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Reduced exercise capacity and self-perceived health status in highrisk patients undergoing lung resection

World Journal of Critical Care Medicine 2021年第5期10卷 232-243页

作者： Janet Rodríguez-Torres Irene Cabrera-Martos Laura López-López Florencio Quero-Valenzuela Lawrence Patrick Cahalin marie carmen valenza Fisioterapia University of GranadaGranada 18016Spain Cardiothoracic Surgery Department Virgen de las Nieves HospitalGranada 18016Spain Physical Therapy University of MiamiMiamiFL 33124United States

BACKGROUND Lung resection represents the main curative treatment modality of non-small cell lung *** with high-risk to develop postoperative pulmonary complications have been classified as“high-risk patients.”Characterizing this population could be important to improve their approach and *** To identify the differences between high and low-risk patients in exercise capacity and self-perceived health status after *** A longitudinal observational prospective cohort study was carried *** undergoing lung resection were recruited from the“Hospital Virgen de las Nieves”(Granada)and divided into two groups according to the risk profile criteria(age≥70 years,forced expiratory volume in 1 s≤70%predicted,carbon monoxide diffusion capacity≤70%predicted or scheduled pneumonectomy).Outcomes included were exercise capacity(Fatigue Severity Scale,Unsupported Upper-Limb Exercise,handgrip dynamometry,Five Sit-to-stand test,and quadriceps hand-held dynamometry)and patient-reported outcome(Euroqol-5 dimensions 5 Levels Visual Analogue Scale).RESULTS In total,115 participants were included in the study and divided into three groups:high-risk,low-risk and control *** discharge high-risk patients presented a poorer exercise capacity and a worse self-perceived health status(P<0.05).One month after discharge patients in the high-risk group maintained these differences compared to the other *** Our results show a poorer recovery in high-risk patients at discharge and 1 mo after surgery,with lower self-perceived health status and a poorer upper and lower limb exercise *** results are important in the rehabilitation field.

关键词： Non-small cell lung cancer Exercise tolerance health status Patient-reported outcomes Postoperative quality of life Exercise test

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ON THE VALIDITY OF THE LOCAL FOURIER ANALYSIS

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Journal of Computational Mathematics 2019年第3期37卷 340-348页

作者： carmen Rodrigo Francisco J.Gaspar Ludmil T.Zikatanov Departamento de Matematica Aplicada IUMAUniversidad de ZaragozaZaragozaSpain CWI Centrum Wiskunde & InformaticaScience Park 1231090 AmsterdamThe Netherlands Department of Mathematics The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USAInstitute for Mathematics and InformaticsBulgarian Academy of SciencesSofia.Bulgaria

Local Fourier analysis(LFA)is a useful tool in predicting the convergence factors of geometric multigrid methods(GMG).As is well known,on rectangular domains with periodic boundary conditions this analysis gives the exact convergence factors of such met *** other boundary conditions are considered,however,this analysis was judged as been heuristic,with limited capabilities in predicting multigrid convergence *** this work,using the Fourier method,we extend these results by proving that such analysis yields the exact convergence factors for a wider class of problems,some of which can not be handled by the traditional rigorous Fourier analysis.

关键词： Local Fourier analysis Multigrid Fourier method

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Perinatal transmission of dengue virus in Puerto Rico: a case report

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Open Journal of Obstetrics and Gynecology 2011年第3期1卷 90-93页

作者： Janice Pérez-Padilla Rafael Rosario-Casablanca Luis Pérez-Cruz carmen Rivera-Dipini Kay marie Tomashek Dengue Branch Division of Vector-Borne Diseases Centers For Disease Control and Prevention San Juan Puerto Rico. HIMA San Pablo Hospital Fajardo Puerto Rico.

We report a laboratory confirmed case of vertical transmission of dengue in a mother-child pair in the eastern part of Puerto Rico. The clinical course of the pregnant female suggested a GBS infection, but laboratory tests confirmed it was dengue infection, one week after delivery. The male infant was healthy at birth, but one week after birth developed clinical complications related to vertical transmission of dengue. This report targets physicians in dengue endemic countries like Puerto Rico to be aware of the possibility of vertical transmission of dengue in symptomatic pregnant patients, especially around the time of delivery.

关键词： Dengue Perinatal Transmission Bloodborne

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Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

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分子细胞生物学报:英文版 2016年第2期8卷 129-143页

作者： Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin *** mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are *** this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse *** of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and *** glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional *** disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

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CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.Iribarren carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

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Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

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Cancer Communications 2023年第4期43卷 508-512页

作者： Georgios Makris Semih Kayhan Marvin Kreuzer Véronique Rüfenacht Erica Faccin Jarl Underhaug carmen Diez-Fernandez Philip A.Knobel Martin Poms Nadine Gougeard Vicente Rubio Aurora Martinez Martin Pruschy Johannes Häberle Division of Metabolism and Children’s Research Center University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Center for Integrative Human Physiology University of ZurichZurichSwitzerland Department of Radiation Oncology Laboratory for Applied RadiobiologyUniversity Hospital ZurichUniversity of ZurichZurichSwitzerland Department of Biomedicine University of BergenBergenNorway Department of Chemistry University of BergenBergenNorway NUVISAN GmbH Neu-UlmBavariaGermany CDR Life Inc. SchlierenZurichSwitzerland Division of Clinical Chemistry and Biochemistry University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Instituto de Biomedicina de Valencia(IBV-CSIC) CIBER de Enfermedades Raras(CIBERER-ISCIII)ValenciaSpain

Dear Editor,Metabolically induced cancer heterogeneity creates a large source of novel potential targets towards an enhanced therapeutic window alone and in combination with classic chemo-and radiotherapy[1,2].This is of particular interest for non-small cell lung cancer(NSCLC),which accounts for more than 80%of all lung tumor types characterized by limited responses to current treatment options[3–5].

关键词： metabolism lung cancer

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Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study

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ChemPhysMater 2022年第1期1卷 62-70页

作者： Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa Maria Del carmen Domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso Mariano Venanzi PEPSA-LAB Department of Chemical Sciences and TechnologyUniversity of Rome Tor VergataVia della Ricerca Scientifica 100133RomeItaly Department of Physics University of Rome‘Sapienza’P.le A.Moro 500185 RomeItaly Centre for Genetic Engineering and Biotechnology PO Box 616210600HavanaCuba School of Science RMIT UniversityMelbourneVIC 3001Australia

The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation ***,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of *** found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide ***,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics.

关键词： Molecular dynamics of peptide oligomers Peptide aggregation Peptide fibrils Peptide nanostructures Therapeutic peptides Treatment of rheumatoid arthritis

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La Tana咖啡厅

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现代装饰 2019年第3期 64-69页

作者： carmen Cheung Ian Lanterman Conrad Brown 彭佳 Ste.marie Art & Design

项目地点_加拿大温哥华美编_纪少佳图空间中采用了许多古典而优雅的家具及饰品,营造出传统的意大利风情La Tana定位为一个提供简餐的小型聚会空间。室内所用材料以深绿色大理石为主,再搭配古老的搁架、定制的木制品、古典纹理的地砖以... 详细信息

项目地点_加拿大温哥华美编_纪少佳图空间中采用了许多古典而优雅的家具及饰品,营造出传统的意大利风情La Tana定位为一个提供简餐的小型聚会空间。室内所用材料以深绿色大理石为主,再搭配古老的搁架、定制的木制品、古典纹理的地砖以及特制的手绘壁纸等,共同营造了一个具有19世纪意大利风格的优雅空间。设计师希望La Tana能让人感到'优雅'和'轻松',让顾客用餐时能够感受到传统的意大利风情。

关键词：大理石室内空间 La Tana 意大利建筑师

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Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence

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World Journal of Gastroenterology 2016年第18期22卷 4547-4558页

作者： Alice Tung Wan Song Rodolphe Sobesky carmen Vinaixa Jérome Dumortier Sylvie Radenne Francois Durand Yvon Calmus Géraldine Rousseau Marianne Latournerie Cyrille Feray Valérie Delvart Bruno Roche Stéphanie Haim-Boukobza Anne-marie Roque-Afonso Denis Castaing Edson Abdala Luiz Augusto Carneiro D’Albuquerque Jean-Charles Duclos-Vallée Marina Berenguer Didier Samuel INSERM Unit 785 Villejuif 94800France Liver and Digestive Organ Transplantation Division Gastroenterology DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Universite Paris-Sud Villejuif 94800France Liver Transplantation Laboratory LIM-37 Sao Paulo 01246-903Brazil AP-HP Hopital Paul Brousse Villejuif 94800France La Fe Hospital University of Valencia and CiberehdValencia 46026Spain Hopital Edouard Herriot Lyon 69003France Hopital Croix Rousse Lyon 69004France AP-HP Hopital Beaujon Clichy 92110France AP-HP Hopital St Antoine Paris 75011France AP-HP Hopital Salpetriere Paris 75013France CHU Pontchaillou Rennes 35000France AP-HP Hopital Henri Mondor Creteil 94010France Viral Hepatitis Laboratory LIM-47 Sao Paulo 01246-903Brazil

AIM: To identify risk factors associated with survival in patients retransplanted for hepatitis C virus(HCV) recurrence and to apply a survival score to this ***: We retrospectively identified 108 patients retransplanted for HCV recurrence in eight European liver transplantation centers(seven in France, one in Spain). Data collection comprised clinical and laboratory variables, including virological and antiviral treatment data. We then analyzed the factors associated with survival in this population. A recently published score that predicts survival in retransplantation in patients with hepatitis C was applied. Because there are currently no uniform recommendations regarding selection of the best candidates for retransplantation in this setting, we also described the clinical characteristics of 164 patients not retransplanted, with F3, F4, or fibrosing cholestatic hepatitis(FCH) post-first graft presenting with hepatic decompensation. RESULTS: Overall retransplantation patient survival rates were 55%, 47%, and 43% at 3, 5, and 10 years, respectively. Patients who were retransplanted for advanced cirrhosis had survival rates of 59%, 52%, and 49% at 3, 5, and 10 years, while those retransplanted for FCH had survival rates of 34%, 29%, and 11%, respectively. Under multivariate analysis, and adjusting for the center effect and the occurrence of FCH, factors associated with better survival after retransplantation were: negative HCV viremia before retransplantation, antiviral therapy after retransplantation, non-genotype 1, a Model for End-stage Liver Disease(MELD) score < 25 when replaced on the waiting list, and a retransplantation donor age < 60 years. Although the numbers were small, in the context of the new antivirals era, we showed that outcomes in patientswho underwent retransplantation with undetectable HCV viremia did not depend on donor age and MELD score. The Andrés score was applied to 102 patients for whom all score variables were available,

关键词： Antivirals Hepatitis C Mortality Prognosis Retransplantation Risk factors

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日本收纳教主的生意经

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商业周刊（中文版） 2019年第4期 10-12页

作者： Lisa Du Isabel Reynolds carmen Reinicke 徐安琪(译) 不详

1月一个寒冷的下午,莱利?索洛纳(Riley Soloner)正在逛曼哈顿上东区的一家Container Store店铺。这家零售商专门经营收纳用品,帮助顾客把杂乱无章的现代生活整理得更加有条不紊。索洛纳想找一个新的洗衣篮,因为他的旧洗衣篮已不能再给... 详细信息

1月一个寒冷的下午,莱利?索洛纳(Riley Soloner)正在逛曼哈顿上东区的一家Container Store店铺。这家零售商专门经营收纳用品,帮助顾客把杂乱无章的现代生活整理得更加有条不紊。索洛纳想找一个新的洗衣篮,因为他的旧洗衣篮已不能再给他带来愉悦了。对许多人来说,这并不是把它扔进垃圾堆的充分理由。但对于曰本家庭整理大师近藤麻理惠(marie Kondo)的信徒来说,即使是一个不起眼的篮子,也应该给主人带来愉悦,否则就应该被扔掉。

关键词：生意经教主日本现代生活曼哈顿垃圾堆索洛整理

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