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Zygotic chromosomal structural aberrations after paternal drug treatment

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Asian Journal of Andrology 2015年第6期17卷 939-941页

作者： Anne marie Downey bernard Robaire Departments of Pharmacology and Therapeuticsand of Obstetrics and Gynecology McGill UniversityMontreal Quebec Canada.

In recent years, the field of male-mediated reproductive toxicology has received growing attention. It is now well-established that many drugs, chemicals, and environmental factors can harm male germ cells by inducing DNA damage. Male germ cells have extensive repair mechanisms that allow detection and repair of damaged DNA during the early phases of spermatogenesis. However, during the later phase of spermiogenesis, when the haploid spermatids undergo chromatin condensation and become transcriptionally quiescent, their ability to repair damaged DNA is lost. It is also thought that the highly compacted chromatin of the sperm can protect DNA against damage. Therefore, it is expected that late spermatids will be most susceptible to DNA damaging agents. Unrepaired or misrepaired damage in the germ cells leads to the generation of spermatozoa with DNA damage that can be transmitted to the next generation. Fortunately, the maternal DNA repair machinery is capable of recognizing and repairing, at least to some degree, damaged paternal DNA after fertilization in the zygote. Therefore, the efficiency of the maternal repair machinery will greatly influence the risk of transmitting paternal DNA damage to offspring.

关键词： Zygotic chromosomal treatment

Density Results in Sobolev Spaces Whose Elements Vanish on a Part of the Boundary

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 823-846页

作者： Jean-marie Emmanuel bernard Laboratoire Analyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of W m,r of functions that vanish on a part γ 0 of the *** author gives a crucial estimate of the Poincar'e constant in balls centered on the boundary of γ ***,the convolution-translation method,a variant of the standard mollifier technique,can be used to prove the density of smooth functions that vanish in a neighborhood of γ 0,in this *** result is first proved for m=1,then generalized to the case where m ≥ 1,in any dimension,in the framework of Lipschitz-continuous ***,as may be expected,it is needed to make additional assumptions on the boundary of γ 0,namely that it is locally the graph of some Lipschitz-continuous function.

关键词： Sobolev空间边界密度元素光滑函数连续函数子空间彭加勒

New steering mechanism for wheeled mobile robots

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Journal of Harbin Institute of Technology(New Series) 2007年第2期14卷 184-188页

作者： Sidibe marie bernard 付宜利徐贺马玉林 School of Mechanical and Electrical Engineering Center of Advanced Manufacturing Technology Harbin Institute of Technology

A new castor wheel mechanism for omni-directional mobile platform is presented. A motion of translation is transformed into a rotation to steer the wheel with the help of a helical path fits into a translation joint and three rollers whose axes are connected to the driving shaft of the wheel. When the path moves in translation it acts on the rollers for steering. The path-roller friction transmission, the wheel kinematics and the maneuverability have been analyzed.

关键词：轮式移动机器人转向机构可操作性机动性螺旋路径

Digital Twin-Assisted Semi-Federated Learning Framework for Industrial Edge Intelligence

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China Communications 2024年第5期21卷 314-329页

作者： Wu Xiongyue Tang Jianhua marie Siew Shien-Ming Wu School of Intelligent Engineering South China University of TechnologyGuangzhou 511442China Electrical and Computer Engineering Department Carnegie Mellon UniversityPittsburghPA 15213United States

The rapid development of emerging technologies,such as edge intelligence and digital twins,have added momentum towards the development of the Industrial Internet of Things(IIo T).However,the massive amount of data generated by the IIo T,coupled with heterogeneous computation capacity across IIo T devices,and users’data privacy concerns,have posed challenges towards achieving industrial edge intelligence(IEI).To achieve IEI,in this paper,we propose a semi-federated learning framework where a portion of the data with higher privacy is kept locally and a portion of the less private data can be potentially uploaded to the edge *** addition,we leverage digital twins to overcome the problem of computation capacity heterogeneity of IIo T devices through the mapping of physical *** formulate a synchronization latency minimization problem which jointly optimizes edge association and the proportion of uploaded nonprivate *** the joint problem is NP-hard and combinatorial and taking into account the reality of largescale device training,we develop a multi-agent hybrid action deep reinforcement learning(DRL)algorithm to find the optimal *** results show that our proposed DRL algorithm can reduce latency and have a better convergence performance for semi-federated learning compared to benchmark algorithms.

关键词： digital twin edge association industrial edge intelligence(IEI) semi-federated learning

Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance Service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia

A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins

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Journal of Renewable Materials 2024年第3期12卷 397-425页

作者： Antonio Pizzi marie-Pierre Laborie Zeki Candan LERMAB University of LorraineFaculty of SciencesBlvd des AiguillettesNancy54000France Chair of Forest Biomaterials Institute of Earth and Environmental SciencesUniversity of FreiburgFreiburgGermany Freiburg Materials Research Center Alberst Ludwig University of FreiburgFreiburg79104Germany Department of Forest Products Engineering Faculty of ForestryIstanbul UniversitySariyerIstanbul34473Turkey

Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based *** are a definite class of sustainable materials of the forestry *** have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several *** review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and *** constitutes a basic but essential summary of what is necessary to know of these sustainable *** doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses.

关键词： Tannins flavonoids sources extraction methods analysis methods

SmartMicro Grid Energy System Management Based on Optimum Running Cost for Rural Communities in Rwanda

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Energy Engineering 2024年第7期121卷 1805-1821页

作者： Fabien Mukundufite Jean marie Vianney Bikorimana Alexander Kyaruzi Lugatona Electrical and Electronic Engineering Department University of RwandaKigaliRwanda Electrical Engineering Department University of Dar es SalaamDar es SalaamTanzania

The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by ***,the aforementioned goal is challenged by households that are scattered in remote *** far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural *** have continuous constraints to meet electricity demands and cannot run income-generating *** current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case *** renewable energy resources available in Remera are the key sources of electricity in that *** generation capacity is estimated based on the load *** microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum *** analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public *** microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to *** considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.

关键词： Load demand load profile optimum running cost power demand satisfaction smart meters and smart micro grid

Development of PROTACS degrading KRAS and SOS1

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Oncology Research 2024年第8期32卷 1257-1264页

作者： GERHARD HAMILTON marie-THERESE EGGERSTORFER SANDRA STICKLER Institute of Pharmacology Medical University of ViennaVienna1090Austria

The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung ***,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of ***,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 *** approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of ***,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal *** of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not *** CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental *** to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin *** highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.

关键词： Proteolysis-targeting chimeras(PROTACs) Kirsten rat sarcoma virus(KRAS) Son of sevenless 1(SOS1) Von Hippel-Lindau Cereblon

Analysis of mid-spatial frequency wavefront distortions from a liquid-cooled flash-lamp pumped Nd:phosphate laser amplifier

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High Power Laser Science and Engineering 2024年第1期12卷 24-29页

作者： Pierre-marie Dalbies Sandy Cavaro Edouard Bordenave Nathalie Blanchot Julien G.Moreau Jérôme Neauport CEA CESTA Le BarpFrance

Mid-spatial frequency wavefront deformation can be deleterious for the operation of high-energy laser systems. When fluid cooled high-repetition-rate amplifiers are used, the coolant flow is likely to induce such detrimental mid-spatial frequency wavefront deformations. Here, we describe the design and performance of a 90 mm × 90 mm aperture, liquid-cooled Nd:phosphate split-slab laser amplifier pumped by flash-lamps. The performance of the system is evaluated in terms of wavefront aberration and gain at repetition rates down to 1 shot per minute. The results show that this single cooled split-slab system exhibits low wavefront distortions in the medium to large period range, compatible with a focus on target, and despite the use of liquid coolant traversed by both pump and amplified wavelengths. This makes it a potential candidate for applications in large high-energy laser facilities.

关键词： flash-lamp pumping high-power laser laser cooling neodymium glass wavefront error