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Effect of WeiJia on carbon tetrachloride induced chronic liver injury

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World Journal of Gastroenterology 2006年第12期12卷 1912-1917页

作者： Pik-Yuen Cheung QiZhang Gan-Rong Bai Chi-Chun Fong Lin Shi Yue-Feng Shi Meng-SuYang DepartmentofBiology Ya-Ou Zhang marie Chia-Mi Lin bernard Chan Jay Chun Hsiang-Fu Kung Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee AvenuKowloonHong Kong SARChina Life Science Division Tsinghua University Graduate School at ShenzhenTsinghua CampusUniversity TownShenzhenChina Institute of Molecular Biology The University of Hong KongPokfulamHong KongSARChina Life Tec Enterprise Limited CentralHong KongSARChina The Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongShatinN.T.Hong Kong SARChina

AIM： To study the effect of WeiJia on chronic liver injury using carbon tetrachloride （CCh） induced liver injury animal model. METHODS： Wistar rats weighing 180-220g were randomly divided into three groups： normal control group （Group A）, CCh induced liver injury control group （Group B） and CCI4 induction with WeiJia treatment group （Group C）. Each group consisted of 14 rats. Liver damage and fibrosis was induced by subcutaneous injection with 40% CCh in olive oil at 3 mL/kg body weight twice a week for eight weeks for Groups B and C rats whereas olive oil was used for Group A rats. Starting from the third week, Group C rats also received daily intraperitoneal injection of *** at a dose of 1.25 μg/kg body weight. Animals were sacrificed at the fifth week （4 male, 3 female）, and eighth week （4 male, 3 female） respectively. Degree of fibrosis were measured and serological markers for liver fibrosis and function including hyaluronic acid （HA）, type Ⅳ collagen （CIV）, γ-glutamyl transferase （γ-GT）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） were determined. Alpha smooth muscle actin （α-SMA） and proliferating cell nuclear antigen （PCNA） immunohistochemistry were also performed. RESULTS： CCl4 induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV,ALT, AST and γ-GT levels after eight weeks of treatment for Group C rats were 58±22 μg/L （P〈0.01）, 57±21 μg/L （P〈0.01）, 47±10 U/L （P〈0.01）, 139±13 U/L （P〈0.05） and 52±21 U/L （P〉0.05） respectively, similar to normal control group （Group A）, but significantly different from CCh induced liver injury control group （Group B）. An increase in PCNA and decrease in α-SMA expression level was also obs

关键词： WeiJia Carbon tetrachloride Liver fibrosis

Development of a brownfield inventory for prioritizing funding outreach in Tucson,Arizona

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Geo-Spatial Information Science 2021年第4期24卷 742-754页

作者： Theresa Foley Ann marie Wolf Chloe Jackson Ryan Stephenson Sonora Environmental Research Institute Inc.(SERI)TucsonAZUSA Pima County ITD/GIS TucsonAZUSA Pima County Community Development&Neighborhood Conservation TucsonAZUS

Fear of liability from the 1980 Comprehensive Environmental Response,Compensation,and Liability Act(CERCLA or Superfund)has prompted developers to build preferentially upon undeveloped green space rather than potentially contaminated former industrial sites,leading to urban sprawl in the suburban areas while blighted properties in the urban core remain vacant.A brownfield is defined as a property in which the presence or potential presence of a hazardous substance or contaminant poses a barrier to *** often create brownfield inventories by performing a site suitability analysis,using distinguishing features such as ecolo-gically and culturally significant areas or neighborhoods that need *** County,Arizona and the Sonora Environmental Research Institute,Inc.(SERI)developed a brownfield inventory of the large,industrial area directly to the west of Davis-Monthan Air Force *** the brownfield target area has few residential neighborhoods and lacks the distinguish-ing features usually used in a brownfield site suitability analysis,the county and SERI used the official tax assessor database and 11 federal,state and county environmental databases to develop a brownfield *** goal of the project was to prioritize properties that stood to benefit from the grant *** final brownfield inventory contained 531 parcels.

关键词： GIS site suitability analysis brownfield urban planning brownfield inventory

Click chemistry in the design of AIEgens for biosensing and bioimaging

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聚集体(英文)

聚集体(英文) 2023年第4期4卷 71-92页

作者： marie-Claire Giel Yuning Hong Department of Biochemistry and Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia

The development of rapid,selective,and sensitivefluorescent sensors is essential for visualizing and quantifying biological molecules and processes in vitro,ex vitro,and in vivo,which is important for not only fundamental biological studies but the accurate diagnosis of *** emergingfield of activity-based sensing(ABS),a sensing method that utilizes molecular reactivity for analyte detection possesses many advantages including high specificity,sensitivity and *** aggrega-tion caused quenching phenomenon which occurs in most conventionalfluorophores results in reduced labeling efficiency of the target analytes and low photobleaching resistance,therefore limiting the applications of the ABS *** contrast,aggre-gation induced emission(AIE)active luminogens(AIEgens)provide exceptional molecular frameworks for *** the many reaction classes utilized in the AIEgen ABS approach,click chemistry has become increasing *** this review,the sensing concepts of the ABS approach with AIEgens and the principles of click chemistry are discussed,followed by a systematic summary of the application of specific click chemistry reactions in AIEgen ABS protocols for the detection of an array of target ***,the utility of click chemistry in the construction of AIEgens for bioimaging will also be showcased throughout the review.

关键词： activity-based sensing aggregation induced emission bioconjugation chemistry click chemistry

Circadian rhythms in the pathogenesis of gastrointestinal diseases

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World Journal of Gastroenterology 2018年第38期24卷 4297-4303页

作者： Pilar Codonr-Franch marie Gombert Department of Pediatrics Obstetrics and GinecologyUniversity of ValenciaValencia 46010Spain Department of Pediatrics Dr.Peset University HospitalValencia 46017Spain Department of Biotechnology University of La RochelleLa Rochelle 17000France

The etiology of digestive pathologies such as irritable bowel syndrome(IBS), inflammatory bowel diseases(IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms(chronodisruption) where the central clock and the peripheral clocks receive incoherent signals, the synchronicity is lost producing implications for health. This lack of coordination could alter the tissue function and cause long term damage to the organs. Life habits such as sleep, physical exercise, social interaction, and feeding times are determinants for stability and integrity of circadian rhythms. In recent years, experimental and clinical studies have consistently evidenced that the alteration of circadian rhythms is associated with the development of digestive pathologies mainly linked to dismotility or changes in microbiota composition. Likewise, it seems reasonable to deep into the importance of chronodisruption as a factor that may participate in the development of pathologies such as IBS, IBD and digestive cancers. Moreover, life habits respecting circadian rhythms should be promoted for the prevention of these diseases. Further studies will allow us a better understanding of the mechanisms acting at molecular level, and the development of new therapeutic targets.

关键词： Circadian rhythms Gastrointestinal diseases Irritable bowel syndrome Inflammatory bowel disease Digestive cancers

Pancreatic function,quality of life and costs at long-term follow-up after acute pancreatitis

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World Journal of Gastroenterology 2010年第39期16卷 4944-4951页

作者： Bodil Andersson marie-Louise Pendse Roland Andersson Department of Surgery Clinical Siences LundLund University Lund University Hospital

AIM:To evaluate long-term endocrine and exocrine pancreatic function,quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis(SAP).METHODS:Patients prospectively included in 2001-2005 were followed-up after 42(36-53)*** function was evaluated with laboratory tests,the oral glucose tolerance test(OGTT),fecal elastase-1 and a *** Form(SF)-36,was ***:Fourteen patients with a history of SAP and 26 with mild acute pancreatitis were *** glucose after OGTT was higher after SAP(9.2 mmol/L vs 7.0 mmol/L,P=0.044).Diabetes mellitus or impaired glucose tolerance in fasting plasma glucose and/or 120 min plasma glucose were more common in SAP patients(11/14 vs 11/25,P=0.037).Sick leave,time until the patients could take up recreational activities and time until they had recovered were all longer after SAP(P <0.001).No significant differences in SF-36 were seen between the groups,or when comparing with age and gender matched reference *** hospital costs,including primary care,follow-up and treatment of complications,were higher after SAP(median€16572 vs €5000,P<0.001).CONCLUSION:Endocrine pancreatic function was affected,especially after severe *** requires greater resource use with long recovery,but most patients regained a good quality of life.

关键词： Acute pancreatitis Endocrine function Exocrine function Quality of life Cost

Maintenance of radiation-induced intestinal fibrosis:Cellular and molecular features

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World Journal of Gastroenterology 2007年第19期13卷 2675-2683页

作者： Valérie Haydont marie-Catherine Vozenin-Brotons UPRES EA 27-10 "Radiosensibilité des tumeurs et tissus sains" Institut de Radioprotection et de Sreté Nucléaire/Institut Gustave Roussy. Villejuif Laboratoire de Radiopathologie. SRBE/DRPH. Institut de Radioprotection et de Sreté Nucléaire Fontenay-aux-Roses France

Recent advances in cell and molecular radiobiology clearly showed that tissue response to radiation injury cannot be restricted to a simple cell-killing process, but depends upon continuous and integrated pathogenic processes, involving cell differentiation and crosstalk between the various cellular components of the tissue within the extracellular matrix. Thus, the prior concept of primary cell target in which a single-cell type （whatever it＇s epithelial or endothelial cells） dictates the whole tissue response to radiation injury has to be replaced by the occurrence of coordinated multicellular response that may either lead to tissue recovery or to sequel development. In this context, the present review will focus on the maintenance of the radiation-induced wound healing and fibrogenic signals triggered by and through the microenvironment toward the mesenchymal cell compartment, and will highlight how sequential and sustained modifications in cell phenotypes will in cascade modify ceU-to-ceU interactions and tissue composition.

关键词： Radiotherapy Fibrosis Fibrogenic differentiation TGF-131 CCN2 Smad Rho ROCK Actincytoskeleton

Synthesis of a novel macrocyclic ligand containing bipyridine units

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Chinese Journal of Chemistry 2000年第3期18卷 384-387页

作者：何永炳 LEHN Jean-marie Department of Chemistry Wuhan University Wuhan Hubei 430072 China

The 6-hydroxymethyl-6'-tetrahydropyranyloxymethyl-2, 2'-bipyridine (2) was synthesized by the reaction of 6,6'-dihydroxymethyl-2, 2'-bipyridine (1) with 3, 4-dihydroxypyran (DHP). ***-6'-iodomethyl-2, 2'-bipyridine (5) was obtained from mesylate and iodizating reaction of compound 2. The coupling of 2 and 5 followed by hydrolysis gave bis(6'-hydroxymethyl-2, 2'-bipyridine-6-methyl) ether (7). The macrocyclic ligand 8 was obtained by treating 7 and 6, 6'-dibromethyl-2, 2'-bipyridine. The synthetic conditions of the intermediate 2 and macocyclic ligand 8 were discussed.

关键词： azacrown ether bipyridine derivative macrocyclic ligand

Displacement manifold method for type synthesis of lower-mobility parallel mechanisms

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Science China(Technological Sciences) 2004年第6期47卷 641-650页

作者： LI Qinchuan HUANG Zhen Jacques marie Hervé Center of Integration Engineering Zhejiang University of SciencesHangzhou 310033China Robotics Research Center Yanshan UniversityQinhuangdao 066004China Ecole Centrale Paris France

Type synthesis of lower-mobility parallel mechanisms is a hot and frontier topic in international academic and industrial field. Based on the Lie group theory, a displacement manifold synthesis method is proposed. For all the nine kinds of lower-mobility parallel mechanisms, the mechanism displacement manifold, limb displacement manifold and the geometrical conditions which guarantee that the intersection of the limb displacement manifold is the desired mechanism displacement manifold are enumerated. Various limb kinematic chains can be obtained using the product closure of displacement subgroup. Parallel mechanisms can be constructed with these limbs while obeying the geometrical conditions. Hence, all the nine kinds of lower-mobility parallel mechanisms can be synthesized using this method. Since displacement manifold deals with finite motion, the result mechanism of synthesis have full-cycle mobility. Novel architectures of lower-mobility parallel mechanisms can be obtained using this method.

关键词： lower-mobility parallel mechanisms Lie group displacement manifold type synthesis

A formal approach using SysML for capturing functional requirements in avionics domain

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Chinese Journal of Aeronautics 2019年第12期32卷 2717-2726页

作者： Shaofan ZHU Jian TANG Jean-marie GAUTHIER Raphael FAUDOU Beijing Aeronautical Science and Technology Research Institute COMACBeijing 102211China Samares-Engineering Blagnac 31700France

In this work,a Model-Based Systems Engineering approach based on Sys ML is *** approach is used for the capture and the definition of functional requirements in avionics *** motivation of this work is triple:guide the capture of functional requirements,validate these functional requirements through functional simulation,and verify efficiently the consistency of these functional *** proposed approach is decomposed into several steps that are detailed to go from conceptual model of avionics domain to a formal functional model that can be simulated in its operating *** achieve this work,a subset of Sys ML has been used as an intermediate modelling language to ensure progressive transformation that can be understood and agreed by system *** concepts are introduced to ensure theoretical consistency of the *** addition,transformation rules are defined and the mappings between concepts of ARP4754 A civil aircraft guidelines and Sys ML are formalized through *** resulting formalization enables engineers to perform functional simulation of the top-level functional architecture extracted from operational ***,the approach has been tested on an industrial avionics system called the Onboard Maintenance System.

关键词： Avionics systems Conceptual model Functional simulation Model-Based Systems Engineering