this SLR study works with the assumption that both business sectors are international in orientation,and complex in their operations from product to *** that extent,research scholars and practitioners in FAIB will need to broaden their efforts in understanding the multiplicity of forces that influences fisheries and aquaculture and its international orientation towards both emerging as well as mature *** SLR suggests a conceptual model in understanding the challenges,the potential barriers as well as avenues for solutions to developing market access for FAIB.

关键词： Market access Fisheries and aquaculture International business Systematic literature review Concordance analysis Bibliometric analysis Research methods

Testicular sperm extraction(TESE)outcomes in the context of malignant disease:a systematic review

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Asian Journal of Andrology 2022年第6期24卷 584-590页

作者： Ludmilla Ogouma Isabelle Berthaut Rachel Lévy Rahaf Haj Hamid marie Prades marie Audouin Nathalie Sermondade Charlotte Dupont Fertility Center(Service de Biologie de la Reproduction CECOS) Tenon Hospital(AP-HPSorbonne-Universite)Paris F-75020France Sorbonne University Saint Antoine Research CenterInserm Us938Paris F-75012France Fertility Center Diaconesses HospitalParis F-75012France

Advances in the oncology field have led to improved survival ***,quality of life after remission is anticipated,which includes the possibility to conceive *** cancer treatments are potentially gonadotoxic,fertility preservation must be *** fertility preservation is mainly based on ejaculated sperm *** this is not possible,testicular sperm extraction(TESE)may be *** identify situations in which TESE has been beneficial,a systematic review was *** search was carried out on the PubMed,Scopus,Google Scholar,and CISMeF databases from 1 January 2000 to 19 March *** Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)recommendations were followed in selecting items of ***-four articles were included in the systematic review,including 15 articles on oncological testicular sperm extraction(oncoTESE),18 articles on postgonadotoxic treatment TESE and 1 article on both oncoTESE and postgonadotoxic treatment *** sperm freezing was possible for 42.9%to 57.7%of patients before gonadotoxic treatment and for 32.4%to 75.5%of patients after gonadotoxic treatment,depending on the type of malignant *** no formal conclusion could be drawn about the chances to obtain sperm in specific situations,our results suggest that TESE can be proposed before and after gonadotoxic *** treatment,TESE is more often proposed for men with testicular cancer presenting with azoospermia since TESE can be performed simultaneously with tumor removal or *** chemotherapy,TESE may be planned if the patient presents with persistent azoospermia.

关键词： cancer fertility preservation oncological testicular sperm extraction spermatozoa testicular sperm extraction

Silkworm silk biomaterials for spinal cord repair: promise for combinatorial therapies

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Neural Regeneration Research 2018年第5期13卷 809-810页

作者： Anna Varone Ann marie Rajnicek Wenlong Huang Institute of Medical Sciences University of Aberdeen

Background：Traumatic injury to the adult mammalian spinal cord results in minimal axonal regrowth,cystic cavity formation at the injury site,poor functional recovery and there is no cure *** to the complex nature of spinal cord injury（SCI）,a combination of therapeutic strategies may offer the most promise for successful regeneration（Ahuja et al.,2017）.

关键词： SCI Figure Silkworm silk biomaterials for spinal cord repair promise for combinatorial therapies

Improved outcome with standardized plan for clinical management of acute decompensated chronic heart failure

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Journal of Geriatric Cardiology 2019年第1期16卷 12-18页

作者： marie-Louise Edvinsson Albin Stenberg Karin Astrom-Olsson Department of Emergency and Internal Medicine University'Hospital of LundSweden Institute of Clinical Sciences L und UniversityL undSweden Department of Cardiology University>Hospital of MalmoSweden

Background Our overall goal is to improve clinical care for inpatients with chronic heart failure(CHF).A retrospective assessment of CHF patients admitted to our hospital over the past decade(2005 vs.2014)indicated a need for better strategies to evaluate clinical treatment,implement best practices and achieve optimal patient *** that purpose,we developed a standardized plan to improve in-hospital treatment of acute decompensated CHF ***&Results Retrospective chart reviews were conducted to compare three cohorts of CHF patients admitted to the University Hospital of Lund at different time points over a 12-year period:2005(365 patients),2014(172 patients)and 2017-2018(57 patients).Little improvement was seen between 2005 and 2014 with respect to one-year mortality(35%vs.34%)and adequate treatment with recommended medications,e.g.,use of renin-angiotensin system blockers(45%vs.51%).A standardized treatment plan was devised to improve outcomes.A third cohort,treated under the plan(2017-2018),was compared with the 2014 ***-year mortality(18%vs.34%)and 30-day readmission(5%vs.30%)were dramatically decreased,and adherence to medication guidelines was *** elements of the plan included well-defined treatment procedures,enhanced communication and teamwork,education,adequate time for treatment(5 days)and post-discharge follow-up as *** peptide(NT-proBNP)levels were useful for assessing patient status,prognosis and response to *** Developmeof a standard plan for clinical management of acute decompensated CHF patients resulted in significant improvements in patient outcome,as reflected in decreased rates of 30-day readmission and one-year mortality.

关键词： Chronic heart failure Medication NT-proBNP Prognosis