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Macular vascularisation changes analysed using OCT angiography after successful rhegmatogenous retinal detachment repair

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 81-87页

作者： marie hartmann Alaa Din Abdin Doris Fraenkel Christian Munteanu Berthold Seitz Shady Suffo Department of Ophthalmology Saarland University Medical CenterHomburg/Saar 66421Germany

AIM:To analyse the macular vascularisation changes analysed using optical coherence tomography angiography(OCTA)after successful rhegmatogenous retinal detachment(RRD)repair by comparing gas vs silicone oil and macula-on vs ***:This retrospective data collection included 77 eyes with RRD that underwent pars plana vitrectomy(PPV)and gas or silicone oil *** performed an OCTA during the postoperative control between 6 and 24mo after the last surgery and evaluated the main parameters measured by OCTA:foveal avascular zone(FAZ)and parafoveolar vascular density(PVD)in the superficial capillary *** patients were divided into four groups:RRD with macular involvement treated with gas tamponade,RRD without macular involvement treated with gas tamponade,RRD with macular involvement treated with silicone oil tamponade and RRD without macular involvement treated with silicone oil tamponade.A one-way ANOVA test combined with post hoc Bonferroni corrections compared FAZ sizes and PVD in all four ***:The FAZ size was statistically significantly larger in eyes with RRD involving the macula than in those not involving it(P=0.005).There was no statistically significant difference in the FAZ sizes of the eyes treated with silicone oil tamponade compared to those treated with gas tamponade(P=0.54).There was no statistically significant difference in the PVD comparing all four ***:Despite the known risks associated with silicone oil,our findings suggest that the type of tamponade used during PPV to treat an RRD has no significant effect on the future integrity of the PVD or the size of the FAZ in the superficial capillary plexus as measured by OCTA.

关键词： retina vitrectomy optical coherence tomography angiography

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Limited potential of resolvin D1 in treatment of cholestatic liver fibrosis

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 587-596页

作者： Kerstin Abshagen Alexander hartmann Laura Grüner marie Liebig Brigitte Vollmar Institute for Experimental Surgery University Medicine RostockRostockGermany

Background:Several studies suggest a role for EPA-and DHA-derived pro-resolving mediators like resolvins in reversing metabolic and inflammatory disturbances seen in various chronic ***,we investigated the effects of resolvin D1(RvD1)on bile duct ligation(BDL)-induced cholestatic liver ***:Mice were treated daily with RvD1 or 0.1%ethanol(control)from the day of BDL until the final observation time *** and liver tissue were collected 2,5 and 14 days after BDL for different ***:RvD1 treatment of mice had no impact on the extent of cholestatic liver injury upon BDL,neither in the acute phase nor in the progressive state of liver *** RvD1 treatment resulted in a significantly reduced activity of hepatic stellate cells as well as reduced deposition of extracellular matrix 2 days after BDL,mice were not protected from inflammation and further fibrosis ***:These data indicate that RvD1 has a limited therapeutic potential to treat cholestatic liver diseases,as it has no significant impact on regression of hepatic necroinflammation and fibrotic changes in bile duct-ligated mice.

关键词： Lipid mediator n-3 polyunsaturated fatty acids bile duct ligation(BDL) mouse model

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Sendai Five Years on: Reflections on the Role of International Law in the Creation and Reduction of Disaster Risk

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International Journal of Disaster Risk Science 2020年第2期11卷 230-238页

作者： marie Aronsson-Storrier School of Law University of ReadingReading RG66EP.UK

This article offers a critical examination of the position of the Sendai Framework for Disaster Risk Reduction 2015–2030 within international law. It is argued that any interrogation into the relationship between international law and disaster risk reduction(DRR) must begin not with existing DRR laws and policies, but rather with an enquiry into the nature of disaster risk and the role of international law in its creation and reduction. It is demonstrated how, while areas such as international human rights law can be utilized to enforce obligations in support of DRR, other areas—in particular international investment law—actively work to undermine DRR efforts. In order for international law to be a productive tool in the reduction of disaster risk, international lawyers must engage with critical work in disaster studies and explore the role that international law has played, and can play, in creating and addressing hazards, vulnerabilities, and capacities.

关键词： Disaster risk creation Disaster risk reduction International law Sendai Framework

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Determination of Electron Collision Cross Sections Set for Tetramethysilane

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Plasma Science and Technology 2007年第6期9卷 756-759页

作者： marie-Claude BORDAGE Toulouse University LAPLACE UMR 5213 CNRS-UPSPaul Sabatier University118Route de Narbonne31062 Toulouse CedexFrance

A swarm analysis technique based on the solution of the Boltzmann equation is used to derive low energy electron collision cross sections for tetramethylsilane （TMS）. The calculated swarm parameters with this first available cross sections set is consistent with measured values of the swarm parameters. Calculations of transport parameters in mixtures of TMS with argon are also presented.

关键词： tetramethysilane electron cross section swarm parameters

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Exploratory Study of Intolerance of Uncertainty and Its Cognitive Processes by the Stroop Task among Parents of a Childhood Cancer Survivor

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Psycho-Oncologie 2023年第4期17卷 257-266页

作者： marie Vander Haegen Anne-marie Service de Psychologie de la santé/Unitéde Research Unit for a Life-Course Perspective on Health and Education-(RUCHE ULiège)University of LiègeLiège4000Belgium

*** study has examined the relationship between the factor of intolerance of uncertainty and its effects on the cognitive processes among parents of a childhood cancer *** of uncertainty is a central factor in generalized anxiety disorder;an anxiety disorder in which impaired processing of cognitive information in the form of cognitive biases is also *** aim of the study was to measure,via a classical Stroop test and an emotional Stroop test,the orientation of selective attention in relation to the uncertainty intolerance ***.61 parents of a childhood cancer survivor(aged 4 to 6 years)were recruited from hospitals in the Province of Liege(Belgium).Parents completed questionnaires on intolerance of uncertainty and its associated factors(i.e.,usefulness of worry,cognitive avoidance,problem-solving attitude,and ruminations)and performed a Stroop test and an emotional Stroop *** correlations and multiple linear regressions were *** results indicated positive and significant correlations between the emotional Stroop(negative interference index)and intolerance to uncertainty but also with repetitive thoughts(ruminations)and *** regressions showed that depressive symptoms seem to contribute to explaining longer latencies for the interference condition(color word written in another color).*** have been published to improve the management of parents of a childhood cancer survivor,but parent-centered neuropsychological studies are still needed and should be developed to improve prevention and detection initiatives for these families.

关键词： Parents childhood cancer survivor Stroop intolerance of uncertainty

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Direct molecular-level near-field plasmon and temperature assessment in a single plasmonic hotspot

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Light(Science & Applications) 2020年第1期9卷 1673-1685页

作者： marie Richard-Lacroix Volker Deckert Leibniz Institute of Photonic Technology(IPHT) Albert-Einstein-Strasse 9D-07745 JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics University of JenaHelmholtzweg 4D-07743 JenaGermany

Tip-enhanced Raman spectroscopy(TERS)is currently widely recognized as an essential but still emergent technique for exploring the ***,our lack of comprehension of crucial parameters still limits its potential as a user-friendly analytical *** tip’s surface plasmon resonance,heating due to near-field temperature rise,and spatial resolution are undoubtedly three challenging experimental parameters to ***,they are also the most fundamentally relevant parameters to explore,because they ultimately influence the state of the investigated molecule and consequently the probed *** we propose a straightforward and purely experimental method to access quantitative information of the plasmon resonance and near-field temperature experienced exclusively by the molecules directly contributing to the TERS *** detailed near-field optical response,both at the molecular level and as a function of time,is evaluated using standard TERS experimental equipment by simultaneously probing the Stokes and anti-Stokes spectral ***-assembled 16-mercaptohexadodecanoic acid monolayers covalently bond to an ultra-flat gold surface were used as a *** of blinking lines in the spectra also provides crucial information on the lateral resolution and indication of atomic-scale thermally induced morphological changes of the tip during the *** study provides access to unprecedented molecular-level information on physical parameters that crucially affect experiments under TERS *** study thereby improves the usability of TERS in day-to-day *** obtained information is of central importance for any experimental plasmonic investigation and for the application of TERS in the field of nanoscale thermometry.

关键词： straight purely thereby

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Variation of Transition Characteristics in a Wall Jet

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Journal of Thermal Science 2003年第2期12卷 167-170页

作者： marie-Francoise Scibilia Centre National de la Recherche Scientifique ParisFrance

The characteristics of a laminar wall jet submitted to different configurations have been experimentally explored in order to obtain a better knowledge of transition modifications,In fact different parameters can accelerate or delay the transition using a smooth or rough surface,heated or not,submitted to vibrations or not .In this study,significant effects can be *** has been possible to measure the beginning of growth rates of disturbance amplitude using a wind tunnel and comparing the results with the linear stability theory.

关键词： wall jet transition acoustic vibration heat transfer turbulence roughness.

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Density Results in Sobolev Spaces Whose Elements Vanish on a Part of the Boundary

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 823-846页

作者： Jean-marie Emmanuel BERNARD Laboratoire Analyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of Wm＇＂ of functions that vanish on a part γ0 of the boundary. The author gives a crucial estimate of the Poincare constant in balls centered on the boundary of γ0. Then, the convolution-translation method, a variant of the standard mollifier technique, can be used to prove the density of smooth functions that vanish in a neighborhood of γ0, in this subspace. The result is first proved for m = 1, then generalized to the case where m 〉 1, in any dimension, in the framework of Lipschitz-continuous domain. However, as may be expected, it is needed to make additional assumptions on the boundary of γ0, namely that it is locally the graph of some Lipschitz-continuous function.

关键词： Density results Boundary value problems Sobolev spaces

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Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor

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Cellular & Molecular Immunology 2021年第7期18卷 1644-1651页

作者： marie Robert Pierre Miossec Department of Clinical Immunology and Rheumatology and immunogenomics and inflammation research unitUniversity of LyonHôpital Edouard HerriotLyonFrance

Tumor necrosis factor(TNF)inhibitors have improved a lot the treatment of numerous diseases,with the well-known example of rheumatoid arthritis(RA).In the early 2000s,postmarketing data quickly revealed an alarming number of severe tuberculosis(TB)under such *** findings were consistent with previous results in mice where TNF is essential for lymph node formation and granuloma *** effects of TNF inhibition on RA synovium structure are very similar to those on granuloma,with changes in cellular interactions,cytokine,and chemokine *** addition to the role of TNF in granuloma,the interleukin(IL)-12/interferon(IFN)-γpathway is required for an efficient host defense against *** and secondary immunodeficiencies affecting this pathway lead to severe bacillus Calmette-Guérin(BCG)reaction or full *** chronic inflammation as in RA induces a systemic Th1 defect that predisposes to TB through specific downregulation of the IL-12Rß2 *** TNF inhibitors are initiated,this transiently increases this risk of TB,through effects on cellular interactions in a latent TB *** a later stage,when a better control disease activity is obtained,the risk of TB is reduced but not *** the clear benefit from TNF inhibition,latent TB infection screening at baseline is essential for an optimal safety.

关键词： tuberculosis TNF inhibition rheumatoid arthritis cytokines

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Skill Optimization Algorithm:A New Human-Based Metaheuristic Technique

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Computers, Materials & Continua 2023年第1期74卷 179-202页

作者： Hadi Givi marie Hubalovska Department of Electrical Engineering Shahreza CampusUniversity of IsfahanIran Department of Technics Faculty of EducationUniversity of Hradec KraloveCzech Republic

Metaheuristic algorithms are widely used in solving optimization *** this paper,a new metaheuristic algorithm called Skill Optimization Algorithm(SOA)is proposed to solve optimization *** fundamental inspiration in designing SOA is human efforts to acquire and improve *** stages of SOA are mathematically modeled in two phases,including:(i)exploration,skill acquisition from experts and(ii)exploitation,skill improvement based on practice and individual *** efficiency of SOA in optimization applications is analyzed through testing this algorithm on a set of twenty-three standard benchmark functions of a variety of unimodal,high-dimensional multimodal,and fixed-dimensional multimodal *** optimization results show that SOA,by balancing exploration and exploitation,is able to provide good performance and appropriate solutions for optimization *** addition,the performance of SOA in optimization is compared with ten metaheuristic algorithms to evaluate the quality of the results obtained by the proposed *** and comparison of the obtained simulation results show that the proposed SOA has a superior performance over the considered algorithms and achievesmuch more competitive results.

关键词： Optimization human-based skill exploration exploitation metaheuristic algorithm

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