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Comparison between type-2 and type-1 myocardial infarction：clinical features, treatment strategies and outcomes

Journal of Geriatric Cardiology 2016年第1期13卷 15-22页

作者： Angel Lopez-Cuenca Miriam Gomez-Molina Pedro J Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-Gomez Maria J Sainchez-Galian Esther Guerrero-Perez mariano valdes Sergio Manzano-Femandez Department of Internal Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Division of Cardiology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of lnternal Medicine University of Murcia Murcia Spain

Objective To assess the differences in incidence, clinical features, current treatment strategies and outcome in patients with type-2vs. type-1 acute myocardial infarction （AMI）.Methods We included 824 consecutive patients with a diagnosis of type-1 or type-2 AMI. Dur-ing index hospitalization, clinical features and treatment strategies were collected in detail. At 1-year follow-up, mortality, stroke, non-fatal myocardial infarction and major bleeding were ***-1 AMI was present in 707 （86%） of the cases while 117 （14%） were classified as type-2. Patients with type-2 AMI were more frequently female and had higher co-morbidities such as diabetes, previous non-ST segment elevation acute coronary syndromes, impaired renal function, anaemia, atrial fibrillation and malignancy. However, preserved left ventricular ejection fraction and normal coronary arteries were more frequently seen, an invasive treatment was less common, and anti-platelet medications, statins and beta-blockers were less prescribed in patients with type-2 AMI. At 1-year follow-up, type-2 AMI was associated with a higher crude mortality risk （HR： 1.75, 95% CI： 1.14-2.68;P = 0.001）, but this association did not remain significant after multivariable adjustment （P = 0.785）. Furthermore, we did not find type-2 AMI to be associated with other clinical *** In this real-life population, compared with type-1, type-2 AMI were predominantly women and had more co-morbidities. Invasive treatment strategies and cardioprotective medications were less used in type-2, while the 1-year clinical outcomes were similar.

关键词： Coronary vessels Follow-up studies Myocardial infarction

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A universal additive concept yields record-high efficient organic solar cells

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Science China Materials 2024年第5期67卷 1670-1671页

作者： mariano Campoy Quiles Institute of Materials Science of Barcelona ICMAB-CSICCampus UAB08193BellaterraSpain

Organic photovoltaics(OPVs)are an emerging light-to-electricity conversion technology that promises flexible,lightweight,semitransparent devices based on abundant and non-toxic organic *** power conversion efficiency under one sun has been increasing at an average pace of approximately 1%every year over the past 10 years,up to current values circa 20%.This has been possible through the continuous synthesis of improved semiconductors.

关键词： additive semiconductors approximate

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Introduction of Dr. Andrew V Schally

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Asian Journal of Andrology 2015年第6期17卷 923-924页

作者： Arturo Mendoza-valdes UROLOGO Hospital Medica Sur Puente dePiedra 150 T2-625 Col. Toriello Guerra Tlalpan14050Mexico DF.

Ifirst met Dr. Andrew V Schally （PhD, MDhc （Multi）, DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA） many years ago, probably around the beginning of the 1990＇s in one of his visits to Mexico City （Figure 1）. He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist.

关键词： Introduction Andrew Schally

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Artificial versus Natural Reuse of CO2 for DME Production：Are We Any Closer？

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Engineering 2017年第2期3卷 166-170页

作者： mariano Martin Department of Chemical Engineering University of Salamanca Salamanca 37008 Spain

This work uses a mathematical optimization approach to analyze and compare facilities that either capturecarbon dioxide （CO2） artificially or use naturally captured COs in the form of lignocellulosic biomass towardthe production of the same product, dimethyl ether （DME）. In nature, plants capture COs via photosynthesisin order to grow. The design of the first process discussed here is based on a superstructure optimizationapproach in order to select technologies that transform lignocellulosic biomass into DME. Biomass is gas-ified; next, the raw syngas must be purified using reforming, scrubbing, and carbon capture technologiesbefore it can be used to directly produce DME. Alternatively, CO2 can be captured and used to produce DMEvia hydrogenation. Hydrogen （H2） is produced by splitting water using solar energy. Facilities based on bothphotovoltaic （PV） solar or concentrated solar power （CSP） technologies have been designed; their monthlyoperation, which is based on solar availability, is determined using a multi-period approach. The currentlevel of technological development gives biomass an advantage as a carbon capture technology, since bothwater consumption and economic parameters are in its favor. However, due to the area required for growingbiomass and the total amount of water consumed （if plant growing is also accounted for）, the decision to use biomass is not a straightforward one.

关键词： Solar energy Photovoltaic Concentrated solar power Biomass Water electrolysis Dimethyl ether

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A call for international research on COVID-19-induced brain dysfunctions

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National Science Review 2021年第12期8卷 13-14页

作者： Pedro A.valdes-Sosa Alan C.Evans Mitchell J.valdes-Sosa Mu-ming Poo Global Brain Consortium University of Electronic Sciences and Technology of China (UESTC) Cuban Neuroscience Center (CNEURO) Cuban Academy of Sciences Global Brain Consortium Royal Society of CanadaMc Gill Center for Integrative Neuroscience Mc Gill University Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of Sciences

The COVID-19 pandemic, still raging worldwide, imposes staggering human and economic costs. These will only increase as many convalescent patients suffer consequences for many *** the virus can target multiple organ s...

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Impact of Cascade Disconnection of Distributed Energy Resources on Bulk Power System Stability:Modeling and Mitigation Requirements

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 412-420页

作者： Fabricio Andrade Mourinho Tatiana mariano Lessa Assis Electrical Engineering Department of the Federal University of Rio de Janeiro(COPPE/UFRJ) Rio de JaneiroRJBrazil

This work presents a new approach to establishing the minimum requirements for anti-islanding protection of distributed energy resources(DERs)with focus on bulk power system *** proposed approach aims to avoid cascade disconnection of DERs during major disturbances in the transmission network and to compromise as little as possible the detection of real islanding *** proposed approach concentrates on the rate-of-change of frequency(RoCoF)protection function and it is based on the assessment of dynamic security regions with the incorporation of a new and straightforward approach to represent the disconnection of DERs when analyzing the bulk power system ***,the impact of disconnection of DERs on the Brazilian Interconnected Power System(BIPS)stability is analyzed,highlighting the importance of modeling such disconnection in electromechanical stability studies,even considering low penetration levels of ***,the proposed approach is applied to the BIPS,evidencing its benefits when specifying the minimum requirements of anti-islanding protection,without overestimating them.

关键词： Anti-islanding protection bulk power system stability distributed energy resource(DER) dynamic security region(DSR)

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Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition

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BIOCELL 2022年第6期46卷 1357-1362页

作者： mariano BIZZARRI PAOLA PONTECORVI Department of Experimental Medicine Systems Biology GroupSapienza University of RomeRome00163Italy

The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular *** stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture,namely by fostering symmetry breakings and transitions across different phenotypic *** process induces a wholecoherent adaptive response,involving the reprogramming of biochemical and gene-expression *** characteristics are especially relevant during development,and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological ***,studying how the cytoskeleton can be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area of interest in cancer and developmental biology.

关键词： Cell scaffolding environmental cues non-equilibrium thermodynamics phenotypic reversion cell fate commitment

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Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach

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Neural Regeneration Research 2019年第5期14卷 762-766页

作者： mariano Bisbal Mónica Sanchez Laboratory of Neurobiology Instituto Mercedes y Martín Ferreyra (INIMEC-CONICET) Universidad Nacional de Córdoba Instituto Universitario Ciencias Biomédicas Córdoba

Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.

关键词： rotenone environmental pollutants toxicity neuronal polarity RhoGTPase RhoA Lfc Arhgef1

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Deltas:a new classification expanding Bates's concepts

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Journal of Palaeogeography 2021年第3期10卷 341-355页

作者： Carlos Zavala mariano Arcuri mariano Di Meglio Agustin Zorzano German Otharan Ainara Irastorza Antonela Torresi Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia BlancaArgentina GCS Argentina SRL Molina Campos 1508000 Bahia BlancaArgentina Consejo Nacional de Investigaciones Científicas y Tecnicas (CONICET)Buenos AiresArgentina

Deltas constitute complex depositional systems formed when a land-derived gravity-flow(carrying water and sediments) discharges into a marine or lacustrine standing body of water. However, the complexity of deltaic sedimentary environments has been oversimplified by geoscientists over the years, considering just littoral deltas as the unique possible type of delta in natural systems. Nevertheless, a rational analysis suggests that deltas can be much more complex. In fact, the characteristics of deltaic deposits will depend on a complex interplay between the bulk density of the incoming flow and the salinity of the receiving water body. This paper explores the natural conditions of deltaic sedimentation according to different density contrasts. The rational analysis of deltaic systems allows to recognize three main fields for deltaic sedimentation, corresponding to(1) hypopycnal(2) homopycnal and(3) hyperpycnal delta settings. The hypopycnal delta field represents the situation when the bulk density of the incoming flow is lower than the density of the water in the basin. According to the salinity of the receiving water body, three different types of hypopycnal littoral deltas are recognized: hypersaline littoral deltas(HSLD), marine littoral deltas(MLD), and brackish littoral deltas(BLD). The basin salinity will determine the capacity of the delta for producing effective buoyant plumes, and consequently the characteristics and extension of prodelta *** littoral deltas(HOLD) form when the density of the incoming flow is roughly similar to the density of the water in the receiving basin. This situation is typical of clean bedload-dominated rivers entering freshwater lakes. Delta front deposits are dominated by sediment avalanches. Typical fallout prodelta deposits are absent or poorly developed since no buoyant plumes are generated. Hyperpycnal deltas form when the bulk density of the incoming flow is higher than the density of the water in the receivi

关键词： Deltas Hyperpycnal flows Homopycnal flows Hypopycnal flows Hyperpycnites Turbidites Sediment gravity flows Gravity flows

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Paul Groussac’s Void:The French Writer and the Argentine Tradition

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Journal of Foreign Languages and Cultures 2021年第2期5卷 39-55,156页

作者： mariano Siskind Harvard University

The French-Argentine Paul Groussac embodied a wide range of writerly functions and cultural-political positions within the Argentine cultural field between the 1880s and the 1920s:writer,playwright,chronicler,traveler,literary,art,and music critic,historian,educator,editor,and director of the National Library during 44 *** essay considers his place in the history of Argentine literature looking at two of the many ways in which he inscribed himself in it The first takes up the production and reproduction of the ontological privilege of French identity as a form of legitimization for his public-and often polemic-interventions,through which he sought to establish scholarly-disciplinary practices,protocols,and conventions that would articulate an entire critical field around his own *** second proposes to think his alternatively weak and strong inscriptions in the literary tradition through his own narrative production:his fiction and dramaturgy,travelogues,and biographical *** other words,this essay situates Groussac in an Argentine literary tradition(conceived as an organic and institutionally sanctioned textual corpus)he believed to have founded and established,a selfrepresentation that led Borges to say that Groussac saw himself as“a missionary of Voltaire among the mulattage.”

关键词： universality particularity tradition modernity literary history travel literature

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