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人类生命早期暴露组(HELIX)：项目理念与设计(续完)

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环境与职业医学 2015年第2期32卷 186-190页

作者： Martine Vrijheid Rémy Slama Oliver Robinson Leda chatzi Muireann coen Peter van den Hazel cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana celine Brochot Luca Bucchini Mariona Bustamante Angel carracedo maribel casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector c.Keun Manolis Kogevinas Rosemary R.c.McEachan Helle Margrete Meltzer Eduard Sabidó per E.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 centre for Research in Environmental Epidemiology(cREAL) Universitat Pompeu Fabra(UPF) cIBER Epidemiologíay Salud Pública(cIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of crete(UOc) HeraklionCreteGreece Imperial college London(IcL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Sensing & control Systems S.L.(S&c) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates consulting S.R.L.(HYLO) RomeItaly centre for Genomic Regulation(cRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de CompostelaSantiago de CompostelaSpain center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddahKingdom of Saudi Arabia Vytauto Didziojo Universitetas(VDU) KaunusLithuania Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT)

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的... 详细信息

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统（GIS）（Beelen等，2013;Eeflens等，2012）、遥感（Dadvand等，2012）和智能手机技术（deNazelle等，2013）使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。

关键词：早期暴露人类生命地理信息系统设计空气污染测量误差体力活动建筑环境

Antioxidant capacity and Bioaccessibility of Synergic Mango (cv. Ataulfo) Peel Phenolic compounds in Edible coatings Applied to Fresh-cut Papaya

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Food and Nutrition Sciences 2015年第3期6卷 365-373页

作者： Gustavo Rubén Velderrain-Rodríguez maribel Ovando-Martínez Mónica Villegas-Ochoa Jesús Fernando Ayala-Zavala Abraham Wall-Medrano Emilio álvarez-Parrilla Tomás Jesús Madera-Santana Humberto Astiazarán-García Orlando Tortoledo-Ortiz Gustavo Adolfo González-Aguilar coordinación en Tecnología de Alimentos de Origen Vegetal Centro de Investigación en Alimentación y Desarrollo Hermosillo México Instituto de ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Chihuahua México Departamento de Nutrición Humana Coordinación de Nutrición Centro de Investigación en Alimentación y Desarrollo Hermosillo México

Edible coatings (Ec) applied to fresh-cut fruits are used to increase their shelf-life and to deliver antioxidant bioactives such as phenolic compounds (Pc) that reduce their oxidative damage while enhance their functional value. However, the combination of different Pc may have synergetic, additive or antagonic effects on the final antioxidant capacity (AOXc). The aim of this study was to examine the AOXc of binary combinations of selected Pc from mango peel and their bioaccessibility from 6% alginate-based Ec applied to fresh-cut papaya, under simulated gastrointestinal conditions. Among equimolar (0.1 mM) combinations, gallic + protocatechuic acids (AB) were synergic in radical scavenging activity (RSA) as assayed by DPPH (90% RSA) and FRAP (0.39 mg TE/mL) methods;when assayed in 6% alginate-based Ec, their RSA increased (117.85% RSA, 0.88 mg TE/mL). The application of Ec + AB to papaya cubes and further in vitro digestion decreased their AOXc probably due to interactions between Ec and papaya’s matrix. Therefore, further studies are needed in order to evaluate the effect of combination of phenolic and Ec applied in other fruits matrix on antioxidants bioaccessibility.

关键词： Edible coating Phenolic Acids Antioxidant capacity Bioaccessibility

上颌4颗切牙缺失的种植修复：一种平台转换的治疗设计

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中国口腔医学继续教育杂志 2012年第4期15卷 193-198页

作者： Xavier Vela-Nebot Victor Mdndez-Blanco Xavier Rodriguez-ciurana maribel Segala-Torres Jaime A. Gil-Lozano 蒋析(译) 陈波(审) 北京大学口腔医学院种植科北京市海淀区中关村南大街22号 100081

选择种植修复的患者，关注的不是种植体，而是种植体所支持的修复体的功能与美观效果，同时希望尽可能提高性价比和缩小手术创伤。如今，上颌前牙种植修复体的美学效果已经能做到非常逼真．和天然牙难以区分。因此．在评估种植修复体时... 详细信息

选择种植修复的患者，关注的不是种植体，而是种植体所支持的修复体的功能与美观效果，同时希望尽可能提高性价比和缩小手术创伤。如今，上颌前牙种植修复体的美学效果已经能做到非常逼真．和天然牙难以区分。因此．在评估种植修复体时，要将其与传统牙支持式固定桥在美学和功能上进行比较。种植修复上颔切牙缺失是口腔种植学中最具挑战性的工作之一。种植体的数目和种植体的位置对于能否获得最佳的最终修复效果尤其重要。本文阐述将2颗平台转换的种植体植入到中切牙的位置，使修复体获得足够的生物机械性能和最佳的美学效果。

关键词：种植修复体切牙缺失上颌前牙种植体植入设计治疗美学效果口腔种植学

INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(待续)

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环境与职业医学 2016年第8期33卷 820-825页

作者： maribel casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群金泰廙 centre for Research in Environmental Epidemiology(cREAL) Universitat Pompeu Fabra(UPF) cIBER Epidemiologíay Salud Pública(cIBERESP) Department of Analytical chemistry University of Cordoba ISGlobal Barcelona Centre for International Health Research(CRESIB)Hospital Clínic-Universitat de Barcelona Instituto de Investigación Biosanitaria de Granada(Granada.ibs) University of Granada Foundation for the Promotion of Health and Biomedical Research in the Valencian Region FISABIO/CSISP Universidad de Valencia Hospital del Mar Medical Research Institute(IMIM)

[背景]产前暴露于双酚A（BPA）及邻苯二甲酸酯会影响胎儿发育；然而该类研究很少，且得出的结果不一致。[目的]对一个西班牙出生队列中488对母婴进行研究，评估产前暴露于BPA及邻苯二甲酸酯是否与胎儿发育相关。[方法]检测第一和第三孕... 详细信息

[背景]产前暴露于双酚A（BPA）及邻苯二甲酸酯会影响胎儿发育；然而该类研究很少，且得出的结果不一致。[目的]对一个西班牙出生队列中488对母婴进行研究，评估产前暴露于BPA及邻苯二甲酸酯是否与胎儿发育相关。[方法]检测第一和第三孕期两次尿液样本中BPA及8种邻苯二甲酸酯[4种邻苯二甲酸二（2-乙基己基）酯代谢物（DEHPm），邻苯二甲酸单卞酯（MBzP）以及3种低分子量邻苯二甲酸酯代谢物（LMWPm）]。另外，估计股骨长度（FL）、头围（Hc）、腹围（Ac）、双顶径（BPD）的生长曲线，估计孕期（12—20周，20～34周）的胎儿体重，并测量出生体重、出生长度、出生头围以及胎盘重量。[结果]总体上，结果并不支持孕期暴露于BPA或DEHPm与胎儿发育参数相关。产前MBzP暴露与20～34孕周的FL呈正相关，MBzP浓度每增加一倍，平均FL增加3．7％（95％cI：0．75，6．63％）。MBzP与男婴出生体重呈正相关（48g；95％cI：6，90），但在女婴中没有相关性（-27g；95％cI：-79，25）（交互作用P=0．04）。LMWPm邻苯二甲酸单丁酯（MnBP）与12—20孕周的Hc呈负相关[平均Hc降低了4．88％（95％cI：-8．36，-1．36％）]。[结论]本研究首次将暴露生物标志重复测量值与胎儿期多种发育参数相结合，发现暴露于BPA或邻苯二甲酸酯与胎儿发育不相关。邻苯二甲酸酯代谢物MBzP与MnBP与部分胎儿发育参数相关，但这些结果还需要重复验证。

关键词：邻苯二甲酸酯胎儿发育超声测量出生队列中孕期双酚A 邻苯二甲酸二(2-乙基己基)酯产前暴露

INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)

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环境与职业医学 2016年第9期33卷 919-921页

作者： maribel casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) centre for Research in Environmental Epidemiology(cREAL) Universitat Pompeu Fabra(UPF) cIBER Epidemiología y Salud Pública(cIBERESP) Department of Analytical chemistry University of Cordoba ISGlobal Barcelona Centre for International Health Research(CRESIB)Hospital Clínic-Universitat de Barcelona Instituto de Investigación Biosanitaria de Granada(Granada.ibs) University of Granada Foundation for the Promotion of Health and Biomedical Research in the Valencian Region FISABIO/CSISP Universidad de Valencia Hospital del Mar Medical Research Institute(IMIM) 不详

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周Hc增长降低有显著相关性（-4．88％；95％cI：-8．36，-1．36），且与EFW增长减低也有... 详细信息

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周Hc增长降低有显著相关性（-4．88％；95％cI：-8．36，-1．36），且与EFW增长减低也有显著相关性（-4．32％；95％cI：-8．33，-0．27）（图3及补充材料表S8）。

关键词：胎儿发育邻苯二甲酸酯超声测量双酚A 中孕期队列相关性出生结局

人类生命早期暴露组(HELIX)：项目理念与设计(待续)

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环境与职业医学 2015年第1期32卷 90-95页

作者： Martine Vrijheid Rémy Slama Oliver Robinson Leda chatzi Muireann coen Peter van den Hazel cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana celine Brochot Luca Bucchini Mariona Bustamante Angel carracedo maribel casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector c.Keun Manolis Kogevinas Rosemary R.c.McEachan Helle Margrete Meltzer Eduard Sabidó perE.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 centre for Research in Environmental Epidemiology(cREAL) Universitat Pompeu Fabra(UPF) cIBER Epidemiología y Salud Pública(cIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of crete(UOc) Imperial college London(IcL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT) Sensing & control Systems S.L(.S&c) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates consulting S.R.L(.HYLO) centre for Genomic Regulation(cRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de Compostela center of Excellence in Genomic Medicine Research King Abdulaziz University Vytauto Didziojo Universitetas(VDU)

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项... 详细信息

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画"生命早期暴露组"。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。

关键词：人类生命早期暴露设计出生队列研究儿童健康生物标志效应评估生命早期

Dendritic cell deficiencies persist seven months after SARS-coV-2 infection

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cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé carmen Gasca-capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias cesar Sotomayor cristina Roca-Oporto Nuria Espinosa carmen Infante-Domínguez Juan carlos crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel cisneros Sonsoles Salto-Alejandre Judith Berastegui-cabrera Pedro camacho-Martínez carmen Infante-Domínguez Marta carretero-Ledesma Juan carlos crespo-Rivas Eduardo Márquez JoséManuel Lomas claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa cordero Javier Sánchez-céspedes Manuela Aguilar-Guisado Almudena Aguilera clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara cristina Amodeo Javier Ampuero María Dolores Avilés maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel candela caballero-Eraso Macarena cabrera Enrique calderón Jesús carbajal-Guerrero Manuela cid-cumplido Yael corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-castillo Aurora González-Estrada Demetrio González carmen Gómez-González Rocío González-León carmen Grande-cabrerizo Sonia Gutiérrez carlos Hernández-Quiles Inmaculada concepción Herrera-Melero Marta Herrero-Romero Luis Jara carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado carmina López Isabel López Álvaro López-Barrios Luis F.López-cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain cardiology and cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of clinical Investigation and clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome coronavirus(SARS-coV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(Dcs)play a key role in the defense against viral infections,for instance plasmacytoid Dcs(pDcs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In cOVID-19 there is a deficit in Dc numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the Dc deficiency,several Dc activation and homing markers were altered in acute cOVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of cD1c+myeloid Dcs and pDcs seven months after SARS-coV-2 ***,the expression of Dc markers such as cD86 and cD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of cOVID-19.

关键词： SARS-coV-2 cOVID-19 Dendritic cell Long-cOVID