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Age,smoking and overweight contribute to the development of intestinal metaplasia of the cardia

World Journal of gastroenterology 2012年第17期18卷 2076-2083页

作者： Christian Felley Hanifa Bouzourene marianne bründler g vanmelle Antoine Hadengue Pierre Michetti gian Dorta Laurent Spahr Emiliano giostra Jean Louis Frossard Service of gastroenterology University Hospital1000 LausanneSwitzerland Institute of Pathology University Hospital1000 LausanneSwitzerland Institute of Social and Preventive Medicine University of Lausanne1000 LausanneSwitzerland Service of gastroenterology Geneva University Hospital1211 GenevaSwitzerland

AIM:To assess the role of Helicobacter pylori(***),gastroesophageal reflux disease(gERD),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia(IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this *** biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of *** and intestinal *** correlation of these factors with the presence of IMC was assessed using logistic ***:IMC was observed in 42% of the *** age,smoking habit and body mass index(BMI) were found as potential contributors to *** risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC = a + s-2B where a = 2,…6 decade of age,s = 0 for non-smokers or ex-smokers,1 for garettes/d,2 for > 10 cigarettes/d and B = 0 for BMI g/m2(BMI g/m2 in females),1 for BMI > 25 kg/m2(BMI > 27 kg/m2 in females).Among potential factors associated with IMC,*** had borderline signif icance(P = 0.07),while gERD showed no signif ***:Age,smoking and BMI are potential factors associated with IMC,while *** and gERD show no significant *** can be predicted in theory by logistic regression analysis.

关键词： Endoscopy gastroesophageal reflux disease Metaplasia Helicobacter pylori Obesity Smoking

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