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Click chemistry in the design of AIEgens for biosensing and bioimaging

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聚集体(英文)

聚集体(英文) 2023年第4期4卷 71-92页

作者： marie-claire Giel Yuning Hong Department of Biochemistry and Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia

The development of rapid,selective,and sensitivefluorescent sensors is essential for visualizing and quantifying biological molecules and processes in vitro,ex vitro,and in vivo,which is important for not only fundamental biological studies but the accurate diagnosis of *** emergingfield of activity-based sensing(ABS),a sensing method that utilizes molecular reactivity for analyte detection possesses many advantages including high specificity,sensitivity and *** aggrega-tion caused quenching phenomenon which occurs in most conventionalfluorophores results in reduced labeling efficiency of the target analytes and low photobleaching resistance,therefore limiting the applications of the ABS *** contrast,aggre-gation induced emission(AIE)active luminogens(AIEgens)provide exceptional molecular frameworks for *** the many reaction classes utilized in the AIEgen ABS approach,click chemistry has become increasing *** this review,the sensing concepts of the ABS approach with AIEgens and the principles of click chemistry are discussed,followed by a systematic summary of the application of specific click chemistry reactions in AIEgen ABS protocols for the detection of an array of target ***,the utility of click chemistry in the construction of AIEgens for bioimaging will also be showcased throughout the review.

关键词： activity-based sensing aggregation induced emission bioconjugation chemistry click chemistry

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用振动防治斑衣蜡蝉

环球科学 2024年第13期 16-17页

作者：克莱尔·玛丽·波特张宇哲(翻译) 不详

自从2014年斑衣蜡蝉(spotted lanternfly)入侵美国并在东海岸肆虐以来,人们一直在寻找消灭它们的办法,然而这种昆虫极难被杀灭。它们摧毁了当地的树木和葡萄藤等果树,被美国宾夕法尼亚大学列为150年来可能最具破坏性的昆虫。斑衣蜡蝉的... 详细信息

自从2014年斑衣蜡蝉(spotted lanternfly)入侵美国并在东海岸肆虐以来,人们一直在寻找消灭它们的办法,然而这种昆虫极难被杀灭。它们摧毁了当地的树木和葡萄藤等果树,被美国宾夕法尼亚大学列为150年来可能最具破坏性的昆虫。斑衣蜡蝉的排泄物被昆虫学家称作“蜜露”,其中会滋生多种病原真菌。

关键词：斑衣蜡蝉昆虫学家病原真菌葡萄藤排泄物东海岸

marie claire Moudru水彩作品欣赏

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美与时代（美学）（下） 2016年第2期 F0002-F0002,F0003页

作者： marie claire Moudru

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities

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World Journal of Gastroenterology 2015年第5期21卷 1436-1443页

作者： Jean-Noel Freund Isabelle Duluc Jean-marie Reimund Isabelle Gross claire Domon-Dell INSERM UMR_S1113 Université de StrasbourgFMTS67200 StrasbourgFrance Centre Hospitalier Universitaire de Strasbourg 67200 StrasbourgFrance

The homeoprotein encoded by the intestinal-specific Cdx2 gene is a major regulator of gut development and homeostasis,also involved in colon cancer as well as in intestinal-type metaplasias when it is abnormally expressed outside the *** the molecular level,structure/function studies have demonstrated that the Cdx2 protein is a transcription factor containing a conserved homeotic DNA-binding domain made ofthree alpha helixes arranged in a helix-turn-helix motif,preceded by a transcriptional domain and followed by a regulatory *** protein interacts with several thousand sites on the chromatin and widely regulates intestinal functions in stem/progenitor cells as well as in mature differentiated ***,this transcription factor also acts trough original nontranscriptional ***,the identification of novel protein partners of Cdx2 and also of a splicing variant revealed unexpected functions in the control of signaling pathways like the Wnt and NF-k B pathways,in double-strand break DNA repair and in premessenger RNA *** novel functions of Cdx2 must be considered to fully understand the complexity of the role of Cdx2 in the healthy intestine and in diseases.

关键词： Homeobox Transcription Signaling DNA repair RNA splicing Intestine Development Cancer Homeostasis

Bubbles and incentives:an experiment on asset markets

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Economic and Political Studies 2021年第1期9卷 68-89页

作者： Stéphane Robin Katerina Stráznická marie claire Villeval Grenoble INP Institute of Engineering and Management Grenoble Applied Economics Laboratory(GAEL)University of Grenoble AlpesGrenobleFrance French National Centre for Scientific Research(CNRS) ParisFrance National Institute for Agricultural Research(INRA) ParisFrance Clermont Research Management(CleRMA) University of Clermont AuvergneClermont-FerrandFrance University of Lyon LyonFrance Group of Economic Analysis and Theory(GATE) French National Centre for Scientific Research(CNRS)EcullyFrance Institute of Labour Economics(IZA) BonnGermany

We explore the effects of competitive incentives and of their time horizon on the evolution of both asset prices and trading activity in experimental asset *** compare(i)a no-bonus treatment;(ii)a short-term bonus treatment in which bonuses are assigned to the best performers at the end of each trading period;(iii)a long-term bonus treatment in which bonuses are assigned to the best performers at the end of the 15 periods of the *** find that the existence of bonus contracts does not increase the likelihood of bubbles but it affects their severity,depending on the time horizon of *** with longterm bonus contracts experience lower price deviations and a lower turnover of assets than markets with either no bonuses or long-term bonus ***-term bonus contracts increase price deviations but only when markets include a higher share of male *** the individual level,the introduction of bonus contracts increases the trading activity of males,probably due to their higher competitiveness.

关键词： Asset market bubbles incentives bonuses risk attitudes experiment

Synthesis of P,N-2,2'-biphenyl derivatives with central chirality

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Science China Chemistry 2010年第9期53卷 1907-1913页

作者： JEAN Ludovic POULIQUEN Michael BLANCHET Jérme LASNE marie-claire ROUDEN Jacques Laboratoire de Chimie Moléculaire et Thioorganique UMR 6507 CNRS-ENSICAEN & Université de Caen-Basse Normandie6 Boulevard du Maréchal Juin14050 CaenInstitut Normand de Chimie MoléculaireMédicinale et Macromoléculaire(INC3M)

Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were *** the compound bearing an acyclic chiral chain,the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2'-position of the biphenyl *** efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand.

关键词： 3-aminopyrrolidines Suzuki coupling biphenyls chiral ligand arylamination

Analysis of Rainfall Intensity-Duration-Frequency Relationship for Rwanda

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Journal of Water Resource and Protection 2016年第7期8卷 706-723页

作者： Negash Wagesho marie claire Department of Water Resources & Irrigation Engineering Arba Minch University Arba Minch Ethiopia Ministry of Defense Kigali Rwanda

Global atmospheric and oceanic perturbations and local weather variability induced factors highly alter the rainfall pattern of a region. Such factors result in extreme events of devastating nature to mankind. Rainfall Intensity Duration Frequency (IDF) is one of the most commonly used tools in water resources engineering particularly to identify design storm event of various magnitude, duration and return period simultaneously. In light of this, the present study is aimed at developing rainfall IDF relationship for entire Rwanda based on selected twenty six (26) rainfall gauging stations. The gauging stations have been selected based on reliable rainfall records representing the different geographical locations varying from 14 to 83 years of record length. Daily annual maximum rainfall data has been disaggregated into sub-daily values such as 0.5 hr, 1 hr, 3 hr, 6 hr and 12 hr and fitted to the probability distributions. Quantile estimation has been made for different return periods and best fit distribution is identified based on least square standard error of estimate. At-site and regional IDF parameters were computed and subsequent curves were established for different return period. The moment ratio diagram (MRD) and L-moment ratio diagram (LMRD) methods have been used to fit frequency distributions and identify homogeneous regions for observed 24-hr maximum annual rainfall. The rainfall stations have been divided into five homogeneous rainfall regions for all 26 stations. The results of present analysis can be used as useful information for future water resources development planning purposes.

关键词： Intensity Duration Frequency Maximum Rainfall Regionalization Rwanda

VICTOR HUGO CET INCONNU?

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法国研究 1985年第4期 31-37页

作者： Par marie-claire Travers

Et qu’aura démontré l’année Victor Hugo?Etait-il besoin de cela pournous rappeler que ce nom formidable,oùroulent toutes les rumeursmarines,est le seul nom d’écrivain francais qui ait atteint les dimen-sions de l’universel?Non,certes,et cela serait plut(?)t fait pour agacer,que cette renommée unique,et cette admiration obligatoire qui en ré-

关键词：二心耳海心材多边责任

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Introduction

Economic and Political Studies 2021年第1期9卷 1-3页

作者： marie claire Villeval University of Lyon LyonFrance Group of Economic Analysis and Theory(GATE) French National Centre for Scientific Research(CNRS)EcullyFrance Institute of Labour Economics(IZA) BonnGermany

Behavioural and experimental economics constitutes a dynamic field of research that has produced new and perhaps more realistic theoretical models of human behaviour,and allowed researchers to test empirically these models in laboratory and/or field *** field is based on models of preferences,beliefs,and decision rules that contrast with standard economic theories assuming selfish individual preferences,perfect and immediate information processing,and rational *** hybridising knowledge from other social and cognitive sciences with economics,behavioural and experimental economics models and tests how cognitive biases and non-standard preferences affect the way people process information,update their beliefs,and make decisions.

关键词： behaviour rational economics