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Allograft artery mycotic aneurysm after kidney transplantation: A case report and review of literature

World Journal of Clinical Cases 2020年第5期8卷 912-921页

作者： Marco Bindi mariano Ferraresso Maria Letizia De Simeis Nicholas Raison Laura Clementoni Serena Delbue Marta Perego Evaldo Favi Renal Transplantation Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy Department of Clinical Sciences and Community Health University of MilanMilan 20122Italy MRC Centre for Transplantation King’s College LondonLondon WC2R 2LSUnited Kingdom Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20100Italy

BACKGROUND Allograft artery mycotic aneurysm(MA)represents a rare but life-threatening complication of kidney *** is widely considered the safest *** to the rarity of the disease and the substantial risk of fatal consequences,experience with conservative strategies is *** date,only a few reports on surgical repair have been *** describe a case of true MA successfully managed by aneurysm resection and arterial *** SUMMARY An 18-year-old gentleman,on post-operative day 70 after deceased donor kidney transplantation,presented with malaise,low urinary output,and worsening renal *** organ preservation fluid cultures,collected at the time of surgery,were positive for Candida *** ultrasound and contrastenhanced computer tomography showed a 4-cm-sized,saccular aneurysm of the iuxta-anastomotic segment of the allograft artery,suspicious for *** lesion was wide-necked and extended to the distal bifurcation of the main arterial branch,thus preventing endovascular stenting and *** multidisciplinary discussion,the patient underwent surgical exploration,aneurysm excision,and re-anastomosis between the stump of the allograft artery and the internal iliac *** procedure was *** and microbiology evaluation of the surgical specimen confirmed the diagnosis of MA caused by Candida *** years after the operation,the patient is doing very well with excellent allograft function and no signs of recurrent *** Surgical repair represents a feasible option in carefully selected patients with allograft artery ***-fungal prophylaxis is advised when preservation fluid cultures are positive.

关键词： Aneurysm Candida Kidney transplant Infection Complication Case report

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巴拿马城波尔地区的社区再生研究

巴拿马城波尔地区的社区再生研究

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作者： ASTRID valdes 北京交通大学

学位级别：硕士

通过对旅游者和当地居民的调查,本研究调查了巴尔博亚大道作为世界遗产保护区提出的建议。调查显示,游客被古老殖民地建筑的外墙所吸引,这些建筑经过精心修复。相比之下,巴拿马人更多地依赖于新的建筑结构,这些建筑结构促进了该地区的... 详细信息

通过对旅游者和当地居民的调查,本研究调查了巴尔博亚大道作为世界遗产保护区提出的建议。调查显示,游客被古老殖民地建筑的外墙所吸引,这些建筑经过精心修复。相比之下,巴拿马人更多地依赖于新的建筑结构,这些建筑结构促进了该地区的活动和生活方式,并且由于保护而减少了。规划当局主要集中在经济可行性问题上,并赞成增加经济流量的商业活动。因此,巴拿马人认为保护“博物馆化”或使“精英”鼓励旅游业,未能保存真正的遗产并回应社区的实际需求。中美洲主要城市的数量,在1821年独立后成为中美洲共和国的首都,大部分位于殖民地区的内陆地区。巴拿马作为例外,从一开始就把他的首都(巴拿马城)建成海边,作为向南美洲的一个重要贸易点,使其成为独特的一个方面。这项工作侧重于使用定性方法进行实地研究,使用直接观察工具,实地记录和文件审查来分析现场。当电网成为大规模再生的对象时,无论传统特征如何,对城市结构的破坏使得保护过程变得相当困难;与城市原始组织同情的温和转变为核心生存和适当保护提供了巨大潜力。由此,本文提出了一种新的城市保护观,更关注保留旧城的本质,或者保留这个地方的“空间精神”,而不是无论城市如何都无法挽救个别建筑物或空间。他们可以在其中发挥作用和生存的环境。

关键词：城市再生城市保护巴尔博亚大道转型太平洋沿岸

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L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin

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World Journal of Gastroenterology 2011年第39期17卷 4414-4420页

作者： Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri mariano Malaguarnera Giovanni Li Volti Fabio Galvano Department of Biological Chemistry Medical Chemistry and Molecular BiologyUniversity of Catania Department of Internal Medicine and Systemic Disease University of Catania Research Center"The Great Senescence" University of Catania

AIM：To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus（HCV）in treatment with Interferonα（IFN-α）plus ***：Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two *** A（n=35）received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B（n=34）received Peg-IFN-αand ribavirin for 12 *** patients underwent laboratory investigations including：red cell count,he-moglobin,white cell count,platelets,bilirubin,alanineaminotransferase（ALT）,aspartate aminotransferase（AST）,and ***：After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8（IU/L;P0.001）,ALT *** 112.3（IU/L;P 0.001）,viremia 4.04 vs 2.36（106 copies/mL;P 0.001）,Hb 1 vs 3.5（g/dL;P0.05）,red blood cells 0.3 vs 1.1（1012/L;P0.001）,white blood cells 1.5 vs 3（10/L;P0.001）and platelets 86 vs 85（×10/L;P0.001）.The end treatment responders were 18 vs 12（60%vs 44%）and the non responders were 12 vs 15（40%vs 50%）[odds ratio（OR）1.65,5%CI =0.65-5.37,*** group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients（50%vs25%）,while the relapsers were 3 vs 5（10%vs 18%）（OR 3.57,5%CI=0.65-1.3,P0.001）.CONCLUSION：L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sus-tained virological response while preventing overtreat-ment.

关键词： L-carnitine Chronic hepatitis C Anemia In-terferon

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The global climate monitor system:from climate data-handling to knowledge dissemination

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International Journal of Digital Earth 2019年第4期12卷 394-414页

作者： Juan mariano Camarillo-Naranjo José Ignacio Álvarez-Francoso Natalia Limones-Rodríguez María Fernanda Pita-López Mónica Aguilar-Alba Department of Physical Geography and Regional Analysis University of SevilleSevilleSpain Department of Human Geography University of SevilleSevilleSpain

This paper summarizes our work on building a data model and a geovisualization tool that provides access to global climate data:the Global Climate Monitor Web *** to this viewer,a complete set of climate-environmental indicators capable of displaying climate patterns on a global scale that is accessible to any potential user(scientists and laypeople)will be built and published using the same online *** data currently available correspond to the CRU TS3.21 version of the Climate Research Unit(University of East Anglia)database–a product that provides data at a spatial resolution of half of a degree in latitude and longitude,spanning January 1901 to December 2012,on a monthly *** January 2013,the datasets feeding the system have been the GHCN-CAMS temperature dataset and the Global Precipitation Climatology Centre(GPCC)First Guess precipitation ***,hydrologists,planners and non-experts users such as media workers,policymakers,non-profit organizations,teachers or students,can access useful climatological information through the Global Climate Monitor system.

关键词： Geovisualization climate indicators global climate databases open-source software

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Toxicity of Mexican native plant extracts against larvae of Aedes aegypti(Diptera: Culicidae)

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 287-291页

作者： Rosario Ruiz-Guerrero Mario Alberto Rodríguez-Pérez mariano Norzagaray-Campos CIITEC-IPN Cerrada de Cecati S/N. Col. Santa Catarina Azcapotzalco Centro de Biotecnología Genómica-IPN Blvd. Del Maestro S/N Colonia Narciso Mendoza CIIDIR-IPN-Sinaloa Bulevar Juan de Dios Bátiz Paredes No 250 Colonia San Joachin. Guasave

Objective: To evaluate five indigenous Mexican plants [Hippocratea excelsa, Hippocratea celastroides, Argemone mexicana(A. mexicana), Tagetes lucida, and Pseudosmodingium perniciosum(P. perniciosum)] toxicity against the fourth instar larvae of the dengue primary vector, Aedes aegypti(A. aegypti).Methods: Each plant part was treated successively with hexane, ethyl acetate, acetone, and methanol to extract potential active components of the plants against the dengue ***: There was a range of toxicity at 24 or 48 h post-exposure for the different plant parts and organic solvent used(LC50 values ranged between 20 and 890 μg/mL). Extracts from seeds of A. mexicana(hexane washing with methanol and acetone) and stem-bark of P. perniciosum(hexane) showed highest toxicity to Ae. aegypti larvae at 48 h post-exposure(LC50 values were80, 50, and 20 μg/mL, respectively), thus making them potential candidates as *** are on-going to characterize the bioactive components of the extracts, through chromatography, for their use as biological tools for the control of the primary dengue ***: A. mexicana and P. perniciosum are good candidates to combat the dengue vector, Ae. aegypti, as they were highly toxic to the larvae.

关键词： Aedes aegypti Dengue Larvicidal activity Plant organic extracts

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Systematic review of ablative therapy for the treatment of renal allograft neoplasms

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World Journal of Clinical Cases 2019年第17期7卷 2487-2504页

作者： Evaldo Favi Nicholas Raison Federico Ambrogi Serena Delbue Maria Chiara Clementi Luca Lamperti Marta Perego Matteo Bischeri mariano Ferraresso Renal Transplantation Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilan 20122Italy MRC Centre for Transplantation King’s College LondonLondon WC2R 2LSUnited Kingdom Department of Clinical Sciences and Community Health University of MilanMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20100Italy

BACKGROUND To date,there are no guidelines on the treatment of solid neoplasms in the transplanted ***,allograft nephrectomy has been considered the only reasonable *** recently,nephron-sparing surgery (NSS) and ablative therapy (AT) have been proposed as alternative procedures in selected *** To review outcomes of AT for the treatment of renal allograft *** We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 *** was searched in March 2019 without time restrictions for all papers reporting on radiofrequency ablation (RFA),cryoablation (CA),microwave ablation (MWA),high-intensity focused ultrasound (HIFU),and irreversible electroporation (IRE) of solid tumours of the kidney *** original manuscripts describing actual cases and edited in English were *** relevant articles were accessed in full *** searches included all pertinent *** studies were also assessed for methodological quality using a tool based on a modification of the Newcastle Ottawa *** on recipient characteristics,transplant characteristics,disease characteristics,treatment protocols,and treatment outcomes were extracted and *** the nature and the quality of the studies available (mostly retrospective case reports and small retrospective uncontrolled case series),a descriptive summary was *** Twenty-eight relevant studies were selected describing a total of 100 AT procedures in 92 *** age at diagnosis ranged from 21 to 71 years whereas time from transplant to diagnosis ranged from 0.1 to 312 *** of the neoplasms were asymptomatic and diagnosed incidentally during imaging carried out for screening purposes or for other clinical *** diagnostic modality was Doppler-ultrasound scan followed by computed tomography scan,and magnetic resonance *** tumour types were: pa

关键词： Ablative therapy Cryoablation Radiofrequency ablation Microwave ablation High-intensity focused ultrasonography Irreversible electroporation Neoplasm Kidney transplant Renal allograft Systematic review

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto E Muñoz Florencia D Pollarsky Mónica Marino mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Interpenetrated Magnesium-Tricalcium Phosphate Composite:Manufacture,Characterization and In Vitro Degradation Test

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Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 319-325页

作者： mariano Casas-Luna Serhii Tkachenko Miroslava Horynova Lenka Klakurkova Pavel Gejdos Sebastian Diaz-de-la-Torre Ladislav Celko Jozef Kaiser Edgar B. Montufar CEITEC-Central European Institute of Technology Brno University of TechnologyPurkyfnova 656/123612 00 BmoCzech Republic CIITEC-Centro de Investigacion e Innovacion Tecnologica Instituto Politocnico NacionalCerrada de CECATI02250 Mexico CityMexico

Magnesium and calcium phosphates composites are promising biomaterials to create biodegradable load-bearing implants for bone regeneration. The present investigation is focused on the design of an interpenetrated magnesium- tricalcium phosphate （Mg-TCP） composite and its evaluation under immersion test. In the study, TCP porous preforms were fabricated by robocasting to have a prefect control of porosity and pore size and later infiltrated with pure commercial Mg through current-assisted metal infiltration （CAMI） technique. The microstructure, composition, distribution of phases and degradation of the composite under physiological simulated conditions were analysed by scanning electron microscopy, elemental chemical analysis and X-ray diffraction. The results revealed that robocast TCP preforms were full infiltrated by magnesium through CAMI, even small pores below 2 μm have been filled with Mg, giving to the composite a good interpenetration. The degradation rate of the Mg-TCP composite displays lower value compared to the one of pure Mg during the first 24 h of immersion test.

关键词： Calcium phosphate Magnesium Liquid metal infiltration Spark plasma sintering Corrosion

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From leaf to whole-plant water use efficiency(WUE)in complex canopies:Limitations of leaf WUE as a selection target

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The Crop Journal 2015年第3期3卷 220-228页

作者： Hipólito Medrano Magdalena Tomás Sebastià Martorell aume Flexas Esther Hernández Joan Rosselló Alicia Pou José-mariano Escalona Josefina Bota Research Group on Plant Biology under Mediterranean Conditions Department of Biology IMEDEA (CSIC-Universitat de les Illes Balears)Carretera de Valldemossa km 7.5 07122 Palma de Mallorca Spain Institute of Life Science Catholic University of Louvain Place de l'Université 1 B-1348 Louvain-la-Neuve Belgium

Plant water use efficiency(WUE) is becoming a key issue in semiarid areas, where crop production relies on the use of large volumes of water. Improving WUE is necessary for securing environmental sustainability of food production in these areas. Given that climate change predictions include increases in temperature and drought in semiarid regions,improving crop WUE is mandatory for global food production. WUE is commonly measured at the leaf level, because portable equipment for measuring leaf gas exchange rates facilitates the simultaneous measurement of photosynthesis and transpiration. However,when those measurements are compared with daily integrals or whole-plant estimates of WUE, the two sometimes do not agree. Scaling up from single-leaf to whole-plant WUE was tested in grapevines in different experiments by comparison of daily integrals of instantaneous water use efficiency [ratio between CO2assimilation(AN) and transpiration(E); AN/E] with midday AN/E measurements, showing a low correlation, being worse with increasing water stress. We sought to evaluate the importance of spatial and temporal variation in carbon and water balances at the leaf and plant levels. The leaf position(governing average light interception) in the canopy showed a marked effect on instantaneous and daily integrals of leaf WUE. Night transpiration and respiration rates were also evaluated, as well as respiration contributions to total carbon balance. Two main components were identified as filling the gap between leaf and whole plant WUE: the large effect of leaf position on daily carbon gain and water loss and the large flux of carbon losses by dark respiration. These results show that WUE evaluation among genotypes or treatments needs to be revised.

关键词： Water use Drought Intrinsic water use efficiency 13C Instantaneous water use efficiency Whole plant water use efficiency

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Modeling the Effect of Irrigation Practices in Flash Floods: A Case Study for the US Southwest

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Journal of Water Resource and Protection 2012年第7期4卷 415-422页

作者： Cesar Canon-Barriga Juan valdes Hoshin Gupta Department of Civil Engineering and Engineering Mechanics The University of Arizona Tucson USA Department of Hydrology and Water Resources The University of Arizona Tucson USA

Conventional streamflow forecasting does not generally take into account the effects of irrigation practice on the magnitude of floods and flash floods. In this paper, we report the results of a study in which we modeled the impacts of an irrigated area in the US Southwest on streamflow. A calibrated version of the Variable Infiltration Capacity model (VIC), coupled with a routing algorithm, was used to investigate two strategies for irrigating alfalfa in the Beaver Creek watershed (Arizona, USA), for the period January to March of 2010, at a resolution of 1.8 km and hourly time step. By incorporating the effects of irrigation in artificially maintaining soil moisture, model performance is improved without requiring changes in the resolution or quality of input data. Peak flows in the watershed were found to increase by 10 to 500 times, depending on the irrigation scenario, as a function of the strategy and the intensity of rainfall. The study suggests that both flood control and irrigation efficiency could be enhanced by applying improved irrigation techniques.

关键词： Irrigation Practices Flash Flood Events Reference Crop Evapotranspiration Soil Saturation Streamflow Forecasts

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