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医疗卫生绩效薪酬支付的国际经验及对中国的启示

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中国卫生政策研究 2015年第2期8卷 27-35页

作者：蒋舒阎川 Anne Girault marie Ferrua aude Fourcade Philippe Loirat Etienne Minvielle 法国卫生部医院质量控制计划课题组法国巴黎94805 法国巴黎第十一大学公共卫生系法国巴黎94805 中央财经大学公共卫生经济与管理研究所北京100081

为提高医疗质量,过去几十年来世界各国在医疗卫生系统设计并推行了"绩效薪酬支付"项目。这些项目针对不同的对象以及单位和部门进行激励。近年,绩效薪酬被逐渐引入我国医疗卫生系统。本文回顾了国际上主要国家(美国、法国和英国等)在医... 详细信息

为提高医疗质量,过去几十年来世界各国在医疗卫生系统设计并推行了"绩效薪酬支付"项目。这些项目针对不同的对象以及单位和部门进行激励。近年,绩效薪酬被逐渐引入我国医疗卫生系统。本文回顾了国际上主要国家(美国、法国和英国等)在医疗卫生体系内推行的绩效薪酬项目,梳理了各国在项目设计时的共性经验,总结了项目设计时需要考虑的关键要素,包括项目的激励对象、绩效指标、激励方式、绩效基准等,并分析这些要素的优缺点及实施中可能出现的问题,旨在为我国的医疗卫生系统绩效薪酬改革提供参考。

关键词：绩效薪酬医院管理医疗质量激励

Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 1-12页

作者： Jean marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier Michel Rayar CHU rennes Service de Chirurgie Hépatobiliaire et DigestiveRennesFrance Universitérennes 1 Facultéde MédecineRennesFrance CHU rennes Service des Maladies du FoieRennesFrance INSERM CIC 1414RennesFrance CHU rennes Service de Maladies Infectieuses et Réanimation MédicaleRennesFrance

Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not ***:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to ***:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were *** groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as *** median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,Prence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically *** of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA *** difference was observed regarding graft(P=0.18)and patient(P=0.16)***:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.

关键词： Liver transplantation(LT) hepatic artery(HA) arterial anastomosis splenic artery(SA)

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma Yuanyuan Wei aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection Phase singularity Surface plasmon

Aims and First Assessments of the French Hydrogen Pathways Project HyFrance3

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Journal of Energy and Power Engineering 2012年第1期6卷 34-40页

作者： Alain Le Duigou marie-Marguerite Quemere Pierre Marion Philippe Menanteau Pascal Houel LaureSinegre Lionel Nadau Aline Rastetter aude Cuni Philippe Mulard Loic Antoine Thierry Alleau I-Tese CEA Gif-Sur-Yvette Cedex 91191 France Departement EPI-ECUELLES EDF R＆D Moret Sur Loing Cedex 77818 France IFP Energies nouvelles 1 et 4 avenue de Bois Preau Rueil Malmaison Cedex 92852 France LEPII Universit# de Grenoble - CNRS Grenoble Cedex 9 BP 47 38040 France DRI GDF SUEZ 361 av du pdt WILSON Saint Denis La Plaine Cedex BP 33 93211 France ALPHEA EURODEV CENTER 4 rue Jules Verne Eurozone Forbach 57600 France AIR LIQUIDE 1 chemin de la porte des loges Jouy-en-Josas BP 126 78354 France TOTAL RAFFINAGE MARKETING La Defense 10 Paris la Defense Cedex 92069 France ADEME 20 avenue du Gresille Angers Cedex 01 BP 90406 49004 France AFH2 28 rue Saint Dominique Paris 75007 France

The HyFrance Group was originally formed in France to support the European project HyWays, by providing （former projects HyFrancel and HyFrance2） the French data and possible hydrogen pathways according to national specificities. HyFrance3 is a new project that focuses on the economic competitiveness of different steps of the hydrogen chain, from the production to end usage, at the time horizon of 2030 in France. The project is coordinated by CEA with the other partners being： ADEME （co-funding）, AFH2, CNRS, IFP, Air Liquide, EdF, GdF Suez, TOTAL, ALPHEA. The project is divided into 4 sub-projects, that address present and future French hydrogen industrial markets for chemical ＆ refinery uses, the analysis of the interplay between wind energy production and storage of hydrogen for different automotive requirements （refuelling stations, BtL plants, H2/NG mix）, massive hydrogen storage to balance various offer and demand characteristics, and the supply network （pipeline option competitiveness vs. trucked in supply） to distribute hydrogen in a French region for automotive applications. Technical and economical issues, as well as GHG emissions, are addressed.

关键词： HyFrance hydrogen industrial techno-economy storage wind energy infrastructure.

Macroscale fluorescence imaging against autofluorescence under ambient light

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Light(Science & Applications) 2018年第1期7卷 151-162页

作者： Ruikang Zhang Raja Chouket marie-aude Plamont Zsolt Kelemen Agathe Espagne Alison G.Tebo Arnaud Gautier Lionel Gissot Jean-Denis Faure Ludovic Jullien Vincent Croquette Thomas Le Saux PASTEUR Département de ChimieÉcole Normale SupérieurePSL UniversitySorbonne UniversitéCNRS75005 ParisFrance Institut Jean-Pierre Bourgin INRAAgroParisTechCNRSSaclay Plant Science(SPS)UniversitéParis-SaclayVersaillesFrance Laboratoire de Physique Statistique École Normale SupérieurePSL Research UniversityUniversitéParis Diderot Sorbonne Paris-CitéSorbonne UniversitéCNRS75005 ParisFrance Institut de biologie de l’École normale supérieure(IBENS) École Normale SupérieureCNRSINSERMPSL Research University75005 ParisFrance

Macroscale fluorescence imaging is increasingly used to observe biological ***,it may suffer from spectral interferences that originate from ambient light or autofluorescence of the sample or its *** this manuscript,we built a simple and inexpensive fluorescence macroscope,which has been used to evaluate the performance of Speed OPIOM(Out of Phase Imaging after Optical Modulation),which is a reference-free dynamic contrast protocol,to selectively image reversibly photoswitchable fluorophores as labels against detrimental autofluorescence and ambient *** tuning the intensity and radial frequency of the modulated illumination to the Speed OPIOM resonance and adopting a phase-sensitive detection scheme that ensures noise rejection,we enhanced the sensitivity and the signal-to-noise ratio for fluorescence detection in blot assays by factors of 50 and 10,respectively,over direct fluorescence observation under constant ***,we overcame the strong autofluorescence of growth media that are currently used in microbiology and realized multiplexed fluorescence observation of colonies of spectrally similar fluorescent bacteria with a unique configuration of excitation and emission ***,we easily discriminated fluorescent labels from the autofluorescent and reflective background in labeled leaves,even under the interference of incident light at intensities that are comparable to *** proposed approach is expected to find multiple applications,from biological assays to outdoor observations,in fluorescence macroimaging.

关键词： ambient illumination light

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哲学家与爱

哲学家与爱

孩子们不允许我们绝望玛丽-奥德·缪莱尔在2023年法兰克福书展上的演讲

作者： (法)奥德·朗瑟兰(aude Lancelin)，(法)玛丽·勒莫尼耶(marie Lemonnier)

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阅读与成才 2023年第5期 113-114页

作者：玛丽-奥德·缪莱尔奇想国(翻译整理) 奇想国

在法国文化中心图书办公室为德国学生举办的展览中,有我为年轻人写的第四本书《轻松学荷兰语》(Le Hollandais sans peine)。这本书讲的是一个法国小男孩学习荷兰语的故事:小男孩和父母一起在德国的露营地度假,但令他父亲失望的是,他完... 详细信息

在法国文化中心图书办公室为德国学生举办的展览中,有我为年轻人写的第四本书《轻松学荷兰语》(Le Hollandais sans peine)。这本书讲的是一个法国小男孩学习荷兰语的故事:小男孩和父母一起在德国的露营地度假,但令他父亲失望的是,他完全拒绝学习德语。为了使父亲高兴——也多亏了他在露营地认识的一个朋友——小男孩假装学习荷兰语。

关键词：法兰克福书展露营地小男孩德国年轻人

Fitness components of Drosophila melanogaster developed on a standard laboratory diet or a typical natural food source

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Insect Science 2016年第5期23卷 771-779页

作者： Torsten Nygaard Kristensen Astrid Kallestrup Henningsen Christian Aastrup Mads Bech-Hansen Lise B. Hoberg Bjerre Benjamin Carlsen marie Hagstrup Sofie Graarup Jensen Pernille Karlsen Line Kristensen Cecillie Lundsgaard Tine MФller Lise D. Nielsen Camilla Starcke Christine Riisager SФrensen Mads Fristrup Schou Department of Chemistry and Bioscience Section of Biology and Environmental Science Aalborg University Aalborg East DK-9220 Denmark Department of Bioscience Aarhus University Aarhus C DK-8000 Denmark

Drosophila melanogaster is often used as a model organism in evolution- ary biology and ecophysiology to study evolutionary processes and their physiological mechanisms. Diets used to feed Drosophila cultures differ between laboratories and are often nutritious and distinct from food sources in the natural habitat, Here we rear D. melanogaster on a standard diet used in our laboratory and a field diet composed of decomposing apples collected in the field. Flies developed on these two diet compositions are tested for heat, cold, desiccation, and starvation resistance as well as developmental time, dry body mass and fat percentage. The nutritional compositions of the standard and field diets were analyzed, and discussed in relation to the phenotypic observations. results showed marked differences in phenotype of flies from the two types of diets. Flies reared on the field diet are more starvation resistant and they are smaller, leaner, and have lower heat resistance compared to flies reared on the standard diet. Sex specific effects of diet type are observed for several of the investigated traits and the strong sexual dimorphism usually observed in desiccation resistance in D. melanogaster disappeared when rearing the flies on the field diet. Based on our results we conclude that care should be taken in extrapolating results from one type of diet to another and especially from laboratory to field diets.

关键词： diet field fitness life-history traits nutrition stress resistance

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux marie-aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO rené Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression