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用离子渗碳和离子渗氮的AISI 316L SS钢制备的扩张奥氏体在高温和高能脉冲离子束辐照下的稳定性

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热处理技术与装备 2014年第2期35卷 59-59页

作者： garcía Molleja J Milanese M Piccoli M Moroso R Niedbalski J Nosei L Bürgi J Bemporad E Feugeas J

经离子渗碳或离子渗氮的奥氏体不锈钢制得扩张奥氏体。两种处理都得到过饱和氮或碳的fcc晶体结构，被高度硬化，能提高耐磨性，同时保持原有的耐腐蚀性。

关键词：离子渗氮离子渗碳奥氏体离子束辐照 AISI 316L 高能脉冲钢制

Glutamine or Glutamine Dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 Diabetic Rats

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 398-407页

作者： Silvia Carla S.F.Azevedo Carlos Vinicius D.da Rosa Ana Luiza M.Wunderlich Laís A.Yamada Isabela R.mariano Camila Bataglini Nayra T.D.Branquinho Scarlett R.Raposo Roberto B.Bazotte Edmara A.Baroni Maria Raquel M.Natali Maria Montserrat D.Pedrosa Vilma A.F.de Godoi Program of Graduate Studies in Cell and Molecular Biology State University of MaringáMaringá87020-900Brazil Program of Graduate Studies in Physiological Sciences State University of MaringáMaringá87020-900Brazil Undergraduation in Biological Sciences University Center of MaringáMaringá87050-390Brazil Department of Pharmacology and Therapeutics State University of MaringáMaringá87020-900Brazil Department of Physiological Sciences State University of MaringáMaringá87020-900Brazil Department of Morphological Sciences State University of MaringáMaringá87020-900Brazil

The effects of the supplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progression of the systemic and hepatic metabolic status of rats having untreated type 1 diabetes mellitus(T1DM)were *** Wistar diabetic rats(streptozotocin,60 mg/kg)were allotted to four groups supplemented by gavage for thirty days as follows:control and diabetic receiving saline;diabetic receiving GLN(248 mg/kg);and diabetic receiving GDP(400 mg/kg).Body weight,plasmatic parameters and kidney function were *** hepatocytes were used to assess gluconeogenic *** and kidney were used for morphological analyses.T1DM decreased the number and increased the area of the hepatocytes,possibly because of the observed enlargement of glycogen *** weight,glomerular area and proteinuria increased,and glomerular filtration rate decreased,in non-supplemented T1DM *** area and proteinuria were reversed by both *** T1DM hepatocytes released less glucose,which could have been diverted to glycogen synthesis and secondary glycogenosis observed in T1DM;this was partially reversed by the *** results point to a possible beneficial effect of glutamine on the metabolic and hepatic impairments of T1DM.

关键词： Type 1 diabetes mellitus L-glutamine glutamine dipeptide gluconeogenesis glycogenosis

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欧洲文化统计

中国文化产业评论 2019年第1期27卷 127-152页

作者：文森特·科利-塞拉诺克里斯蒂娜·帕尔多-加西亚玛利亚·卡瓦列尔-塔拉索纳王莹(译) 西班牙瓦伦西亚大学云南大学

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得... 详细信息

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得尤其重要。在此背景下,本文汇编了国际机构在文化统计和测量方面的最新努力,为文化经理人的工作提供便利。具体而言,本文总结了欧洲国家和欧盟层面现有的文化统计资源,其中包括一组欧洲文化观测台的汇总表。

关键词：文化文化统计欧洲统计局国家统计局

语句判断任务:通过可靠的fMRI绘制个体接受性语言映射区域图

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国际医学放射学杂志 2010年第6期 593-593页

作者： A.Sanjuán C.Forn N.Ventura-Campos A.Rodríguez-Pujadas M.garcía-Porcar V.Belloch 李玥巍 Departamento de Psicología Básica Clínica y PsicobiologíaUniversitat Jaume IAvda.Sos Baynats/n12071Castellón de la PlanaSpain

目的测试语句判断(SV)任务可靠地激活接受性语言区的能力。术前评价神经外科病人的语言能力有助于对术后效果的判定。产生语言任务已被成功地详细说明,但是更多矛盾的结果出现在接受性语言映射图中。材料与方法

关键词：功能MRI 接受性语言韦尼克氏区术前偏侧

Pulmonary vein stenosis:Etiology,diagnosis and management

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World Journal of Cardiology 2016年第1期8卷 81-88页

作者： Pablo Pazos-López Cristina garcía-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo Department of Cardiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Department of Radiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Diagnostic Imaging Unit Galaria Empresa Pública de Servicios Sanitarios Hospital do Meixoeiro

Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS.

关键词： Pulmonary vein stenosis Pulmonary vein stenosis etiology Pulmonary vein stenosis causes Pulmonary vein stenosis diagnosis Pulmonary vein stenosis management Pulmonary vein stenosis treatment

Incidenee and time-varying predictors of HIV and sexually transmitted infections among male sex workers in Mexico City

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Infectious Diseases of Poverty 2021年第1期10卷 36-45页

作者： Karla Y.Ganley Marta Wilson-Barthes Andrew R.Zullo Sandra G.Sosa-Rubi Carlos J.Conde-Glez Santa garcia-Cisneros Mark N.Lurie Brandon D.L.Marshall Don Operario Kenneth H.Mayer Omar Galarraga Department of Narrative Medicine Columbia UniversityNew YorkNYUSA Department of Epidemiology School of Public HealthBrown UniversityProvide neeRlUSA Department of Health Services Policyand PracticeSchool of Public HealthBrown University121 South Main StreetBox G-121S-2ProvidenceRl 02912USA National Institute of Public Health(INSP) CuernavacaMorelosMexico Department of Behavioral and Social Science School of Public HealthBrown UniversityProvidenceRlUSA Fenway Health and Harvard University BostonMAUSA.

Background:Male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(HIV).We quantified incidence rates of STIs and identified their time-varying predictors among male sex workers in Mexico ***:From January 2012 to May 2014,male sex workers recruited from the largest HIV clinic and community sites in Mexico City were tested for chlamydia,gonorrhea,syphilis,hepatitis,and HIV at baseline,6-months,and *** nee rates with 95%bootstrapped confide nee limits were *** examined potential timevarying predictors using generalized estimating equations for a population averaged ***:Among 227 male sex workers,median age was 24 and baseline HIV prevalence was 32%.Incidence rates(per 100 person-years)were as follows:HIV[5.23;95%confidence interval(CI):2.15-10.31],chlamydia(5.15;95%CI:2.58-9.34),gonorrhea(3.93;95%CI:1.88-7.83),syphilis(13.04;95%CI:8.24-19.94),hepatitis B(2.11;95%CI:0.53-4.89),hepatitis C(0.95;95%CI:0.00-3.16),any STI except HIV(30.99;95%CI:21.73-40.26),and any STI including HIV(50.08;95%CI:37.6062.55).In the multivariable-adjusted model,incident STI(excluding HIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95%CI:0.00-0.68)compared to those who reported inconsistently using condoms during anal and vaginal ***:Incidence of STIs is high among male sex workers in Mexico *** condom use is an important protective factor for STIs,and should be an important comp on ent of interventions to prevent incide nt infect i ons.

关键词： Male sex worker Men who have sex with men HIV Sexually transmitted infection Transmission Risk factor Mexico

非增强CT预测阴性结石病人输尿管结石的发生

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国际医学放射学杂志 2012年第6期 604-604页

作者： A.Ciudin M.P.Luque Galvez R.Salvador Izquierdo A.Franco de Castro E.garcia-Cruz J.Alcover garcía 赵阳 Urology Department Hospital Clínic BarcelonaCalle Villarroel 17008036 BarcelonaSpain

目的确定非增强CT(uCT)能否在肾结石形成前发现肾乳头内的钙沉积。方法回顾性分析413例结石病例,确定其中31例有输尿管结石病史且uCT可显示结石,而在结石形成前的uCT检查无阳性发现的病人(结石正在成形组)。设立对照组(31例),由无结石... 详细信息

目的确定非增强CT(uCT)能否在肾结石形成前发现肾乳头内的钙沉积。方法回顾性分析413例结石病例,确定其中31例有输尿管结石病史且uCT可显示结石,而在结石形成前的uCT检查无阳性发现的病人(结石正在成形组)。设立对照组(31例),由无结石病史且uCT检查无阳性发现的活体肾捐献者组成。所有CT检查中,在肾乳头尖端和相邻区均使用两个大小分别为0.05cm2和0.1cm2的兴趣区进行CT衰减测量。两组间的统计学对照采用t检验及配对t检验。结果结石正在成形组肾乳头顶部的CT衰减较高,与对照组对比的结果为45.2HU:32.1HU,P=0.001,结石正在成形组的肾乳头顶部的CT衰减甚至高于已形成结石的病例,其结果显示为44.2HU:32.1HU,P=0.003。而肾乳头的衰减在结石形成前组和已形成结石组没有显著差别(45.2HU:44.2HU,P=0.82)。结论即使在结石形成前,结石正在成形期的病人肾乳头显示更高的密度。此结果可帮助诊断那些正处于结石形成过程中的高危人群。

关键词：结石病肾结石肾钙斑 CT平扫肾乳头

肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)

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中华神经外科疾病研究杂志 2010年第1期9卷 22-22页

作者： Maria Stella Carro Wei Keat Lim mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone

The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.

关键词：脑瘤细胞分子生理学临床分析

肿瘤治疗后灌注参数改变有助于预测高级别星形细胞瘤病人的生存期

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国际医学放射学杂志 2017年第5期 617-617页

作者： R.Sanz-Requena A.J.Revert-Ventura G.garcía-Martí F.Salamé-Gamarra A.Pérez-Girbés E.Mollá-Olmos 华蓓 Radiology Department Hospital Quirónsalud Valencia

摘要目的高级别胶质瘤的肿瘤血管特征及瘤周体积随治疗而改变。本研究评估以T2*加权灌注参数变化为预测因子预测总生存期（OS）。方法纳入45例经组织学证实的高

关键词：高级别星形细胞瘤生存期灌注参数