检索结果-南通市图书馆

Hepato-splenic lymphoma:a rare entity mimicking acute hepatitis:A case report

World Journal of Gastroenterology 2003年第6期9卷 1381-1384页

作者： Federico Perfetto Roberto Tarquini Francesco mancuso Simonetta di Lollo Silvia Tozzini Giampiero Bellesi Giacomo Laffi Department of Internal Medicine University of FlorenceItaly Department of Human Pathology and Oncology University of FlorenceItaly Department of Hematology University of FlorenceItaly

We reported a case of non-Hodgkin's lymphoma where liver involvement was the predominant clinical manifestation.A 27-year old man presented wiht markedly elevated serum aspartate aminotrasferase,alanine aminotransferase and lactate dehydrogenase,reduced prothrombin activity,thrombocytopenic purpura and hepato-splenomegaly without ***,toxic, autoimmune and metabolic liver diseases were excluded. Bone marrow biopsy showed an intracapillary infiltration of T-lymphocytes with no evidence of lipid storage disease. Because of a progressive spleen enlargement,splenectomy was *** examination showed lymphomatous intrasinuses invasion of the spleen. Immunohistochemical investigation revealed the T phenotype of the neoplastic cells:CD45+,CD45RO+, CD3+,CD4-,CD8-,TIAl-.About 50 % of the lymphoid cells expressed CD56 *** diagnosis of hepatosplenic T cell lymphoma was *** patient was treated with chemotherapy,which induced a complete *** months later,he had a first relapse with increased aspartate aminotransferase,alanine aminotransferase,lactate dehydrogenase, thrombocytopenic purpura and blast in the peripheral blood. In spite of autologous bone marrow transplantation,he died twenty months after the *** in the absence of a mass lesion or lymphoadenopathy,hepatosplenic T- cell lymphoma should be considered in the differential diagnosis of a patient whose clinical course is atypical for acute hepatic dysfunction.

关键词： Acute Disease Adult Diagnosis, Differential Hepatitis Humans Liver Neoplasms Lymphoma, Non-Hodgkin Male Splenic Neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Will vaccine-derived protective immunity curtail COVID-19 variants in the US?

引用

Infectious Disease Modelling 2021年第1期6卷 1110-1134页

作者： Marina mancuso Steffen E.Eikenberry Abba B.Gumel Arizona State University School of Mathematical and Statistical SciencesTempeAZ85287USA Department of Mathematics and Applied Mathematics University of PretoriaPretoria0002South Africa

Multiple effective vaccines are currently being deployed to combat the COVID-19 pandemic,and are viewed as the major factor in marked reductions of disease burden in regions with moderate to high vaccination *** effectiveness of COVID-19 vaccination programs is,however,significantly threatened by the emergence of new SARS-COV-2 variants that,in addition to being more transmissible than the wild-type(original)strain,may at least partially evade existing vaccines.A two-strain(one wildtype,one variant)and two-group(vaccinated or otherwise)mechanistic mathematical model is designed and used to assess the impact of the vaccine-induced cross-protective efficacy on the spread the COVID-19 pandemic in the United *** analysis of the model shows that,in the absence of any co-circulating SARS-CoV-2 variant,the vaccine-derived herd immunity threshold needed to eliminate the wild-type strain can be achieved if 59%of the US population is fully-vaccinated with either the Pfizer or Moderna *** threshold increases to 76%if the wild-type strain is co-circulating with the Alpha variant(a SARS-CoV-2 variant that is 56%more transmissible than the wild-type strain).If the wild-type strain is co-circulating with the Delta variant(which is estimated to be 100%more transmissible than the wild-type strain),up to 82%of the US population needs to be vaccinated with either of the aforementioned vaccines to achieve the vaccine-derived herd *** sensitivity analysis of the model reveal the following four parameters as the most influential in driving the value of the reproduction number of the variant strain(hence,COVID-19 dynamics)in the US:(a)the infectiousness of the co-circulating SARS-CoV-2 variant,(b)the proportion of individuals fully vaccinated(using Pfizer or Moderna vaccine)against the wild-type strain,(c)the cross-protective efficacy the vaccines offer against the variant strain and(d)the modification parameter accounting for the reduced infectio

关键词： COVID-19 Vaccine Wild-type Variant Reproduction number Herd immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heminephrectomy for a large renal mass in a horseshoe kidney: A case report outlining a robotic assisted laparoscopic approach

引用

Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 78-81页

作者： Matthew mancuso Benjamin B.Beech David W.Chapman Blair St Martin Faculty of Medicine and Dentistry University of AlbertaEdmontonT6G 2R7Canada Division of Urology Department of SurgeryUniversity of AlbertaEdmontonT6G 2R7Canada

With an incidence of 1/500,a horseshoe kidney is not *** discovered in horseshoe kidney however are quite rare,and prove difficult to surgically manage due to complex vascular *** variable surgical approaches previously described,only a select few robot-assisted cases have been *** case describes one such robot-assisted laparoscopic heminephrectomy,with the use of indocyanine green and an endovascular stapler to successfully demarcate ischemia and achieve hemostasis *** complications were encountered,and pathology revealed a pT1bN0 clear cell renal cell carcinoma with negative surgical margins,demonstrating the feasibility of our approach.

关键词： Horseshoe kidney Robot-assisted Laparoscopic Partial nephrectomy Tumour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of portopulmonary hypertension:New perspectives

引用

World Journal of Gastroenterology 2013年第45期19卷 8252-8257页

作者： Luigi mancuso Francesca Scordato Michela Pieri Eliana Valerio Andrea mancuso Department of Cardiologia Ospedale Cervello90100 Palermo Italy Cardiologia Clinica Candela 90100 Palermo Italy Epatologia e Gastroenterologia Ospedale Niguarda Cà Granda Milano 20162 Milano Italy Medicina Interna 1 ARNAS Civico 90100 Palermo Italy

Portopulmonary hypertension(PPHTN)is a known complication of ***-to-severe PPHTN implies an extremely poor *** occurs in 5%-10%of patients referred for liver transplantation(LT),and probably with an higher incidence in patients with large portosystemic *** with moderate-tosevere pulmonary hypertension have been previously excluded from LT because of the extremely high surgical risk and since the post-transplant outcome reported was ***,new perspectives in the management of patients with portopulmonary hypertension are *** fact,some pulmonary vasoactive drugs have become routine in the treatment of patients with idiopathic pulmonary *** drugs,particularly epoprostenol,have been recently introduced in the treatment of patients with PPHTN,and have been shown to be effective in reducing pulmonary artery pressure as well as pulmonary vascular ***,recent studies seem to demonstrate that treatment with pulmonary vasoactive drugs could allow liver transplantation with acceptable surgical risks and excellent *** there are not large series nor prospective studies addressing this topic,the clinical scenario of patients with PPHTN seems to be positively changing.

关键词： Portopulmonary hypertension Cirrhosis Liver transplantation Management Epoprostenol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An in vitro prototype of a porcine biomimetic testis-like cell culture system： a novel tool for the study of reassembled Sertoli and Leydig cells

引用

Asian Journal of Andrology 2018年第2期20卷 160-165页

作者： Iva Arato Giovanni Luca Francesca mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore Department of Experimental Medicine University of Perugia Perugia 06100 Italy Division of Medical Andrology and Endocrinology of Reproduction University of Perugia and Saint Mary Hospital Terni 05100 Italy Department of Internal Medicine and Pediatrics Morsani College of Medicine University of South Florida Tampa 33612 FL USA Division of Endocrinology Fondazione Policlinico Universitario 'A. Gemelli' 00168 Rome Italy Department of Medicine University of Perugia Perugia 06100 Italy

At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors （testicular cross-talk）, mainly orchestrated by gonadotropins such as luteinizing hormone （LH） and follicle-stimulating hormone （FSH） that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells. We have evaluated Sertoli and Leydig cells obtained from 15- to 20-day-old neonatal pig testes in terms of purity and function. Subsequently, purified Sertoli and enriched Leydig cells were subjected to coincubation to obtain an in vitro prepubertal porcine testis-like culture system. We performed enzyme-linked immunosorbent assay （ELISA） for anti-Mullerian hormone （AMH）, inhibin B, and testosterone secretion in the medium, and Real-lime PCR analysis of AMH, inhibin B, FSH-r, aromatase, LHr, and 3βHSD mRNA expression levels. This in vitro testis-like system was highly responsive to the effects of human gonadotropins and testosterone. AMH mRNA expression and secretion declined, and inhibin-B increased, while FSH-receptor expression was downregulated upon FSH/LH exposure/treatment. Finally, the production of testosterone was increased selectively upon LH treatment. In summary, our proposed model could help to better determine the action of human gonadotropins on Sertoli and Leydig cells. The potential usefulness of the system for shedding light into male infertility-related issues is evident.

关键词： human gonadotropins Leydig cells prepubertal biomimetic testis Sertoli cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Palladium-Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions

引用

Chinese Journal of Chemistry 2023年第23期41卷 3223-3228页

作者： Aleksandr Voronov Francesco Pancrazzi Ana Maria Constantin Raimondo Maggi Raffaella mancuso Bartolo Gabriele Diego Olivieri Carla Carfagna Alessandro Casnati Francesco Rispoli Laura Baldini Nicola Della Ca Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA)University of ParmaParco Area delle Scienze17/A43124 Parma (PR)Italy Center for Energy and Environment (CIDEA) University of ParmaParco Area delle Scienze 181/A43124 Parma (PR)Italy Laboratory of Industrial and Synthetic Organic Chemistry (LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia P.Bucci 12/C87036 Arcavacata di RendeCosenza (CS)Italy Department of Biomolecular Sciences University of Urbino “Carlo Bo”Piazza Rinascimento 661029 Urbino (PU)Italy Department of Industrial Chemistry “T.Montanari” University of BolognaViale Risorgimento 440136 Bologna (BO)Italy

A highly selective palladium-catalyzed carbonylation of 2-alkynylanilines bearing an amide moiety to condensed six-membered heterocyclic structures has been developed under mild conditions(room temperature and atmospheric pressure of CO).The carbonylative protocol is also compatible with CO surrogates,such as benzene-1,3,5-triyl triformate(TFBen)or the newly developed calix[6]arenes functionalized with six formate groups(CLX[6]CO),which are both capable to release CO in situ.A series of tricyclic fused heterocycles containing the important oxazino-quinolinone scaffold have been selectively obtained(only the 6-endo-dig cyclization mode has been observed)in good to excellent yields(up to 99%).

关键词： Pd-catalysis Carbonylation Alkynes CO surrogates 6-endo-dig Calixarenes C1 building blocks Domino reactions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Volatile organic compound emission and biochemical properties of degraded Ultisols ameliorated by no tillage and liming

引用

Pedosphere 2020年第5期30卷 597-606页

作者： Laura GIAGNONI Cosimo TAITI Paloma LEON Corrado COSTA Paolo MENESATTI Rafael ESPEJO Clara GOMEZ-PACCARD Chiquinquira HONTORIA Eduardo VAZQUEZ Marta BENITO Stefano mancuso Giancarlo RENELLA Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceP.le delle Cascine 18Florence 50144(Italy) Departamento de Production Agraria E.T.S.I.AgrondmicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridAvda.Complutense s/nMadrid 28040(Spain) Consiglio per la Ricerca in Agricoltura e I'Analisi dell'Economia Agraria(CREA)-Unita di Ricerca per ilngegneria Agraria via della Pascolare 16Monterotondo ScaloRM 00015(Italy) Department of Soil Biogeochemistry and Soil Ecology University of BayreuthDr.Hans-Frisch-Strafie 1-3Bayreuth 95448(Germany) University of Padua Department of AgronomyFoodNatural ResourcesAnimals and Environment(DAFNAE)Viale dell'Universita 16Legnaro 35020(Italy)

TTie Ultisols in the Rana de Canamero area in Southwest Spain showed aluminum(Al)phytotoxicity,and the clearance of natural vegetation and decades of intensive conventional agriculture caused the deplation of soil organic matter(SOM).Therefore,we studied the long-term effects of no tillage and liming using sugar beet foam(SF)and red gypsum(RG),alone or in combination,on the restoration of Ultisols affected by acidification,Al phytotoxicity,and SOM *** measured the main soil chemical properties,soil microbial biomass,soil enzyme activities involved in carbon,nitrogen,phosphorus,and sulfur mineralization,and the emission of volatile organic compounds(VOCs).The results indicated that liming effectively neutralized the soil acidity in the long term and,in combination with no tillage,significantly increased soil microbial biomass and enzyme ***-three VOCs were detected using the proton transfer reaction-time of flight(PTR-ToF)technique,and both liming and tillage changed the VOC emission *** greatest difference in VOC emission pattern was observed between no-tilled un-amended soils and tilled lime-amended soils,suggesting the activation of different metabolic pathways within the microbial communities of soils under different *** in VOC emission patterns could be attributed to the decomposition of carbohydrates,which were also sustained by the higher enzyme activities in the lime-amended soils.

关键词： carbohydrate decomposition degraded soils long-term field trial soil acidity soil enzyme activities soil microbial biomass soil restoration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A caval homograft for Budd-Chiari syndrome due to inferior vena cava obstruction

引用

World Journal of Hepatology 2013年第5期5卷 292-295页

作者： Andrea mancuso Luigi Martinelli Luciano De Carlis Antonio Gaetano Rampoldi Giovanni Magenta Aldo Cannata Luca Saverio Belli Epatologia e Gastroenterologia Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Cardiochirurgia Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Chirurgia Generale e dei Trapianti Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Radiologia Interventistica Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Cardiologia 3 Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly

Transjugular intrahepatic portosystemic shunt (TIPS) is the standard treatment of Budd-Chiari syndrome (BCS) non responsive to medical therapy. However, patients with inferior vena cava (IVC) obstruction proximal to the atrium do not benefit from TIPS and a surgical approach is mandatory. We report the case of BCS due to intrapericardial IVC obstruction. We describe a novel surgical approach using a fresh caval homograft. An attempt to balloon dilatation of the IVC obstruction was complicated by right atrial disruption with tamponade and ventricular fibrillation. Lately, the patient successfully underwent a reconstruction of the cavo-atrial continuity by the interposition of a fresh caval homograft, a novel surgical approach never described before for BCS. Further follow-up revealed progressive reduction and resolution of ascites, and overall clinical improvement. IVC obstruction near to the atrium can be surgically approached with a new technique consisting in inferior vena cava resection and replacement with a caval homograft.

关键词： Budd-Chiari syndrome Inferior vena cava Occlusion Surgery Liver transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular carcinoma in thalassemia:A critical review

引用

World Journal of Hepatology 2010年第5期2卷 171-174页

作者： Andrea mancuso Emergency Area Ospedali Riuniti di Sciacca(Ag)

Due to blood transfusions,thalassemics are often infected with either hepatitis C virus(HCV)or hepatitis B virus and often have *** carcinoma(HCC)has emerged in thalassemics only recently as a result of the improvement in thalassemia *** fact,a prospective study estimated an HCC incidence inβ-thalassemia of about 2%.Although data are scanty,HCC screening in thalassemics with risk factors for HCC should be carried *** treatments have some efficacy in HCV infected thalassemics despite partial contraindication to ribavirin and iron ***,there are no data on how HCV treatment translates into HCC *** data suggest that HCC treatment in thalassemics should generally have the same outcomes as in *** coexistence of severe comorbidities makes liver transplantation challenging,this therapeutic possibility should not be precluded for well selected HCCβ-thalassemia *** fact,2 transfusion dependent adult HCCβ-thalassemia patients have recently undergone successful liver transplantation with a good *** conclusion,HCC seems to be a developing issue in thalassemia and HCC screening should be carried *** treatment,including liver transplantation,can be performed in selected patients. A multidisciplinary effort is needed for management.

关键词： Thalassemia Hepatocellular carcinoma Hemochromatosis Screening Complication Liver trans- plantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

To mask or not to mask:Modeling the potential for face mask use by the general public to curtail the COVID-19 pandemic

引用

Infectious Disease Modelling 2020年第1期5卷 293-308页

作者： Steffen E.Eikenberry Marina mancuso Enahoro Iboi Tin Phan Keenan Eikenberry Yang Kuang Eric Kostelich Abba B.Gumel School of Mathematical and Statistical Sciences Arizona State UniversityTempeAZ85287USA

Face mask use by the general public for limiting the spread of the COVID-19 pandemic is controversial,though increasingly recommended,and the potential of this intervention is not well *** develop a compartmental model for assessing the communitywide impact of mask use by the general,asymptomatic public,a portion of which may be asymptomatically *** simulations,using data relevant to COVID-19 dynamics in the US states of New York and Washington,suggest that broad adoption of even relatively ineffective face masks may meaningfully reduce community transmission of COVID-19 and decrease peak hospitalizations and ***,mask use decreases the effective transmission rate in nearly linear proportion to the product of mask effectiveness(as a fraction of potentially infectious contacts blocked)and coverage rate(as a fraction of the general population),while the impact on epidemiologic outcomes(death,hospitalizations)is highly nonlinear,indicating masks could synergize with other nonpharmaceutical ***,masks are found to be useful with respect to both preventing illness in healthy persons and preventing asymptomatic *** mask adoption scenarios,for Washington and New York state,suggest that immediate near universal(80%)adoption of moderately(50%)effective masks could prevent on the order of 17e45%of projected deaths over two months in New York,while decreasing the peak daily death rate by 34e58%,absent other changes in epidemic *** very weak masks(20%effective)can still be useful if the underlying transmission rate is relatively low or decreasing:InWashington,where baseline transmission is much less intense,80%adoption of such masks could reduce mortality by 24e65%(and peak deaths 15e69%),compared to 2e9%mortality reduction in New York(peak death reduction 9e18%).Our results suggest use of face masks by the general public is potentially of high value in curtailing community transmission and the burden

关键词： Face mask Non-pharmaceutical intervention Cloth mask N95 respirator Surgical mask SARS-CoV-2 COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：